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World Journal of Clinical Cases 2024年第2期12卷 425-430页

作者： Seha Ahn Youngkyu Moon department of Thoracic and cardiovascular Surgery Eunpyeong St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea

BACKGROUND Inflammatory myofibroblastic tumors(IMTs)are exceptionally rare neoplasms with intermediate malignant *** is the accepted treatment option,aiming for complete resection with clear *** SUMMARY A 39-year-old woman presented with a growing solitary pulmonary nodule measuring 2.0 cm in the right upper lobe(RUL)of the *** patient underwent a RUL anterior segmentectomy using uniportal video-assisted thoracoscopy.A preliminary tissue diagnosis indicated malignancy;however,it was later revised to an *** to the absence of a minor fissure between the right upper and middle lobes,an alternative resection approach was ***,we utilized indocyanine green injection to aid in delineating the intersegmental *** an uneventful recovery,the patient was discharged on the third postoperative ***,annual chest tomography scans were scheduled to monitor for potential local *** This case underscores the challenges in diagnosing and managing IMTs,showing the importance of accurate pathologic assessments and tailored surgical strategies.

关键词： Uniportal video-assisted thoracoscopic surgery Fissureless Anterior segmentectomy Inflammatory fibroblastic tumor Case report

Prognostic relevance of ventricular arrhythmias in surgical patients with gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1787-1795页

作者： Jiao-Jie Xue Su-Tian Hu Chong-Chong Wang Zhi-Chong Chen Shi-Yao Cheng Shu-Qi Yu Hua-Jing Peng Yi-Tao Zhang Wei-Jie Zeng department of cardiovascular Internal Medicine Sun Yat-sen University Sixth Affiliated HospitalGuangzhou 510655Guangdong ProvinceChina department of cardiovascular Internal Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700Guangdong ProvinceChina department of Ultrasound Fuwai HospitalChinese Academy of Medical Sciences ShenzhenShenzhen 518052Guangdong ProvinceChina department of Kidney Internal Medicine Sun Yat-sen University First Affiliated HospitalGuangzhou 510062Guangdong ProvinceChina

BACKGROUND Individuals diagnosed with gastrointestinal tumors are at an increased risk of developing cardiovascular *** which,ventricular arrhythmia is a prevalent clinical *** suggests that ventricular arrhythmias may have predictive value in the prognosis of patients with gastrointestinal *** To explore the prognostic value of ventricular arrhythmias in patients with gastrointestinal tumors receiving *** We retrospectively analyzed data from 130 patients undergoing gastrointestinal tumor *** patients were evaluated by a 24-h ambulatory electrocardiogram(ECG)at the Sixth Affiliated Hospital of Sun Yat-sen University from January 2018 to June ***,41 general healthy age-matched and sexmatched controls were *** were categorized into survival and non-survival *** primary endpoint was all-cause mortality,and secondary endpoints included major adverse cardiovascular events(MACEs).RESULTS Colorectal tumors comprised 90%of *** ambulatory ECG monitoring revealed that among the 130 patients with gastrointestinal tumors,100(76.92%)exhibited varying degrees of premature ventricular contractions(PVCs).Ten patients(7.69%)manifested non-sustained ventricular tachycardia(NSVT).The patients with gastrointestinal tumors exhibited higher PVCs compared to the healthy controls on both conventional ECG[27(21.3)vs 1(2.5),P=0.012]and 24-h ambulatory ECG[14(1.0,405)vs 1(0,6.5),P35/24 h to all-cause mortality,and NSVT was associated with ***,neither PVC burden nor NSVT independently predicted outcomes according to multivariate *** Patients with gastrointestinal tumors exhibited elevated ***>35/24 h and NSVT detected by 24-h ambulatory ECG were prognos

关键词： Ventricular arrhythmia Gastrointestinal tumor Major adverse cardiovascular events Prognostic Surgery

Home Blood Pressure Monitoring and Its Association With Blood Pressure Control Among Hypertensive Patients With High cardiovascular Risk in China

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Cardiology Discovery 2024年第1期4卷 15-22页

作者： Jiaying Li Aoxi Tian Jiamin Liu Jinzhuo Ge Yue Peng Xiaoming Su Jing Li National Clinical Research Center for cardiovascular diseases National Health Commission Key Laboratory of Clinical Research for Cardiovascular MedicationsState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNational Center for Cardiovascular DiseasesBeijing 100037China

Objective:Home blood pressure monitoring(HBPM)is viewed as a facilitating factor in the initial diagnosis and long-term management of treated ***,evidence remains scarce about the effectiveness of HBPM use in the real *** study aimed to examine the associations of HBPM use with blood pressure(BP)control and medication ***:This prospective cohort study included hypertensive patients with high cardiovascular risk who were aged≥50 *** baseline,information about types of BP monitor,frequency of HBPM,perception of anti-hypertensive treatment,and measured office BP were *** the 1-year follow-up(visits at 1,2,3,6,and 12 months),information on medication adherence was collected at each *** 2 major outcomes were BP control at baseline and medication adherence during the 1-year follow-up.A log-binomial regression model was used to examine the association between frequency of HBPM and outcomes,stratified by the perceptions of anti-hypertensive ***:A total of 5,363 hypertensive patients were included in the *** age was(64.6±7.2)years,and 41.2%(2,208)were *** the total patients,85.9%(4,606)had a home BP monitor and 47.8%(2,564)had an incorrect perception of anti-hypertensive ***,24.2%(1,299)of patients monitored their BP daily,37.6%(2,015)weekly,17.3%(926)monthly,and 20.9%(1,123)less than *** baseline,the systolic BP and diastolic BP were(146.6±10.8)mmHg and(81.9±10.6)mmHg,respectively,and 28.5%(1,527)of patients had their BP *** of whether the patients had correct or incorrect perceptions of anti-hypertensive treatment,there is no significant association between HBPM frequency and BP control at *** the 1-year follow-up,23.9%(1,280)of patients had non-adherence to medications at least *** patients with an incorrect perception of anti-hypertensive treatment,those monitoring BP most frequently(daily)had the highest non-adherence rate(29.

关键词： Hypertension Home blood pressure monitoring Blood pressure control Medication adherence

Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions

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Genes & diseases 2024年第2期11卷 874-889页

作者： Yancheng Lai Xiaole Lu Yankai Liao Pei Ouyang Hai Wang Xian Zhang Guanglong Huang Songtao Qi Yaomin Li department of Neurosurgery Institute of Brain DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Laboratory for Precision Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Glioblastoma(GBM)is the most common intrinsic and aggressive primary brain tumor in adults,with a median survival of approximately 15 *** heterogeneity is considered responsible for the treatment resistance and unfavorable ***-mesenchymal transition(PMT)represents GBM malignant progression and recurrence,which might be a breakthrough to understand GBM heterogeneity and overcome treatment *** is a complicated process influenced by crosstalk between GBM and tumor microenvironment,depending on intricate ligand-receptor *** this review,we summarize the autocrine and paracrine pathways in the GBM microenvironment and related ligand-receptor interactions inducing *** also discuss the current therapies targeting the PMT-related autocrine and paracrine ***,this review offers a comprehensive understanding of the failure of GBM-targeted therapy and ideas for future tendencies of GBM treatment.

关键词： Autocrine Glioblastoma Ligand-receptor interaction Microenvironment Paracrine Proneural-mesenchymal transition

Paternal mixed exposure to nicotine/ethanol/caffeine damaged cartilage quality in paternal/offspring rats and its differential glucocorticoid regulation mechanisms

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Food Science and Human Wellness 2024年

作者： Yi Liu Hao Xiao Yi Liu Bin Li Hui Wang Liaobin Chen Division of Joint Surgery and Sports Medicine， department of Orthopedic Surgery， Zhongnan Hospital of Wuhan University Hubei Provincial Key Laboratory of Developmentally Originated disease Joint disease Research Center of Wuhan University department of Pharmacology， Wuhan University School of Basic Medical Sciences

Nicotine， ethanol， and caffeine are the most common exogenous substances in the men’s living environment， but their effects on the cartilage quality in the father and offspring have not been reported. According to the average daily intake of adult men， we constructed a male rat model of paternal mixed exposure (PME) to low-dose nicotine (0.1 mg/kg.d)， ethanol (0.5 g/kg.d)， and caffeine (7.5 mg/kg.d) for 8 weeks. Then， the male rats mated with normal female rats to obtain offspring. The results showed that PME reduced the cartilage quality of paternal and offspring rats. Among them， the paternal cartilage was damaged by enhancing matrix degradation， while the offspring cartilage was damaged by reducing matrix synthesis. The cartilage damage in male offspring rats was more evident than in female offspring. It was further confirmed that differential GC regulation mechanisms were the main reasons for the intergenerational differential damage of paternal/offspring cartilage quality caused by PME. In addition， the sex hormone receptor AR and ERβ mediated the sex difference of PME-induced fetal cartilage dysplasia by affecting the binding degree of GR/P300. This study provided a theoretical and experimental basis for guiding male healthy lifestyle and exploring early prevention and treatment strategies for paternal diseases.

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Dopamine Inhibits the Expression of Hepatitis B Virus Surface and e Antigens by Activating the JAK/STAT Pathway and Upregulating Interferon-stimulated Gene 15 Expression

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 443-456页

作者： Xiaoquan Liu Xiuqing Pang Zhiping Wan Jinhua Zhao Zhiliang Gao Hong Deng department of Infectious diseases Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Key Laboratory of Liver disease Research Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou GuangdongChina Key Laboratory of Tropical disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouGuangdongChina

Background and Aims:Hepatitis B virus(HBV)infection is a major risk factor for cirrhosis and liver cancer,and its treatment continues to be *** previously demonstrated that a dopamine analog inhibited the packaging of pregenomic RNA into *** present study aimed to determine the effect of dopamine on the expressions of hepatitis B virus surface and e antigens(HBsAg and HBeAg,respectively)and to elucidate the underlying ***:We used dopamine-treated HBVinfected HepG2.2.15 and NTCP-G2 cells to monitor HBsAg and HBeAg expression *** analyzed interferon-stimulated gene 15(ISG15)expression in dopamine-treated *** knocked down ISG15 and then monitored HBsAg and HBeAg expression *** analyzed the expression of Janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway factors in dopamine-treated *** used dopamine hydrochloride-treated adeno-associated virus/HBV-infected mouse model to evaluate HBV DNA,HBsAg,and HBeAg *** virus was collected from HepAD38.7 cell culture ***:Dopamine inhibited HBsAg and HBeAg expression and upregulated ISG15 expression in HepG2.2.15 and HepG2-NTCP cell ***15 knockdown increased HBsAg and HBeAg expression in HepG2.2.15 ***-treated cells activated the JAK/STAT pathway,which upregulated ISG15 *** the adeno-associated virus-HBV murine infection model,dopamine downregulated HBsAg and HBeAg expression and activated the JAK-STAT/ISG15 ***:Dopamine inhibits the expression of HBsAg and HBeAg by activating the JAK/STAT pathway and upregulating ISG15 expression.

关键词： Hepatitis B virus Dopamine JAK-STAT/ISG15 axis HBV surface antigen HBV e antigen HepG2.2.15 cell line Human NTCP-expressing HepG2 cell line HepAD38 cell line

Psychological Status and Warfarin Therapy in Patients after Valve Replacement during the COVID-19 Pandemic:A Cross-sectional Study

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Current Medical Science 2024年第4期44卷 686-691页

作者： Xiao-yan CHEN Sheng HE Zhen TAN Feng GAO Hui JIANG Lu CHEN Li YANG Yu-shan LIU Si-yi HE department of cardiovascular Surgery The General Hospital of Western Theater CommandChengdu610083China department of Digestive Medicine The General Hospital of Western Theater CommandChengdu610083China department of General Surgery The General Hospital of Western Theater CommandChengdu610083China

Objective The standardization of warfarin anticoagulant therapy is the key to lifelong treatment for patients after heart valve *** present study explored the possible risk factors for anxiety and depression during the coronavirus disease 2019(COVID-19)pandemic and analyzed the influence of psychological state on medication *** Eligible patients received a web-based questionnaire survey via the Wenjuanxing platform during outpatient *** was evaluated by the Self-Rating Depression Scale(SDS).Anxiety was evaluated by the Self-Rating Anxiety Scale(SAS).Medication adherence was evaluated by the Morisky *** A total of 309 patients(aged 52.2±11.4 years)were included in the present *** SDS score of all included patients was 36.9±9.4 points,of which 11(3.6%)patients were diagnosed as having *** SAS score of all included patients was 43.1±9.3 points,of which 71(23%)patients were diagnosed as having *** patients(2.3%)had both anxiety and *** regression analysis revealed that only monthly income was an independent influencing factor for *** anxiety,patients who underwent repeated operations had a 2.264-fold greater risk,and patients who received combination medication had a 2.140-fold greater *** bleeding events and coagulation disorders could be observed in patients with anxiety,depression or *** anxiety occurred,patients showed worse medication ***,depression had no significant effect on medication *** During the COVID-19 pandemic,the detection rate of mental illnesses such as anxiety and depression was high,which seriously affected the medication safety of *** of its influencing factors will provide a reference for further standardized regulation of warfarin anticoagulant therapy after valve replacement.

关键词： Warfarin COVID-19 valve replacement depression anxiety

A Global Decomposition Analysis of the Effect of Population Aging on Disability-Adjusted Life Years Associated with cardiovascular disease—204 Countries and Territories,1990-2021

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China CDC weekly 2024年第39期6卷 1004-1010,I0001-I0006页

作者： Na Sun Xiaocan Jia Xuezhong Shi Feng Jiang Chaojun Yang Yongli Yang department of Computer and Health Statistics College of Public HealthZhengzhou UniversityZhengzhou CityHenan ProvinceChina department of disease Prevention and Control Zhengzhou University HospitalZhengzhou CityHenan ProvinceChina

What is already known about this topic?The influence of population aging on the disabilityadjusted life years(DALYs)associated with cardiovascular disease(CVD)is acknowledged,yet the magnitude of this impact remains *** is added by this report?This research quantified the influence of population aging on CVD DALYs from 1990 to 2021 through decomposition *** findings revealed that the proportion of DALYs attributable to aging varied widely,ranging from‒77.0%to 148.9%across 204 *** was significant variation in the attributed DALY proportions among different countries or territories and types of *** heart disease and stroke emerged as the leading contributors to DALYs influenced by *** are the implications for public health practice?Globally,the association of population aging with increased CVD DALYs underscores the critical need for enhancing health systems to cater to the needs of older *** the burden of CVD DALYs linked to demographic aging can be achieved by investing in resources and adjusting fertility policies.

关键词： aging attributed critical

β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie Leng Dong-Wei Fan Wan-Qiong Yuan Chun-Li Song department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

Effects of forsythin extract in Forsythia leaves on intestinal microbiota and short-chain fatty acids in rats fed a high-fat diet

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Food Science and Human Wellness 2024年第2期13卷 659-667页

作者： Lanlan Gui Shaokang Wang Jing Wang Wang Liao Zitong Chen Da Pan Hui Xia Guiju Sun Su Tian department of Nutrition and Food Hygiene School of Public HealthSoutheast UniversityNanjing 210009China Nanjing Municipal Center for disease Control and Prevention Nanjing 210003China department of Nutrition and Food Hygiene School of Public HealthHebei Medical UniversityShijiazhuang 050017China

Forsythia suspensa,belonging to the deciduous shrubs of the Luteaceae family,a traditional Chinese medicine,has effects of alleviating swelling,clearing heat,detoxification and promoting blood *** leaves of *** contain multiple chemical components and have a long history of use in folk medicines and health *** purpose of this study was to explore the effects of forsythin extract from *** leaves on intestinal microbiota and short-chain fatty acid(SCFA)content in rats with obesity induced by a high-fat *** extract in *** leaves increased the abundance of the intestinal microbiota,ameliorated intestinal microbiota disorders and inhibited the increase in total SCFA content in the intestinal tract in rats with obesity induced by a high-fat *** results suggested that forsythin extract in *** leaves may slow the development of obesity induced by a high-fat diet;thus,its active components and efficacy are worthy of further study.

关键词： Forsythin High-fat diet Intestinal microbiota Short-chain fatty acid(SCFA)