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Adaptive evolution to the natural and anthropogenic environment in a global invasive crop pest,the cotton bollworm

The Innovation 2023年第4期4卷 91-101页

作者： Minghui Jin Henry L.North Yan Peng Hangwei Liu Bo Liu Ruiqing Pan Yan Zhou Weigang Zheng Kaiyu Liu Bo Yang Lei Zhang Qi Xu Samia Elfekih Wendy A.Valencia-Montoya Tom Walsh Peng Cui Yongfeng Zhou Kenneth Wilson Chris Jiggins Kongming Wu Yutao Xiao Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Gene Editing Technologies(Hainan)Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518116China The State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesWest Yuanmingyuan RoadBeijing 100193China Department of Zoology University of CambridgeCambridge CB21SZUK College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China Lancaster Environment Centre Lancaster UniversityLancaster LA14YWUK Berry Genomics Corporation Beijing 102200China Institute of Entomology School of Life SciencesCentral China Normal UniversityWuhan 430079China Australian Centre for Disease Preparedness(ACDP) CSIRO Health&BiosecurityEast GeelongVIC 3169Australia Bio21 Institute and the School of Biosciences The University of MelbourneMelbourneVIC 3010Australia Department of Organismic and Evolutionary Biology and Museum of Comparative Zoology Harvard UniversityCambridgeMA 02138USA CSIRO Land and Water Black Mountain LaboratoriesCanberraACT 2601Australia

The cotton bollworm,Helicoverpa armigera,is set to become the most economically devastating crop pest in the world,threatening food security and biosafety as its range expands across the *** to understanding the eco-evolutionary dynamics of ***,and thus its management,is an understanding of population connectivity and the adaptations that allow the pest to establish in unique *** assembled a chromosome-scale reference genome and re-sequenced 503 individuals spanning the species range to delineate global patterns of connectivity,uncovering a previously cryptic population structure.

关键词： connectivity cotton evolution

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Evolution of enhanced innate immune evasion by SARS-CoV-2

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四川生理科学杂志 2021年第10期43卷 1695-1695页

作者： Lucy G Thorne Division of Infection and Immunity University College London London UK QBI Coronavirus Research Group (QCRG) University of California San Francisco San Francisco CA USA Quantitative Biosciences Institute (QBI) University of California San Francisco San Francisco CA USA J. David Gladstone Institutes San Francisco CA USA Department of Cellular and Molecular Pharmacology University of California San Francisco San Francisco CA USA Division of Virology Department of Pathology Addenbrooke’s Hospital University of Cambridge Cambridge UK Epithelial Stem Cell Biology and Regenerative Medicine Laboratory The Francis Crick Institute London UK MIT Computer Science and Artificial Intelligence Laboratory MIT Cambridge MA USA Broad Institute of MIT and Harvard Cambridge MA USA European Molecular Biology Laboratory (EMBL) European Bioinformatics Institute Wellcome Genome Campus Hinxton UK Department of Microbiology Icahn School of Medicine at Mount Sinai New York NY USA Global Health and Emerging Pathogens Institute Icahn School of Medicine at Mount Sinai New York NY USA Howard Hughes Medical Institute San Francisco CA USA Division of Advanced Therapies National Institute for Biological Standards and Control South Mimms UK Cardiovascular Research Institute University of California San Francisco San Francisco CA USA The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York NY USA Department of Medicine Division of Infectious Diseases Icahn School of Medicine at Mount Sinai New York NY USA Department of Pathology Molecular and Cell-Based Medicine Icahn School of Medicine at Mount Sinai New York NY USA

Emergence of SARS-CoV-2 variants of concern(VOCs)suggests viral adaptation to enhance human-to-human transmission1,*** much effort has focused on characterisation of spike changes in VOCs,mutations outside spike likely contribute to *** we used unbiased abundance proteomics,phosphoproteomics,RNAseq and viral replication assays to show that isolates of the Alpha(B.1.1.7)variant3 more effectively suppress innate immune responses in airway epithelial cells,compared to first wave *** found that Alpha has dramatically increased subgenomic RNA and protein levels of N,Orf9b and Orf6,all known innate immune *** of Orf9b alone suppressed the innate immune response through interaction with TOM70,a mitochondrial protein required for RNA sensing adaptor MAVS ***,the activity of Orf9b and its association with TOM70 was regulated by *** propose that more effective innate immune suppression,through enhanced expression of specific viral antagonist proteins,increases the likelihood of successful Alpha transmission,and may increase in vivo replication and duration of *** importance of mutations outside Spike in adaptation of SARS-CoV-2 to humans is underscored by the observation that similar mutations exist in the Delta and Omicron N/Orf9b regulatory regions.

关键词： outside likely alone

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多方共赢的政策设计案例:宁夏盐池县县级医院包干制

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中国卫生经济 2014年第11期33卷 8-10页

作者：简伟研 Winnie Yip William Hsiao 陈文胡敏北京大学医学部公共卫生学院 Blavatnik School of Government University of Oxford OxfordOX1 4JJ UK Harvard School of Public Health cambridge Massachusetts 02138 UK 复旦大学公共卫生学院

2009年以来,我国多个地区都开展了各具特色的卫生改革尝试。总结这些改革的经验对于深化我国医药卫生体制有着积极意义。文章以宁夏回族自治区盐池县县级医院支付制度改革为核心,系统阐述了这次改革的政策安排并对政策效果进行了初步的... 详细信息

2009年以来,我国多个地区都开展了各具特色的卫生改革尝试。总结这些改革的经验对于深化我国医药卫生体制有着积极意义。文章以宁夏回族自治区盐池县县级医院支付制度改革为核心,系统阐述了这次改革的政策安排并对政策效果进行了初步的评价。通过剖析这些安排对医疗服务提供者的激励作用,着重分析了这次改革如何实现"医、患、保多方共赢"的政策目标。

关键词：县级医院总额包干制案例研究宁夏

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Systematic investigation of millimeter-wave optic modulation performance in thin-film lithium niobate

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Photonics Research 2022年第10期10卷 2380-2387页

作者： YIWEN ZHANG LINBO SHAO JINGWEI YANG ZHAOXI CHEN KE ZHANG KAM-MAN SHUM DI ZHU CHI HOU CHAN MARKO LONČAR CHENG WANG Department of Electrical Engineering City University of Hong KongKowloonHong KongChina John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMassachusetts 02138USA Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVirginia 24061USA State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong KongChina Institute of Materials Research and Engineering Agency for ScienceTechnology and Research(A^(*)STAR)Singapore 138634Singapore

Millimeter-wave(mmWave)band(30–300 GHz)is an emerging spectrum range for wireless communication,short-range radar,and sensor ***-optic modulators that could efficiently convert mmWave signals into the optical domain are crucial components for long-haul transmission of mmWave signals through optical *** these ultrahigh frequencies,however,the modulation performances are highly sensitive to the transmission line loss as well as the velocity-and impedance-matching conditions,while precise measurements and modeling of these parameters are often *** we present a systematic investigation of the mmWave-optic modulation performances of thin-film lithium niobate modulators through theoretical modeling,electrical verifications,and electro-optic measurements at frequencies up to 325 *** on our experimentally verified model,we demonstrate thin-film lithium niobate mmWave-optic modulators with a measured 3-dB electro-optic bandwidth of 170 GHz and a 6-dB bandwidth of 295 *** device also shows a low RF half-wave voltage of 7.3 V measured at an ultrahigh modulation frequency of 250 *** work provides a comprehensive guideline for the design and characterization of mmWave-optic modulators and paves the way toward future integrated mmWave photonic systems for beyond-5G communication and radar applications.

关键词： millimeter lithium film

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Phylogeny,ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae(Onygenales):Blastomyces,Emergomyces,Emmonsia,Emmonsiellopsis

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Fungal Diversity 2018年第3期90卷 245-291页

作者： Yanping Jiang Karolina Dukik Jose F.Munoz Lynne Sigler Ilan S.Schwartz Nelesh P.Govender Chris Kenyon Peiying Feng Bert Gerrits van den Ende J.Benjamin Stielow Alberto M.Stchigel Hongguang Lu Sybren de Hoog Department of Dermatology The Affiliated HospitalGuizhou Medical UniversityGuiyangChina Westerdijk Fungal Biodiversity Institute UtrechtThe Netherlands Center of Expertise in Mycology of RadboudUMC/Canisius Wilhelmina Hospital NijmegenThe Netherlands Institute of Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Broad Institute of MIT and Harvard CambridgeMAUSA and Biological Sciences EdmontonABCanada Division of Infectious Diseases Department of MedicineFaculty of Medicine and DentistryUniversity of AlbertaEdmontonABCanada Global Health Institute Faculty of Medicine and Health SciencesUniversity of AntwerpAntwerpBelgium A Division of the National Health Laboratory ServiceJohannesburgSouth Africa Sexually Transmitted Infection Unit Institute of Tropical MedicineAntwerpBelgium Third Affiliated Hospital Sun Yat-Sen UniversityGuangzhouChina Thermo Fisher Scientific LandsmeerThe Netherlands Mycology Unit and IISPV University Rovira i VirgiliReusTarragonaSpain

The family Ajellomycetaceae(Onygenales)includes mammal-associated pathogens within the genera Blastomyces,Emmonsia,Histoplasma and Paracoccidioides,as well as the recently described genera,Emergomyces that causes disease in immunocompromised hosts,and Emmonsiellopsis,known only from *** further assess the phylogenetic relationships among and between members of these genera and several previously undescribed species,we sequenced and analyzed the DNA-directed RNA polymerase II(rPB2),translation elongation factor 3-a(TEF3),b-tubulin(TUB2),28S large subunit rDNA(LSU)and the internal transcribed spacer regions(ITS)in 68 strains,in addition to morphological and physiological *** better understand the thermal dimorphism among these fungi,the dynamic process of transformation from mycelial to yeast-like or adiaspore-like forms was also assessed over a range of temperatures(6–42C).Molecular data resolved the relationships and recognized five major well-supported lineages that correspond largely to the genus ***,typified by Emmonsia parva,is a synonym of Blastomyces that also accommodates Blastomyces helicus(formerly Emmonsia helica).Emmonsia crescens is phylogenetically distinct,and found closely related to a single strain from soil without known *** silverae,Emergomyces canadensis,Emergomyces europaeus and Emmonsia sola are newly *** all of the taxa are associated with human and animal *** crescens,*** and *** are prevalently associated with pulmonary disease in humans or *** helicus,***,Emergomyces africanus,***,***,*** and ***(formerly Emmonsia pasteuriana)are predominantly found in human hosts with immune disorders;no animal hosts are known for these species except ***.

关键词： Ajellomycetaceae Onygenales Phylogeny Ecology Thermal dimorphism Systemic infection Taxonomy

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Accurate de novo design of membrane-traversing macrocycles

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四川生理科学杂志 2022年第8期44卷 1474-1474页

作者： Gaurav Bhardwaj Institute for Protein Design University of Washington Seattle WA 98195 USA Department of Medicinal Chemistry University of Washington Seattle WA 98195 USA Biological Physics Structure and Design program University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Molecular Cell and Biology program University of Washington Seattle WA 98195 USA Institute for Molecular Bioscience Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science The University of Queensland Brisbane QLD 4072 Australia Department of Chemistry and Chemical Biology and Center for Biotechnology and Interdisciplinary Sciences Rensselaer Polytechnic Institute Troy NY 12180 USA Molecular Engineering and Sciences Program University of Washington Seattle WA 98195 USA Departamento de Quίmica Fίsica Universidad de Valencia Avenida Dr. Moliner 50 Burjassot 46100 Valencia Spain Department of Medicine Division of Allergy and Infectious Disease University of Washington Seattle WA USA Department of Chemistry and Biochemistry University of California-Los Angeles Los Angeles CA USA Takeda Pharmaceuticals Inc. Cambridge MA USA Howard Hughes Medical Institute University of Washington Seattle WA 98195 USA

We use computational design coupled with experimental characterization to systematically investigate the design principles for macrocycle membrane permeability and oral *** designed 1846-12 residue macrocycles with a wide range of predicted structures containing noncanonical backbone modifications and experimentally determined structures of 35;29 are very close to the computational *** such control,we show that membrane permeability can be systematically achieved by ensuring all amide(NH)groups are engaged in internal hydrogen bonding interactions.84 designs over the 6-12 residue size range cross membranes with an apparent permeability greater than 1×10^(-6)cm/s.

关键词： residue cycles backbone

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Research progress in electrospinning engineering for all-solid-state electrolytes of lithium metal batteries

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Journal of Energy Chemistry 2021年第10期30卷 253-268,I0008页

作者： Manxi Wang Yaling Wu Min Qiu Xuan Li Chuanping Li Ruiling Li Jiabo He Ganggang Lin Qingrong Qian Zhenhai Wen Xiaoyan Li Ziqiang Wang Qi Chen Qinghua Chen Jinhyuk Lee Yiu-Wing Mai Yuming Chen College of Environmental Science and Engineering Fujian Normal UniversityFuzhou 350000FujianChina Fujian Key Laboratory of Innate Immune Biology Biomedical Research Center of South Chinaand College of Life ScienceFujian Normal UniversityFuzhou 350000FujianChina College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350000FujianChina State Grid Fujian Maintenance Company Fuzhou 350000FujianChina CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350000FujianChina Department of Nuclear Science and Engineering and Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139United States Department of Mining and Materials Engineering McGill UniversityMontréalQC H3A 0C5Canada Centre for Advanced Materials Technology(CAMT) School of AerospaceMechanical and Mechatronics Engineering J07The University of SydneyNSW 2006Australia State Key Laboratory of Structural Chemistry Fuzhou 350000FujianChina

Owing to safety issue and low energy density of liquid lithium-ion batteries(LIBs),all-solid-state lithium metal batteries(ASLMBs)with unique all-solid-state electrolytes(SEs)have attracted wide *** arises mainly from the advantages of the SEs in the suppression of lithium dendrite growth,long cycle life,and broad working temperature range,showing huge potential applications in electronic devices,electric vehicles,smart grids,and biomedical ***,SEs suffer from low lithiumion conductivity and low mechanical integrity,slowing down the development of practical *** engineering is of great efficiency in tuning the structure and composition of the SEs with improved lithium-ion conductivity and mechanical *** various available technologies for nanostructure engineering,electrospinning is a promising technique because of its simple operation,cost-effectiveness,and efficient integration with different *** this review,we will first give a simple description of the electrospinning ***,the use of electrospinning technique in the synthesis of various SEs is summarized,for example,organic nanofibrous matrix,organic/inorganic nanofibrous matrix,and inorganic nanofibrous matrix combined with other *** current development of the advanced architectures of SEs through electrospinning technology is also presented to provide references and ideas for designing high-performance ***,an outlook and further challenges in the preparation of advanced SEs for ASLMBs through electrospinning engineering are given.

关键词： Solid-state composite electrolyte Lithium metal batteries Electrospinning engineering Organic/inorganic matrices

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Applications of smartphone-based near-infrared(NIR)imaging,measurement,and spectroscopy technologies to point-of-care(POC)diagnostics

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第3期22卷 171-189页

作者： Wenjing HUANG Shenglin LUO Dong YANG Sheng ZHANG Ningbo Research Institute Zhejiang UniversityNingbo315100China Department of Bioengineering School of EngineeringThe University of TokyoTokyo113-8656Japan Institute of Combined Injury State Key Laboratory of TraumaBurn and Combined InjuryCollege of Preventive MedicineThird Military Medical UniversityChongqing400038China Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownBoston02129USA Division of Biomedical Engineering Renal DivisionDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridge02139USA State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou310027China

The role of point-of-care(POC)diagnostics is important in public *** the support of smartphones,POC diagnostic technologies can be greatly *** opportunity has arisen from not only the large number and fast spread of cell-phones across the world but also their improved imaging/diagnostic *** a tool,the smartphone is regarded as part of a compact,portable,and low-cost system for real-time POC,even in areas with few *** combining near-infrared(NIR)imaging,measurement,and spectroscopy techniques,pathogens can be detected with high *** whole process is rapid,accurate,and low-cost,and will set the future trend for POC *** this review,the development of smartphone-based NIR fluorescent imaging technology was described,and the quality and potential of POC applications were discussed.

关键词： Point-of-care(POC)diagnostics Near-infrared(NIR)fluorescent imaging Aggregation-induced emission(AIE) Smartphone-based imaging Fluorescent probe

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It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis

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Stroke & Vascular Neurology 2019年第5期4卷 28-35页

作者： Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators Stroke Division of Clinical NeurosciencesUniversity of NottinghamNottinghamUK Stroke Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurology Semmelweis UniversityBudapestHungary Department of Internal Medicine and Cardiology Oslo University HospitalOsloNorway Stroke Unit Santa Maria della Misericordia HospitalUniversity of PerugiaPerugiaItaly Department of Neurology Singapore General HospitalSingaporeSingapore Neurology Bispebjerg and Frederiksberg HospitalCopenhagenDenmark Tallaght Hospital Trinity College DublinDublinIreland Department of Medicine Hawke's Bay District Health BoardHastingsNew Zealand Department of Clinical Science Danderyd HospitalKarolinska InstituteStockholmSweden Department of Medicine University of ThessalyLarissaGreece Neurology Selcuk University Faculty of MedicineKonyaTurkey Neurology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurology Clinical County Emergency HospitalTargu MuresRomania Neurology Beijing Tiantan HospitalBeijingChina Centre for Clinical Brain Sciences EdinburghUK

Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid *** assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)*** ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of *** on prestroke antihypertensives were also randomised to stop or continue their medication for 7 *** primary outcome was the modified Rankin Scale(mRS)at day *** carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic *** 2023(60.5%)ischaemic stroke participants had carotid *** compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 *** outcomes did not differ across bilateral stenosis *** Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 *** appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis.

关键词： stenosis carotid hypertensive

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Third-order nonlinear optical susceptibility of crystalline oxide yttria-stabilized zirconia

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Photonics Research 2020年第2期8卷 110-120页

作者： GUILLAUME MARCAUD SAMUEL SERNA KARAMANIS PANAGHIOTIS CARLOS ALONSO-RAMOS XAVIER LE ROUX MATHIAS BERCIANO THOMAS MAROUTIAN GUILLAUME AGNUS PASCAL AUBERT ARNAUD JOLLIVET ALICIA RUIZ-CARIDAD LUDOVIC LARGEAU NATHALIE ISAC ERIC CASSAN SYLVIA MATZEN NICOLAS DUBREUIL MICHEL RERAT PHILIPPE LECOEUR LAURENT VIVIEN Centre de Nanosciences et Nanotechnologies(C2N) Université-Paris-SudCNRS UMR 9001Universite Paris-SaclayOrsay 91405France Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMasschusetts 02139USA Department of Physics Bridgewater State UniversityBridgewaterMassachusetts 02325USA Institut des Sciences Analytiques et de Physico-Chimie pour l’Environnement et les Matériaux CNRSUniversite de Pau et des Pays de l’Adour64053 Pau CedexFrance Laboratoire Charles Fabry Institut d’Optique Graduate SchoolCNRSUniversitéParis-Saclay91127 Palaiseau CedexFrance LP2N Institut d’Optique Graduate SchoolCNRSUniv.Bordeaux33400 TalenceFrance

Nonlinear all-optical technology is an ultimate route for the next-generation ultrafast signal processing of optical communication *** nonlinear functionalities need to be implemented in photonics,and complex oxides are considered as promising candidates due to their wide panel of *** this context,yttria-stabilized zirconia(YSZ)stands out,thanks to its ability to be epitaxially grown on silicon,adapting the lattice for the crystalline oxide family of *** report,for the first time to the best of our knowledge,a detailed theoretical and experimental study about the third-order nonlinear susceptibility in crystalline *** self-phase modulation-induced broadening and considering the in-plane orientation of YSZ,we experimentally obtained an effective Kerr coefficient of n2YSZ=4.0±2×10^-19 m^2·W^-1 in an 8%(mole fraction)YSZ *** agreement with the theoretically predicted n2YSZ=1.3×10^-19 m^2·W^-1,the third-order nonlinear coefficient of YSZ is comparable with the one of silicon nitride,which is already being used in nonlinear *** promising results are a new step toward the implementation of functional oxides for nonlinear optical applications.

关键词： materials. nonlinear crystalline

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