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国际医学放射学杂志 2015年第1期 64-64页

作者： Y.Dori M.M.Zviman M.Itkin Division of cardiology and Department of Radiology Children’s Hospital of Philadelphia

目的验证以钆喷酸葡胺注射液经腹股沟淋巴结注射行动态四维经淋巴结内对比剂增强MR淋巴管成像的可行性。材料与方法所有过程执行研究中动物应用规定并

关键词： MR 四维淋巴管淋巴系统对比剂增强

Papillary fibroelastoma of the aortic valve:An unusual cause of angina

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World Journal of cardiology 2013年第4期5卷 102-105页

作者： Madan Raj Aryal Madan Badal Naba Raj Mainali Leena Jalota Rajesh Pradhan Department of Medicine Reading Health SystemWest ReadingPA 19611United States Department of Medicine Division of CardiologyThomas Jefferson University HospitalPhiladelphiaPA 19107United States

Papillary fibroelastoma of the aortic valve is an uncommon benign tumor of the heart that can present with embolic *** report a case of 54-year-old lady with exertional chest pain and prior history of ST segment elevation myocardial infarction who was subsequently found to have a fibroelastoma of the aortic *** absence of angiographically significant coronary artery disease and resolution of anginal symptoms post-surgery in our patient points to the possibility of fibroelastoma causing these anginal *** uncommon,fibroelastoma are being recognized more frequently with the help of transesophageal ***,in the absence of significant coronary artery disease,we emphasize the importance of consideration of papillary fibroelastoma of the aortic valve as a cause of *** also discuss the key aspects of the fibroelastoma including presentation,diagnostic modalities and treatment options.

关键词： Papillary fibroelastoma Angina Aortic valve Surgical resection Embolic event

双向腔肺动脉吻合术患者在Fontan手术前的诊断性评估:应用非侵入性手段已足够?

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 48-48页

作者： Ro P.S. Rychik J. Cohen M.S. J.J. Rome 高登峰 Division of cardiology Th e Children's Hosp. of Philadelphia Philadelphia PA United StatesDr.

Objectives This study was designed to determine if a subset of patients who ha ve undergone bidirectional cavopulmonary anastomosis could be identified in whic h catheterization was of little benefit before completion of the Fontan procedur e. Background Diagnostic evaluation before Fontan procedure has typically includ ed cardiac catheterization. However, the overall management strategy for patient s with functional single ventricle has evolved to include staging bidirectional cavopulmonary anastomosis in most, and it has become uncommon to exclude patient s from Fontan based on catheterization data. Methods Patients who underwent bidi rectional cavopulmonary anastomosis and had complete echocardiograms and cathete rizations within three months of each other between January 1992 and October 199 7 were evaluated with a series of clinical and echocardiographic characteristics to identify a subset in whom catheterization was predicted to be of little adde d value (“no-cath”group). The predictive value and sensitivity of these crite ria in excluding patients who required additional intervention, were excluded fr om Fontan, or died within 30 days of Fontan was determined. Results A total of 9 9 patients who underwent bidirectional cavopulmonary anastomosis at 6.7 months ( range 2.9 months to 14 years) were studied; 46 met criteria for the “no-cath” group. Noninvasive criteria stratified all patients who died (n=5) or did not pr oceed to Fontan (n =1) and 9 of 11 who required additional interventions to the “cath”group. Thus, the negative predictive value of these criteria was 93%. C onclusions Our data suggest that catheterization before Fontan could be avoided in a large percentage of patients without adversely affecting outcome; prospecti ve evaluation of this strategy is warranted.

关键词：动脉吻合术 Fontan手术导管组功能性单心室心导管检查超声检查结果超声心动图阴性预测值附加效应介入术

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双磷酸改性血管支架作为基因载体的研究

国际生物医学工程杂志 2012年第1期35卷 3-7,I0001页

作者：王勇俞玫张琳华马桂蕾 Ilia Fishbein Ivan S. Alferiev Robert J. Levy 宋存先中国医学科学院北京协和医学院生物医学工程研究所天津300192 PA 19104 USA Division of Cardiology The Children＇s Hospital of Philadelphia

目的将基因通过化学偶联和特异性免疫结合在双磷酸氨基酯改性的316L不锈钢冠状动脉支架上，评价支架改性和负载质粒DNA的效果。方法金属支架首先利用双磷酸氨基酯改性引入氨基活性基团，化学偶联抗DNA抗体，然后免疫偶联质粒DNA，得到... 详细信息

目的将基因通过化学偶联和特异性免疫结合在双磷酸氨基酯改性的316L不锈钢冠状动脉支架上，评价支架改性和负载质粒DNA的效果。方法金属支架首先利用双磷酸氨基酯改性引入氨基活性基团，化学偶联抗DNA抗体，然后免疫偶联质粒DNA，得到血管支架上负载抗体和基因的模型。结果利用x射线光电子能谱（xPs）和原子力显微镜（AFM）等分析确定了支架表面磷酸氨基的存在，同位素标记验证了改性后支架表面结合的抗体具有很好的稳定性和结合容量。结论双磷酸氨基改性的血管支架表层富含可反应氨基，可以作为新型反应界面，与生物活性分子进行偶联反应。

关键词：支架双磷酸酯质粒DNA 基因载体

左心发育不全时升主动脉和主动脉弓的形态学研究:外科意义

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 61-62页

作者： Ilbawi A.M. Spicer D.E. Bharati S. 韩瑞娟 University of Pennsylvania School of MedicinePhiladelphiaPaUnited States

目的:左心发育不全患者的升主动脉和主动脉弓由于血流减少而致发育不全。在本研究中,对小主动脉内狭窄或内折区域所致梗阻存在与否及其程度进行量化,并对其外科意义进行讨论。方法:研究96例左心发育不全样本,对特定部位进行测量以评估... 详细信息

目的:左心发育不全患者的升主动脉和主动脉弓由于血流减少而致发育不全。在本研究中,对小主动脉内狭窄或内折区域所致梗阻存在与否及其程度进行量化,并对其外科意义进行讨论。方法:研究96例左心发育不全样本,对特定部位进行测量以评估狭窄区域。

关键词：升主动脉左心患者主动脉升部发育不全外科

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胎儿外科手术产生的急性心血管效应

世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 25-26页

作者： Rychik J. Cohen M.S. 郝广华 Fetal Heart Program Children's Hospital of Philadelphia 34th St and Civic Center Blvd Philadelphia PA 19104 United States Dr.

Background-Prenatal surgery for congenital anomalies can prevent fetal demise or alter the course of organ development, resulting in a more favorable condition at birth. The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system. Methods and Results-Echocar-diography was used to evaluate the heart before, during, and early after fetal surgery for congenital anomalies, including repair of myelomeningocele(MMC, n=51), resection of intrathoracic masses (ITM, n=15), tracheal occlusion for congenital diaphragmatic hernia (CDH, n=13), and resection of sacrococcygeal teratoma (SCT, n=4). Fetuses with MMC all had normal cardiovascular systems entering into fetal surgery,whereas those with ITM, CDH, and SCT all exhibited secondary cardiovascular sequelae of the anomaly present. At fetal surgery, heart rate increased acutely, and combined cardiac output diminished at the time of fetal incision for all groups including thzose with MMC, which suggests diminished stroke volume. Ventricular dysfunction and valvular dysfunction were identified in all groups, as was acute constriction of the ductus arteriosus. Fetuses with ITM and SCT had the most significant changes at surgery. Conclusions-Acute cardiovascular changes take place during fetal surgery that are likely a consequence of the physiology of the anomaly and the general effects of surgical stress, tocolytic agents, and anesthesia. Echocardiographicmonitoring during fetal surgery is an important adjunct in the management of these patients.

关键词：胎儿外科心血管效应肿块切除术胎儿心率骶尾部畸胎瘤先天性膈疝先天异常脊膜膨出超声心动图动脉导管

携带基因的冠状动脉支架和心血管再狭窄的基因治疗

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透析与人工器官 2005年第3期16卷 8-12页

作者：宋存先金旭 R J Levy BD Klugherz S DeFelice 中国医学科学院中国协和医科大学生物医学工程研究所 The Division of cardiology Childrens Hospital of PhiladelphiaPA19104USA

通过在血管支架上固定化抗体并结合腺病毒载体实现了血管内部定位基因运载。可治疗经皮冠状动脉腔内形术及放置支架术后再狭窄疾病。

关键词：基因冶疗抗腺病毒抗体再狭窄

对伴或不伴主动脉弓梗阻的室间隔缺损行早期修复的神经发育预后

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 57-57页

作者： Kaltman J.R. Jarvik G.P. Bernbaum J. 刘宇 Division of cardiology Children's Hospital of Philadelphia34th and Civic Center BlvdPhiladelphiaPA 19104United States.Dr

Objectives: Cross-sectional studies of intermediate-term survivors of infant cardiac surgery have revealed a high frequency of neurodevelopmental disabiliti es. Few data exist regarding neurodevelopmental outcome of infants undergoing su rgical intervention for a ventricular septal defect. The purpose of this study w as to evaluate the neurodevelopmental outcome at 1 year of age of children who h ad surgical repair in infancy of a ventricular septal defect or a ventricular se ptal defect with aortic arch obstruction. Methods: Children who underwent repair of a ventricular septal defect or single-stage repair of a ventricular septal defect with aortic arch obstruction at less than 6 months of age were assessed a t 1 year of age by using the Bayley Scales of Infant Development II, which yield s the Mental Development Index and the Psychomotor Development Index, both with an expected mean of 100±15. Results: At 1 year, 55 patients(ventricular septal defect alone=36; ventricular septal defect with aortic arch obstruction=19) retu rned for evaluation. The mean Mental Development Index was 92.6±11.7, with 3(5 %) patients scoring 70 or less. The mean Psychomotor Development Index was 86.1 ±16.4, with 10(18%) patients scoring 70 or less. Patients with a suspected or confirmed genetic syndrome had both a lower Mental Development Index score(P=.01 1) and a lower Psychomotor Development Index score(P=.001). Mental Development I ndex and Psychomotor Development Index were independent of anatomic(specifically aortic arch obstruction) and intraoperative factors(specifically deep hypotherm ic circulatory arrest). Conclusions: Neurodevelopmental outcome at 1 year of age was within the normal limits for most patients who underwent repair of a ventri cular septal defect or a ventricular septal defect with aortic arch obstruction during infancy.

关键词：单纯室间隔缺损神经发育障碍主动脉弓梗阻早期修复婴幼儿发育量表运动发育指数患儿心理

皮肤胆固醇含量增加Framingham风险评估的效能

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世界核心医学期刊文摘（心脏病学分册） 2007年第3期3卷 16-17页

作者： Sprecher D.L. Pearce G.L. 吴晓燕 Dr.Department of Medicine Experimental Therapeutics The University of Pennsylvania Philadelphia PA United States

引言:研究表明,皮肤组织胆固醇含量(SkinTc)与血管造影所示病变有关。现在,作者进一步研究同时合并高SkinTc和高传统危险因素负荷患者的多支血管病变(至少两支血管狭窄>50%)相对风险。方法:入选患者(n=649)在进行血管造影前即刻检测Ski... 详细信息

引言:研究表明,皮肤组织胆固醇含量(SkinTc)与血管造影所示病变有关。现在,作者进一步研究同时合并高SkinTc和高传统危险因素负荷患者的多支血管病变(至少两支血管狭窄>50%)相对风险。方法:入选患者(n=649)在进行血管造影前即刻检测SkinTc。

关键词： Framingham 传统危险因素多支血管病变支血管血管造影相对风险风险评估危险分层总

Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia

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生理通讯 2013年第6期32卷 135-145页

作者： Yajing Wang Jianli Zhao Yanqing Zhang Wayne Bond Lau Li-Yuan Jiao Baojiang Liu Yuexing Yuan Xiaoliang Wang Ling Tao Erhe Gao Walter J. Koch Xin-Liang Ma Department of Physiology Shanxi Medical University Taiyuan 030001 China Department of Emergency Medicine Thomas Jefferson University Philadelphia PA 19107 United States Department of Anesthesiology First Affiliated Hospital Shanxi Medical University Taiyuan 030001 China Department of cardiology Fourth Military Medical University Xian 710032 China Center for Translational Medicine Temple University Medical School Philadelphia PA 19107 United States

2013年10月12—13日中国生理学会张锡钧基金会第十二届全国青年优秀生理学学术论文交流会在湖南长沙顺利召开。由各省生理学会推荐的37名参赛选手的论文参与评选，会议展示了选手们近3年来在生理学研究方面所取得的最新研究成果。经过... 详细信息

2013年10月12—13日中国生理学会张锡钧基金会第十二届全国青年优秀生理学学术论文交流会在湖南长沙顺利召开。由各省生理学会推荐的37名参赛选手的论文参与评选，会议展示了选手们近3年来在生理学研究方面所取得的最新研究成果。经过专家对参评者论文和现场报告的综合评判，评出一等奖、二等奖、三等奖、特别奖、最佳表达奖、最佳答辩奖和最佳图标奖共11名。从2013年第6期开始，《生理通讯》将陆续转载获奖者的参评论文各一篇，以飨读者。

关键词：生理学研究成果专家论文