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Cell and gene therapy for arrhythmias： Repair of cardiac conduction damage

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Journal of Geriatric Cardiology 2011年第3期8卷 147-158页

作者： Yong-Fu Xiao cardiac rhythm disease management Medtronic lnc. 8200 Coral Sea Street NE Mounds View MN 55112 USA

Action potentials generated in the sinoatrial node （SAN） dominate the rhythm and rate of a healthy human heart. Subsequently, these action potentials propagate to the whole heart via its conduction system. Abnormalities of impulse generation and/or propagation in a heart can cause arrhythmias. For example, SAN dysfunction or conduction block of the atrioventricular node can lead to serious bradycardia which is currently treated with an implanted electronic pacemaker. On the other hand, conduction damage may cause reentrant tachyarrhythmias which are primarily treated pharmacologically or by medical device-based therapies, including defibrillation and tissue ablation. However, drug therapies sometimes may not be effective or are associated with serious side effects. Device-based therapies for cardiac arrhythmias, even with well developed technology, still face inadequacies, limitations, hardware complications, and other challenges. Therefore, scientists are actively seeking other alternatives for antiarrhythmic therapy. In particular, cells and genes used for repairing cardiac conduction damage/defect have been investigated in various studies both in vitro and in vivo. Despite the complexities of the excitation and conduction systems of the heart, cell and gene-based strategies provide novel alternatives for treatment or cure of cardiac arrhythmias. This review summarizes some highlights of recent research progress in this field.

关键词： cell therapy gene therapy conduction repair arrhythmia

cardiac arrhythmia and heart failure： From bench to bedside

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Journal of Geriatric Cardiology 2011年第3期8卷 131-132页

作者： Yong-Fu Xiao cardiac rhythm disease management Medtronic Inc. 8200 Coral Sea Street NE MVN46 Mounds View MN 55112 USA

cardiac arrhythmia is an abnormal rate and/or rhythm of a heart due to its abnormal electrical impulse origination and/or propagation. Various etiologies can cause arrhythmias. Heart failure （HF） is a clinical syndr... 详细信息

关键词： cardiac arrhythmia heart failure aging

Six Years Clinical Experience and Surgical Considerations in management of cardiac Myxoma in Iraqi Center for Heart disease—Single Center Experience

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World Journal of Cardiovascular Surgery 2022年第8期12卷 173-183页

作者： Hozhan Hussein Blbas Abdulameer Mohsin Hussein Muhammad Mahmud Salim Laith Saleh Alkaaby Abdulsalam Y. Taha Department of cardiac Surgery Surgical Specialty Hospital—Cardiac Center College of Medicine Hawler Medical University Erbil Iraq Department of Thoracic and Cardiovascular Surgery College of Medicine University of Baghdad Baghdad Iraq Department of cardiac Surgery Surgical Specialty Hospital—Cardiac Center Erbil Iraq Department of cardiac Surgery Iraqi Center for Heart Diseases Baghdad Iraq Department of Thoracic and Cardiovascular Surgery College of Medicine University of Sulaimani Sulaymaniyah Iraq

Background: cardiac myxomas are the most frequently encountered benign cardiac tumors that if left untreated are inexorably progressive and potentially fatal. Surgery is the only way of treatment, and if not treated with the right surgical technique recurrence occurs. Objectives: In this single center study we documented the patterns of presentation, localization, surgical approaches and outcome of cardiac myxomas. Methods: This is a retrospective study of 20 patients who underwent surgical removal of atrial myxoma from January 2010 to December 2015. All patients underwent general investigations, and echocardiography was performed on all patients and surgery was done using extracorporeal circulation and mild hypothermia. Results: The ages of the patients ranged from 14 years to 71 years, with a mean of 51.45 years. Most myxomas (75%) originated from left atrium, 20% from right atrium and biatrial in 5% of cases. The male-to-female ratio was 1:2.3 (14 females and 6 males). Myxomas were more common in blood group A+ and B+. Chief complaints were dyspnea (70%) and palpitation (50%). The majority of masses were attached to the interatrial septum (65%) and four of cases (20%) arose from the lateral wall. Right atrial trans-septal incision was used in 55% of cases. No recurrence was recorded in our study. Six patients had postoperative complications, mainly in the form of arrhythmia (3 cases), bleeding (0ne case) and renal failure (one case) which resulted in the death of the patient. Conclusions: cardiac myxoma excision account for a very small percentage of cardiac procedures. Immediate surgical treatment is indicated because of high risk of embolization and sudden death. cardiac myxomas can be excised with a low rate of mortality and morbidity. Follow-up examination, including echocardiography, should be performed regularly.

关键词： Atrial Myxoma cardiac Tumors cardiac Surgery

计算机模型和仿真在心脏病研究中的应用(待续)

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中华高血压杂志 2013年第9期21卷 805-807页

作者： LI Qin-ce ZHOU Lu-fang Department of Medicine Division of Cardiovascular Disease Department of biomedical Engineering cardiac rhythm management Laboratory The Comprehensive Cardiovascular Center University of Alabama at Birmingham Birmingham ALUSA 35294

随着计算机性能的提高，计算机模型被广泛应用于研究心肌细胞电生理与新陈代谢的内在机制，其在探索各种心脏病的诱因与疗法中也具有独特的应用价值。虽然计算机模型只是对真实存在系统的近似描述,但是一个成熟的心脏模型不仅能够模拟... 详细信息

随着计算机性能的提高，计算机模型被广泛应用于研究心肌细胞电生理与新陈代谢的内在机制，其在探索各种心脏病的诱因与疗法中也具有独特的应用价值。虽然计算机模型只是对真实存在系统的近似描述,但是一个成熟的心脏模型不仅能够模拟系统中各种生理过程，而且能够预测整个系统在非正常甚至疾病状态下的动态反应。本文简述了计算机心脏模型的发展历史和最新进展，并列举了其在一些心脏疾病研究中的应用。因篇幅所限，本文仅讨论单细胞的情况，有关二维多细胞组织和三维心脏模型的综述请参考相关文献。

关键词：计算机模型心脏病心肌细胞电生理仿真模拟系统心脏模型新陈代谢生理过程

计算机模型和仿真在心脏病研究中的应用(续前)

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中华高血压杂志 2013年第10期21卷 905-908页

作者： LI Qin-ce ZHOU Lu-fang Department of Medicine Division of Cardiovascular Disease Department of biomedical Engineering cardiac rhythm management Laboratory The Comprehensive Cardiovaseular Center University of Alabama at Birmingham Birmingham ALUSA 35294

在细胞层面，离子通道的改变通常对应于遗传性心律失常综合征，例如长QT综合征（long Q-T syndrome, LQTS）和Brugada综合征（Brugada syndrome，BrS），主要体现在编码心肌细胞离子通道的基因发生突变。Clancy和Rudy模拟了SCN 5 0A基因... 详细信息

在细胞层面，离子通道的改变通常对应于遗传性心律失常综合征，例如长QT综合征（long Q-T syndrome, LQTS）和Brugada综合征（Brugada syndrome，BrS），主要体现在编码心肌细胞离子通道的基因发生突变。Clancy和Rudy模拟了SCN 5 0A基因的KPQ基因突变（获得功能的基因突变）所导致的LQTS，模拟结果显示，基因突变导致的钠电流失活门多肽的改变中断钠电流失活，从而引起后期钠电流的产生。这导致了电动势时程的延长和QT间期的延长，从而形成LQTS。

关键词：计算机模型心肌细胞离子通道遗传性心律失常综合征 Brugada综合征心脏病基因突变仿真长QT综合征

Comparison of the prognostic value of frailty assessment tools in patients aged≥65 years hospitalized in a cardiac care unit with acute coronary syndrome

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Journal of Geriatric Cardiology 2022年第5期19卷 343-353页

作者： Wojciech Nowak Ilona Kowalik Małgorzata Kuzin Agnieszka Krauze Anna Mierzyńska Ewa Sadowy Kamil Marcinkiewicz Janina Stępińska Department of Intensive cardiac Therapy National Institute of CardiologyWarsawPoland Clinical Research Support Center National Institute of CardiologyWarsawPoland Department of Coronary Artery disease and cardiac Rehabilitation National Institute of CardiologyWarsawPoland

BACKGROUND Frailty is associated with adverse events in elderly patients with acute coronary syndrome(ACS).Our aim was to compare the prognostic value of four frailty scales in patients aged≥65 years hospitalized with ACS in a cardiac care unit(CCU).METHODS Patients aged≥65 years with ACS were *** was assessed using the Fried frailty scale(reference standard),the Edmonton Frail Scale(EFS),the FRAIL scale,and the Clinical frailty scale(CFS).The primary end point was all-cause mortality and the secondary end point was unscheduled *** One hundred and seventy four patients aged≥65 years with ACS were *** median follow-up was 637.5 *** was identified in 41.4%,40.2%,39.1%and 36.3%patients by the Fried frailty scale,EFS,FRAIL scale and CFS,*** agreement coefficients were 0.88,0.86,and 0.79 for the FRAIL scale,EFS and CFS,*** the Cox regres-sion model,frailty was associated with all-cause mortality regardless of the scale used(univariate:hazard ratio[HR]95%CI=10.5,2.4-46.8 Fried frailty scale;12.0,2.7-53.4 FRAIL scale;7.1,2.0-25.2 EFS;8.3,2.4-29.6 ***:HR=5.1,1.1-23.8 Fried frailty scale;5.7,1.2-26.8 FRAIL scale;3.7,1.0-14.0 EFS;4.2,1.1-15.9 CFS).The FRAIL scale had the highest *** the uni-variate analysis,frailty was associated with unscheduled rehospitalization(HR=3.2,1.7-6.0 Fried frailty scale;3.4,1.8-6.3 FRAIL scale;3.5,1.8-6.6 EFS;3.1,1.7-5.8 CFS).In the multivariate analysis,only the EFS independently predicted unscheduled rehospit-alization(HR=2.2,1.1-4.63).CONCLUSIONS Frailty assessed by the Fried frailty scale,FRAIL scale,EFS and CFS is associated with all-cause mortality and unscheduled rehospitalization in elderly patients hospitalized in a CCU with *** adjusted HR of the FRAIL scale for all-cause mortality was the highest among the scales compared,whereas the EFS was an independent predictor of unscheduled *** data should be taken into consider

关键词： patients mortality coronary

The impact of frailty on in-hospital complications in elderly patients with acute coronary syndrome

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Journal of Geriatric Cardiology 2023年第3期20卷 174-184页

作者： Wojciech Nowak Ilona Kowalik Michał Nowicki Tomasz Cichocki Janina Stępińska Department of Intensive cardiac Therapy National Institute of CardiologyWarsawPoland Clinical Research Support Center National Institute of CardiologyWarsawPoland Department of Coronary Artery disease and cardiac Rehabilitation National Institute of CardiologyWarsawPoland

BACKGROUND Acute coronary syndrome(ACS)is linked to a range of in-hospital complications,and age is recognized as risk factor for adverse *** between physiological and chronological age are explained by ***,the relationship between frailty and in-hospital complications is not *** Assessment of frailty in patients was carried out using the FRAIL ***-hospital complications assessed included,bleeding,infection,arrhythmia,acute kidney injury(AKI),delirium,stroke/transient ischemic attack(TIA),liver injury,hypoglycemia,length of stay in the cardiac care unit(CCU).RESULTS Of the 174 patients,frailty was identified in 39.1%and pre-frailty in 29.9%.Frailty was associated with a higher incidence of all types of bleeding(frail ***:45.5%vs.16.7%,P3 days)(OR:3.7[1.9-7.3]).CONCLUSIONS Frailty was associated with an increased risk of numerous in-hospital complications in elderly patients who had been

关键词： patients complications coronary

Unplanned J-valve implantation during open heart surgery for severe valvular annulus and ventricle calcification

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Journal of Geriatric Cardiology 2022年第12期19卷 1003-1006页

作者： Tian-Ge LUO Bo LI Jie HAN Hai-Bo ZHANG cardiac Valve Centre Department of Cardiac SurgeryBeijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijingChina Department of cardiac Surgery People’s Hospital of Liaoning ProvinceShenyangChina

Aortic annulus calcification(AC)and mitral AC are common in patients with cardiac valvular disease.[1]Procedures to resect or debride aortic AC and mitral AC may lead to cerebral emboli,heart failure,arrhythmia,coronary artery lesions,and even ventricular rupture.[2]Therefore,it is often a challenge for surgeons to choose an appropriate surgical strategy for patients with severe valvular AC.[3,4]A sutureless valve is a good choice,doing away with the need to take time to remove the AC,but many countries do not have this *** aortic valve implantation(TAVI)and transcatheter mitral valve replacement(TMVR)have developed rapidly during recent years.

关键词： mitral implantation calcification

Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target