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Beamline design for multipurpose muon beams at csns EMuS

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Nuclear Science and Techniques 2024年第5期35卷 1-12页

作者： Yang Hong Ying-Peng Song Lu-Ping Zhou Jing-Yu Tang Zhi-Hao Zhou Nikolaos Vassilopoulos Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China Radiotherapy Physics and Technology center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Xi’an Jiaotong University Health Science center Xi’an 710049China Department of Radiation Oncology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

A new muon beam facility,called the Experimental Muon Source(EMuS),was proposed for construction at the China Spallation Neutron Source(csns).The design of the complex muon beamlines for the EMuS baseline scheme,which is based on superconducting solenoids,superferric dipoles and room-temperature magnets,is presented herein.Various muon beams,including surface muons,decay muons and low energy muons,have been developed for multipurpose applications.The optics design and simulation results of the trunk beamline and branch beamlines are presented.With a proton beam power of 25 kW at a standalone target station that consists of a conical graphite target and high-field superconducting solenoids,the muon beam intensity in the trunk beamline varies from 10^(7)/s for surface muons to 10^(10)/s for high-momentum decay muons.And at the endstations,these values vary from 10^(5)/s for surface muons to 10^(8)/s for decay muons.

关键词： Surface muons Decay muons Muon beamline Superconducting solenoids Multi-channel electrostatic separator

Response of PM_(2.5)-bound elemental species to emission variations and associated health risk assessment during the COVID-19 pandemic in a coastal megacity

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Journal of Environmental Sciences 2022年第12期34卷 115-127页

作者： Guochen Wang Kan Huang Qingyan Fu Jia Chen Juntao Huo Qianbiao Zhao Yusen Duan Yanfen Lin Fan Yang Wenjie Zhang Hao Li Jian Xu Xiaofei Qin Na Zhao Congrui Deng Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China Shanghai Environmental Monitoring center Shanghai 200030China Pudong New District Environmental Monitoring station Shanghai 200122China Chinese Research Academy of Environmental Sciences Beijing 100012China IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health Fudan UniversityShanghai 200433China Institute of Eco-Chongming(IEC) Shanghai 202162China

The coronavirus(COVID-19)pandemic is disrupting the world from many aspects.In this study,the impact of emission variations on PM_(2.5)-bound elemental species and health risks associated to inhalation exposure has been analyzed based on real-time measurements at a remote coastal site in Shanghai during the pandemic.Most trace elemental species decreased significantly and displayed almost no diel peaks during the lockdown.After the lockdown,they rebounded rapidly,of which V and Ni even exceeded the levels before the lockdown,suggesting the recovery of both inland and shipping activities.Five sources were identified based on receptor modeling.Coal combustion accounted for more than 70%of the measured elemental concentrations before and during the lockdown.Shipping emissions,fugitive/mineral dust,and waste incineration all showed elevated contributions after the lockdown.The total non-carcinogenic risk(HQ)for the target elements exceeded the risk threshold for both children and adults with chloride as the predominant species contributing to HQ.Whereas,the total carcinogenic risk(TR)for adults was above the acceptable level and much higher than that for children.Waste incineration was the largest contributor to HQ,while manufacture processing and coal combustion were the main sources of TR.Lockdown control measures were beneficial for lowering the carcinogenic risk while unexpectedly increased the non-carcinogenic risk.From the perspective of health effects,priorities of control measures should be given to waste incineration,manufacture processing,and coal combustion.A balanced way should be reached between both lowering the levels of air pollutants and their health risks.

关键词： COVID-19 lockdown PM_(2.5)-bound elemental species Source apportionment Health risk Shanghai

The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages

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Acta Pharmaceutica Sinica B 2022年第1期12卷 197-209页

作者： Yanping Wu Xiang Luo Qingqing Zhou Haibiao Gong Huaying Gao Tongzheng Liu Jiaxu Chen Lei Liang Hiroshi Kurihara Yi-Fang Li Rong-Rong He Guangdong engineering Research center of Chinese Medicine&Disease Susceptibility Jinan UniversityGuangzhou 510632China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education College of PharmacyJinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China Formula-pattern Research center School of Traditional Chinese MedicineJinan UniversityGuangzhou 510632China Integrated Chinese and Western Medicine Postdoctoral Research station Jinan UniversityGuangzhou 510632China Institute of Tumor Pharmacology College of PharmacyJinan UniversityGuangzhou 510632China

The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies;however, the underlying mechanism remains underexplored. In this study, we discovered that impaired macrophage phagocytosis contributed to the psychological stressevoked tumor susceptibility, and the stress hormone glucocorticoid(GC) was identified as a principal detrimental factor. Mechanistically, GC disturbed the balance of the "eat me" signal receptor(low-density lipoprotein receptor-related protein-1, LRP1) and the "don’t eat me" signal receptor(signal regulatory protein alpha, SIRPa). Further analysis revealed that GC led to a direct, glucocorticoid receptor(GR)-dependent trans-repression of LRP1 expression, and the repressed LRP1, in turn, resulted in the elevatedgene level of SIRPa by down-regulating mi RNA-4695-3 p. These data collectively demonstrate that stress induces the imbalance of the LRP1/SIRPa axis and entails the disturbance of tumor cell clearance by macrophages. Our findings provide the mechanistic insight into psychological stress-evoked tumor susceptibility and indicate that the balance of LRP1/SIRPa axis may serve as a potential therapeutic strategy for tumor treatment.

关键词： Psychological stress Tumorigenesis Macrophages Phagocytosis LRP1 SIRPa Therapeutic target

LncRNA109897-JrCCR4-JrTLP1b forms a positive feedback loop to regulate walnut resistance against anthracnose caused by Colletotrichum gloeosporioides

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Horticulture Research 2023年第6期10卷 214-227页

作者： Rui Zhou Yuhui Dong Changxi Wang Jianning Liu Qiang Liang Xiaoye Meng Xinya Lang Shengyi Xu Wenjun Liu Shuhui Zhang Nan Wang Ke Qiang Yang Hongcheng Fang State Forestry and Grassland Administration Key Laboratory of Silviculture in the Downstream Areas of the Yellow River Shandong Taishan Forest Ecosystem Research StationCollege of ForestryShandong Agricultural UniversityTai’anShandongChina271018 Department of Natural Resources Of Shandong Province Forestry Protection and Development Service CenterJinanShandongChina250000 State Key Laboratory of Crop Biology College of Horticulture Sciences and EngineeringShandong Agricultural UniversityTai’anShandongChina271018

Walnut anthracnose induced by Colletotrichum gloeosporioides is a disastrous disease that severely restricts the development of the walnut industry in China.Long non-coding RNAs(lncRNAs)are involved in adaptive responses to disease,but their roles in the regulation of walnut anthracnose resistance response are not well defined.In this study,transcriptome analysis demonstrated that a C.gloeosporioides-induced lncRNA,lncRNA109897,located upstream from the target gene JrCCR4,upregulated the expression of JrCCR4.JrCCR4 interacted with JrTLP1b and promoted its transcriptional activity.In turn,JrTLP1b induced the transcription of lncRNA109897 to promote its expression.Meanwhile,transient expression in walnut leaves and stable transformation of Arabidopsis thaliana further proved that lncRNA,JrCCR4,and JrTLP1b improve the resistance of C.gloeosporioides.Collectively,these findings provide insights into the mechanism by which the lncRNA109897-JrCCR4-JrTLP1b transcriptional cascade regulates the resistance of walnut to anthracnose.

关键词： CCR4 resistance TLP

Identification of new aptamer BC-3 targeting RPS7 from rapid screening for bladder carcinoma

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Genes & Diseases 2023年第5期10卷 2137-2150页

作者： Yunyi Liu Juan Li Hailong Ou Dan Qi Bei Hu Yuxi Xu Jian Hu Yi Xiong Luling Xia Jason HHuang Xiaoxiao Hu Erxi Wu State Key Laboratory of Chemo/Biosensing and Chemometrics College of BiologyMolecular Science and Biomedicine Laboratory and Aptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan 410082China Shenzhen Research Institute Hunan UniversityShenzhenGuangdong 518000China Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTX 76508USA Department of Respiratory Medicine The Third Xiangya HospitalCentral South UniversityChangshaHunan 410013China Texas A&M University School of Medicine College StationTX 77843USA Texas A&M University School of Pharmacy College StationTX 77843USA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical SchoolThe University of Texas at AustinAustinTX 78712USA Greater Bay Area Institute for Innovation Hunan UniversityGuangzhouGuangdong 511300China

Aptamers,short single DNA or RNA oligonucleotides,have shown immense application potential as molecular probes for the early diagnosis and therapy of cancer.However,conventional cell-SELEX technologies for aptamer discovery are time-consuming and laborious.Here we discovered a new aptamer BC-3 by using an improved rapid X-Aptamer selection process for human bladder carcinoma,for which there is no specific molecular probe yet.We show that BC-3 exhibited excellent affinity in bladder cancer cells but not normal cells.We demonstrate that BC-3 displayed high selectivity for tumor cells over their normal counterparts in vitro,in mice,and in patient tumor tissue specimens.Further endocytosis pathway analysis revealed that BC-3 internalized into bladder cancer cells via clathrin-mediated endocytosis.Importantly,we identified ribosomal protein S7(RPS7)as the binding target of BC-3 via an integrated methodology(mass spectrometry,colocalization assay,and immunoblotting).Together,we report that a novel aptamer BC-3 is discovered for bladder cancer and its properties in the disease are unearthed.Our findings will facilitate the discovery of novel diagnostic and therapeutic strategies for bladder cancer.

关键词： Bladder cancer Cell-SELEX Clathrin-mediated endocytosis Intracellular colocalization Ribosomal protein S7 X-aptamer selections

Relationships between daily growth of different groups of swordtip squid(Uroteuthis edulis)and environmental variables in the East China Sea

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Acta Oceanologica Sinica 2022年第8期41卷 52-61页

作者： Nan Li Yan Wang Zhou Fang Xinjun Chen Zhiping Feng College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China National engineering Research center for Oceanic Fisheries Shanghai Ocean UniversityShanghai 201306China Key Laboratory of Sustainable Exploitation of Oceanic Fisheries Resources of Ministry of Education Shanghai Ocean UniversityShanghai 201306China Key Laboratory of Oceanic Fisheries Exploration Ministry of Agriculture and Rural AffairsShanghai 201306China Scientific Observing and Experimental station of Oceanic Fishery Resources Ministry of Agriculture and Rural AffairsShanghai 201306China

Swordtip squid(Uroteuthis edulis)is one of the important economical fishing target species in the East China Sea.Uroteuthis edulis is characterized by rapid growth,extensive migration,and long spawning period and sensitive to surrounding environment.In order to assess its stock status,it is necessary to explore its spawning season,growth patterns of different populations and their relationship with the environment in advance.In this paper,based on the samples of U.edulis collected in the East China Sea from September 2017 to March 2018,we explored the relationships between daily growth of statolith microstructure and environmental variables by gradient forest method and generalized additive model.The spawning season of U.edulis was found to be nearly one year,and two dominant season groups were found:the spring group with the peak period of April and the summer group with the peak period of August.Water temperature in the depth of 25 m(Temp_25),sea surface temperature(SST)and zonal velocity were the key environmental variables for the daily growth of April-spawning group.The most suitable environmental conditions for the growth of April-spawning group were water temperature(24-27℃)and velocity(0.1-0.3 m/s).SST,Temp_25 and mixed layer depth were the key environment variables for the daily growth of August-spawning group.The most suitable environmental conditions for the growth of Augustspawning group were water temperature(21-28℃)and water depth(0-50 m).Key environmental variables of different groups suggested that early growth was significantly affected by seasonal changes of water temperature,current velocity and prey abundance.This study explored the relationships between early growth and environmental variables and provided the scientific guidance for the management and conservation of U.edulis.

关键词： East China Sea Uroteuthis edulis statolith microstructure environmental variables

Calculation of hydrogen and helium concentrations for csns target

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Chinese Physics C 2016年第3期40卷 140-146页

作者：潘冬冬梁泰然殷雯姚泽恩 School of Nuclear and technology Lanzhou University Spallation Neutron Source engineering center for target and Instrument Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of Science Dongguan Branch Institute of High Energy PhysicsChinese Academy of Sciences School of Physics and Electronic Information Inner Mongolia University for the Nationalities

The China Spallation Neutron Source（csns） is driven by protons whose energies are about 1.6 GeV.At such high energies, the spallation neutrons lead to the formation of large amounts of helium, hydrogen and new heavier species in the form of transmutation products. These hydrogen, helium and transmutation products have a critical effect on the mechanical properties on the one hand and exacerbate the displacement radiation damage on the other hand. In this paper, the background hydrogen/helium concentrations and the maximum hydrogen/helium concentrations near cracks in a tungsten target for csns have been calculated at temperatures of 100 and 300 by applying a theoretical model. For the csns tungsten target plate, we find the maximum hydrogen concentration near the tips of cracks ranges from 3.0×10^（-2）–2×10^（-1）, which exceeds the hydrogen background concentration by 1.2–1.8 times; the maximum helium concentration near the tips of cracks ranges from 3.0×10^（-4）- 1.2×10^（-3）, which exceeds the helium background concentration by 2- 4 times; the maximum hydrogen/helium concentration increases with the increase of the transfer length across the surfaces of the target and it decreases with the increase of temperature.

关键词： csns hydrogen concentration helium concentration tungsten target

DNA aptamer S11e recognizes fibrosarcoma and acts as a tumor suppressor

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Bioactive Materials 2022年第6期7卷 278-291页

作者： Yunyi Liu Cheng Peng Hui Zhang Juan Li Hailong Ou Yang Sun Chaoqi Wen Dan Qi Xiaoxiao Hu Erxi Wu Weihong Tan State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of BiologyCollege of Chemistry and Chemical EngineeringMolecular Science and Biomedicine Laboratory and Aptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan410082China Shenzhen Research Institute Hunan UniversityShenzhenGuangdong518000China Institute of Cancer and Basic Medicine Chinese Academy of SciencesThe Cancer Hospital of the University of Chinese Academy of SciencesHangzhouZhejiang310022China Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTX76508USA Texas A&M University Colleges of Medicine and Pharmacy College StationTX77843USA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical SchoolThe University of Texas at AustinAustinTX78712USA Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineAnd College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai200240China

Fibrosarcoma is a serious malignant mesenchymal tumor with strong invasiveness,high recurrence,and poor prognosis.Currently,surgical resection is the main treatment for fibrosarcoma.However,due to the lack of specific biomarkers,the inability to accurately diagnose fibrosarcoma can lead to sub-optimal surgical outcomes and decreased survival.Here,we seek to address this translational barrier and we show that DNA aptamer S11e was able to recognize fibrosarcoma cells(HT1080)but not human embryonic lung fibroblast cells with Kd values in the nanomolar range.In addition,we found that S11e discerned tumors in HT1080 xenograft mouse models and tumor tissues from fibrosarcoma patients.Furthermore,we demonstrated that S11e internalized into HT1080 cells independent of the lysosome pathway and located in mitochondria.Moreover,we revealed that S11e promoted the apoptosis of HT1080 cells and inhibited HT1080 cell migration.Finally,we investigated the biologically functional cellular target of S11e using a mass spectrometry approach,and identified that Diablo/SMAC protein is a cellular binding protein of S11e,by interacting to which S11e inhibited HT1080 cell migration and invasion.Taken together,these results provide the evidence that S11e may be useful for early diagnosis,targeted therapy,and prognostication of fibrosarcoma.

关键词： Fibrosarcoma Aptamer Mitochondria Apoptosis Migration

A stable biocompatible porous coordination cage promotes in vivo liver tumor inhibition

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Nano Research 2021年第10期14卷 3407-3415页

作者： Yu Liang Yu Fang Yong Cui Hongcai Zhou State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China School of Chemistry and Chemical engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Texas A&M UniversityCollege StationTX 77843USA

Many emerging strategies in chemo-,gene-,and immunotherapy require the accumulation of reagents in the cell nucleus.However,their delivery into the nucleus is often limited.Nuclear delivery could be enhanced with a rationally designed cargo-delivery scaffold,but this approach has rarely been successfully implemented.Herein,a stable,biocompatible molecular capsule that encapsulates and delivers camptothecin,a DNA topoisomerase I inhibitor,into the nucleus of living cells was reported.Nuclear delivery is facilitated by the ultra-small diameter,zero net charge,and hydrophobicity of the capsule.The encapsulated drug complex displays superior toxicity towards multiple cancer cells over the free drug,the Food and Drug Administration(FDA)approved drugs,as well as conventionally reported drug vectors.Additionally,it inhibits liver cancer tumor growth in a xenograft mouse model.Modification of the properties of such molecular capsules may make it possible to design therapeutic strategies that target specific cell organelles.

关键词： metal-organic polyhedron biocompatible cage compound cavity drug delivery