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Bridging fulminant myocarditis patients to recovery or advanced therapies with veno-arterial extracorporeal membrane oxygenation:a single-center retrospective study

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World Journal of Emergency Medicine 2024年第6期15卷 481-485页

作者： Jing Wang Gang Liu Yuan Teng Jian Wang Shujie Yan Qian Wang Tianlong Wang Han Zhang Bingyang Ji Department of cardiopulmonary Bypass Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China

Fulminant myocarditis(FM)is a severe inflammatory cardiac disease,typically triggered by viral pathogens or autoimmune disorders.[1,2]Early symptoms of the disease can be mild and nonspecific,but in certain cases,pati... 详细信息

关键词： patients myocarditis cardiac

Cold-inducible RNA-binding protein as a novel target to alleviate blood-brain barrier damage induced by cardiopulmonary bypass

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中国循环杂志 2018年第S1期 128-129页

作者： Mingyue Liu Yongnan Li Yiwei Liu Shujie Yan Gang Liu Qiaoni Zhang Bingyang Ji Department of cardiopulmonary Bypass State Key Laboratory of Cardiovascular Medicine National Center for Cardiovascular DiseaseFuwai HospitalCAMS and PUMC

Background Hypothermia provides neuroprotection and alleviates cerebral injury after cardiopulmonary bypass (CPB). The mechanism of cold-inducible RNA-binding protein (CIRP), which has been reported to be facilitated ...

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Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase

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Chinese Journal of Cancer 2015年第4期34卷 166-176页

作者： Peng Wang Yi-Chen Sun Wen-Hua Lu Peng Huang Yumin Hu Sun Yat-sen University Cancer center State Key Laboratory of Oncology in South China Collaborative Innovation center for Cancer Medicine Institute of cardiopulmonary Cerebral Resuscitation Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center

Introduction:Oncogenic aaivation of the K-ras gene occurs in >90%of pancreatic ductal carcinoma and plays a critical role in the pathogenesis of this *** of reactive oxygen species(ROS) has also been observed in a wide spectrum of *** study aimed to investigate the mechanistic association between K-ras-induced transformation and increased ROS stress and its therapeutic implications in pancreatic ***:ROS level,NADPH oxidase(NOX) aaivity and expression,and cell invasion were examined in human pancreatic dua epithelial E6E7 cells transfeaed with K-ras^(G12V) compared with parental E6E7 *** cytotoxic effea and antitumor effect of capsaicin,a NOX inhibitor,were also tested in vitro and in ***:K-ras transfeaion caused activation of the membrane-associated redox enzyme NOX and elevated ROS generation through the phosphatidylinositol 3'-kinase(PI3K) ***,capsaicin preferentially inhibited the enzyme aaivity of NOX and induced severe ROS accumulation in K-ras-transformed cells compared with parental E6E7 ***,capsaicin effeaively inhibited cell proliferation,prevented invasiveness of /(-ras-transformed pancreatic cancer cells,and caused minimum toxicity to parental E6E7 *** vivo,capsaicin exhibited antitumor aaivity against pancreatic cancer and showed oxidative damage to the xenograft tumor ***:K-ras oncogenic signaling causes increased ROS stress through NOX,and abnormal ROS stress can selectively kill tumor cells by using NOX *** study provides a basis for developing a novel therapeutic strategy to effectively kill K-ras-transformed cells through a redox-mediated mechanism.

关键词： NAD(P)H氧化酶基因转化癌细胞胰腺癌 NADPH氧化酶氧化还原酶抗肿瘤活性杀伤

Outcome prediction value of National Early Warning Score in septic patients with community-acquired pneumonia in emergency department: A single-center retrospective cohort study

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World Journal of Emergency Medicine 2020年第4期11卷 206-215页

作者： Hai-jiang Zhou Tian-fei Lan Shu-bin Guo Emergency Medicine Clinical Research center Beijing Chao-yang HospitalCapital Medical University&Beijing Key Laboratory of Cardiopulmonary Cerebral ResuscitationBeijingChina Department of Allergy Beijing Shijitan HospitalCapital Medical UniversityBeijingChina

BACKGROUND:To evaluate the accuracy of National Early Warning Score(NEWS)in predicting clinical outcomes(28-day mortality,intensive care unit[ICU]admission,and mechanical ventilation use)for septic patients with community-acquired pneumonia(CAP)compared with other commonly used severity scores(CURB65,Pneumonia Severity Index[PSI],Sequential Organ Failure Assessment[SOFA],quick SOFA[qSOFA],and Mortality in Emergency Department Sepsis[MEDS])and admission lactate ***:Adult patients diagnosed with CAP admitted between January 2017 and May 2019 with admission SOFA≥2 from baseline were *** characteristics were *** primary outcome was the 28-day mortality after admission,and the secondary outcome included ICU admission and mechanical ventilation *** prediction value of parameters above was compared using receiver operating characteristics(ROC)*** regression analyses were carried out to determine the risk factors for the 28-day ***-Meier survival curves were plotted and compared using optimal cut-off values of qSOFA and ***:Among the 340 enrolled patients,90 patients were dead after a 28-day follow-up,62 patients were admitted to ICU,and 84 patients underwent mechanical *** single predictors,NEWS achieved the largest area under the receiver operating characteristic(AUROC)curve in predicting the 28-day mortality(0.861),ICU admission(0.895),and use of mechanical ventilation(0.873).NEWS+lactate,similar to MEDS+lactate,outperformed other combinations of severity score and admission lactate in predicting the 28-day mortality(AUROC 0.866)and ICU admission(AUROC 0.905),while NEWS+lactate did not outperform other combinations in predicting mechanical ventilation(AUROC 0.886).Admission lactate only improved the predicting performance of CURB65 and qSOFA in predicting the 28-day mortality and ICU ***:NEWS could be a valuable predictor in septic patients with CAP in emergency depa

关键词： Community-acquired pneumonia Sepsis National Early Warning Score(NEWS) Intensive care unit Emergency departments

Myocardial protection during heart surgery in China

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Chinese Medical Journal 2007年第1期120卷 62-67页

作者： Bingyang Ji Jinping Liu myocardial protection cardiopulmonary bypass cardiac surgeryDepartment of Pediatric Cardiology Hershey Medical Center PennState College of Medicine USA Department of cardiopulmonary Bypass Cardiovascular InstituteFuwai Hospital Peking Union Medical College ＆ ChineseAcademy of Medical Sciences Beijing 100730 China

Myocardial protection （MP） is the key for cardiopulmonary bypass （CPB） heart surgery. MP during cardiac surgery （CS） aims to preserve myocardial function while providing a bloodless and motionless operating field. Strategies on how to attenuate or prevent post-ischemic myocardial dysfunction that occurs intra-operatively during CS have been discussed for more than half a century. In 1950, Bigelow et al, first reported to decrease myocardial oxygen demand by means of hypothermia. Moreover, Melrose and coworkers2 described the use of electromechanical cardiac arrest induced by potassium infusion, permitting CS to be performed on a non-beating flaccid heart and clear surgical field. The combination of both of these techniques has been the golden standard in MP during surgery until now, allowing surgery with excellent clinical outcome. In 1975, Braimbridge et al introduced a crystalloid solution into clinical practice at St. Thomas Hospital. By the 1980s, blood-based potassium solutions were advocated to further improve MP and to reduce myocardial enzymes release based on the theory that blood would be a superior delivery vehicle for its oxygenating and buffering ***, the majority of MP strategies now available do allow patients to undergo conventional and complex CS with an operative mortality rate ranging from less than 2% to 4%.

关键词： myocardial protection cardiopulmonary bypass cardiac surgery

Iatrogenic atrial septal defects after transseptal puncture for percutaneous left atrial appendage occlusion and their hemodynamic effects

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Journal of Geriatric Cardiology 2022年第9期19卷 675-684页

作者： Ioannis Drosos Roberta De Rosa Philipp C.Seppelt Sebastian Cremer Silvia Mas-Peiro Katrin Hemmann Jana Oppermann Recha Blessing Mariuca Vasa-Nicotera Andreas M.Zeiher Zisis Dimitriadis Division of Cardiology Department of Medicine IIIUniversity Hospital FrankfurtGoethe University Frankfurt am MainFrankfurtGermany German center for Cardiovascular Research(DZHK) BerlinGermany cardiopulmonary Institute(CPI) FrankfurtGermany center of Cardiology University Medical Center MainzMainzGermany Di-vision of Cardiology and Intensive Care Department of Internal MedicineSt.Ansgar HospitalHöxterGermany

Background Percutaneous left atrial appendage occlusion(LAAO)requires puncture of the interatrial *** immediate hemodynamic effects of iatrogenic atrial septal defects(iASD)after LAAO have not been examined so *** aimed at evaluat-ing these effects through invasive measurements of pressure and oxygen ***,we assessed the incidence of per-sistent iASD at three *** Forty-eight patients scheduled for percutaneous LAAO were prospectively included in the *** and oxygen saturation were measured(1)in the right atrium(RA)before transseptal puncture,(2)in the left atrium(LA)through the transseptal sheath after transseptal puncture,(3)in the LA after removal of introducer sheath,and(4)in the RA after removal of introducer *** echocardiography was performed at three months to detect *** Pressure in the RA increased significantly after removing the introducer sheath(P=0.034),whereas no difference was found in oxygen saturation in the RA(P=0.623).Pressure measurement in the LA showed no significant difference after re-moving the introducer sheath(P=0.718).Oxygen saturation in the LA also showed no significant difference(P=0.129).Follow-up transesophageal echocardiogram at 3 months revealed a persistent iASD in 4 patients(8.5%).CONCLUSIONS Our study suggests that iASD after percutaneous LAAO does not result in significant shunts directly after the procedure,although a significant increase of mean right atrial pressure can be *** iASDs after percutaneous LAAO seem to be relatively rare at three months.

关键词： atrial septal puncture

Original article：Extracorporeal membrane oxygenation during double-lung transplantation： single center experience

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Chinese Medical Journal 2010年第3期123卷 269-273页

作者： XU Ling-feng LI Xin GUO Zhen XU Mei-yin GAO Cheng-xin ZHU Jin-hong JI Bing-yang Department of cardiopulmonary Bypass Department of Anesthesiology Department of Thoracic Surgery Department of cardiopulmonary Bypass Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background For patients with end-stage lung diseases, lung transplantation is the final therapeutic option. Sequential double-lung transplantation is recognized as an established procedure to avoid cardiopulmonary bypass （CPB）. But some of the sequential double-lung transplantations require CPB support during the surgical procedure for various reasons. However, conventional CPB may increase the risk of bleeding and early allograft dysfunction. Extracorporeal membrane oxygenation （ECMO） is more advantageous than conventional CPB during the perioperative period of transplantation. Replacing traditional CPS with ECMO is promising for those patients needing cardiopulmonary support during a sequential double-lung transplantation procedure. This study aimed to summarize the preliminary experience of ECMO practice in lung transplantation.Methods Between November 2002 and October 2008, twelve patients with end-stage lung diseases undergoing sequential double-lung transplantation were subjected to ECMO during the surgical procedure. Eleven patients were prepared for the procedure via transverse thoracostomy （clamshell） and cannulated through the ascending aorta and right atrium for ECMO. The first patient who underwent bilateral thoracotomy for bilateral sequential lung transplantation required emergency ECMO via the femoral artery and vein during the second lung implantation. The Medtronic centrifugal pump and ECMO package （CBIV97R1, Medtronic, Inc., USA） were used for all of the patients. Results During ECMO, the blood flow rate was set between 1.8-2.0 ***-1 to keep hemodynamic and oxygen saturation stable; colloid oncotic pressure was maintained at more than 18 mmHg with albumin and hematocrit （HCT） kept at 28% or more. Two patients died early in this series and the other 10 patients were weaned from ECMO successfully. The duration of ECMO was 1.38-67.00 hours, and postoperative intubation was 10,5-67.0 hours. Conclusions As an established technique of cardiopulmon

关键词： sequential double-lung transplantations extracorporeal membrane oxygenation cardiopulmonary bypass

Pheochromocytoma with abdominal aortic aneurysm presenting as recurrent dyspnea,hemoptysis,and hypotension:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4754-4759页

作者： Hai-Yang Zhao Yong-Zhen Zhao Yu-Mei Jia Xue Mei Shu-Bin Guo Emergency Medicine Clinical Research center Beijing Chaoyang HospitalCapital Medical University&Beijing Key Laboratory of Cardiopulmonary Cerebral ResuscitationBeijing 100020China Department of Endocrinology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND Pheochromocytomas are rare endocrine tumors with various clinical manifestations,and few of them might present with profound,life-threatening *** SUMMARY We report the case of a 65-year-old man who complained of sudden dyspnea and hemoptysis for half a *** was no obvious cause for the patient to have dyspnea,coughing,or coughing up to approximately 100 mL of fresh ***,he was diagnosed with pheochromocytoma crisis(PCC),coexisting with an abdominal aortic aneurysm(AAA).CONCLUSION We report a case of pheochromocytoma presenting with recurrent hemoptysis,dyspnea and hypotension coexisting with an *** not only proved the uncommon manifestations of pheochromocytoma but also directed clinicians to consider PCC among the possible diagnoses when meeting similar ***,surgical excision is the most beneficial method for the treatment of pheochromocytoma coexisting with AAA when the situation is stable.

关键词： Emergency Hemoptysis Hypotension Pheochromocytoma crisis Abdominal aortic aneurysm Case report

Prevention of ventilator-associated pneumonia with inhaled antibiotics

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World Journal of Emergency Medicine 2024年第3期15卷 165-168页

作者： Stephan Ehrmann Jie Li Intensive Care Medicine INSERM CIC 1415CRICS-TriggerSep FCRIN research networkUniversity Hospital Center in ToursTours 37044France Respiratory Pathology Research center National Institute of Health and Medical ResearchTours 37000France Department of cardiopulmonary Sciences Division of Respiratory CareRush UniversityChicago 60612USA

The direct delivery of inhaled antibiotics to the respiratory tract has been a subject of enduring interest among medical practitioners and researchers due to the associated favorable *** interest has been particularly pronounced in the context of critically illpatients,wherehealthcare-associatedpulmonary infections represent a significant challenge,driving continued exploration of inhaled antibiotics for intubated *** high-level evidence has shown a very promising application in the field of ventilator-associated pneumonia (VAP) prevention.^([1]).

关键词： pneumonia ventilator respiratory