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Coronary angiographies of patients with recurrent acute coronary syndrome following coronary artery bypass grafting

Chinese Medical Journal 2005年第7期118卷 612-614页

作者： JIAYu-he YANGYue-jin WEIYi-zhen YAOMin HUSheng-shou cardiovasculardepartment FuwaiHospitalPekingUnionMedicalCollegeChineseAcademyofMedicalSciencesBeijing100037China

Coronary artery bypass grafting (CABG) is considered as a more complete means of revascularization than percutaneous coronary intervention (PCI). However, acute coronary syndrome (ACS) can still occur after CABG. The culprit vessel can be the graft vessel or the native vessel. Many questions remain unanswered in the Chinese literature regarding this topic: what are the short- and long-term pathological changes that induce ACS? Is there any difference between arterial and venous grafts with respect to the frequency of restenosis? Are there any patterns of ACS-related vessels in different periods after CABG? We aim to answer these fundamental questions by analyzing coronary angiographies of patients with recurrent ACS following CABG and provide evidence for reducing post-CABG restenosis.

关键词： coronary artery bypass grafting · acute coronary syndrome · coronary angiography

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Improved Cardiac Contractility of Human Recombinant Growth Hormone on the Congestive Heart Failure of Pig

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Journal of Bionic Engineering 2005年第2期2卷 87-91页

作者： YangPing HeYu-quan ZengHong NiJin-song YunQing-jun HuangXiao-ping LiShu-mei CadiovascularDepartment China-JapanUnionHospitalofJilinUniversityChangchun130021P.R.China DepartmentofPathdogy SchoolofBasicMedicalSciencesofJilinUniversityChangchun130021P.R.China cardiovasculardepartment SecondHospitalofJilinUniversityChangchun130041P.R.China

The enhanced cardiac contractility effect of human recombinant growth hormone (hr-GH) on the congestive heart failure (CHF) was studied on the pig. To build a pig model of congestive heart failure, a temporary artificial cardiac pacemaker was implanted in the pig’s body and paced at 220 beats to 240 beats per minute for 1 week. After the model of congestive heart failure was successfully set up, the frequency of the pacemaker was changed to 150 beats to 180 beats per minute to maintain the CHF model stable. Pigs were divided into three groups: The hr-GH group in which 0.5 mg/kg per day of hr-GH was administrated intramuscularly for 15 days, the injection control group in which an equal amount of physiological saline was injected intramuscularly, and a normal control group. The left ventricular diastolic end pressure was (10.60±2.41) mmHg in the hr-GH group, but (19.00±3.81) mmHg in the saline control group (P<0.01); Cardiac output was (1.86±0.13) L/min in the hr-GH group, but (1.56±0.18) L/min in the saline control group (P<0.05); Peripheral vascular resistance was (56.88±7.51) mmHg·(L/min) -1 in the hr-GH group, whereas (70.30±11.59) mmHg·(L/min) -1 in the saline control group (P<0.05); +dp/dt max was (2900±316.23) and (2280±286.36) in the hr-HG group and the saline control group respectively (P<0.05). The results show that hr-GH enhances myocardial contractility of CHF, and the CHF model built by a temporary artificial cardiac pacemaker at a high rate of stimulation is reasonable and applicable.

关键词： human recombinant growth hormone improved cardiac contractility experimental animal model temporary artificial cardiac pacemaker congestive heart failure

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