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Depression and anxiety among cancer patients visiting a tertiary care cancer hospital

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World Journal of Psychiatry 2024年第2期14卷 287-295页

作者： Maheshor Kaphle Diya Bajracharya Nirmala Regmi Dipsikha Aryal Rajesh Karki Department of Public Health Peoples Dental College and HospitalTribhuvan UniversityKathmandu 44600BagmatiNepal Department of Public Health CiST CollegePokhara UniversityKathmandu 44600BagmatiNepal Department of Oncology Kanti HospitalMaharajgunjKathmandu 44600Nepal Central Department of Public Health Institute of MedicineTribhuvan UniversityMaharajgunjKathmandu 44600BagmatiNepal

BACKGROUND cancer patients frequently experience psychological problems related to reactions to cancer diagnosis,cancer type and stage,treatment effects,recurrence,fear of end-of-life,survivorship,and financial *** and anxiety are both psychological and physiological disturbances among cancer *** To assess the prevalence of depression and anxiety among cancer patients attending a tertiary care cancer *** A cross-sectional study was conducted at Bhaktapur cancer hospital in Kathmandu Valley among 220 cancer patients aged from 18 years to 70 *** approval was taken from the Institutional Review Committee of CiST *** sampling was used to interview patients with the standardized Patient-Health Questionnaire(PHQ-9)for Depression and hospital Anxiety and Depression sub-scale(HADS-A)for ***-Data was used for data entry and transferred to SPSS Version 25 for *** The study revealed that of 220 patients,most of the respondents belonged to the age group 51-60 *** than half 131(59.6%)of the respondents were female,most of them had depression,and one-third had *** the respondents,124(56.4%)had mild depression,70(31.8%)had moderate depression,and 3(1.3%)had severe depression;79(35.9%)had mild anxiety,64(29.1%)had moderate anxiety,and 4(1.8%)had severe *** Most respondents were depressed and one-third had *** than half and nearly one-third had mild and moderate depression,respectively,and nearly one-third had mild and moderate anxiety,which is higher than other studies.

关键词： Anxiety cancer patients Depression Nepal Prevalence

The Journey of SRS: An Initial Experience of Starting Sterotactic Radiosurgery Facility at Purbanchal cancer hospital—First in Nepal

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2023年第2期12卷 37-50页

作者： Birendra Kumar Yadav Karthik Nagamuthu Alok Thakur Kushal Rizal Umesh Kumar Sharma Ujwal Rai Dinesh Thapa Shishir Thapa Kumar Chinnappan Amit Kumar Dubey Suraj Gurung Aman Yadav Utpalkant Kumar Ranjay Kumar Department of Radiation Oncology Purbanchal Cancer Hospital Jhapa Nepal Department of Radiology Purbanchal Cancer Hospital Jhapa Nepal Deapartment of Pathology Purbanchal Cancer Hospital Jhapa Nepal Department of Neurosurgery Purbanchal Cancer Hospital Jhapa Nepal

Introduction: Radiotherapy (RT) is a vital cancer treatment modality for both curative and palliative purposes. Nepal is a developing country with a population of around 30 million people. cancer affects 100 - 120 people out of every 100,000, and the figure is increasing. The number of radiation facility machines in the country is still countable in fingers. Purbanchal cancer hospital, Nepal is the first comprehensive cancer facility capable of performing stereotactic radiosurgery (SRS). Our facility has cutting-edge Varian Truebeam Linear Accelerators with millennium MLC, which makes SRS and SRT’S for intracranial lesions such as small benign and malignant tumors much easier. In addition to SRS, we are the pioneers of SBRT for lung using 4DCT, interstitial & intraluminal brachytherapy, RPM Gated & DIBH modalities in Nepal. Methods & Materials: The purpose of this study is to share our experience in establishing an SRS facility in the country, which includes training the RT team on the importance of process accuracy, patient selection, patient assessment, mould preparation, and describing image data acquisition, target, and organ at risk delineation on CT and MRI images, treatment planning process, and quality assurance. Results & Discussion: The plans for all SRS and SRT cases are based on target coverage, OAR sparing, hotspot inside the target, conformity index, heterogeneity index, and dose fall off. To select the final plan, we used strict passing criteria such as a conformity index Paddick (CIPaddick) more than 0.85, a falloff between 100% and 50% of less than 5.5 mm (maximum 6 mm in irregular targets), and a hotspot inside the target between 115 to 140 percent, as per clinical standards. In addition, we determined the CILomax and CIRTOG for each case. Passing criteria for verification plans are set as minimum of 95% for a 2% percentage dose difference (% DD) and a 2-mm distance to an agreement (DTA). We also gathered demographic data from patients treated in t

关键词： Conformity Index Double Shell Positioning System Electronic Portal Imaging Device Linear Accelerator Millennium MLC Octavius Detector 1500 Setup Field

Distribution and drug resistance of pathogenic bacteria isolated from cancer hospital in 2013

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Chinese Journal of cancer Research 2014年第6期26卷 698-704页

作者： Linjuan Liu Qi Li Qingyun Zhang Guohong Wang Guobin Xu Ji Zhang Department of Laboratory Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital & Institute Department of Infection Management Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital & Institute

Objective： To understand distribution and drug resistance of pathogenic bacteria from a specialized cancer hospital in 2013 in order to provide a basis for rational clinical antimicrobial agents. Methods： Pathogenic bacteria identification and drug sensitivity tests were performed with a VITEK 2 compact automatic identification system and data were analyzed using WHONET5.6 ***： Of the 1,378 strains tested, 980 were Gram-negative bacilli, accounting for 71.1%, in which Klebsiella pneumonia, Escherichia coli and Pseudomonas aeruginosa were the dominant strains. We found 328 Gram-positive coccus, accounting for 23.8%, in which the amount of Staphylococcus aureus was the highest. We identified 46 fungi, accounting for 4.1%. According to the departmental distribution within the hospital, the surgical departments isolated the major strains, accounting for 49.7%. According to disease types, lung cancer, intestinal cancer and esophagus cancer were the top three, accounting for 20.9%, 17.3% and 14.2%, respectively. No strains were resistant to imipenem, ertapenem or ***： Pathogenic bacteria isolated from the specialized cancer hospital have different resistance rates compared to commonly used antimicrobial agents; therefore antimicrobial agents to reduce the morbidity and mortality of infections should be used.

关键词： Tumor pathogenic bacteria distribution drug resistance rate

Knowledge Practical Attitude of Health Professionals on Breast cancer at the hospital of the District of the Commune IV of Bamako

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Surgical Science 2024年第5期15卷 342-356页

作者： Moussa Samaké Souleymane B. Dembelé Sirama Diarra Yely Dianessy Abdou Guiré Dorcas Laurel Sodjiné Yede Amaguiré Saye Brahima Dembele Birama Traoré Thierno Nadio Ibrahima Maiga Mahamane Dicko Modibo Diarra Siaka Konaté Amadou Maiga Bakary Tientigui Dembele Adégné Togo General Surgery Department of Bamako District IV hospital Bamako Mali Obstetric Gynecology Department of the Bamako District IV hospital Bamako Mali Department of Ophthalmology of the hospital of the District of the Commune IV of Bamako Bamako Mali Imaging Service of the Bamako District IV hospital Bamako Mali Anesthesia and Resuscitation Service of the hospital of the District of the Commune IV of Bamako Bamako Mali Internal Medicine Department of the District hospital of Commune IV of Bamako Bamako Mali General Surgery Department Kolondjeba Referral Health Centre Sikasso Mali General Surgery Department of the Gabriel Touré University Hospital Bamako Mali

Introduction: The level of knowledge and attitude of health professionals about breast cancer are important determinants. General objective: To study the knowledge, attitude and practice of health professionals of the hospital of the district of the commune IV on breast cancer. Methodology: This was a cross-sectional, prospective, descriptive, qualitative and quantitative study. The study period was from 01 October 2022 to December 2022. Results: In one week of survey, 110 health workers (intern, obstetrician nurse, general practitioners and specialists) received the survey sheet, 80 health workers informed it, a participation rate of 73%. The male sex was most represented at 63.75% with a sex ratio of 1.76. The average age was 39.59 years with extremes of 22 and 61 years. The clinical signs evoked by the participants were: breast nodule (81.25%), followed by breast discharge (48.75%). In relation to risk factors: interns and obstetrician nurses had no good knowledge, 51.72% of general practitioners had good knowledge, 43.48% of specialist doctors had good knowledge, and 5.88% of the wise had good knowledge. Conclusion: Breast cancer is a common pathology around the world, health professionals are at the forefront of the fight against breast cancer, and this fight cannot be effective without trained personnel.

关键词： Knowledge Attitude Practice Health Personnel Breast cancer

Clinical characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital

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cancer Biology & Medicine 2020年第1期17卷 199-207页

作者： Xiaonan Cui Daiwei Han Marjolein AHeuvelmans Yihui Du Yingru Zhao Lei Zhang Harry JMGroen Geertruida Hde Bock Monique DDorrius Matthijs Oudkerk Rozemarijn Vliegenthart Zhaoxiang Ye Department of Radiology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Radiology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Epidemiology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Medisch Spectrum Twente Department of PulmonologyEnschede 7512 KZThe Netherlands Department of Thoracic Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Pulmonary Diseases University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands University of Groningen University Medical Center GroningenGroningen 9713 GZThe Netherlands

Objectives:To evaluate the characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer ***:Patients with pulmonary nodules 4–25 mm in diameter detected via computed tomography(CT)in 2013 were consecutively *** analysis was restricted to patients with a histological nodule diagnosis or a 2-year follow-up period without nodule growth confirming benign *** information was collected from hospital ***:Among the 314 nodules examined in 299 patients,212(67.5%)nodules in 206(68.9%)patients were *** to benign nodules,malignant nodules were larger(18.0 mm vs.12.5 mm,P<0.001),more often partly solid(16.0%vs.4.7%,P<0.001)and more often spiculated(72.2%vs.41.2%,P<0.001),with higher density in contrast-enhanced CT(67.0 HU vs.57.5 HU,P=0.015).Final diagnosis was based on surgery in 232 out of 314(73.9%)nodules,166 of which were identified as malignant[30(18.1%)stage III or IV]and 66 as *** 36 nodules(11.5%),diagnosis was confirmed by biopsy and the remainder verified based on stability of nodule size at follow-up imaging(n=46,14.6%).Among 65 nodules subjected to gene(EGFR)mutation analyses,28(43.1%)cases(EGFR19 n=13;EGFR21 n=15)were identified as EGFR mutant and 37(56.9%)as EGFR *** to surgery,the majority of patients[n=194(83.6%)]received a contrast-enhanced CT scan for staging of both malignant[n=140(84.3%)]and benign[n=54(81.8%)]*** of positron emission tomography(PET)-CT was relatively uncommon[n=38(16.4%)].Conclusions:CT-derived nodule assessment assists in diagnosis of small to intermediate-sized malignant pulmonary ***,contrast-enhanced CT is commonly used as the sole diagnostic confirmation technique for pre-surgical staging,often resulting in surgery for late-stage disease and unnecessary surgery in cases of benign nodules.

关键词： Lung nodule diagnosis computed tomography pathology China

Combined Treatment Strategy and Outcome of High Risk Neuroblastoma: Experience of the Children’s cancer hospital-Egypt

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Journal of cancer Therapy 2013年第9期4卷 1435-1442页

作者： Emad Moussa Mohamed Fawzy Alaa Younis Maged El Shafei Mohamed Saad Zaghloul Naglaa El Kinaai Amal Refaat Noha Atta Alaa El Haddad Department of Pathology National Cancer Institute Cairo University and Children’s Cancer Hospital Egypt Cairo Egypt Department of Pediatric Oncology Children’s Cancer Hospital-Egypt Cairo and Clinical Oncology Department Faculty of Medicine Menufeya University Menufeya Egypt Department of Pediatric Oncology National Cancer Institute Cairo University and Children’s Cancer Hospital-Egypt Cairo Egypt Department of Radiodiagnosis National Cancer Institute Cairo University and Children’s Cancer Hospital-Egypt Cairo Egypt Department of Radiotherapy National Cancer Institute Cairo University and Children’s Cancer Hospital-Egypt Cairo Egypt Department of Research Children’s Cancer Hospital-Egypt Cairo Egypt Department of Surgical Oncology National Cancer Institute Cairo University and Children’s Cancer Hospital-Egypt Cairo Egypt

Background: Neuroblastoma (NB) is remarkable for its wide spectrum of clinical behavior and biological characteristics in relation to outcome. The use of aggressive therapy, including autologous hematopoietic stem cell transplantation (HSCT) and the addition of isoretionin (cis-Retinoic Acid/cis-RA), has increased survival rates of patients with advanced disease. Methods: Pediatric 271 newly diagnosed high risk NB patients were prospectively enrolled into the study. Patients received neoadjuvant chemotherapy of alternating cycles: [cyclophosphamide, doxorubicin, vincristine (CAdO)] and [etoposide, carboplatin]. Intensification courses of “ICE” (ifosfamide, carboplatin, and etoposide) regimen were administered to patients with bone marrow (BM) residual infiltration. Whenever safely feasible, complete surgical resection or debulking of the primary tumor was attempted for patients achieving partial response. Eligible patients underwent HSCT, while radiation therapy to the primary and metastatic sites, as well as maintenance with cis-RA was given for 6 months. Results: The median age of our patients was 2.8 years with male to female ratio of 1.65:1. At 4 years, the overall and event free survivals were 33.7% and 23.3% for the entire group under study, with significantly higher rates (42.7% and 35.6%, respectively) for HSCT patients (n = 94;p 0.001). The outcome was also significantly correlated with response to induction therapy, pathological subtype, as well as other variables. Conclusion: Myeloablative therapy followed by stem cell rescue is regarded as the most important goal of high risk NB treatment to improve survival till present. Each of consolidation HSCT, post induction disease status, as well as international neuroblastoma pathology classification (INPC) subtype was an independent predictive variable of survival. A collaborative effort with an emphasis on biologic characteristics of aggressive disease and tailored therapy needs to be strengthened to further o

关键词： High-Risk Neuroblastoma Treatment Outcome

Iridium Implantation in T1 and T2 cancers of Anterior Tongue: Report from B. P. Koirala Memorial cancer hospital, Nepal

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2012年第3期1卷 73-77页

作者： Vijayakumar Narayanan Bibek Acharya Chaurasia Pradumna Prasad Dejkumar Gautam Clinical Director Cancer Care Kenya Nairobi Kenya Department of Otorhinolaryngology B. P. Koirala Memorial Cancer Hospital Bharatpur Nepal Department of Radiation Oncology B. P. Koirala Memorial Cancer Hospital Bharatpur Nepal

Early stage cancers of tongue are treated traditionally with a wide local excision or hemiglossectomy, but the preservation of normal speech and swallowing are hampered. Most of the patients are treated with external beam irradiation to achieve the best locoregional control as only a limited number of tongue cancers can be excised. Underdeveloped nations with finite resources are still dependent on cobalt based external beam radiotherapy and sometimes a Linear Accelerator with two dimensional planning. This treatment has many limitations, as the large radiation fields irradiate not only the tumor but also normal tissue. The sequalae include mucositis, dry mouth, teeth and gum injury, spinal cord damage and rarely mandibular necrosis. Intensity modulated radiotherapy, which can abrogate these side effects, is not available to these patients. Irradiation using implanted solid radioactive sources into the tumor tissue is a viable option in this context. This kind of treatment is termed as brachytherapy and if the implant is introduced into the tissue then it is interstitial brachytherapy. This report details our experience in interstitial implantation, planning, dosimetry and treatment. Diagnosed cancers of anterior 2/3rd of lateral border of tongue with T1 N0M0 or T2 N0M0 stages were subjected to Iridium implantation under general anesthesia. Orthogonal films were taken and planning done with brachyvision treatment planning system. High dose rate radiotherapy was delivered as per the prescription. Excellent local control of the tumor was achieved with no undue morbidity to the adjacent structures. The patients were asked to undergo regular follow up. Surgical salvage was advised in cases of nodal recurrence. Interstitial implantation is a treatment that can be safely administered in early stage cancers of the tongue. This has remarkable efficacy and is also a patient friendly procedure.

关键词： Oral Cavity cancer Interstitial Brachytherapy Implantation Remote After loader

Adherence to medication: A nation-wide study from the Children's cancer hospital, Egypt

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World Journal of Psychiatry 2013年第2期3卷 25-33页

作者： Hanan El Malla Nathalie Ylitalo Helm Ulrica Wilder?ng Yasser El Sayed Elborai Gunnar Steineck Ulrika Kreicbergs Division of Clinical cancer Epidemiology Department of OncologySahlgrenska University Hospital Department of Medical Epidemiology and Biostatistics Karolinska Institutet Children’s cancer hospital (CCHE 57357) National cancer Institute Division of Clinical cancer Epidemiology Department of Oncology and PathologyKarolinska Institutet Department of Women’s and Children’s Health Karolinska Institutet Sophiahemmet University College

AIM: To investigate adherence to medical regimen and predictors for non-adherence among children with cancer in Egypt. METHODS: We administered two study specific questionnaires to 304 parents of children diagnosed with cancer at the Children's cancer hospital in Cairo, Egypt, one before the first chemotherapy treatment and the other before the third. The questionnaires were translated to colloquial Egyptian Arabic, and due, to the high illiteracy level in Egypt an interviewer read thequestions in Arabic to each parent and registered the answers. Both questionnaires consisted of almost 90 questions each. In addition, a Case Report Form was filled in from the child's medical journal. The study period consisted of 7 mo(February until September 2008) and we had a participation rate of 97%. Descriptive statistics are presented and Fisher's exact test was used to check for possible differences between the adherent and non-adherent groups. A P-value below 0.05 was considered significant. Software used was SAS version 9.3 for Windows(SAS Institute Inc., Cary, NC, United States).RESULTS: Two hundred and eighty-one(90%) parents answered the second questionnaire, regarding their child's adherence behaviour. Approximately two thirds of the children admitted to their third chemotherapy treatment had received medical recommendations upon discharge from the first or second chemotherapy treatment(181/281, 64%). Sixty-eight percent(123/181) of the parents who were given medical recommendations reported that their child did not follow the recommendations. Two main predictors were found for non-adherence: child resistance(111/123, 90%) and inadequate information(100/123, 81%). In the adherent group, 20% of the parents(n = 12/58) reported trust in their child's doctor while 14 percent 8/58 reported trust in the other health-care professionals. Corresponding numbers for the non-adherent group are 8/123(7%) for both their child's doctor and other health-care professionals. Almost all of

关键词： cancer Adherence to medical regimen Non-compliance Patient-physician communication Paediatric oncology Psycho-oncology Psychosocial

Occupational risk factors among nursing staff in outpatient injection room of cancer hospital and corresponding protective measures: a review

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中西医结合护理（中英文） 2015年第2期1卷 1-3页

作者： WANG Yan XIE Feina Department of Radiology SunYat-Sen University Cancer Center Department of Hepatology SunYat-Sen University Cancer Center

The aim and objective of this review is to figure out potential occupational risk factors among nursing staff in outpatient injection room and to provide corresponding *** are several main factors summarized,including needle injury,cytotoxic drug,radiological hazard,disinfection,social and psychological factors and management systems. Findings suggest that stable management system and awareness of self- protections are two key points in prevention and control of occupational hazard in outpatient injection room of cancer hospital.

关键词： cancer nursing injection room risk factors