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Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Signal Transduction and Targeted Therapy 2021年第4期6卷 1171-1198页

作者： Kieran Joyce Georgina Targa Fabra Yagmur Bozkurt Abhay Pandit School of Medicine National University of IrelandGalwayIreland curam SFI Research Centre for Medical DevicesNational University of IrelandGalwayIreland

Biomaterials have had an increasingly important role in recent decades,in biomedical device design and the development of tissue engineering solutions for cell delivery,drug delivery,device integration,tissue replacement,and *** is an increasing trend in tissue engineering to use natural substrates,such as macromolecules native to plants and animals to improve the biocompatibility and biodegradability of delivered *** the same time,these materials have favourable mechanical properties and often considered to be biologically *** importantly,these macromolecules possess innate functions and properties due to their unique chemical composition and structure,which increase their bioactivity and therapeutic potential in a wide range of *** much focus has been on integrating these materials into these devices via a spectrum of cross-linking mechanisms,little attention is drawn to residual bioactivity that is often hampered during isolation,purification,and production ***,we discuss methods of initial material characterisation to determine innate bioactivity,means of material processing including cross-linking,decellularisation,and purification techniques and finally,a biological assessment of retained bioactivity of a final *** review aims to address considerations for biomaterials design from natural polymers,through the optimisation and preservation of bioactive components that maximise the inherent bioactive potency of the substrate to promote tissue regeneration.

关键词： biomaterials linking potential

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The role of digital technologies in supporting and improving fishery and aquaculture across the supply chain-Quo Vadis?

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Aquaculture and Fisheries 2023年第4期8卷 365-374页

作者： Neil J.Rowan Bioscience Research Institute Technological University of the ShannonMidlands Midwest(TUS)AthloneN37 HD68Ireland Empower Eco^(™)Innovation Hub TUSAthloneN37 HD68Ireland curam Research Centre NUIGalwayH91 TK33Ireland

Fish constitute important high protein products to meet the demands of an increasing global ***,the continued depletion of wild fish stocks is leading to increased strain on the aquaculture sector in terms of sustaining the supply of fish and seafood to global *** the fact that aquaculture is more diversified than other agriculture sectors,there are significant pressures on the industry to continue innovating in order to enable sustainability including increased fish production,improved appropriate selection of species,disease mitigation,reduced wastage,preventing environmental pollution and generating more employment *** viewpoint article addresses how digital transformation can help support and meet expansion needs of the fisheries/aquaculture industries that includes exploiting and harnessing ICT,IoT,Cloud-edge computing,AI,machine learning,immersive technologies and *** technologies are bringing significant operational benefits for global food chain,improving efficiencies and productivity,reducing waste,contamination and food *** focus on digital technologies has recently evolved to Industry 5.0 where AI and robotics are coupled with the human mind in order to advance human-centric *** viewpoint describes the role of Quadruple helix Hub(academic-industry-government and society)in delivering a convergent holistic approach to meeting the diversity of fishery industry needs by connecting and placing fisheries centrally in a defined ecosystem of *** includes specialist training,testing technologies,providing access to finance and fostering disruption through aquaculture accelerator initiatives such as that provided by Hatch *** digital Innovation Hubs trans-regionally,nationally and internationally will also help mitigate against significant risks for the fisheries and aquaculture industry including climate change,global pandemics and conflicts that can jeopardize fish an

关键词： Digital transformation Sustainability End-to-end monitoring Food processing Disruptive innovation

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Angiography-derived radial wall strain predicts coronary lesion progression in non-culprit intermediate stenosis

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Journal of Geriatric Cardiology 2022年第12期19卷 937-948页

作者： Zhi-Qing WANG Bo XU Chun-Ming LI Chang-Dong GUAN Yue CHANG Li-Hua XIE Su ZHANG Jia-Yue HUANG Patrick W Serruys William Wijns Liang-Long CHEN Sheng-Xian TU Department of Cardiology Fujian Heart Medical CenterFujian Institute of Coronary Heart DiseaseFujian Medical University Union HospitalFujianChina Biomedical Instrument Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Cardiology National Clinical Research Center for Cardiovascular DiseasesFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina The Lambe Institute for Translational Medicine and curam University of GalwayGalwayIreland

BACKGROUND Intermediate coronary lesions(ICLs)are highly prevalent but ported mixed *** strain has been associated with plaque vulnerability,yet its role in predicting lesion progression is largely *** purpose of this study was to determine the predictive value of angiography-derived radial wall strain(RWS)for progression of untreated non-culprit *** Post-hoc analysis was conducted in a study cohort including 603 consecutive patients with 808 ICLs identified at index procedure with angiographic follow-up of up to two *** analysis was performed on selected angiographic frames with minimal foreshortening and vessel *** progression was defined as≥20%increase in percent diameter *** Lesion progression occurred in 49 ICLs(6.1%)with a median follow-up period of 16.8 *** RWS(RWSmax),frequently located at the proximal and throat plaque regions,distinguished progressive ICLs from silent *** largest area under the curve value of 0.75(95%CI:0.67–0.82,P12.6%.According to this threshold,178 ICLs were classified as having a high strain *** to a high strain amplitude with RWS_(max)>12.6%was independently associated with an increased risk of lesion progression(adjusted HR=6.82,95%CI:3.67–12.66,P<0.001).CONCLUSIONS Assessment of RWS from coronary angiography is feasible and provides independent prognostic value in patients with untreated ICLs.

关键词： coronary stenosis strain

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Adhesive hydrogels in osteoarthritis:from design to application

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Military Medical Research 2023年第5期10卷 652-679页

作者： Wang-Lin Duan Li-Ning Zhang Raghvendra Bohara Sergio Martin-Saldana Fei Yang Yi-Yang Zhao Yong Xie Ya-Zhong Bu Abhay Pandit Institute of Medical Engineering Department of BiophysicsSchoolof Basic Medical SciencesHealth Science CenterXi’an JiaotongUniversityXi’an 710061China Department of Rehabilitation Medicine the First Medical CenterChinese PLA General HospitalNo.28 Fuxing RoadHaidian DistrictBeijing 100853China curam SFI Research Centre for Medical DevicesUniversity of GalwayGalway H91 TK33Ireland Beijing National Laboratory for Molecular Sciences State Key Laboratoryof Polymer Physics and ChemistryInstitute of ChemistryChineseAcademy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academyof SciencesBeijing 100049China Department of Orthopedics the Fourth Medical CenterChinese PLAGeneral HospitalBeijing 100853China National Clinical Research Center for Orthopedics Sports Medicineand RehabilitationBeijing 100853China

Osteoarthritis(OA)is the most common type of degenerative joint disease which affects 7%of the global population and more than 500 million people *** research frontier is the development of hydrogels for OA treatment,which operate either as functional scaffolds of tissue engineering or as delivery vehicles of functional *** approaches address the big challenge:establishing stable integration of such delivery systems or *** hydrogels provide possible solutions to this ***,few studies have described the current advances in using adhesive hydrogel for OA *** review summarizes the commonly used hydrogels with their adhesion mechanisms and ***,recognizing that OA is a complex disease involving different biological mechanisms,the bioactive therapeutic strategies are also *** presenting the adhesive hydrogels in an interdisciplinary way,including both the fields of chemistry and biology,this review will attempt to provide a comprehensive insight for designing novel bioadhesive systems for OA therapy.

关键词： Adhesive hydrogel Osteoarthritis Functional additives Cartilage regeneration Interdisciplinary therapy

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