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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.fernandez-Parrilla David Reyes-Corona Yazmin M.flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava Daniel Martinez-fong departamento de fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia department of Pharmacology Wayne State University School of MedicineDetroitMIUSA departamento de física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico departamento de fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNf)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNf expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNf gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNf in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNf in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNf *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNf gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

Vapor Phase decarbonylation of furfural to furan over Nickel Supported on SBA-15 Silica Catalysts

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Modern Research in Catalysis 2016年第3期5卷 85-94页

作者： Diana Vargas-Hernández Juan Miguel Rubio-Caballero Ramon Moreno-Tost Josefa María Mérida-Robles José Santamaría-González Antonio Jiménez-López María Ana Pérez-Cruz Rosario Hernández-Huesca Pedro Maireles-Torres catedrática conacyt—Universidad de Sonora Hermosillo México departamento de Química Inorgánica Cristalografía y Minerología (Unidad Asociada al ICP-CSIC) Facultad de Ciencias Universidad de Málaga Málaga Spain facultad de ciencias Químicas Benemérita Universidad Autónoma de Puebla Puebla México

Vapor-phase transformations of furfural over SBA-15 silica supported Ni catalysts under H2 in a continuous-flow reactor at atmospheric pressure and 170°C and 230°C were investigated. Two different samples having Ni loadings of 5 and 20 wt% (denoted here by SBA-5Ni and SBA-20Ni, respectively) were prepared by impregnation and characterized by atomic absorption spectroscopy, N2 sorption analysis, X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy. furan and furfuryl alcohol were two primary products resulting, respectively, from decarbonylation and hydrogenation of furfural. Under the conditions of the study, both reactions exhibited structure sensitivity evidenced by changes in product selectivities with variable Ni loadings. Compared with SBA-20Ni, the 5 wt% Ni catalyst showed better catalytic activity, reaching a furfural conversion of 100 mol% and a selectivity to furan of 98 mol%, after 5 h of time-on-stream at 230°C.

关键词： Ni-SBA-15 furfural Hydrogenation furan furfuryl Alcohol

Synthesis of activated carbons from black sapote seeds,characterization and application in the elimination of heavy metals and textile dyes

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Chinese Journal of Chemical Engineering 2020年第2期28卷 613-623页

作者： Alejandra Alicia Peláez-Cid Vincent Romero-Hernández Ana María Herrera-González Alejandro Bautista-Hernández Oscar Coreno-Alonso facultad de Ingeniería Benemérita Universidad Autónoma de PueblaMexico Instituto de ciencias Básicas e Ingeniería Universidad Autónoma del Estado de HidalgoMexico División de Ingenierías Universidad de GuanajuatoMexico

Many different techniques may be used to remove industrial pollutants from wastewater. Adsorption using activated carbon has been reported to be an effective method. This work proposes the use of a vegetable residue(black sapote seeds) as a raw material for its synthesis. These carbons were chemically activated using phosphoric acid and carbonized at 673 and 873 K. Adsorption isotherms were constructed for the textile dyes on the carbons, and this data was treated using Langmuir’s equation to quantitatively describe the adsorption process. The synthesized carbons were characterized using fTIR, EA, SEM, Nitrogen adsorption(specific surface areas of 879 and 652 m2·g-1), and their points of zero charge(2.1 and 2.3). It was possible to adsorb both heavy metals and textile dyes present in aqueous solutions and wastewaters using these activated carbons. Heavy metals were adsorbed almost completely by both carbons. Cationic dyes where adsorbed(58–59.8 mg·g-1) in greater amounts compared to anionic dyes(10–58.8 mg·g-1). The amount of anionic dyes adsorbed increased almost 30% by changing the pH of the solutions. One of the carbons was thermally regenerated on three occasions without losing its adsorption capacity and it was proved in a flow system.

关键词： Activated carbons Black sapote seeds Heavy metal adsorption Textile dye adsorption Wastewater treatment

A DYNAMICS APPROACH TO THE COMPUTATION Of EIGENVECTORS Of MATRICES

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Journal of Computational Mathematics 2005年第6期23卷 657-672页

作者： S. Jiménez L. Vézquez Colaborador honorifico Dept. Matemátiea AplicadaUniversidad Complutense de Madrid 28040 Madrid Spain dept. matemdtica Aplicada Facultad de Informática Universidad Complutense de Madrid 28040 Madrid Spain Centro de Astrobiologla CSIC/INTA 28850 Torrejón de Ardoz Madrid Spain

We construct a family of dynamical systems whose evolution converges to the eigenvectors of a general square matrix, not necessarily symmetric. We analyze the convergence of those systems and perform numerical tests. ... 详细信息

关键词： Smallest real eigenvalue Iterative method

Gromov Hyperbolicity of Periodic Planar Graphs

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Acta Mathematica Sinica,English Series 2014年第1期30卷 79-90页

作者： Alicia CANTóN Ana GRANADOS Domingo PESTANA José Manuel RODRíGUEZ departamento de ciencias Aplicadas a la Ingeniería Naval ETSINUniversidad Politécnica de MadridAvenida Arco de la Victoria4Ciudad Universitaria28040 MadridSpain Mathematics Division St.Louis University (Madrid Campus)Avenida del Valle 348003 MadridSpain departamento de matemáticas Universidad Carlos III de MadridAvenida de la Universidad 308911 LeganésMadridSpain

The study of hyperbolic graphs is an interesting topic since the hyperbolicity of a geodesic metric space is equivalent to the hyperbolicity of a graph related to *** main result in this paper is a very simple charact... 详细信息

关键词： Planar graphs periodic graphs Gromov hyperbolicity infinite graphs geodesics

Recent Advances in Synthesis and Properties of Hybrid Halide Perovskites for Photovoltaics

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Nano-Micro Letters 2018年第4期10卷 167-200页

作者： C.C.Vidyasagar Blanca M.Muoz flores Víctor M.Jimnez Prez Universidad Autónoma de Nuevo León Facultad de Ciencias Químicas Ciudad Universitaria School of Basic Sciences and Research in Chemistry Rani Channamma University

The progress made by the scientific community in emerging photovoltaic technologies over the past two decades has been outstanding. Numerous methods have been developed for the preparation of hybrid organic–inorganic perovskite solar cells. The power conversion efficiency has been up to 14% by a one-step vacuum deposition technique. A serious concern is the toxicity of the materials. In this review, several methods aimed at resolving these problems to some extent have been compiled, including eco-friendly synthesis. further efficiency enhancements are expected following optimization, and a better fundamental understanding of the internal electron charge transfer, electron–hole diffusion to the corresponding layers, flexibility, and stability-dependent bandgaps is reported. This paper explores the green synthesis of organic–inorganic perovskites for industrialization. Concerning the above facts, a simple low-cost model called‘‘dispersed photovoltaic cells' ' is presented.

关键词： Perovskites Solar cells Organic–inorganic perovskites Synthetic routes fluorescence

Alpha Centauri System and Meteorites Origin

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Journal of Applied Mathematics and Physics 2018年第11期6卷 2370-2381页

作者： Gustavo V. López Juan A. Nieto departamento de fsica CUCEI Universidad de Guadalajara Guadalajara México facultad de ciencias fsico-matemáticas de la Universidad Autónoma de Sinaloa Culiacán México facultad de ciencias de la Tierra y el Espacio de la Universidad Autónoma de Sinaloa Culiacán México

We propose a mathematical model for determining the probability of meteorite origin, impacting the earth. Our method is based on axioms similar to both the complex networks and emergent gravity. As a consequence, we are able to derive a link between complex networks and Newton’s gravity law, and as a possible application of our model we discuss several aspects of the Bacubirito meteorite. In particular, we analyze the possibility that the origin of this meteorite may be alpha Centauri system. Moreover, we find that in order for the Bacubirito meteorite to come from alpha Cen and be injected into our Solar System, its velocity must be reduced one order of magnitude of its ejected scape velocity from alpha Cen. There are several ways how this could happened, for example through collision with the Oort cloud objects (located outside the boundary of our Solar System), and/or through collisions within the Solar meteorites belt (located between Mars and Jupiter). We also argue that it may be interesting to study the Bacubirito meteorite from the perspective of the recently discovered Oumuamua object.

关键词： Complex Networks Meteorite origin Alpha Centauri System

Alkyl Thiophene Vinylene Electropolimerization in C<sub>8</sub>mimPf<sub>6</sub>, Potential Use in Solar Cells

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Materials Sciences and Applications 2017年第5期8卷 405-417页

作者： Vania Rojas francisco Martínez Jean Christian Bernède Linda Cattin Guenadez Alexander Efimov Helge Lemmetyinen departamento de Ciencia de los Materiales Facultad de Ciencias Físicas y Matemáticas Universidad de Chile Santiago Chile Lamp Facultè de Sciences et des Tecniques Université de Nantes Nantes France department of Chemistry and Bioengineering Tampere University of Technology Hervanta Finland

We report the electrosynthesis of a novel semiconductor polymer based on alkyl vinylthiophene derivative in the presence of an ionic liquid (IL). The polymerization was performed under galvanostatic conditions and the polymer was studied as potential donor component of a multilayer heterojunction organic solar cell (OSC). The monomer used was (E)-1,2-di-(3-octyl-2-thienyl) vinylene (OTV) and the IL used for the electropolymerization was 1-octyl-3-methylimidazole hexafluorophosphate C8mimPf6. Optical properties, stability and morphology of the polymer were analyzed using fT-IR, UV-vis, Raman and XPS spectroscopy. Voltammetry analysis and scanning electron microscopy (SEM-EDX) were also performed on the polymer. The OSC assembled with the polymer of OTV was used as electro donor and C60 as acceptor. Molybdenum trioxide (MoO3) and bathocuproine (BCP) were used as buffer layer between anode and cathode respectively. I-V curves, in the dark and under AM 1.5 solar simulator were performed to measure its efficiency.

关键词： Conducting Polymer Vinylene Thiophene Ionic Liquids Organic Solar Cells

Scholz’s Third Conjecture: A demonstration for Star Addition Chains

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Applied Mathematics 2013年第10期4卷 1-2页

作者： José Maclovio Sautto Vallejo Agustín Santiago Moreno Carlos N. Bouza Herrera Verónica Campos Guzmán facultad de matemática y Computación Universidad de la Habana Ciudad de La Habana Cuba facultad de matemáticas Universidad Autónoma de Guerrero Guerrero México Universidad Autónoma de Guerrero Unidad Académica de Ciencias y Tecnologías de la Información Guerrero México

This paper presents a brief demonstration of Scholz’s third conjecture [1] for n numbers such that their minimum chain addition is star type [2]. The demonstration is based on the proposal of an algorithm that takes as input the star-adding chain of a number n, and returns a string in addition to x = 2n - 1??of length equal to l (n) + n - 1. As for any type addition chain star of a number n, this chain is minimal demonstrates the Scholz’s third Conjecture for such numbers.

关键词： Addition Chain Exponentiation Short Chain Scholz’s Conjecture