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Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

Bio-Design and Manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar Evangelos Daskalakis Paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

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A Privacy-preserving Energy Management System Based on Homomorphic Cryptosystem for IoT-enabled Active Distribution Network

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 167-178页

作者： Qian Hu Siqi Bu Wencong Su Vladimir Terzija the Department of Physics Hong Kong Baptist UniversityHong KongChina the Department of Electrical and Electronic Engineering Shenzhen Research InstituteThe Hong Kong Polytechnic UniversityHong KongChina the Department of Electrical and Computer Engineering University of Michigan-DearbornDearbornMI 48128USA the School of Engineering Newcastle UniversityNewcastleUK

Active distribution network(ADN),as a typically cyber-physical system,develops with the evolution of Internet of Things(IoTs),which makes the network vulnerable to cybersecurity *** this paper,the eavesdropping attacks that lead to privacy breaches are addressed for the IoT-enabled ADN.A privacy-preserving energy management system(EMS)is proposed and empowered by secure data exchange protocols based on the homomorphic *** the information transmission among distributed generators and load customers in the EMS,private information including power usage and electricity bidding price can be effectively protected against eavesdropping *** correctness of the final solutions,e.g.,optimal market clearing price and unified power utilization ratio,can be deterministically *** simulation results demonstrate the effectiveness and the computational efficiency of the proposed homomorphically encrypted EMS.

关键词： Eavesdropping attack energy management system homomorphic cryptosystem Internet of Things(IOTs) active distribution network(ADN) privacy-preserving

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Improving the hydrostability of zeolitic imidazolate framework coatings using a facile silk fibroin protein modification method

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Nano research 2024年第7期17卷 6247-6257页

作者： Xiuming Wei Ting Chen Siyu Chen Qian Jia Nurul Ain Mazlan Allana Lewis Norbert Radacsi Yi Huang School of Engineering Institute for Materials&ProcessesThe University of EdinburghRobert Stevenson RoadEdinburghEH93FBUK EASTCHEM School of Chemistry The University of St AndrewsPurdie BuildingNorth HaughSt AndrewsKY169STUK

Zeolitic imidazolate frameworks(ZIFs)are an important subclass of metal-organic frameworks(MOFs)with zeolite-type topology,which can be fabricated under ambient synthesis ***,the applications of ZIFs are commonly limited due to the weak hydrostability of their metal–ligand coordination bonds,particularly under humid and aqueous *** this work,as an example,the hydrolysis behaviours of ZIF-L with a special focus on ZIF-L coatings were tested at aqueous conditions with a wide range of pHs to systematically study and fundamentally understand their structural stability and degradation *** ZIF-L powder and ZIF-L coatings were severely damaged after only 24 h in aqueous ***,the ZIF-L coatings showed two distinct hydrolyzation pathways regardless of pH conditions,exhibiting either a ring-shaped etching or unfolding *** the ZIF-L powders were hydrolyzed almost identically across all pH *** this new understanding,a facile silk fibroin(SF)protein modification method was developed to enhance the hydrostability of ZIF-L coatings in aqueous *** effect of protein concentration on surface coating was systemically ***-L coating retained its surface morphology after soaking in water and demonstrated switchable super wetting properties and superior separation performance for oil/water *** a result,the quick SF protein modification significantly enhanced the stability of ZIF-L coatings under various pHs,while retaining their switchable wetting property and excellent separation performance.

关键词： zeolitic imidazole framework-L(ZIF-L) ZIF-L coatings silk fibroin protein hydrostability enhancement oil/water separation

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Effect of thermo-mechanical treatment on microstructure and mechanical properties of wire-arc additively manufactured Al-Cu alloy

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Journal of Central South University 2024年第7期31卷 2181-2193页

作者： ZHANG Tao QIN Zhen-yang GONG Hai WU Yun-xin CHEN Xin Light Alloy research Institute Central South UniversityChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China Welding and Additive Manufacturing Centre Cranfield UniversityBedfordMK430ALUK

Wire-arc additive manufacture(WAAM)has great potential for manufacturing of Al-Cu ***,inferior mechanical properties of WAAM deposited material restrict its industrial ***-layer cold rolling and thermo-mechanical heat treatment(T8)with pre-stretching deformation between solution and aging treatment were adopted in this *** effects on hardness,mechanical properties and microstructure were analyzed and compared to the conventional heat treatment(T6).The results show that cold rolling increases the hardness and strengths,which further increase with T8 *** ultimate tensile strength(UTS)of 513 MPa and yield stress(YS)of 413 MPa can be obtained in the inter-layer cold-rolled sample with T8 treatment,which is much higher than that in the as-deposited *** cold-rolled samples show higher elongation than that of as-deposited ones due to significant elimination of porosity in cold rolling;while both the T6 and T8 treatments decrease the *** cold rolling and pre-stretching deformation both contribute to the formation of dense and dispersive precipitatedθ′phases,which inhibits the dislocation movement and enhances the strengths;as a result,T8 treatment shows better strengthening effect than the T6 *** strengthening mechanism was analyzed and it was mainly related to work hardening and precipitation strengthening.

关键词： wire-arc additive manufacture inter-layer cold rolling thermal-mechanical treatment microstructure mechanical properties strengthening mechanism

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A detailed comparison of the composition of(RE)-Ba-Cu-O-Ag bulk superconductors

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Superconductivity 2024年第1期9卷 87-94页

作者： J.V.J.Congreve Y.Shi A.R.Dennis H.Druiff N.C.Tutt D.A.Cardwell J.H.Durrell Department of Engineering University of CambridgeCambridgeUK

The homogeneity of the microstructure and composition are critical in determining the properties of rare earthbarium‐cuprate,single grain bulk superconductors[(RE)BCO].The magnitude of the trapped magnetic field achieveable in these technologically important materials,in particular,is influenced heavily by the size and distribution of(RE)_(2)BaCuO_(x)(RE‐211)flux pinning inclusions in the bulk microstructure,whereas the size and distribution of silver agglomerates present within the bulk superconducting matrix correlate directly with improved mechanical *** careful engineering,these materials have significant potential for application in range of devices related to energy storage,medicine,electro‐magnetic machinery and microelectronic *** of(RE)BCO bulk superconductors typically involves heating a powder compact above its peritectic decomposition temperature followed by slow cooling to facilitate the growth of a single ***(RE)BCO composition has a different peritectic temperature and growth rate,which,therefore,necessitates different requirements in the heating *** fabrication temperature and growth rate,for example,may have an effect on the RE‐211 and silver distribution,which may,in turn,affect the superconducting properties of the resulting single *** this work we compare the distributions of silver and RE‐211 in the single grain microstructures of YBCOAg,GdBCO‐Ag,EuBCO‐Ag and SmBCO‐Ag bulk superconductors using optical microscopy,scanning electron microscopy and energy dispersive X‐ray *** observe that the distributions are very similar along both the a/b‐axis and c‐axis of these *** suggests that factors other than the maximum temperature used to achieve peritectic decomposition and the rate of single grain growth are particularly influential in determining the properties of the as‐processed samples in the top seeded melt growth *** observation demonstrates there is freedom to us

关键词： YBCO‐Ag GdBCO‐Ag SmBCO‐Ag EuBCO‐Ag Composition Bulk superconductor

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A systematic scoping review of study methodology for randomized controlled trials investigating probiotics in athletic and physically active populations

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Journal of Sport and Health Science 2024年第1期13卷 61-71页

作者： Alex E.Mohr David B.Pyne Geovana Silva Fogaça Leite Deborah Akins Jamie Pugh College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA research Institute for Sport and Exercise University of CanberraCanberraACT 2617Australia Laboratory of Functional Fermented Food Faculty of Pharmaceutical SciencesUniversity of São PauloSão Paulo 05508-030Brazil research Institute for Sport and Exercise Sciences Liverpool John Moores UniversityLiverpool L33AFUK

Background:The purported ergogenic and health effects of probiotics have been a topic of great intrigue among researchers,practitioners,and the lay public *** has also been an increased research focus within the realm of sports science and exercise medicine on the athletic gut ***,compared to other ergogenic aids and dietary supplements,probiotics present unique study *** objectives of this systematic scoping review were to identify and characterize study methodologies of randomized controlled trials investigating supplementation with probiotics in athletes and physically active ***:Four databases(MEDLINE,CINAHL,Cochrane CENTRAL,and Cochrane Database of Systematic Reviews)were searched for randomized controlled studies involving healthy athletes or physically active *** intervention with probiotics and inclusion of a control and/or placebo group were *** peer-reviewed articles in English were considered,and there were no date *** were extracted and presented in tabular form to detail study protocols,characteristics,and *** in randomized controlled trials was determined with the RoB 2.0 ***:A total of 45 studies were included in the review,with 35 using a parallel group design and 10 using a cross-over *** half the studies used a single probiotic and the other half a multi-strain *** probiotic dose ranged from 2×10^(8)to 1×10^(11)colony forming units daily,and the length of intervention was between 7 and 150 *** than half the studies directly assessed gastrointestinal symptoms,gut permeability,or the gut *** sex ratio of participants was heavily weighted toward males,and only 3 studies exclusively investigated ***-level adverse events were reported in only 2 studies,although the methodology of reporting varied *** risk of bias was generally low,although details on randomization were lacking in some s

关键词： Exercise Experimental methodology Gastrointestinal symptoms Gut microbiota Probiotic supplementation

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A coordinated operation method of wind-PV-hydrogenstorage multi-agent energy system

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Global Energy Interconnection 2024年第4期7卷 446-461页

作者： Tengfei Ma Wei Pei Yanhong Yang Hao Xiao Chenghong Tang Weiqi Hua Institute of Electrical Engineering of Chinese Academy of Sciences Beijing 100190P.R.China State Grid Electric Power research Institute Nanjing 211103P.R.China Department of Electronic Electrical and Systems EngineeringUniversity of BirminghamBirmingham B152TTUK

Wind-photovoltaic(PV)-hydrogen-storage multi-agent energy systems are expected to play an important role in promoting renewable power utilization and *** this study,a coordinated operation method was proposed for a wind-PVhydrogen-storage multi-agent energy ***,a coordinated operation model was formulated for each agent considering peer-to-peer power ***,a coordinated operation interactive framework for a multi-agent energy system was proposed based on the theory of the alternating direction method of ***,a distributed interactive algorithm was proposed to protect the privacy of each agent and solve coordinated operation ***,the effectiveness of the proposed coordinated operation method was tested on multi-agent energy systems with different structures,and the operational revenues of the wind power,PV,hydrogen,and energy storage agents of the proposed coordinated operation model were improved by approximately 59.19%,233.28%,16.75%,and 145.56%,respectively,compared with the independent operation model.

关键词： Wind-PV-hydrogen-storage Multi-agent energy system Renewable power to hydrogen Coordinated operation Peer-to-peer power trading

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Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease

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Neural Regeneration research 2024年第1期19卷 100-115页

作者： Jianjian Chu Weicong Zhang Yan Liu Baofeng Gong Wenbo Ji Tong Yin Chao Gao Danqi Liangwen Mengqi Hao Cuimin Chen Jianhua Zhuang Jie Gao You Yin Department of Neurology Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical UniversityShanghaiChina School of Pharmacy University College LondonLondonUK Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineClinical Pharmacy Innovation InstituteShanghai Jiao Tong University School of MedicineShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical research unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina

The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease *** re,there is an urgent need for new effective *** underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease *** inflammation can restore neuronal function,promote neuro regeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's *** review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's *** review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.

关键词： Alzheimer's disease anti-inflammation blood-brain barrier drug delivery microglia nanoparticles neuroinflammation plant extracts

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Matrix Assisted Laser Desorption Ionization Time of Flight(MALDI-TOF)-Mass Spectrometry and^(13)C-NMR-Identified New Compounds in Paraberlinia bifoliolata(Ekop-Beli)Bark Tannins

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Journal of Renewable Materials 2024年第3期12卷 553-568页

作者： Liliane Nga Benoit Ndiwe Achille Bernard Biwolé Antonio Pizzi Jean Jalin Eyinga Biwole Joseph Zobo Mfomo Laboratory of Forest Resources and Wood Valorization Training Unit in Engineering SciencesPost Graduate School of Fundamental and Applied SciencesUniversity of DoualaP.O.Box 1872DoualaCameroun Laboratory of Mechanics Training Unit in Engineering SciencesPost Graduate School of Fundamental and Applied SciencesUniversity of DoualaP.O.Box 2701DoualaCameroun Laboratory of Studies and research on Wood Material(LERMAB) University of LorraineNancyFrance

Extracts of plant origin,particularly tannins,are attracting growing interest for the sustainable development of materials in the industrial *** discovery of new tannins is therefore *** aim of this work was to contribute to the understanding of the properties of Paraberlinia bifoliolata tannin by Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectroscopy MALDI-TOF/MS and Carbon 13 Nuclear Magnetic Resonance(13C NMR).The chemical composition of tannin extracted from Paraberlinia bifoliolata bark was determined,as was the mechanical strength of the resin hardened with Acacia nilotica *** by successive water extraction was 35%.MALDI-TOF/MS analysis revealed the presence of three new compounds in this tannin,previously unknown in this family of *** are 3-hydroxyproline acid,N-methyl-4-hydroxypipecolic acid and N-methyl-5-dihydroxypipecolic *** identification of the above molecules means that this tannin can be used for industrial applications,as a resin in the manufacture of particleboard and in the formulation of green corrosion *** information is reinforced by 13C NMR spectrometry,which indicates the presence of several polyflavonoid units,confirming the condensed nature of the *** analysis of the resin formed by the purified tannin of Paraberlinia bifoliolata to which a vegetal biohardener has been added provided a Modulus of Elasticity(MOE)value of 4840 MPa at 150℃,confirming its possible use as a binder resin in the manufacture of wood panels as well as for the formulation of a corrosion inhibitor.

关键词： Tannin Paraberlinia bifoliolata Central African wood species MALDI-TOF/MS 13C NMR bark extracts thermomechanical behaviour wood-binder

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Development of innovative tripartite partnership for China’s engagement in global health: recommendations from China-Tanzania Cooperation Project on Malaria Control

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贫困所致传染病(英文) 2024年第2期13卷 1-3页

作者： Ma Xuejiao Lu Shenning Ding Wei Deng Shanying Wang Duoquan Xiao Ning Mlacha Yeromin Husain Lewis Zhou Xiaonong National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Center for Tropical Diseases National Center for International Research On Tropical Diseases Shanghai China University of Hong Kong Hong Kong China School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China Ifakara Health Institute Dar-es-Salaam Tanzania Institute of Development Studies Brighton UK

Tripartite partnership, compared with the bilateral model, is envisioned as an opportunity to foster stronger and more trusting partnerships [1]. However, China has historically been characterized as principally reliant on bilateral engagement in global health [2]. The China-Tanzania Cooperation Project on Malaria Control was conducted by National Institute of Parasitic Diseases at China CDC and Chinese Center for Tropical Diseases research, Ifakara Health Institute in Tanzania and funding agencies from 2015 to 2022, with an aim to explore the applicability of Chinese experience on malaria control to reduce malaria disease burden in the local context of Tanzania. In the tripartite project funded by the former uk Department for International Development (DFID) and later the Bill & Melinda Gates Foundation (BMGF), China's partners were expected to share the extensively parallel practices achieved from the control and elimination of malaria for over 70 years, uk's partners were to deliver resources and design global health strategies, while Tanzanian local staff collaborated with triangular partners to ensure the project implementation [3]. In the project, the trilateral cooperation has transparent management mechanism to ensure the concrete management and implementation of the project [4] (Additional file 1: Figure S1). This Brief is to provide recommendations for China's engagement in global health by distilling the experience from the innovative tripartite partnership of the project.

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