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Perspective on automated in vivo drug screening using the chodl mutant zebrafish line

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Neural Regeneration Research 2022年第11期17卷 2437-2438页

作者： Ana-Maria Oprisoreanu center for regenerative therapies dresden(crtd) TU Dresden

Since the early 2000s, the popularity of zebrafish in in vivo drug screening has shown a substantial *** zebrafish has become an important screening tool covering a wide range of tissue-specific pathologies and diseas... 详细信息

关键词： fish vivo screening

Challenges in microRNAs’ targetome prediction and validation

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Neural Regeneration Research 2019年第10期14卷 1672-1677页

作者： Jesus Eduardo Rojo Arias Volker Busskamp center for regenerative therapies (crtd) Technische Universit?t Dresden

MicroRNAs(miRNAs)are small RNA molecules with important roles in post-transcriptional regulation of gene *** recent years,the predicted number of miRNAs has skyrocketed,largely as a consequence of high-throughput sequencing technologies becoming *** dramatic increase in miRNA candidates poses multiple challenges in terms of data deposition,curation,and *** multiple databases containing miRNA annotations and targets have been developed,ensuring data quality by validating miRNA-target interactions requires the efforts of the research *** order to generate databases containing biologically active miRNAs,it is imperative to overcome a multitude of hurdles,including restricted miRNA expression patterns,distinct miRNA biogenesis machineries,and divergent miRNA-mRNA interaction *** the present review,we discuss recent advances and limitations in miRNA prediction,identification,and ***,we focus on the most enriched neuronal miRNA,miR-124,and its gene regulatory network in human neurons,which has been revealed using a combined computational and experimental approach.

关键词： miRNAs miRNA regulation miR-124 wTO analysis miRNA biogenesis miRNA prediction miRNA identification miRNA validation

MAP4K inhibition as a potential therapy for amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第8期19卷 1639-1640页

作者： Shuaipeng Ma Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon center for regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA

Amyotrophic lateral sclerosis(ALS)is a rare neurological disease,featuring gradual loss of muscle controls due to degeneration of motor ***,there is currently no cure for *** available therapies only offer a limited e... 详细信息

关键词： degeneration sclerosis MAP4

Base editing: a promising tool to rescue spinal muscular atrophy

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4436-4438页

作者： Priyanka Bhatia Jared Sterneckert center for regenerative therapies TU dresden(crtd) Technische Universität(TU)DresdenDresdenGermany Medical Faculty Carl Gustav Carus of TU dresden DresdenGermany

In a new Science publication,Arbab and colleagues observe a substantial improvement in life span and motor functions of adenosine-base edited spinal muscular atrophy(SMA)mice with restored endogenous survival motor neuron(SMN)protein expression and regulation.1 This study provides proof-of-principle for the use of adenosine base editing(ABE)as a possible one-time,permanent therapy for SMA.

关键词： atrophy muscular endogenous

Liver transplantation and resection in patients with hepatocellular cancer and portal vein tumor thrombosis: Feasible and effective?

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 123-128页

作者： Prashant Bhangui Institute of Liver Transplantation and regenerative Medicine Medanta–The MedicitySector 38GurgaonDelhi NCR 122001India

Patients with locally advanced hepatocellular cancer(HCC)and portal vein tumor thrombosis(PVTT)have a dismal prognosis since limited treatment options are available for *** recent years,effective systemic therapy,and advances in the understanding of technicalities and effectiveness of ablative therapies especially radiotherapy,have given some hope to prolong survival in *** review summarized recent evidence in literature regarding the possible role of liver resection(LR)and liver transplantation(LT)in patients with locally advanced HCC and PVTT with no extrahepatic *** therapies have helped make curative resection or LT a reality in selected *** review emphasizes on the key points to focus on when considering surgery in these patients,who are usually relegated to palliative systemic therapy *** patient selection based on tumor biology,documented downstaging based on imaging and decrease in tumor marker levels,and an adequate waiting period to demonstrate stable disease,may help obtain satisfactory long-term outcomes post LR or LT in an intention to treat strategy in patients with HCC and PVTT.

关键词： Hepatocellular carcinoma Portal vein tumour thrombosis Downstaging therapies Living donor liver transplantation and resection Outcomes

In vitro Response of Human Mesenchymal Stromal Cells to Titanium Coated Peek Films and Their Suitability for Magnetic Resonance Imaging

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Journal of Materials Science & Technology 2015年第5期31卷 427-436页

作者： Cindy Elschner Carolin Noack Carolin PreilBler Andreas Krause Ulrich Scheler Ute Hempel Leibniz-Institut fr Polymerforschung dresden e.V. Hohe Str.601069 DresdenGermany crtd/dfg-center for regenerative therapies dresden Fetscherstr.10501307 DresdenGermany Institut fr Physiologische Chemie Technische Universitt DresdenFiedlerstr.4201307 DresdenGermany NaMlab gGmbH Nthnitzer Str.6401187 DresdenGermany

Medical imaging is an important tool for the post-operative checkup of an accurate position of an implant as well as for monitoring the integration in the adjacent tissue that may influence the success of a medical ***,the possibility to use imaging methods is associated with the implant material and all the established metallic materials for surgery do not show a proper 'imaging compatibility'.The present study is a combined investigation of the in vitro response to human mesenchymal stromal cells（hMSC） and magnetic resonance imaging（MRI） compatibility of the potential material combination polyetheretherketone/titanium（PEEK/Ti） for medical *** of the advantageous imaging properties and the mechanical and chemical stability,PEEK becomes more and more an alternative to common metallic implant materials like titanium or ***,PEEK is a bioinert material having a limited ability for direct bone *** to its excellent biocompatibility,Ti was chosen as coating material to enhance the cellular *** result is a combination with advantageous properties:the magnetic susceptibility and elastic modulus close to bone,corrosion resistance and mechanical flexibility of PEEK and the excellent biocompatibility of *** appearance of metal-related artifact was discussed in electrical resistivity and magnetic ***,two titanium coatings have been investigated:a complete coating and a structured surface avoiding surface *** determine the in vitro biocompatibility,the cell responses were assessed in terms of the overall morphology of the hMSC and their cell area distribution,proliferation,osteogenic differentiation and mineral *** cellular stress was evaluated by the prostaglandin *** bonded materials both produced no disturbing artifacts in magnetic resonance *** to the pure PEEK material,the titanium coated specimens showed an enhanced biocompatibilit

关键词： Polyetheretherketone Titanium coating Biocompatibi

In vivo bioluminescence imaging to elucidate stem cell graft differentiation

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Neural Regeneration Research 2020年第1期15卷 61-62页

作者： Stefanie Vogel Mathias Hoehn Markus Aswendt Technische Universitat dresden DFG-Research Center for Regenerative Therapies Dresden(CRTD)DresdenGermany Cognitive Neuroscience Institute of Neuroscience and Medicine(INM-3)Research Center JuelichJuelichGermany Leiden University Medical center Department of RadiologyLeidenThe Netherlands University of Cologne Faculty of Medicine and University Hospital CologneDepartment of NeurologyCologneGermany

Neurological disorders including neurodegeneration(e.g.,Alzheimer’s disease and Parkinson’s disease)and acute injuries(e.g.,stroke and traumatic brain injury)are the leading cause group of disability-adjusted life years and the second leading cause group of *** to other tissues,the adult brain retains only a very limited repair *** neurogenesis,the lifelong generation of new neurons,declines with age and in degenerative diseases,such as Alzheimer’s ***,independently of age,the proliferation and migration of endogenous stem cells is stimulated after brain injuries and might be related to recovery processes(Adamczak et al.,2017).The limited number of endogenous stem cells during adulthood is one of the major limitations for an efficient regeneration of the injury affected brain ***,the transplantation of neural stem or progenitor cells(NSCs/NPCs)is extensively studied in mouse models and applied in first clinical trials with the aim to replace dysfunctional or lost neural cells and thus to restore brain function.

关键词： injuries endogenous replace

Graphene-calcium carbonate coating to improve the degradation resistance and mechanical integrity of a biodegradable implant

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Journal of Magnesium and Alloys 2024年第1期12卷 394-404页

作者： Lokesh Choudhary Parama Chakraborty Banerjee R.K.Singh Raman Derrek E.Lobo Christopher D.Easton Mainak Majumder Frank Witte Jörg F.Löffler Department of Mechanical and Aerospace Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Department of Chemical and Biological Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale Science and Engineering Laboratory(NSEL) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CSIRO Materials Science and Engineering Bayview AvenueClaytonVIC 3168Australia Julius Wolff Institute and Berlin Brandenburg center for regenerative therapies Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Laboratory of Metal Physics and Technology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body *** necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical *** this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite *** analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.

关键词： Graphene coating Biodegradable implant Hydroxyapatite Corrosion Magnesium alloy

Searching for the optimal precondition procedure for mesenchymal stem/stromal cell treatment:Facts and perspectives

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World Journal of Stem Cells 2024年第6期16卷 615-618页

作者： Yu-Dong Zhao Yong-Can Huang Wei-Shi Li Department of Orthopedic Peking University Third HospitalBeijing 100191China Shenzhen Engineering Laboratory of Orthopaedic regenerative Technologies Orthopaedic Research CenterPeking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

Mesenchymal stem/stromal cells are potential optimal cell sources for stem cell therapies,and pretreatment has proven to enhance cell vitality and *** a recent publication,Li et al explored a new combination of pretreatment ***,we present an editorial to comment on their work and provide our view on mesenchymal stem/stromal cell precondition.

关键词： Mesenchymal stem cell Precondition Hypoxia Inflammation