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Evidences of hydroxytyrosol as an anti-inflammatory agent in Parkinson’s disease:insights into the mechanisms of action

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Neural Regeneration Research 2021年第5期16卷 992-993页

作者： Ruth Hornedo-Ortega Ana María Espinosa-Oliva Axe Molécules d’Intérêt Biologique(MIB) Unitéde Recherche OenologieEA4577USC 1366 INRAISVVUniversitéde BordeauxBordeauxFrance departamento de Bioquímica y Biología Molecular Facultad de FarmaciaUniversidad de Sevillaand Instituto de Biomedicina de Sevilla(IBiS)Hospital Universitario Virgen del Rocío/CSICSevilleSpain

Neuroinflammation in neurodegenerative diseases:Inflammatory processes play a critical role in neurodegenerative diseases,such as Parkinson’s disease(PD).Thus,neuroinflammation is involved in the progression and development of these diseases,becoming an important pathological *** cells,the“macrophages”from central nervous system,are the initiating cells of the innate immune response against different stimuli in the brain.

关键词： inflammation diseases insight

Long-Term Effect of Organic and Mineral Fertilization on Soil Physical Properties Under Greenhouse and Outdoor Management Practices

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Pedosphere 2011年第4期21卷 443-453页

作者： J.F.HERENCIA P.A.GARCíA-GALAVíS C.MAQUEDA Instituto de Investigación y Formación Agraria y Pesquera "Las Torres-Tomejil" sevilla (IFAPA) Carretera Sevilla-Cazalla de la Sierrra km 12.241200 Alcalá del RíoSeville (Spain) Instituto de Recursos Naturales y Agrobiología (csic) Apdo.1052.41080-Sevilla (Spain)

To evaluate the use of organic amendments as an alternative to conventional fertilization,a 10-year experiment on a loam soil was conducted under a crop rotation system in both greenhouse and outdoor plots applied with chemical fertilizers (NPK) and vegetal compost (organic fertilizer) in the Guadalquivir River Valley,*** effect of these two different fertilization regimes on the soil physical properties was *** organic carbon (OC),soil bulk density (BD),soil water retention (WR),available water content (AWC),aggregate stability (AS),and soil physical quality (dexter's index,S) were *** use of organic fertilizer increased OC and resulted in a significant increase in AS and a decrease in BD compared to the mineral fertilizer application in both greenhouse and outdoor *** outdoor plots showed the lowest BD values whereas the greenhouse plots showed the highest AS *** the last years of the 10-year experiment the S parameter was significantly higher in organic fertilizer plots,especially for greenhouse *** the end of the study period,there were no significant differences in WR at field capacity (FC) between treatments in both systems;the AWC was also similar in the greenhouse plots but higher in the mineral outdoor *** mineral fertilizer treatments,a small improvement in the physical properties was also observed due to the utilization of less aggressive tillage compared with the previous intensive cropping *** soil properties were correlated with soil *** sustainable management techniques such as the use of organic amendments and low or no tillage improved soil physical properties,despite the differences in management that logically significantly affected the results.

关键词： aggregate stability bulk density organic matter vegetal compost water retention

Periodic Solutions in Unbounded Domains for the Boussinesq System

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Acta Mathematica Sinica,English Series 2010年第5期26卷 837-862页

作者： Elder Jesús VILLAMIZAR-ROA María ngeles RODRíGUEZ-BELLIDO Marko Antonio ROJAS-MEDAR Escuela de Matemáticas Universidad Nacional de Colombia Dpto. Ecuaciones Diferenciales y Análisis Numérico Universidad de Sevilla Aptdo Dpto. de Ciencias Básicas Facultad de Ciencias Universidad del Bío BíoCampus Fernando May

Assuming that the external forces of the system are small enough, the reference temperature being a periodic function, we study the existence, the uniqueness and the regularity of time-periodic solutions for the Boussinesq equations in several classes of unbounded domains of Rn. Our analysis is based on the framework of weak-Lp spaces.

关键词： Boussinesq equations strong periodic solutions unbounded domains

On the Restricted Arc-connectivity of s-geodetic Digraphs

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Acta Mathematica Sinica,English Series 2010年第10期26卷 1865-1876页

作者： Camino BALBUENA Pedro GARCíA-VZQUEZ departament de Matemàtica Aplicada Ⅲ Universitat Politècnica de Catalunya departamento de Matemática Aplicada I Universidad de Sevilla E.T.S. de Arquitectura

For a strongly connected digraph D the minimum ,cardinality of an arc-cut over all arc-cuts restricted arc-connectivity λ′（D） is defined as the S satisfying that D - S has a non-trivial strong component D1 such that D - V（D1） contains an arc. Let S be a subset of vertices of D. We denote by w＋（S） the set of arcs uv with u ∈ S and v S, and by w-（S） the set of arcs uv with u S and v ∈ S. A digraph D = （V, A） is said to be λ′-optimal if λ′（D） =ξ′（D）, where ξ′（D） is the minimum arc-degree of D defined as ξ（D） = min {ξ′（xy）： xy ∈ A}, and ξ′（xy） = min（｜ω＋（{x,y}）｜, ｜w-（{x,y}）｜, ｜w＋（x） ∪ w- （y）｜, ｜w- （x） ∪ω＋（y）｜}. In this paper a sufficient condition for a s-geodetic strongly connected digraph D to be λ′-optimal is given in terms of its diameter. Furthermore we see that the h-iterated line digraph Lh（D） of a s-geodetic digraph is λ′-optimal for certain iteration h.

关键词： Restricted arc-connectivity arc-cut diameter s-geodetic digraph line digraph

Microcontroller-Based Sinusoidal Voltage Generation for Electrical Bio-Impedance Spectroscopy Applications

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Journal of Computer and Communications 2016年第17期4卷 51-58页

作者： Juan A. Castro A. Olmo Pablo Pérez A. Yúfera departamento de Tecnología Electrónica Universidad de Sevilla Seville Spain Instituto de Microelectrónica de sevilla CSIC Sevilla Spain

A sinusoidal voltage wave generator is proposed based on the use of micro-processor digital signals with programmable duty-cycles, with application to real-time Electrical Cell-substrate Impedance Spectroscopy (ECIS) assays in cell cultures. The working principle relies on the time convolution of the programmed microcontroller (μC) digital signals. The expected frequency is easily tuned on the bio-impedance spectroscopy range [100 Hz, 1 MHz] thanks to the μC clock frequency selection. This system has been simulated and tested on the 8 bits μC ArduinoTM Uno with ATmega328 version. Results obtained prove that only three digital signals are required to fit the general specification in ECIS experiments, below 1% THD accuracy, and show the appropriateness of the system for the real-time monitoring of this type of biological experiments.

关键词： Sinusoidal Voltage Generator Electrical Cell-Substrate Impedance Spectroscopy (ECIS) Bioimpedance Microcontroller (µC) Total Harmonic Distortion (THD)

ABAting the Response:A Novel ABA Signal Terminator that Disrupts the Hormone Co-receptor Complex

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Molecular Plant 2020年第9期13卷 1241-1243页

作者： Akhtar Ali Jose M.Pardo Dae-Jin Yun Institute of Glocal Disease Control Konkuk UniversitySeoul 05029Republic of Korea department of Biomedical Science&Engineering Konkuk UniversitySeoul 05029South Korea Instituto de Bioquimica Vegetal y Fotosintesis cicCartujaCSIC-Universidad de SevillaAmericoVespucio 49Sevilla 41092Spain

The phytohormone abscisic acid(ABA)regulates multiple physiological processes such as embryo morphogenesis,seed maturation and germination,leaf senescence,fruit ripening,and stress adaptation(Gupta et al.,2020).ABA levels quickly rise in response to conditions leading to water deficit,including the developmental processes of seed drying and dormancy,as well as early post-germinative growth(Chen et al.,2020).Several proteins,commonly regarded as the ABA signaling core components,have been identified.

关键词： Gupta Signal Complex

Kinematic analysis of flexible bipedal robotic systems

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 795-818页

作者： R.FAZEL A.M.SHAFEI S.R.NEKOO department of Mechanical Engineering Shahid Bahonar University of KermanKerman ***Iran departamento de Ingenieria de Sistemas y Automatica Escuela Técnica Superior de IngenieriaUniversidad de SevillaSeville 41092Spain

In spite of its intrinsic complexities,the passive gait of bipedal robots on a sloping ramp is a subject of interest for numerous *** distinguishes the present research from similar works is the consideration of flexibility in the constituent links of this type of robotic *** is not a far-fetched assumption because in the transient(impact)phase,due to the impulsive forces which are applied to the system,the likelihood of exciting the vibration modes increases ***,the human leg bones that are involved in walking are supported by viscoelastic muscles and ***,for achieving more exact results,it is essential to model the robot links with viscoelastic *** this end,the Gibbs-Appell formulation and Newton's kinematic impact law are used to derive the most general form of the system's dynamic equations in the swing and transient phases of *** most important issue in the passive walking motion of bipedal robots is the determination of the initial robot configuration with which the system could accomplish a periodic and stable gait solely under the effect of gravitational *** extremely unstable nature of the system studied in this paper and the vibrations caused by the impulsive forces induced by the impact of robot feet with the inclined surface are some of the very serious challenges encountered for achieving the above-mentioned *** overcome such challenges,an innovative method that uses a combination of the linearized equations of motion in the swing phase and the algebraic motion equations in the transition phase is presented in this paper to obtain an eigenvalue *** solving this problem,the suitable initial conditions that are necessary for the passive gait of this bipedal robot on a sloping surface are *** effects of the characteristic parameters of elastic links including the modulus of elasticity and the Kelvin-Voigt coefficient on the walking stability of this type of

关键词： bipedal robot flexible link swing phase transient phase eigenvalue problem Kelvin-Voigt coefficient

Towards Bio-impedance Based Labs： A Review

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Journal of Electrical Engineering 2016年第3期4卷 116-127页

作者： Pablo Perez Andres Maldonado Alberto Yufera Gloria Huertas Adoracion Rueda Jose Luis Huertas Instituto de Microelectr6nica de sevilla Universidad de Sevilla CSIC Sevilla 41092 Spain Dpt. Electronic Technology ETSIL Universidad de Sevilla Sevilla 41012 Spain Dpt. Electronic and Electromagnetism F. Physics Universidad de Sevilla Sevilla 41012 Spain

In this article, some of the main contributions to BI （Bio-Impedance） parameter-based systems for medical, biological and industrial fields, oriented to develop micro laboratory systems are summarized. These small systems are enabled by the development of new measurement techniques and systems （labs）, based on the impedance as biomarker. The electrical properties of the life mater allow the straightforward, low cost and usually non-invasive measurement methods to define its status or value, with the possibility to know its time evolution. This work proposes a review of bio-impedance based methods being employed to develop new LoC （Lab-on-a-Chips） systems, and some open problems identified as main research challenges, such as, the accuracy limits of measurements techniques, the role of the microelectrode-biological impedance modeling in measurements and system portability specifications demanded for many applications.

关键词： Bio-impedance sensing signal conditioning circuits microelectrode OBT (Oscillation Based Test) LoC.

Topological Minors in Bipartite Graphs

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Acta Mathematica Sinica,English Series 2011年第11期27卷 2085-2100页

作者： Camino BALBUENA Martin CERA Pedro GARCIA-VAZQUEZ Juan Carlos VALENZUELA departament de Matematica Aplicada III Universitat Politecnica de Catalunya C/ Jordi Girona 1-3 （ Edifici C2 Despatx 302） 08034 Barcelona Spain departamento de Matemdtica Aplicada I Universidad de SeviUa EUIT Agrlcola Ctra. Utrera Kin. 1 41013 Sevilla Spain departamento de Matemdtica Aplicada I Universidad de Sevilla ETS Arquitectura Avda. Reina Mercedes 2 41012 Sevilla Spain departamento de Matemdticas Universidad de Cddiz EPS Algeciras Avda. Ramdn Puyol s/n 11202 Algeciras Spain

For a bipartite graph G on m and n vertices, respectively, in its vertices classes, and for integers s andt such that 2≤ s ≤ t, 0≤ m-s ≤ n-t, andre＋n≤ 2s＋t-1, we prove that if G has at least mn- （2（m - s）＋ n - t） edges then it contains a subdivision of the complete bipartite K（s,t） with s vertices in the m-class and t vertices in the n-class. Furthermore, we characterize the corresponding extremal bipartite graphs with mn- （2（m - s）＋ n - t ＋ 1） edges for this topological Turan type problem.

关键词： Bipartite graphs extremal graph theory topological minor