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Current status and impact of the Young Scientist Foundation of the National Natural Science Foundation on Chinese young scholars in cardiovascular research

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Science China(Life Sciences) 2024年第10期67卷 2294-2296页

作者： Fei Gao Zhenzhen Chen Wendong Li Hujun Jiang Rui Wang department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Hypertension Center Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular DiseasesBeijing 100037China department of Vascular Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China department of Health Sciences National Natural Science Foundation of ChinaBeijing 100085China

cardiovascular disease(CVD)remains the leading cause of disease burden globally,and continued efforts are required in identifying new targets for CVD prevention and treatment(Vaduganathan et al.,2022).Breakthroughs in... 详细信息

关键词： prevention modality

The Combined Effects of High Temperatures and Ozone Pollution on Medical Emergency Calls—Jinan City,Shandong Province,China,2013–2019

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China CDC weekly 2024年第2期6卷 30-35,I0001-I0007页

作者： Huiyun Chang Chong Liu Xingyi Geng Xiumiao Peng Ke Huang Liheng Wang Liangliang Cui department of Scientific Research and Education Jinan Municipal Center for Disease Control and PreventionJinan Municipal Center for Disease Control and Prevention Affiliated to Shandong UniversityJinan CityShandong ProvinceChina Jinan Health Well Development Center Jinan CityShandong ProvinceChina department of Environmental Health Jinan Municipal Center for Disease Control and PreventionJinan CityShandong ProvinceChina department of Emergency Jinan Medical Emergency CenterJinan CityShandong ProvinceChina

What is already known about this topic?Studies have extensively documented the separate and independent effects of extreme temperature and ozone on morbidity and mortality associated with respiratory and circulatory *** is added by this report?The study revealed a significant association between elevated temperature,ozone pollution,and the combined effect of high temperature and ozone pollution with an increased risk of all-cause medical emergency calls(MECs)and MECs specifically related to neurological *** are the implications for public health practice?Interventional measures should be implemented to mitigate exposure to high temperatures and ozone ***,during the warm season,it is crucial for relevant authorities to focus on disseminating scientific information regarding the health impacts of elevated temperatures and ozone ***,timely public health advisories should be issued to alert the public effectively.

关键词： ozone elevated pollution

Screening for metabolic dysfunction-associated fatty liver disease:Time to discard the emperor’s clothes of normal liver enzymes?

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World Journal of Gastroenterology 2024年第22期30卷 2839-2842页

作者： Chen-Xiao Huang Xiao-Dong Zhou Calvin Q Pan Ming-Hua Zheng Metabolic Dysfunction-Associated Fatty Liver disease Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina department of cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Division of Gastroenterology and Hepatology Department of MedicineNew York University Langone HealthNew York University Grossman School of MedicineNew YorkNY 11355United States Institute of Hepatology Wenzhou Medical UniversityKey Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang ProvinceWenzhou 325000Zhejiang ProvinceChina

Metabolic dysfunction-associated fatty liver disease(MAFLD)is the most prevalent chronic liver condition *** liver enzyme-based screening methods have limitations that may missed diagnoses and treatment *** Chen et al,the risk of developing MAFLD remains elevated even when alanine aminotransferase levels fall within the normal ***,there is an urgent need for advanced diagnostic techniques and updated algorithms to enhance the accuracy of MAFLD diagnosis and enable early *** paper proposes two potential screening methods for identifying individuals who may be at risk of developing MAFLD:Lowering these thresholds and promoting the use of noninvasive liver fibrosis scores.

关键词： Metabolic dysfunction-associated fatty liver disease Non-alcoholic fatty liver disease Alanine aminotransferase Liver enzymes Screening Noninvasive liver fibrosis scores

SARS-CoV-2 and innate immunity:the good,the bad,and the"goldilocks"

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Cellular & Molecular Immunology 2024年第2期21卷 171-183页

作者： Benjamin L.Sievers Mark T.K.Cheng Kata Csiba Bo Meng Ravindra K.Gupta department of Medicine University of CambridgeCambridgeUK Cambridge Institute of Therapeutic Immunology&Infectious disease(CITID) Department of MedicineUniversity of CambridgeCambridgeUk

An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of *** about this interplay can not only help us identify biological mechanisms but also reveal pathogen vulnerabilities that can be leveraged *** humoral response to SARS-CoV-2 infection has been the focus of intense research,and the role of the innate immune system has received significantly less ***,we review current knowledge of the innate immune response to SARS-CoV-2 infection and the various means SARS-CoV-2 employs to evade innate defense *** also consider the role of innate immunity in SARS-CoV-2 vaccines and in the phenomenon of long COVID.

关键词： SARS-CoV-2 Innate immune response Interferon Cytokines Inflammation Antiviral targets

The diagnostic value of tenascin-C in acute aortic syndrome

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Journal of Geriatric Cardiology 2024年第3期21卷 359-368页

作者： Ming MA Wei CHEN Hai-Long CAO Jun PAN Qing ZHOU Xin-Long TANG Dong-Jin WANG department of Thoracic and cardiovascular Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingChina department of Thoracic and cardiovascular Surgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingChina department of Thoracic surgery Kunshan Hospital of Traditional Chinese MedicineJiangsuChina

OBJECTIVES Misdiagnosis of acute aortic syndrome(AAS)significantly increases ***-C(TN-C)is an extracellular matrix glycoprotein related to cardiovascular *** elevation of TN-C in AAS and whether it can discriminate suddenonset of acute chest pain in Chinese remains *** We measured the plasma concentration of TN-C by ELISA in a cohort of 376 patients with chest or back *** to discriminate AAS from acute coronary syndrome(ACS)were compared and *** From October 2016 to September 2021,376 undiagnosed patients with chest or back pain were enrolled.166 of them were finally diagnosed as AAS,100 were ACS and 110 without cardiovascular diseases(NCV).TN-C was significantly elevated in AAS at 18.18 ng/mL(IQR:13.10–27.68)compared with 7.51 ng/mL(IQR:5.67–11.38)in ACS(Pdiseases.

关键词： acute cardiovascular elevated

Establishment of a nomogram model for predicting therapy complications in patients with polycythemia and deep venous thrombosis

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World Journal of Clinical Cases 2024年第22期12卷 4881-4889页

作者： Ming-Xian Zhao Guo-Jie Li department of Vascular Surgery Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist HospitalXining 810000Qinghai ProvinceChina

BACKGROUND Patients with deep venous thrombosis(DVT)residing at high altitudes can only rely on anticoagulation therapy,missing the optimal window for surgery or ***,under these conditions,patient outcomes can be easily complicated by high-altitude polycythemia(HAPC),which increases the difficulty of treatment and the risk of recurrent *** prevent reaching this point,effective screening and targeted interventions are ***,this study analyzes and provides a reference for the clinical prediction of thrombosis recurrence in patients with lower-extremity DVT combined with *** To apply the nomogram model in the evaluation of complications in patients with HAPC and DVT who underwent anticoagulation *** A total of 123 patients with HAPC complicated by lower-extremity DVT were followed up for 6-12 months and divided into recurrence and non-recurrence groups according to whether they experienced recurrence of lower-extremity *** data and laboratory indices were compared between the groups to determine the influencing factors of thrombosis recurrence in patients with lowerextremity DVT and *** study aimed to establish and verify the value of a nomogram model for predicting the risk of thrombus *** Logistic regression analysis showed that age,immobilization during follow-up,medication compliance,compliance with wearing elastic stockings,and peripheral blood D-dimer and fibrin degradation product levels were indepen-dent risk factors for thrombosis recurrence in patients with HAPC complicated by DVT.A Hosmer-Lemeshow goodness-of-fit test demonstrated that the nomogram model established based on the results of multivariate logistic regression analysis was effective in predicting the risk of thrombosis recurrence in patients with lowerextremity DVT complicated by HAPC(χ^(2)=0.873;P>0.05).The consistency index of the model was 0.802(95%CI:0.799-0.997),indicating its good accuracy and discriminat

关键词： Anticoagulation therapy Deep vein thrombosis of the lower extremities High-altitude polycythemia Logistic regression analysis Nomogram model Thrombosis recurrence

Application of multi-planar reconstruction technique in endovascular repair of aortic dissection

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World Journal of Clinical Cases 2024年第17期12卷 2989-2994页

作者： Guo-Jie Li Ming-Xian Zhao department of Vascular Surgery Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist HospitalXining 810000Qinghai ProvinceChina

BACKGROUND Endovascular repair of aortic dissection is an effective method commonly used in the treatment of Stanford type B aortic *** placement during the operation was one-time and could not be repeatedly adjusted during the ***,it is of great significance for cardiovascular physicians to fully understand the branch status,position,angle,and other information regarding aortic arch dissection before *** To provide more references for clinical cardiovascular physicians to develop treatment *** Data from 153 patients who underwent endovascular repair of aortic dissection at our hospital between January 2021 and December 2022 were retrospectively *** patients underwent multi-slice spiral computed tomography *** on distinct post-image processing techniques,the patients were categorized into three groups:Multiplanar reconstruction(MPR)(n=55),volume reconstruction(VR)(n=46),and maximum intensity projection(MIP)(n=52).The detection rate of aortic rupture,accuracy of the DeBakey classification,rotation,and tilt angles of the C-arm during the procedure,dispersion after stent release,and the incidence of late complications were recorded and *** The detection rates of interlayer rupture in the MPR and VR groups were significantly higher than that in the MIP group(P0.05).The scatter rate of markers and the incidence of complications in the MPR group were significantly lower than those in the VR and MIP groups(P<0.05).CONCLUSION The application of MPR in the endovascular repair of aortic dissection has improved the detection rate of dissection rupture,the accuracy of a

关键词： Multiplanar reconstruction Endovascular repair of aortic dissection Image-processing technology Rate of aortic rupture Volume reconstruction

Targeting oral-gut microbial transmission in diabetic coronary heart disease:unveiling key pathogenic mechanisms

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Science China(Life Sciences) 2024年第10期67卷 2287-2288页

作者： Ismail Cimen Aab cardiovascular Research Institute Department of MedicineUniversity of Rochester School of Medicine and DentistryRochester 14642USA

Diabetes significantly exacerbates the occurrence and adverse prognosis of coronary heart disease(CHD),emphasizing the importance of focusing on the prevention and management of diabetesrelated *** study identifies and verifies for the first time a distinctive oral-gut microbiota profile in patients with diabetic coronary heart disease(DCHD),marked by an increased abundance of oral Fusobacterium nucleatum and gut Lactobacillus.

关键词： coronary prevention diabetic

Establishment and Application of a Radiation Dose Rate Model for Nuclear Medicine Examinees

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China CDC weekly 2024年第23期6卷 553-557,I0019-I0025页

作者： Yuehua Hu Xinyu He Wenjia Zhao Lixin Ding Meiying You Zihan Li Xinyu Liu Miaomiao Wang Siyi Chen Ziwei Lu Lei Qu Kuke Ding Li Zhang Qiuxian Fu Office of Epidemiology Chinese Center for Disease Control and PreventionBeijingChina department of Oncology Central Hospital Affiliated to Shandong First Medical UniversityJinan CityShandong ProvinceChina National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijingChina National Center for Chronic and Noncommunicable disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Laboratory Animal Center Chinese Center for Disease Control and PreventionBeijingChina National Institute of Parasitic diseases Chinese Center for Disease Control and PreventionShanghaiChina Office of Public Health Management Chinese Center for Disease Control and PreventionBeijingChina Hainan Medical University Haikou CityHainan ProvinceChina

Introduction:Traditional methods for determining radiation dose in nuclear medicine include the Monte Carlo method,the discrete ordinate method,and the point kernel integration *** study presents a new mathematical model for predicting the radiation dose rate in the vicinity of nuclear medicine ***:A new algorithm was created by combining the physical model of“cylinder superposition”of the human body with integral analysis to assess the radiation dose rate in the vicinity of nuclear medicine ***:The model accurately predicted radiation dose rates within distances of 0.1–3.0 m,with a deviation of less than 11%compared to observed *** model demonstrated greater accuracy at shorter distances from the radiation source,with a deviation of only 1.55%from observed values at 0.1 ***:The model proposed in this study effectively represents the spatial and temporal distribution of the radiation field around nuclear medicine patients and demonstrates good agreement with actual *** model has the potential to serve as a radiation dose rate alert system in hospital environments.

关键词： method. deviation cylinder