检索结果-南通市图书馆

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 199-206页

作者： Laurent NAVARRO Guy COURBEBAISSE Jean-Charles PINOLI Ecole Nationale Supérieure des Mines de Saint-Etienne Centre Ingénierie et Santé (CIS) and LPMG UMR 5148 CNRS 158 cours Fauriel 42023 Saint-Etienne cedex 2 France Medical Imaging Research Center (creatis-LRMN) UMR 5220 CNRS U630 INSERM Université Lyon 1 INSA Lyon Bat. Blaise Pascal 7 Av. Jean Capelle 69621 Villeurbanne France

A new lighting and enlargement on phase spectrogram （PS） and frequency spectrogram （FS） is presented in this paper. These representations result from the coupling of power spectrogram and short time Fourier transform （STFT）. The main contribution is the construction of the 3D phase spectrogram （3DPS） and the 3D frequency spectrogram （3DFS）. These new tools allow such specific test signals as small slope linear chirp, phase jump case of musical signal analysis is reported. The main objective is to and small frequency jump to be analyzed. An application detect small frequency and phase variations in order to characterize each type of sound attack without losing the amplitude information given by power spectrogram

关键词： Frequency spectrogram (FS) Phase spectrogram (PS) Time-frequency representations Musical signals

维普期刊数据库

Targeted therapy for capillary-venous malformations

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance creatis umr 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS umr8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

Ferritin surplus in mouse spleen 14 months after intravenous injection of iron oxide nanoparticles at clinical dose

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2016年第8期9卷 2398-2410页

作者： Alexandre Tamion Matthias Hillenkamp Arnaud Hillion Valentin A. Maraloiu Ioana D. Vlaicu Mariana Stefan Daniela Ghica Hugo Rositi Fabien Chauveau Marie-Genevieve Blanchin Marlene Wiart Veronique Dupuis Institut Lumiere Matiere UMR5306 Universite Lyon 1- CNRS Universite de Lyon 69622 Villeurbanne cedex France National Institute of Materials Physics 105bis AtomistilorSt. R-077125 Bucharest-Magurele Romania CNRS UMR 5220 INSERM U1044 INSA de Lyon Universite de Lyon Lyon 1 CREATIS 69003 Lyon France CRNL-BIORAN CNRS UMR5292 INSERM U 1028 Universite Lyon 1 59 BD PINEL 69677 Bron France

In this study, we followed the biodegradation of ultra-small superparamagnetic iron oxide nanoparticles injected intravenously at clinical doses in mice. An advanced fitting procedure for magnetic susceptibility curves and low- temperature hysteresis loops was used to fully characterize the magnetic size distribution as well as the magnetic anisotropy energy of the injected P904 nano- particles （Guerbet Laboratory）. Additional magnetometry measurements and transmission electronic microscopy observations were systematically performed to examine dehydrated samples from the spleen and liver of healthy C57B16 mice after nanoparticle injection, with sacrifice of the mice for up to 14 months. At 3 months after injection, the magnetic properties of the spleen and liver were dramatically different. While the liver showed no magnetic signals other than those also present in the reference species, the spleen showed an increased magnetic signal attributed to ferritin. This surplus of ferritin remained constant up to 14 months after injection.

关键词： nanoparticles biodegradation iron oxide nanomagnetism contrast agent

超极化气体~3He-MR通气功能成像在肺功能正常的小儿囊性纤维化病人治疗功效评价的研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2010年第3期 285-286页

作者：李智勇 E. Bannier K. Cieslar K. Mosbah F. Aubert F. Duboeuf Z. Salhi creatis LRMN CNRS UMR 5220 INSERM U630Université de Lyon

摘要目的评价超极化气体3He-MR成像在呼吸气量测试结果正常[平均1s用力呼气容积(FEV1)=112%±14.5%]的小儿囊性纤维化(

关键词：超极化气体 MR 肺功能小儿

CODE FOR ENCRYPTION HIDING DATA INTO GENOMIC DNA OF LIVING ORGANISMS

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

CODE FOR ENCRYPTION HIDING DATA INTO GENOMIC DNA OF LIVING O...

Endoscopic and histologic characteristics of serrated lesions

2008 9th International Conference on Signal Processing(ICSP’2008)

作者： Robert Goutte Lab creatis LRMN UMR CNRS 5220Inserm U 630INSA LyonFrance.21 avenue Jean CapelleBatiment Leonard de Vinci 69621 Villeurbanne cedex

Recent research has considered DNA an interesting medium for long-term and ultra compact information storage and a stegomedium for hidden *** components of DNA with encoded information can be added to the genome of living organisms,such as common *** this approach,a medium for very height-densities information storage,watermarks for protection patents of genetically modified organisms（GMOs） and secure public keys for decrypting hidden information in steganocryptography,can be *** this paper,we have selected a Bacillus subtilis gene（tatAD） and use the specific properties of silent mutations to obtain a biologically innocuous *** adapted code for the message insertion in this gene is proposed.

关键词： DNA genome coding steganography living organism

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第10期21卷 2896-2904页

作者： Driffa Moussata Gilles Boschetti Marion Chauvenet Karine Stroeymeyt Stéphane Nancey Franoise Berger Thierry Lecomte Bernard Flourié Department of Gastroenterology Lyon Sud Hospital Inserm Unit creatis - umr5220 - INSERM1044 Lyon University Department of Pathology H?pital Lyon Sud Department of Gastroenterology Tours Hospital

In recent years , a second pathway for colonic carcinogenesis , distinct from the adenomatous pathway, has been explored. This is referred to as serrated pathway and includes three types of polyp,characterised by a serrated appearance of the crypts:hyperplastic polyps(HP),sessile serrated adenomas(SSA)or lesions,and traditional serrated *** lesion has its own genetic,as well as macroscopic and microscopic morphological *** of their flat aspect,their detection is easier with chromoendoscopy(carmin indigo or narrow-band imaging).However,as we show in this review,the distinction between SSA and HP is quite *** is now recommended to resect in one piece as it is possible the serrated polyps with a control in a delay depending on the presence or not of *** different types of lesion are described in detail in the present review in general population,in polyposis and in inflammatory bowel diseases *** review highlights the need to improve characterization and understanding of this way of colorectal cancerogenesis.

关键词： Hyperplastic polyp Traditional serrated adenoma Se

Screening for hypertension-mediated organ damage and aetiology:still of value after 65 years of age?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2022年第11期19卷 791-801页

作者： Delphine Thiolliere Brahim Harbaoui Claire Falandry Marc Bonnefoy Jean-Christophe Lega Pierre Lantelme Pierre-Yves Courand Fédération de cardiologie Hôpital de la Croix-Rousse et Hôpital Lyon SudHospices Civils de LyonLyonFrance Universitéde Lyon CREATISCNRS UMR5220INSERM U1044INSA-LyonUniversitéClaude Bernard LyonFrance Service Universitaire de Gériatrie Hôpital Lyon SudHospices Civils de LyonLyonFrance CarMeN UniversitéClaude Bernard Lyon 1OullinsFrance Service de médecine interne et pathologies vasculaires Groupe d’Etude Multidisciplinaires des Maladies Thrombotiques(GEMMAT)Hôpital Lyon SudHospices Civils de LyonLyonFrance Universitéde Lyon Equipe Evaluation et Modélisation des Effets ThérapeutiquesLaboratoire de Biologie et Biométrie EvolutiveCNRS UMR 5558UniversitéClaude BernardLyonFrance

BACKGROUND Secondary forms and hypertension-mediated organ damage(HMOD) may differ between younger and older hypertensive *** aim of the present study was to explore the specificity of HMOD and secondary forms in patients≥ 65 years in comparison to younger ones in a contemporary *** We analysed 938 patients recruited between 2004 and 2014(Cardiology department,Croix-Rousse Hospital,Lyon)who had at baseline HMOD and secondary forms screening among them 190 were≥ 65 *** The mean(2.1±0.8 vs.1.2±0.9,P 10 m/s was the most frequent HMOD in patients≥ 65 years(90.1%),while echocardiographic left ventricular hypertrophy was the most common in the younger patients(45.0%).Among ECG left ventricular indexes,only R wave in aVL lead was significantly more frequently observed in patients≥ 65 years(32.6%) than in younger ones(19.0%,P <0.001).The frequency of secondary hypertension was not significantly different between younger and older patients(respectively;30.5% vs.27.8%,P=0.487).The most frequent aetiology was primary aldosteronism regardless of age,followed by renovascular hypertension(6.3% vs.3.3%,P=0.038).Among older patients,3.2% were treated with adrenalectomy and 6.3% with percutaneous transluminal renal *** Extensive screening of HMOD in older patients may be questionable as nearly all patients had one;aetiology must however be explored as a third of older patients had a secondary form.

关键词： Extensive screening of HMOD in older patients may be questionable as nearly all patients had one aetiology must however be explored as a third of older patients had a secondary form

维普期刊数据库

GENETIC CODING IN DIGITAL IMAGERY

在线全文

学校读者我要写书评

暂无评论

GENETIC CODING IN DIGITAL IMAGERY

2型糖尿病病人的心肌收缩功能损害:采用刺激回波位移编码MR电影成像显示

第七届国际信号处理会议

作者： Robert GOUTTE Lab creatis UMR CNRS 5515 INSA Batiment Blaise Pascal 69621 VILLEURBANNE Cedex France

The main objective of this study is to extend the potentialities of bioinformatic and the tools of molecular genetic to storage, indexing and digital image processing. A first approach consist to

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

国际医学放射学杂志 2013年第1期 61-62页

作者： L.Ernande H.Thibault C.Bergerot P.Moulin H.Wen G.Derumeaux 赵健仪 creatis UMR CNRS 5220INSERM U1044Université Jean Monnet Saint-EtienneCHU Saint-EtienneUniversité de LyonLyonFrance

目的通过与正常对照组的对比,确定刺激回波位移编码(DENSE)电影MRI能否有助于发现和确定2型糖尿病病人的亚临床心肌收缩功能损害的表现。材料与方法获单位伦理委员会许可和受试者的知情同意后,37例无明显心脏疾患的2型糖尿病病人和23名... 详细信息

目的通过与正常对照组的对比,确定刺激回波位移编码(DENSE)电影MRI能否有助于发现和确定2型糖尿病病人的亚临床心肌收缩功能损害的表现。材料与方法获单位伦理委员会许可和受试者的知情同意后,37例无明显心脏疾患的2型糖尿病病人和23名年龄匹配的对照组参与本前瞻性研究。受试者进行二维DENSE采集的MR电影扫描。在短轴位影像中,分别测量收缩期时左心室底部、中部和心尖部的圆周收缩应变(Ecc)和半径收缩应变(Err)。在四腔心和二腔心图像上测量纵向收缩应变(Ell)。统计检测方法包括组间相关性系数及多元线性回归分析。结果 Ecc、Err与Ell在观察者内的组间相关系数值分别为0.85、0.95和0.90,而观察者间的组间相关系数值为0.79、0.91和0.80。左心室射血分数位于参考值范围内,组间无明显差异。糖尿病病人较对照组的Ecc(-14.4%±1.6%与-17.0%±1.6%,P<0.001)、Err(36.2%±10.9%与44.4%±9.9%,P=0.006)和Ell(-12.9%±2.1%与-15.5%±1.6%,P<0.001)均减低。最后,糖尿病组在控制年龄、性别、高血压、体质量指数和左心室容量因素后,与Ecc(P<0.001)、Err(P=0.05)和Ell(P=0.01)间存在相关性。结论电影DENSE这种运动编码MRI技术,具有较高的空间分辨力,可用于心肌收缩应变能力的评价,有助于显示糖尿病病人亚临床期心脏收缩能力损害。

关键词：心肌收缩糖尿病病人功能损害回波 MR 编码

Host evolution in Mastomys natalensis(Rodentia:Muridae):An integrative approach using geometric morphometrics and genetics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2015年第6期10卷 505-514页

作者： Aude LALIS Allowen EVIN Marc JANIER Lamine KOIVOGUI Christiane DENYS umr 7205 Institute of Systematic Evolution and Biodiversity(ISYEB)National Museum of Natural History CNRSSorbonne UniversitiesParisFrance Institute of Evolutionary Sciences-Montpellier(ISEM) University of MontpellierCNRSIRDEPHEMontpellierFrance Department of Archaeology University of AberdeenAberdeenUK Plateforme ANIMAGE-creatis Faculty of Medicine Lyon-EstClaude Bernard University Lyon 1LyonFrance National Institute of Public Health Guinea CHU DonkaConakryGuinea

The commensal rodent Mastomys natalensis is the natural reservoir of Lassa arenavirus(LASV),which causes hemorrhagic fever in West *** study a possible effect of the virus on phenotypic and genotypic variation of its persistently infected host,we compared LASV-positive and non-infected wild-caught *** LASV effects on the phenotypic variation were explored using standard external morphometric measurements,geometric morphometric analyses of the cranial size and shape,and brain case *** genetic variability of *** specimens was assessed using 9 polymorphic microsatellite *** of sex and age,LASV-infected animals had smaller external body measurements,reproductive organs,skull size and brain case *** shape differences between the 2 groups are represented by a lateral constriction of the entire *** genetic variability revealed consanguinity only among the LASV-positive *** hypothesize that growth impairment may result in a selective disadvantage for LASV-infected ***,leading to a preferably commensal lifestyle in areas where the LAVS is endemic and,thereby,increasing the risk of LASV transmission to humans.

关键词： host evolution genetic diversity inbreeding skull shape variation