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Science Bulletin 2023年第20期68卷 2456-2466,M0006页

作者：郑赫然张增恺 Erik Dietzenbacher 周雅 Johannes Tobben 冯奎双 Daniel Moran 蒋萌单钰理王道平刘晓宇李莉赵丹丹孟靖区家敏关大博 The Bartlett School of Sustainable Construction University College LondonLondon WC1H 0QBUK State Key Laboratory of Marine Environmental Science College of Environment and EcologyXiamen UniversityXiamen 361102China Faculty of Economics and Business University of GroningenGroningen 9747 AGNetherlands Key Laboratory of City Cluster Environmental Safety and Green Development Ministry of EducationSchool of EcologyEnvironment and ResourcesGuangdong University of TechnologyGuangzhou 510006China Gesellschaft für Wirtschaftliche Strukturforschung mbH Osnabrck 49080Germany Social Metabolism and Impacts Potsdam Institute for Climate Impact ResearchMember of the Leibniz AssociationPotsdam 14412Germany Department of Geographical Sciences University of MarylandCollege Park MD 20742USA The Climate and Environmental Research Institute NILU Lillestrøm 2007Norway Industrial Ecology Programme Department of Energy and Process TechnologyNorwegian University of Science and TechnologyTrondheim 7010Norway School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUK Department of Geography King’s College LondonLondon WC2R 2LSUK Department of Computer Science and Technology University of CambridgeCambridge CB30FDUK Research and Promotion Center for Green and Low-carbon Development Environmental Development Center of the Ministry of Ecology and EnvironmentBeijing 100029China School of Economics and Management China University of GeosciencesBeijing 100083China Department of Built Environment Aalto UniversityEspoo 02150Finland Department of Sociology Utrecht UniversityUtrecht 3584 CSNetherlands Ministry of Education Key Laboratory for Earth System Modelling Department of Earth System ScienceTsinghua UniversityBeijing 100084China

中国城市在全球碳减排中扮演着核心角色,然而中国城市间巨大的经济发展差异深刻影响了中国城市减排的进程.城际供应链连接了城市的生产和消费,被认为是塑造地区分化和减排疲软的因素之一,但该效应在先前的研究中往往没有得到充分的考虑... 详细信息

中国城市在全球碳减排中扮演着核心角色,然而中国城市间巨大的经济发展差异深刻影响了中国城市减排的进程.城际供应链连接了城市的生产和消费,被认为是塑造地区分化和减排疲软的因素之一,但该效应在先前的研究中往往没有得到充分的考虑.本文对2012年中国309个城市的供应链进行建模.利用该模型,我们揭示了城市间存在显著的碳不平等:中国最富裕的10个城市的人均碳足迹相当于美国的水平,而中国一半的城市则低于全球平均水平.然而,这种显著的碳不平等也蕴含着新的减排机遇,即对32个超高排放城市,根据其富裕程度、产业结构和供应链的位置采取不同的减排策略,将可创造高达1.4亿吨的碳配额,距离碳达峰值增加了30%的空间.额外的碳配额足够使经济发展欠发达人口的平均生活水平达到中上收入水平,突出了城市层面的合作机制具有促进公平和减排目标收敛的巨大潜力.

关键词：经济发展差异供应链产业结构收入水平碳配额杠杆效应减排策略碳减排

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Nature：死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统

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现代生物医学进展 2016年第31期16卷 I0002-I0002页

作者： Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri National Cancer Institute National Institutes of Health (NIH) Bethesda Maryland 20892 USA Center for Cell Engineering and Department of Medicine Memorial Sloan Kettering Cancer Center New York New York 10065 USA Laboratory of Lymphocyte Signalling and Development The Babraham Institute Cambridge CB22 3AT UK

在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。... 详细信息

在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。

关键词：免疫系统肿瘤细胞死亡钾离子免疫细胞无机离子肿瘤组织研究人员

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乡级基本生育健康服务成本及效果的测量方法

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中国初级卫生保健 1997年第9期11卷 23-25页

作者：唐松源刘伟张开宁 Gerald Bloom 顾杏元 Joan Kaufman 昆明医学院健康研究所 650031 Institute of Development Studies at the University of Sussex Brighton BN19RE UK 上海医科大学 200032 Abt Associates Inc.55 wheeler street cambridge Massachusetts USA

本文借鉴国内外相关研究,结合云南省一个典型农业县双柏县的大庄乡、鄂嘉乡实际,就乡级基本生育健康的成本及效果的测量方法进行了较为深入的讨论。

关键词：乡级生育健康服务成本效果分析

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基于红外相机数据估算浙江省开化县野猪种群数量

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兽类学报 2023年第5期43卷 523-532页

作者：陈小南田佳刘鸣章申云逸余建平刘锋申小莉李晟钱江源国家公园管理局开化324300 北京大学生命科学学院北京100871 Department of Electrical Engineering and Computer Science Laboratory for Information and Decision SystemsMassachusetts Institute of TechnologyCambridgeMassachusetts 02139USA 浙江省开化县林业局开化324300 中国科学院植物研究所植被与环境变化国家重点实验室北京100093

野猪(Sus scrofa)具有较强的繁殖力和对多种环境的适应能力,近年来在我国多地出现种群明显增长,因野猪损毁农林作物、伤人而引发的人兽冲突事件频发。为针对野猪的计划性捕猎与种群管理提供科学支持,本研究以浙江省开化县为例,基于红外... 详细信息

野猪(Sus scrofa)具有较强的繁殖力和对多种环境的适应能力,近年来在我国多地出现种群明显增长,因野猪损毁农林作物、伤人而引发的人兽冲突事件频发。为针对野猪的计划性捕猎与种群管理提供科学支持,本研究以浙江省开化县为例,基于红外相机实地调查数据对野猪种群数量进行估算。选用开化县2020年9—10月429个位点的红外相机监测数据,包括有效相机工作日23690 d,共记录到964次野猪的独立探测。利用Royle-Nichols模型,结合地形、植被、人类影响的环境变量因子和野猪家域面积参数,估计了野猪种群密度及分布。结果显示,研究区内野猪数量为(5548±2343)头(mean±95%C.I.);在与野猪家域面积大小相当的网格中,野猪的平均种群密度为每平方千米(2.38±0.61)头(mean±SD);野猪密度与海拔和居民点密度呈负相关关系,与森林覆盖率呈弱正相关关系。基于以上结果,结合实际管理需求,建议研究区域内的野猪捕猎活动选择在其种群密度较高的农田、种植园以及森林与农田交错区域开展。当地主管部门与钱江源国家公园未来应依托系统布设的红外相机监测网络,整合捕猎获取的个体信息记录和其他来源的数据,修正和完善种群动态模型,建立长期种群动态监测机制。

关键词：野猪种群管理人兽冲突计划性捕猎种群密度估计红外相机

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Insensitivity of a turbulent laser-plasma dynamo to initial conditions

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Matter and Radiation at Extremes 2022年第4期7卷 50-64页

作者： A.F.A.Bott L.Chen P.Tzeferacos C.A.J.Palmer A.R.Bell R.Bingham A.Birkel D.H.Froula J.Katz M.W.Kunz C.-K.Li H-S.Park R.Petrasso J.S.Ross B.Reville D.Ryu F.H.Séguin T.G.White A.A.Schekochihin D.Q.Lamb G.Gregori Department of Physics University of OxfordOxfordUnited Kingdom Department of Astrophysical Sciences University of PrincetonPrincetonNew Jersey 08544USA Department of Physics and Astronomy University of RochesterRochesterNew York 14627USA Laboratory for Laser Energetics University of RochesterRochesterNew York 14623USA School of Mathematics and Physics Queens University BelfastBelfastUnited Kingdom Rutherford Appleton Laboratory ChiltonDidcotUnited Kingdom Department of Physics University of StrathclydeGlasgowUnited Kingdom Massachusetts Institute of Technology CambridgeMassachusetts 02139USA Lawrence Livermore National Laboratory LivermoreCalifornia 94550USA Max-Planck-Institut für Kernphysik HeidelbergGermany Department of Physics School of Natural SciencesUNISTUlsanSouth Korea Department of Physics University of NevadaRenoNevada 89557USA Department of Astronomy and Astrophysics University of ChicagoChicagoIllinois 60637USA

It has recently been demonstrated experimentally that a turbulent plasma created by the collision of two inhomogeneous,asymmetric,weakly magnetized,laser-produced plasma jets can generate strong stochastic magnetic fields via the small-scale turbulent dynamo mechanism,provided the magnetic Reynolds number of the plasma is sufficiently *** this paper,we compare such a plasma with one arising from two pre-magnetized plasma jets whose creation is identical save for the addition of a strong external magnetic field imposed by a pulsed magnetic field *** investigate the differences between the two turbulent systems using a Thomson-scattering diagnostic,x-ray selfemission imaging,and proton *** Thomson-scattering spectra and x-ray images suggest that the external magnetic field has a limited effect on the plasma dynamics in the *** the external magnetic field induces collimation of the flows in the colliding plasma jets and although the initial strengths of the magnetic fields arising from the interaction between the colliding jets are significantly larger as a result of the external field,the energies and morphologies of the stochastic magnetic fields post-amplification are *** conclude that,for turbulent laser-plasmas with supercritical magnetic Reynolds numbers,the dynamo-amplified magnetic fields are determined by the turbulent dynamics rather than the seed fields or modest changes in the initial flow dynamics of the plasma,a finding consistent with theoretical expectations and simulations of turbulent dynamos.

关键词： turbulent initial stochastic

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NOTUM inhibition increases endocortical bone formation and bone strength

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Bone Research 2019年第1期7卷 54-65页

作者： Robert Brommage Jeff Liu Peter Voge Faika Mseeh Andrea Y.Thompson David G.Potter Melanie K.Shadoan Gwenn M.Hansen Sabrina Jeter-Jones Jie Cui Dawn Bright Jennifer P.Bardenhagen Deon D.Doree Sofia Moverare-Skrtic Karin H.Nilsson Petra Henning Ulf H.Lerner Claes Ohlsson Arthur T.Sands James E.Tarver David R.Powell Brian Zambrowicz Qingyun Liu Lexicon Pharmaceuticals The WoodlandsTXUSA Wntrix HoustonTXUSA PRA Health Sciences RaleighNCUSA University of Pennsylvania PhiladelphiaPAUSA Regeneron Pharmaceuticals TarrytownNYUSA University of Texas HoustonTXUSA Centre for Bone and Arthritis Research Institute of MedicineThe Sahlgrenska Academy at University of GothenburgGothenburgSweden Centre for Bone and Arthritis Research University of GothenburgGothenburgSweden Biogen CambridgeMAUSA St.Jude Children’s Research Hospital MemphisTNUSA MD Anderson Cancer Center HoustonTXUSA Bethyl Laboratories MontgomeryTXUSA Merck RahwayNJUSA Nurix San FranciscoCAUSA

The disability,mortality and costs caused by non-vertebral osteoporotic fractures are *** osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral *** bone is a major determinant of non-vertebral bone *** identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable *** bone thickness was substantially elevated in Notum?/?*** is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not *** orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were *** increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone ***,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures.

关键词： disability osteoporosis fractures

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Tropical forest canopies and their relationships with climate and disturbance： results from a global dataset of consistent field-based measurements

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Forest Ecosystems 2018年第1期5卷 77-90页

作者： marion pfeifer alemu gonsamo william woodgate luis cayuela andrew r.marshall alicia ledo timothy c.e.paine rob marchant andrew burt kim calders colin courtney-mustaphi aida cuni-sanchez nicolas j.deere dereje denu jose gonzalez de tanago robin hayward alvaro lau manuel j.macía pieter i.olivier petri pellikka hamidu seki deo shirima rebecca trevithick beatrice wedeux charlotte wheeler pantaleo k.t.munishi thomas martin abdul mustari philip j.platts school of natural and environmental sciences newcastle universityUpon TyneNewcastle NE1 7RUUK department of geography and planning university of torontoONCanada land and water commonwealth scientific and industrial research organisationYarralumlaACTAustralia school of mathematical and geospatial sciences rmit universityGPO Box 2476VMelbourneVIC 3001Australia department of biology geologyphysics and inorganic chemistryuniversidad rey juan carlosE-28933 MostolesMadridSpain tropical forest and peopleresearch centre university of the sunshine coastsippy DownsAustralia environment department university of yorkYorkUK flamingo land ltd. MaltonUK the institute of biological and environmental sciences environmental modelling groupuniversity of aberdeenAberdeenUK biological and environmental sciences university of stirlingStirling FK9 4L AUK york institute for tropical ecosystems environment departmentuniversity of yorkYork YO10 5NGUK department of geography university college londonGower StreetLondon WC1E 6BTUK earth observation climate and optical groupnational physical laboratoryHampton RoadTeddingtonMiddlesex TW11 0LWUK department of archaeology and ancient history uppsala universitetP.O.Box 256-751 05 UppsalaSESweden center for macroecology evolution and climateuniversity of copenhagenUniversitetsparken 152100 CopenhagenDKDenmark durrell institute of conservation and ecology(dice) school of anthropology and conservationuniversity of kentCanterbury CT2 7NRUK department of biology college of natural sciencesjimma universityJimmaEthiopia wageningen university&research laboratory of geo-information science and remote sensingDroevendaalsesteeg 36708 PB Wageningenthe Netherlands center for international forestry research(cifor) Situ GedeSindang BarangBogor 16680Indonesia departamento de biología área de botánicauniversidad autónoma de madridcalle Darwin 2-28049 MadridESSpain conservation ecology research unit university of pretoriaHatfieldPretoriaSouth Af

Background： Canopy structure, defined by leaf area index （LAI）, fractional vegetation cover （FCover） and fraction of absorbed photosynthetically active radiation （fAPAR）, regulates a wide range of forest functions and ecosystem services. Spatially consistent field-measurements of canopy structure are however lacking, particularly for the tropics. Methods： Here, we introduce the Global LAI database： a global dataset of field-based canopy structure measurements spanning tropical forests in four continents （Africa, Asia, Australia and the Americas）. We use these measurements to test for climate dependencies within and across continents, and to test for the potential of anthropogenic disturbance and forest protection to modulate those dependences. Results： Using data collected from 887 tropical forest plots, we show that maximum water deficit, defined across the most arid months of the year, is an important predictor of canopy structure, with all three canopy attributes declining significantly with increasing water deficit. Canopy attributes also increase with minimum temperature, and with the protection of forests according to both active （within protected areas） and passive measures （through topography）. Once protection and continent effects are accounted for, other anthropogenic measures （e.g. human population） do not improve the model. Conclusions： We conclude that canopy structure in the tropics is primarily a consequence of forest adaptation to the maximum water deficits historically experienced within a given region. Climate change, and in particular changes in drought regimes may thus affect forest structure and function, but forest protection may offer some resilience against this effect.

关键词： Leaf area index Fractional vegetation cover Fraction of absorbed photosynthetically active radiation,Human population pressure Protected areas Drought Climate change

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Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

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四川生理科学杂志 2021年第1期43卷 138-138页

作者： Peter Horby The affiliations of the members of the writing committee are as follows: the Centre for Tropical Medicine and Global Health Nuffield Department of Medicine (P.H. J.T. J.A.W. N.J.W.) Nuffield Department of Population Health (M.M. L.L. J.L.B. N.S. J.R.E. E.J. R.H. M.J.L.) the Medical Research Council (MRC) Population Health Research Unit (N.S. J.R.E. R.H. M.J.L.) University of Oxford the Oxford University Hospitals NHS Foundation Trust (K.J. M.J.L.) and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (M.J.L.) Oxford University Hospitals of Leicester NHS Trust and University of Leicester Leicester (M.W.) the Regional Infectious Diseases Unit North Manchester General Hospital (A.U.) University of Manchester (A.U. T.F.) and Manchester University NHS Foundation Trust (T.F.) Manchester the Research and Development Department Northampton General Hospital Northampton (E.E.) the Department of Respiratory Medicine North Tees and Hartlepool NHS Foundation Trust Stockton-on-Tees (B.P.) University Hospitals Birmingham NHS Foundation Trust and Institute of Microbiology and Infection University of Birmingham Birmingham (T.W.) James Cook University Hospital Middlesbrough (J.W.) North West Anglia NHS Foundation Trust Peterborough (J.F.) the Department of Infectious Diseases Cardiff and Vale University Health Board and the Division of Infection and Immunity Cardiff University Cardiff (J.U.) Roslin Institute University of Edinburgh Edinburgh (J.K.B.) the School of Life Course Sciences King’s College London (L.C.C.) and the Intensive Care National Audit and Research Centre (K.R.) London the NIHR Southampton Clinical Research Facility and Biomedical Research Centre University Hospital Southampton NHS Foundation Trust and University of Southampton Southampton (S.N.F.) the Department of Mathematics and Statistics Lancaster University Lancaster (T.J.) the MRC Biostatistics Unit University of Cambridge Cambridge (T.J.) and the Respiratory M

Background:Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019(Covid-19)on the basis of in vitro activity and data from uncontrolled studies and small,randomized ***:In this randomized,controlled,open-label platform trial comparing a range of possible treatments with usual care in patients hospitalized with Covid-19,we randomly assigned 1561 patients to receive hydroxychloroquine and 3155 to receive usual *** primary outcome was 28-day mortality.

关键词： mortality patients Patients

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The diploid genome sequence of an Asian individual

The diploid genome sequence of an Asian individual

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培育生物产业，发展绿色经济——第五届中国生物产业大会·2011基因科学与产业发展论坛

作者： Laurie Goodman Ines Hellmann Michael Inouye John Pool Karsten Kristiansen Gane Ka-Shu Wong Rasmus Nielsen Richard Durbin Lars Bolund Beijing Genomics Institute at Shenzhen Departments of Integrative Biology and Statistics University of CaliforniaBerkeleyCalifornia 94720USA The Wellcome Trust Sanger Institute Wellcome Trust Genome CampusHinxtonCambridge CB10 1SAUK Departments of Integrative Biology and Statistics University of CaliforniaBerkeleyCalifornia94720USA Department of Biochemistry and Molecular Biology University of Southern DenmarkOdense M DK-5230Denmark Beijing Genomics Institute at Shenzhen Shenzhen 518000China Department of Biological Sciences and Department of Medicine University of AIbertaEdmonton ABT6G 2E9Canada Insitute of Human Genetics University of AarhusAarhus DK-8000Denmark

Here we present the first diploid genome sequence of an Asian *** genome was sequenced to 36-fold average coverage using massively parallel sequencing *** aligned the short reads onto the NCBI human reference genome to 99.97%coverage,and guided by the reference genome,we used uniquely mapped reads to assemble a high-quality consensus sequence for 92%of the Asian individual's *** identified approximately 3 million single-nucleotide polymorphisms(SNPs) inside this region,of which 13.6%were not in the dbSNP *** analysis showed that SNP identification had high accuracy and consistency,indicating the high sequence quality of this *** also carried out heterozygote phasing and haplotype prediction against HapMap CHB and JPT haplotypes (Chinese and Japanese,respectively),sequence comparison with the two available individual genomes(*** and J. ***),and structural variation *** variations were considered for their potential biological *** sequence data and analyses demonstrate the potential usefulness of next-generation sequencing technologies for personal genomics.

关键词： The diploid genome sequence of an Asian individual

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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