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Chinese Medical Journal 2023年第9期136卷 1114-1116页

作者： Yupeng Lai Yanpeng Zhang Zhihao Lei Yihong Huang Tongxin Ni Pin He Xiaoling Li Chiduo Xu Jun Xia Meiying Wang Department of Rheumatology and Immunology Shenzhen Second People’s HospitalShenzhenGuangdong 510000China Department of Laboratory Shenzhen Second People’s HospitalShenzhenGuangdong 510000China Department of Neurology Shenzhen Second People’s HospitalShenzhenGuangdong 510000China Department of Cardiology Shenzhen University General HospitalShenzhenGuangdong 510000China Department of Radiology Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenGuangdong 510000China Community Health Service Management Center The Eighth Affiliated Hospital of Sun Yat-Sen UniversityShenzhenGuangdong 510000China Department of Radiology Shenzhen Second People’s HospitalShenzhenGuangdong 510000China

To the Editor:The risk factors for the development of radiographic axial spondyloarthritis(SpA)are still *** studies found that a high concentration of serum uric acid(SUA)leads to deposition of monosodium urate(MSU)in different joints of other rheumatic arthritis diseases except ***,it has been reported that gout could mimic ***,our study explored whether the development of radiographic axial SpA is related to high SUA concentration.

关键词： serum axial concentration.

Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology

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World Journal of Gastroenterology 2015年第24期21卷 7529-7544页

作者： Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven Unitat de Recerca Biomèdica Hospital Universitari de Sant JoanInstitut d’Investigacio Sanitària Pere VirgiliUniversitat Rovira i VirgiliCampus of International Excellence Southern Catalonia Servei de Cirurgia General i de l’Aparell Digestiu Hospital Universitari de Sant Joan de ReusUniversitat Rovira i Virgili Metabolomics Platform Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas AsociadasIISPVUniversitat Rovira i Virgili Research and Collaborations General Electric Healthcare Metabolism and cancer Group Transla-tional Research LaboratoryCatalan Institute of OncologyGirona Biomedical Research Institute

AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical ***: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected

关键词： Fatty liver disease Magnetic resonanceimaging Lipids Magnetic resonance spectroscopy Metabolomics Mitochondrial function Morbid obesity Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis

BRCA2 promoter polymorphism is associated with breast cancer prognosis in Chinese women

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Chinese Medical Journal 2014年第11期127卷 2012-2015页

作者： Liu Lu Fang Yi Fan Jianlin Hu Jianming Xu Xiaoting Jin Xiaohong Wang Xiuzhen Deng Min Wang Jing Liu Wei Department of Pathology First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Abdominal Surgical Oncology Cancer Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100021 China Department of Stomatology Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China Department of Obstetrics and Gynaecology First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Radiation Oncology First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Anesthesiology First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Pathology Soochow University Suzhou Jiangsu 215006 China Department of Pathology Soochow University Suzhou Jiangsu215006 China

Background Breast cancer 2 （BRCA2） is an important breast cancer-susceptibility *** polymorphisms in BRCA2 may affect its transcription and be associated with cancer *** We identified five polymorphisms of the BRCA2 promoter region by in silico searching and direct sequencing：-254A/G （rs3092989）,-908A/G （rs206117）,-1134A/G （rs206115）,-1144C/T （rs206116）,and-1260CTTAGA/-（rs3072036）.The-908A/G,-1134A/G,-1144C/T,and-1260CTTAGA/-polymorphisms were genotyped by direct sequencing in 491 breast cancer patients,and the-254A/G polymorphism was genotyped by *** The-1144C/T polymorphism was associated with clinical *** of the TT genotype had longer disease-free intervals （DFIs,P=0.029）,especially among patients with sporadic unilateral breast cancer （P=0.010）.Linkage disequilibrium （LD） analysis showed that all the five single nucleotide polymorphisms （SNPs） were in LD （D＇〉0.8）.Carriers of haplotypes containing the-1144T allele showed longer DFIs （P=0.049）,and the result was more significant in patients with sporadic unilateral cancer （P=0.018）.There were no significant associations between the other polymorphisms and *** The results of this study suggest that homozygosity for the BRCA2 T（-1144） allele is associated with a longer DFI in Chinese women with breast *** functional studies are warranted to clarify this relationship.

关键词： breast cancer prognosis polymorphism promoter BRCA2

Transcriptional landscapes of de novo root regeneration from detached Arabidopsis leaves revealed by time-lapse and single-cell RNA sequencing analyses

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Plant Communications 2022年第4期3卷 83-104页

作者： Wu Liu Yuyun Zhang Xing Fang Sorrel Tran Ning Zhai Zhengfei Yang Fu Guo Lyuqin Chen Jie Yu Madalene SIson Teng Zhang Lijun Sun Hongwu Bian Yijing Zhang Li Yang Lin Xu National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of Sciences300 Fenglin RoadShanghai 200032China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing100049China Department of Plant Pathology University of GeorgiaAthensGA 30602USA College of Life Sciences Shanghai Normal UniversityShanghai 200234China Hainan Institute of Zhejiang University Yazhou Bay Science and Technology CitySanya 572025China School of Life Sciences Nantong UniversityNantongChina Institute of Genetic and Regenerative Biology Key Laboratory for Cell and Gene Engineering of Zhejiang ProvinceCollege of Life SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and DevelopmentDepartment of BiochemistryInstitute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China These authors contributed equally to this article Department of Pharmacology and Chemical Biology UPMC Hillman Cancer CenterMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA

Detached Arabidopsis thaliana leaves can regenerate adventitious roots,providing a platformfor studying de novo root regeneration(DNRR).However,the comprehensive transcriptional framework of DNRR remains ***,we provide a high-resolution landscape of transcriptome reprogramming from wound response to root organogenesis in DNRR and show key factors involved in ***-lapse RNA sequencing(RNA-seq)of the entire leaf within 12 h of leaf detachment revealed rapid activation of jasmonate,ethylene,and reactive oxygen species(ROS)pathways in response *** analyses confirmed that ethylene andROSmay serve as wound signals to ***,time-lapse RNA-seq within 5 d of leaf detachment revealed the activation of genes involved in organogenesis,wound-induced regeneration,and resource allocation in the wounded region of detached leaves during adventitious *** studies showed that BLADE-ON-PETIOLE1/2,which control aboveground organs,PLETHORA3/5/7,which control root organogenesis,and ETHYLENE RESPONSE FACTOR115,which controlswound-induced regeneration,are involved in ***,single-cell RNA-seq data revealed gene expression patterns in thewounded region of detached leaves during adventitious ***,our study not only provides transcriptome tools but also reveals key factors involved in DNRR from detached Arabidopsis leaves.

关键词： single-cell RNA-seq time-lapse RNA-seq de novo root regeneration plant regeneration wounding Arabidopsis thaliana

CRISPR-based screening identifies XPO7 as a positive regulatorof senescence

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Protein & Cell 2023年第8期14卷 623-628页

作者： Lan-Zhu Li Kuan Yang Yaobin Jing Yanling Fan Xiaoyu Jiang Si Wang Guang-Hui Liu Jing Qu Shuai Ma Weiqi Zhang State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China School of Future Technology University of Chinese Academy of SciencesBeijing 100190China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China

Dear Editor,Cells enter senescence,or irreversible growth arrest,when exposed to stressors such as DNA damage,epigenetic alterations and chronic inflammation(Zhao and Chen,2022).In aging and aging-related diseases,sen... 详细信息

关键词： alterations organs

Characterization of intratumor microbiome in cancer immunotherapy

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The Innovation 2023年第5期4卷 27-29页

作者： Zhao Zhang Qian Gao Xiangmei Ren Mei Luo Yuan Liu Peilin Liu Yun Liu Youqiong Ye Xiang Chen Hong Liu Leng Han MOE Key Laboratory of Metabolism and Molecular Medicine Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai200032China Department of Dermatology Hunan Engineering Research Center of Skin Health and DiseaseHunan Key Laboratoryof Skin Cancer and PsoriasisNational Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangshaHunan 410008China Center for Epigenetics and Disease Prevention Institute of Biosciences and TechnologyTexas A&M UniversityHoustonTX 77030USA Department of Clinical Laboratory Xiangya HospitalCentral South UniversityChangsha 410008China Shanghai Institute of Immunology Department of Immunology and MicrobiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Translational Medical Sciences Collge of MedicineTexas A&M UniversityHoustonTX 77030USA Brown Center for Immunotherapy Indiana University School of MedicineIndianapolisIN 46202USA Department of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisIN 46202USA

Dear Editor,As an illuminating cancer hallmark,polymorphic microbiomes profoundly impact cancer phenotypes by promoting or repressing cancer initiation and progression.1 Diversity and composition in the gut microbiome are significantly associated with the response rate of anti-PD1 immunotherapy in melanoma.2 In addition to the gut microbiome,a large number of microbiomes colonizing in human tumors have been shown to play significant roles in cancer development.3 However,a comprehensive understanding of intratumor microbiomes in cancer immunotherapy is lacking,largely due to the challenge of investigating intratumor microbiomes in anti-cancer immunotherapy.

关键词： immunotherapy PD1 cancer

mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic,mesenchymal and neural stem cells

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Protein & Cell 2022年第9期13卷 676-682页

作者： Qun Chu Feifei Liu Yifang He Xiaoyu Jiang Yusheng Cai Zeming Wu Kaowen Yan Lingling Geng Yichen Zhang Huyi Feng Kaixin Zhou Si Wang Weiqi Zhang Guang-Hui Liu Shuai Ma Jing Qu Moshi Song State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China Aging Translational Medicine Center International Center for Aging and CancerXuanwu HospitalCapital Medical UniversityBeijing 100053China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Chongqing Renji Hospital University of Chinese Academy of SciencesChongqing 400062China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

Dear Editor,Stem cells,including pluripotent stem cells and adult stem cells,possess the remarkable capability of being able to selfrenew while at the same time having potential to differentiate into different cell lineages and functionally distinct cell *** embryonic stem cells(hESCs)can differentiate into all adult stem cell types,including human mesenchymal stem cells(hMSCs)and human neural stem cells(hNSCs),but can also give rise to all terminally differentiated cell types(Wang et al.,2021a).Through the continuous replenishment of differentiated cells,stem cells support tissue homeostasis and respond to tissue *** the promising applications of stem cells in cell therapy and regenerative medicine,insights into molecular events underlying stem cell maintenance,self-renewal ability and pluripotency,continue to garner strong interest(Shan et al.,2021).Although metabolic pathways have been implicated in the reciprocal regulations of stem cell self-renewal and differentiation as well as organ homeostatic maintenance(Garcia-Prat et al.,2017),central aspects of how metabolic requirements differ and are regulated across the various types of human stem cells in our body remain enigmatic.

关键词： injuries homeostasis neural

Photodynamic Therapy in the Healing of the Areolo-Papillary Complex after Mastectomy—Case Report

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Health 2018年第3期10卷 326-333页

作者： Maria da Glória Karan Marquetti Marquetti Marcus Vinícius de Mello Pinto Aline Ronis Lamara Laguardia Valente Rocha Julio Guilherme Silva Anny Chi Daniel Almeida Costa Higher Education Center of Foz do Iguacu—CESUFOZ Paraná Brazil Biomedical Studies by Italian University Institute of Rosario—IUNIR Santa Fe de la Vera Cruz Argentina Celulare Institute in Itaipava Petropólis Rio de Janeiro Brazil University of Caratinga UNEC Caratinga Brazil The Master’s and PhD program in Rehabilitation Sciences at University Center Augusto Motta—UNISUAM Rio de Janeiro Brazil Marcos Thomé Institute Ponta Grossa Paraná Brazil Center Medicine School of Higher Education of Valenca—CESVA/FAA Rio de Janeiro Brazil

Some breast reconstruction surgeries after mastectomy, or even reductive mammoplasty, may evolve unexpectedly when the areolopapillary complex heals and develop dehiscences, necrosis and delayed healing. The purpose of this case report was to verify the efficacy of photodynamic therapy in wound healing of the areolopapillary complex. This was a case report of a female patient with diabetes, fibromyalgia and diagnosed with breast cancer, with necrotic areolopapillary complex, after debridement, photodynamic therapy started with clobetasol propionate associated with methylene blue and low power laser application. At the beginning of the treatment with photodynamic therapy, the wound had 6 centimeters of diameter, and after 19 sessions, the wound was closed completely with normalization of the color of the nipple. The photodynamic therapy is advancing a lot in healing of infected wounds and complex wounds. It can be said that in this case report, photodynamic therapy was fundamental for the complete healing, being considered a promising treatment and another alternative for dermatofunctional physiotherapists.

关键词： Photodynamic Therapy Wound Healing Photomedicine

香丹制剂对LPS诱导的血管内皮细胞NF-κΒ活性的影响

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四川中医 2008年第1期26卷 31-33页

作者：孔祥丽阎蓉华李绚罗照田吴琦王伯瑶四川大学口腔生物医学工程重点实验室四川成都610041 四川大学华西医学中心基础医学与法医医学院病理生理教研室感染免疫研究室四川成都610041 The UT MD Anderson cancer Center Box 354

目的:探讨中药复方香丹注射液对血管内皮细胞核转录因子NF-κB及抑制因子IκB活性的干预作用。方法:采用MTT法及形态学方法观察香丹注射液对人脐静脉血管内皮细胞活性的影响,用Sandwich ELISA定量分析法和定量免疫细胞技术,检测NF-κB... 详细信息

目的:探讨中药复方香丹注射液对血管内皮细胞核转录因子NF-κB及抑制因子IκB活性的干预作用。方法:采用MTT法及形态学方法观察香丹注射液对人脐静脉血管内皮细胞活性的影响,用Sandwich ELISA定量分析法和定量免疫细胞技术,检测NF-κB活性及胞浆内IκB含量。结果:有效剂量范围的香丹注射液能抑制血管内皮细胞的生长,拮抗NF-κB活性及抑制IκB降解(P<0.01)。结论:香丹注射液的抗炎作用可能与其拮抗NF-KBp65活化有关。

关键词：香丹注射液 LPS NF-κB IκB

The role of stereotactic body radiotherapy in hepatocellular carcinoma:guidelines and evidences

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Journal of the National cancer Center 2022年第3期2卷 171-182页

作者： Yulin Hu Caining Zhao Ren Ji Wenqi Chen Qi Shen CL Chiang Jeff Chan Lingyu Ma Hongwei Yang Tiffany Wong Susannah Ellsworth Chung-Mau Lo Laura A.Dawson Feng-Ming(Spring)Kong Graduate School Shenzhen UniversityShenzhenChina Department of Clinical Oncology The University of Hong Kong-Shenzhen HospitalShenzhenChina Department of Clinical Oncology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Division of Hepatobiliary&Pancreatic Surgery Department of SurgeryThe University of Hong Kong-Shenzhen HospitalShenzhenChina Department of Radiation Oncology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina Department of Radiology Division of Interventional RadiologyThe University of Hong Kong-Shenzhen HospitalShenzhenChina Department of Radiation Oncology University of Pittsburgh Medical CenterPittsburghUSA Radiation Medicine program Princess Margaret HospitalUniversity Health NetworkTorontoCanada Department of Clinical Oncology Queen Mary HospitalHong Kong University Li Ka Shing Faculty of MedicineHong KongChina

Hepatocellular carcinoma(HCC)is a common malignancy with high mortality *** surgery can be curative in early-stage disease,80% of patients cannot undergo surgical *** body radiotherapy(SBRT),an emerging,non-invasive,precision treatment,has shown promising results across various stages of HCC and has thus been adopted in practice to varying degrees around the *** article aims to review current guideline recommendations on SBRT,clinical evidence,and outcome comparisons with other local treatment *** are also made to compare the differences in clinical trials between Asian and Western countries.

关键词： Hepatocellular carcinoma Stereotactic body radiotherapy Guidelines Liver local treatment Local tumor control