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Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce C V Campbell Marc Fisher Lee H Schwamm Mark Parsons Hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina China National Clinical Research center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and comprehensive Stroke center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)was not inferior to alteplase for ischaemic stroke within *** study aimed to investigate the efficacy and safety of rhTNK-tPA in patients who had an ischaemic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-III(TRACE III)is a multicentre,prospective,randomised,open-label,blind endpoint,controlled clinical *** who had an ischaemic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salvageable tissue(ischaemic core volume6s at 24 hours and NIHSS score change from baseline at *** outcomes are symptomatic intracerebral haemorrhage within 36 hours and mortality at 90 *** TRACE III will provide evidence for the efficacy and safety of rhTNK-tPA in patients who had an ischaemic strokes due to anterior circulation LVO beyond *** registration number NCT05141305.

关键词： Therapy random Rational

The Dynamic Impact of Ocean on Continent

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International Journal of Geosciences 2024年第9期15卷 698-719页

作者： Yongfeng Yang Water Resources comprehensive Development center Bureau of Water Resources of Shandong Province Jinan China

Around 71% of the Earth’s surface is covered by oceans with depths that exceed several kilometers, while continents are geographically enclosed by these vast bodies of water. The principle of fluid mechanics stipulates that water yields pressure everywhere in the container that holds it, and the water pressure against the wall of container generates force. Ocean basins are naturally gigantic containers of water, in which continents form the walls of the containers. In this study, we present that the ocean water pressure against the walls of continents generates enormous force, and determine the distribution of this force around continents and estimate its amplitude to be of the order of 1017 N per kilometer of continent width. Our modelling suggests that the stresses yielded by this force are mostly concentrated on the upper part of the continental crust, and their magnitudes reach up to 2.0 - 6.0 MPa. Our results suggest that the force may have significantly impacted the dynamics of continent (lithospheric plate) and its evolution.

关键词： Ocean Water Pressure Force Continent Ocean-Continent Interaction Stress Earthquake Plate Motion

A Dynamic Coupling of Ocean and Plate Motion

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International Journal of Geosciences 2024年第9期15卷 737-763页

作者： Yongfeng Yang Water Resources comprehensive Development center Bureau of Water Resources of Shandong Province Jinan China

Plate motion representing a remarkable Earth process is widely attributed to several primary forces such as ridge push and slab pull. Recently, we have presented that the ocean water pressure against the wall of continents may generate enormous force on continents. Continents are physically fixed on the top of the lithosphere that has been already broken into individual plates, this attachment enables the force to be laterally transferred to the lithospheric plates. In this study, we combine the force and the existing plate driving forces (i.e., ridge push, slab pull, collisional, and shearing) to account for plate motion. We show that the modelled movements for the South American, African, North American, Eurasian, Australian, Pacific plates are well agreement with the observed movements in both speed and azimuth, with a Root Mean Square Error (RMSE) of the modelled speed against the observed speed of 0.91, 3.76, 2.77, 2.31, 7.43, and 1.95 mm/yr, respectively.

关键词： Ocean Water Pressure Force Ocean-Continent Interaction Plate Driving Force Lithospheric Plate Plate Motion

Reducing language barriers, promoting information absorption, and communication using fanyi

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中华医学杂志(英文版) 2024年第16期137卷 2024 Jul 22页

作者： Wang Difei Chen Guannan Li Lin Wen Shaodi Xie Zijing Luo Xiao Zhan Li Xu Shuangbin Li Junrui Wang Rui Wang Qianwen Yu Guangchuang Nanfang Hospital Southern Medical University Guangzhou Guangdong China Department of Bioinformatics School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong China comprehensive Technology center of Lianyungang Customs Lianyungang Jiangsu China Department of Oncology The Affiliated Cancer Hospital of Nanjing Medical University &amp Jiangsu cancer Hospital Nanjing Jiangsu China Department of Laboratory Medicine Microbiome Medicine Center Zhujiang Hospital Southern Medical University Guangzhou Guangdong China

Interpreting genes of interest is essential for identifying molecular mechanisms, but acquiring such information typically involves tedious manual retrieval. To streamline this process, thefanyi package offers tools to retrieve gene information from sources like National center for Biotechnology Information (NCBI), significantly enhancing accessibility. Additionally, understanding the latest research advancements and sharing achievements are crucial for junior researchers. However, language barriers often restrict knowledge absorption and career development. To address these challenges, we developed thefanyi package, which leverages artificial intelligence (AI)-driven online translation services to accurately translate among multiple languages. This dual functionality allows researchers to quickly capture and comprehend information, promotes a multilingual environment, and fosters innovation in academic community. Meanwhile, the translation functions are versatile and applicable beyond biomedicine research to other domains as well. Thefanyi package is freely available at https://***/YuLab-SMU/fanyi.

关键词： Multilingualism Communication barriers Translating Artificial intelligence Single-cell analysis Gene expression profiling Biological markers

Percutaneous decannulation of extracorporeal membrane oxygenation using MANTA device:A real-world single-center experience

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World Journal of Cardiology 2024年第10期16卷 574-579页

作者： Ioannis Milioglou Alice Qian Pedro Rafael Vieira de Oliveira Salerno Gabriel Tensol Rodrigues Pereira Luis Augusto Palma Dallan Kelsey E Gray Michael Morrison Yasir Abu-Omar Mohammad Eldiasty Cristian Baeza Department of Cardiology University Hospitals Cleveland Medical CenterClevelandOH 44106United States Department of Surgery University Hospitals Cleveland Medical Center and Case Western Reserve University School of MedicineClevelandOH 44106United States

BACKGROUND The MANTA vascular closure device(VCD)represents a novel approach to achieving hemostasis after large-bore femoral access *** clinical studies have evaluated the efficacy of the MANTA device across a range of patient populations undergoing different ***,there is still a paucity of data available concerning the use of MANTA devices in aiding the decannulation of venoarterial extracorporeal membrane oxygenation(VAECMO).AIM To present our single-center experience of utilizing the MANTA VCD in patients undergoing this *** This single-center study included all patients undergoing percutaneous decannulation of femoral VA-ECMO using the MANTA plug-based VCD between January 2021 and October 2023 at University Hospitals Cleveland Medical *** criteria were adult patients who required prolonged(>24 hours)hemodynamic support with *** included all-cause mortality,hemostasis,bleeding,limb ischemia,and site *** This is a retrospective cohort study of 19 patients with a mean age of 56.8 *** of them were males with a mean body mass index of *** most common extracorporeal membrane oxygenation indication was acute coronary syndrome complicated by cardiogenic shock at 36.8%.The mean length of intensive care unit stay for these patients was 18.8±8.42 *** out of 19 patients survived to *** MANTA device was successfully deployed in 19 patients,with 10 procedures conducted at the bedside and 9 in an operating room *** hemostasis was achieved within 5 minutes of MANTA deployment in 17 out of 19 *** 2 patients manual compression after Manta deployment was required to achieve adequate ***,acute lower extremity ischemia was noted in two patients,necessitating endovascular *** infections were reported at the site of MANTA *** Overall,based on our experience and that of other centers,the MANTA VCD

关键词： Extracorporeal membrane oxygenation MANTA Decannulation Hemostasis Ischemia

The evolving landscape of biliary tract cancers:comparing French and US National comprehensive cancer Network guidelines

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 850-853页

作者： Muhammet Ozer Ilyas Sahin Department of Medical Oncology Dana Farber Cancer InstituteHarvard Medical SchoolBostonMAUSA Division of Hematology/Oncology Department of MedicineUniversity of FloridaGainesvilleFLUSA University of Florida Health cancer center GainesvilleFLUSA

Biliary tract cancers(BTCs)constitute a heterogeneous group of hepatobiliary malignancies originating along the biliary *** up to 20%of primary hepatobiliary tumors consist of BTCs(1).The primary risk factors include cholelithiasis,chronic inflammatory diseases of the bile ducts,non-alcoholic steatohepatitis(NASH),liver cirrhosis,tobacco use,and chronic viral hepatitis B and C infections(2).

关键词： Clinical practice biliary tract cancers(BTCs) French guidelines National comprehensive cancer Network guidelines(NCCN guidelines)

Adaptability of two cellulase producing strains Bacillus sp. SH and Aspergillus oryzae Y21 in whole wheat dough and impact on the quality of whole wheat bread

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Food Science and Human Wellness 2024年

作者： Yingli Liu Shengjie Zhong Xiaoming Wei Maosi Fan Min Cai Zhengkai Wang Jing Wang National center of Technology Innovation for Grain Industry (comprehensive Utilization of Edible By-products)， Key Laboratory of Special Food Supervision Technology for State Market Regulation，Beijing Technology and Business University

Compared to refined wheat flour， whole wheat flour contains higher nutrients， but its high content of dietary fiber can have a significant impact on the quality of the final product. Therefore， how to enable consumers to obtain health benefits from whole wheat flour and improve the processing performance of whole wheat products has become a concern. The purpose of this study is to apply two strains Bacillus sp. SH and Aspergillus oryzae Y21 with cellulase production capacity and study their adaptability in whole wheat dough. The results indicate that the addition of cellulase-producing strains enhanced the acid production ability of whole wheat dough， rapidly reduced its pH value and insoluble dietary fiber content， and significantly increased the water-soluble arabinoxylan and water-soluble dietary fiber content. During the fermentation process， the viscoelasticity of the dough decreased， free sulfhydryl content increased， wet gluten content decreased， and the degree of reduction was consistent with the degree of acidification. Moreover， the proteolytic activity of the dough was increased， and the hydrolysis of gliadin was the most extensive. Bacillus sp. SH showed a higher advantage and has been used in whole wheat bread making. Increasing the proportion of strain SH in whole wheat bread can improve the structural characteristics and texture of the bread. When SH (5 × 107CFU/g) is added to whole wheat bread， its hardness， elasticity， chewiness， and resilience can be similar to those of bread made from control group wheat flour， far exceeding that of whole wheat bread without adding SH. The addition of cellulase producing strains has obvious advantages in the development of whole-wheat dough， and also promote the development of whole wheat fermented foods as staple foods.

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Efficacy of a Nutritional Cream Intervention to Treat Depression in Rescuers:A Randomized Controlled Trial

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Biomedical and Environmental Sciences 2024年第7期37卷 754-761页

作者： Qiao Wang Hengyu Luan Chunyan Li Rufang Gong Qiongxuan Li Jiayi Deng Xiaoyong Sai Department of Statistics and Epidemiology The Graduate School of the Chinese PLA General HospitalBeijing 100853China comprehensive Internal Medicine Western Medical Branch of PLA General HospitalBeijing 100144China Department of Respiratory The First Medical Center of PLA General HospitalBeijing 100853China Department of Pharmacy Intravenous Admixture Services(PIVAS) The First Medical Center of PLA General HospitalBeijing 100853China

Objective To explore the effectiveness of a nutritional intervention in rescuers who screened positive for *** A randomized controlled trial design was *** June to August,2022,4,460 rescuers were screened using the Self-Rating Depression Scale(SDS),and 1,615 positive cases were ***-one volunteers were recruited and randomly divided into a nutritional intervention group and a control *** intervention group received health education and nutritional intervention(a compound paste therapy primarily composed of red roses and Seville orange flowers),while the control group received psychological *** scores were assessed before and after the *** There was a statistically significant decline in SDS scores in the nutritional intervention group after the intervention(P<0.05).Furthermore,the SDS scores of the intervention group were significantly lower than those of the control group,both before and after the intervention(P<0.05).No severe adverse reactions were observed during safety *** The nutritional intervention effectively reduced the depression scores in *** nutritional intervention is recommended for rescuers who initially screen positive for depression.

关键词： Nutritional intervention Rescuers Depression Randomized controlled trial

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Effects of cellulase-producing strains on the nutritional and soluble dietary fiber properties of whole wheat flour

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Food Science and Human Wellness 2024年

作者： Yingli Liu Shengjie Zhong Maosi Fan Zhengkai Wang Min Cai Xiaoming Wei Jing Wang National center of Technology Innovation For Grain Industry (comprehensive Utilization of Edible by-products)， Key Laboratory of Special Food Supervision Technology for State Market Regulation，Beijing Technology and Business University

Whole wheat flour is a food raw material rich in macronutrients， but its application in baking industry is limited due to the existence of a large amount of insoluble dietary fiber in bran. In order to make full use of this resource， we first screened twelve cellulase-producing strains， and then extracted soluble dietary fiber (SDF) from whole wheat flour after fermentation with 3 strains of Aspergillus sp. and 2 strains of Bacillus sp.， respectively. The effects of different strains on nutritional characteristics， SDF yield， structure improvement， and antioxidant activity of whole wheat flour were compared. The results showed that fermentation of whole wheat significantly increased the yield of SDF， the content of nutritive active substances， and improved the physicochemical structure and antioxidant activity of SDF in vitro. Scanning electron microscopy (SEM)， X-ray diffraction and liquidity characteristics show that the fermentation to make whole wheat SDF has more porous microstructure and crystallinity of lower molecular weight. Fourier transform infrared spectrum showed that there were differences in functional group types between C-SDF and F-SDF. These changes together improved the hydration performance and antioxidant activity of whole wheat SDF， including water holding capacity， oil holding capacity， cholesterol adsorption， DPPH， ABTS and hydroxyl radical scavenging， and lipase activity inhibition. Bacillus sp. SH and Aspergillus oryzae Y21 are ideal strains for fermentation of improved whole wheat， which has the potential of antioxidant properties while improving nutritional properties and food quality.

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