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未来食品学报(英文) 2024年第1期4卷 83-90页

作者： Yun Xie Xuemei Nie Chang Wang Xiuli Xu Feng Zhang Institute of Food Safety Chinese Academy of Inspection and QuarantineBeijing 100176China Key Laboratory of Food quality and Safety for State Market Regulation Chinese Academy of Inspection&QuarantineBeijing 100176China

Due to the lack of effective assessment method,overheated milk commodities are often marketed as pasteurized milk on the market,which was sold in high price by ***,this article aims to establish an approach based on metabolomics to monitor thermal processing temperature of bovine *** data of bovine milk samples heated at temperatures ranging from 60℃to 150℃were achieved by ultra-performance liquid chromatography-high-resolution mass spectrometry(UPLC-HRMS)platform,followed by multivariate data analysis.A regular variation pattern of chemical composition as temperature rises was pictured,furthermore.N^(∈)carboxymethyl lysine(CML),N^(∈)-carboxyethyl lysine(CEL),*** and lysinoalanine(LAL)were identified as 5 of the most contributed compounds to discriminate pasteurized and ultra-high-temperature(UHT)*** the comprehensive study on their content changes,we concluded that the optimal temperature range was 90-100℃for the generation of CML and CEL in this experiment,moreover.110~120℃for LAL.S0~100℃for pentosidine and 130-140℃for ***,a predicted rule to discriminate pasteurized and UHT milk was preliminarily established based on the ratios of CML/***/pentosidine and CML/*** could be applied in food labelling authentication of commercial bovine milk after further validation.

关键词： Metabolomics Heat treatment Bovine milk Pasteurization Utra-high-temperature

Using MsfNet to Predict the ISUP Grade of Renal Clear Cell Carcinoma in Digital Pathology Images

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Computers, Materials & Continua 2024年第1期78卷 393-410页

作者： Kun Yang Shilong Chang Yucheng Wang Minghui Wang Jiahui Yang Shuang Liu Kun Liu Linyan Xue College of quality and Technical Supervision Hebei UniversityBaoding071002China National and Local Joint Engineering Research Center of Metrology Instrument and System Hebei UniversityBaoding071002China Hebei Technology Innovation Center for Lightweight of New Energy Vehicle Power System Hebei UniversityBaoding071002China

Clear cell renal cell carcinoma(ccrcC)represents the most frequent form of renal cell carcinoma(RCC),and accurate International Society of Urological Pathology(ISUP)grading is crucial for prognosis and treatment *** study presents a new deep network called Multi-scale Fusion Network(MsfNet),which aims to enhance the automatic ISUP grade of ccrcC with digital histopathology pathology *** MsfNet overcomes the limitations of traditional ResNet50 by multi-scale information fusion and dynamic allocation of channel *** model was trained and tested using 90 Hematoxylin and Eosin(H&E)stained whole slide images(WSIs),which were all cropped into 320×320-pixel patches at 40×*** achieved a micro-averaged area under the curve(AUC)of 0.9807,a macro-averaged AUC of 0.9778 on the test *** Gradient-weighted Class Activation Mapping(Grad-CAM)visually demonstrated MsfNet’s ability to distinguish and highlight abnormal areas more effectively than *** t-Distributed Stochastic Neighbor Embedding(t-SNE)plot indicates our model can efficiently extract critical features from images,reducing the impact of noise and redundant *** results suggest that MsfNet offers an accurate ISUP grade of ccrcC in digital images,emphasizing the potential of AI-assisted histopathological systems in clinical practice.

关键词： Renal cell carcinoma computer-aided diagnosis pathology image deep learning machine learning

3D hand pose and shape estimation from monocular RGB via efficient 2D cues

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Computational Visual Media 2024年第1期10卷 79-96页

作者： Fenghao Zhang Lin Zhao Shengling Li Wanjuan Su Liman Liu Wenbing Tao Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis&treatment School of Biomedical EngineeringSouth Central Minzu UniversityWuhan430074China National Key Laboratory of Science and Technology of Multi-spectral Information Processing School of Artificial Intelligence and AutomationHuazhong University of Science and TechnologyWuhan430074China

Estimating 3D hand shape from a single-view RGB image is important for many ***,the diversity of hand shapes and postures,depth ambiguity,and occlusion may result in pose errors and noisy hand *** full use of 2D cues such as 2D pose can effectively improve the quality of 3D human hand shape *** this paper,we use 2D joint heatmaps to obtain spatial details for robust pose *** also introduce a depth-independent 2D mesh to avoid depth ambiguity in mesh regression for efficient hand-image *** method has four cascaded stages:2D cue extraction,pose feature encoding,initial reconstruction,and reconstruction ***,we first encode the image to determine semantic features during 2D cue extraction;this is also used to predict hand joints and for ***,during the pose feature encoding stage,we use a hand joints encoder to learn spatial information from the joint ***,a coarse 3D hand mesh and 2D mesh are obtained in the initial reconstruction step;a mesh squeeze-and-excitation block is used to fuse different hand features to enhance perception of 3D hand ***,a global mesh refinement stage learns non-local relations between vertices of the hand mesh from the predicted 2D mesh,to predict an offset hand mesh to fine-tune the reconstruction *** and qualitative results on the FreiHAND benchmark dataset demonstrate that our approach achieves state-of-the-art performance.

关键词： hand 3D reconstruction deep learning image features 3D mesh

Notopterygium Incisum Extract Promotes Apoptosis by Preventing the Degradation of BIM in Colorectal Cancer

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Current Medical Science 2024年第4期44卷 833-840页

作者： Jun-he CHEN Cheng-ming WEI Qian-yu LIN Zi WANG Fu-ming ZHANG Mei-na SHI Wen-jian LAN Chang-gang SUN Wan-jun LIN Wen-zhe MA State Key Laboratory of quality Research in Chinese Medicine Macao University of Science and TechnologyMacao999078China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510006China College of Traditional Chinese Medicine Weifang Medical UniversityWeifang261053China

Objective Colorectal cancer(crc),a prevalent malignancy worldwide,has prompted extensive research into anticancer *** Chinese medicinal materials offer promising avenues for cancer management due to their diverse pharmacological *** study investigated the effects of Notopterygium incisum,a traditional Chinese medicine named Qianghuo(QH),on crc cells and the underlying *** The sulforhodamine B assay and colony formation assay were employed to assess the effect of QH extract on the proliferation of crc cell lines HCT116 and *** iodide(PI)staining was utilized to detect cell cycle progression,and PE Annexin V staining to detect *** blotting was conducted to examine the levels of apoptotic proteins,including B-cell lymphoma 2-interacting mediator of cell death(BIM),B-cell lymphoma 2(Bcl-2),Bcl-2-associated X protein(BAX)and cleaved caspase-3,as well as BIM stability after treatment with the protein synthesis inhibitor *** expression of BAX was suppressed using lentivirus-mediated shRNA to validate the involvement of the BIM/BAX axis in QH-induced *** in vivo effects of QH extract on tumor growth were observed using a xenograft ***,APC^(Min+)mice were used to study the effects of QH extract on primary intestinal *** QH extract exhibited significant in vitro anti-crc activities evidenced by the inhibition of cell proliferation,perturbation of cell cycle progression,and induction of ***,QH extract significantly increased the stability of BIM proteins,which undergo rapid degradation under unstressed *** of BAX,the downstream effector of BIM,significantly rescued QH-induced ***,the in vitro effect of QH extract was recapitulated in *** extract significantly inhibited the tumor growth of HCT116 xenografts in nude mice and decreased the number of intestinal polyps in the APC^(Min+)*** QH extract

关键词： Notopterygium incisum colorectal cancer apoptosis B-cell lymphoma 2-interacting mediator of cell death

Comparison of UV-based advanced oxidation processes for the removal of different fractions of NOM from drinking water

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Journal of Environmental Sciences 2023年第4期126卷 387-395页

作者： Zhenxing Yao Mingquan Wang Ruibao Jia Qinghua Zhao Li Liu Shaohua Sun Shandong Province City water Supply and Drainage water quality Monitoring Center Jinan 250101China

This study examined the effectiveness for degradation of hydrophobic (HPO),transphilic(TPI) and hydrophilic (HPI) fractions of natural organic matter (NOM) during UV/H_(2)O_(2),UV/TiO_(2)and UV/K2S2O8(UV/PS) advanced oxidation processes (AOPs).The changing characteristics of NOM were evaluated by dissolved organic carbon (DOC),the specific UV absorbance (SUVA),trihalomethanes formation potential (THMFP),organic halogen adsorbable on activated carbon formation potential (AOXFP) and parallel factor analysis of excitation–emission matrices (PARAFAC-EEMs).In the three UV-based AOPs,HPI fraction with low molecular weight and aromaticity was more likely to degradate than HPO and TPI,and the removal efficiency of SUVA for HPO was much higher than TPI and HPI *** terms of the specific THMFP of HPO,TPI and HPI,a reduction was achieved in the UV/H_(2)O_(2)process,and the higest removal rate even reached to 83%.UV/TiO_(2)and UV/PS processes can only decrease the specific THMFP of *** specific AOXFP of HPO,TPI and HPI fractions were all able to be degraded by the three UV-based AOPs,and HPO content is more susceptible to decompose than TPI and HPI ***/H_(2)O_(2)was found to be the most effective treatment for the removal of THMFP and AOXFP under given conditions.C1 (microbial or marine derived humic-like substances),C_(2) (terrestrially derived humic-like substances)and C_(3) (tryptophan-like proteins) fluorescent components of HPO fraction were fairly labile across the UV-based AOPs treatment.C_(3) of each fraction of NOM was the most resistant to degrade upon the UV-based *** from this study may provide the prediction about the consequence of UV-based AOPs for the degradation of different fractions of NOM with varied characteristics.

关键词： Advanced oxidation processes Natural organic matter Trihalomethanes Organic halogen adsorbable on activated carbon Parallel factor analysis

Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance

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Chinese Journal of Natural Medicines 2024年第4期22卷 341-355页

作者： WANG Hao GENG Xiaolong AI Fangbin YU Zhilun ZHANG Yan ZHANG Beibei LV Cheng GAO Ruiyang YUE Bei DOU Wei The MOE Key Laboratory of Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicinesand the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese MedicineInstitute of Chinese Materia MedicaSchool of Traditional Chinese Materia MedicaShanghai University of Traditional Chinese Medicine(SHUTCM)Shanghai 201203China

Rheumatoid arthritis(RA)is a chronic autoimmune disorder marked by persistent synovial inflammation and joint degradation,posing challenges in the development of effective ***,an alkaloid found in lotus leaf,has shown promising anti-inflammatory and anti-tumor effects,yet its efficacy in RA treatment remains *** study investigated the antiproliferative effects of nuciferine on the MH7A cell line,a human RA-derived fibroblast-like synoviocyte,revealing its ability to inhibit cell proliferation,promote apoptosis,induce apoptosis,and cause G1/S phase ***,nuciferine significantly reduced the migration and invasion capabilities of MH7A *** therapeutic potential of nuciferine was further evaluated in a collagen-induced arthritis(CIA)rat model,where it markedly alleviated joint swelling,synovial hyperplasia,cartilage injury,and inflammatory *** also improved collagen-induced bone erosion,decreased pro-inflammatory cytokines and serum immunoglobulins(IgG,IgG1,IgG2a),and restored the balance between T helper(Th)17 and regulatory T cells in the spleen of CIA *** results indicate that nuciferine may offer therapeutic advantages for RA by decreasing the proliferation and invasiveness of FLS cells and correcting the Th17/Treg cell imbalance in CIA rats.

关键词： Rheumatoid arthritis Collagen-induced arthritis Fibroblast-like synoviocyte Immune imbalance Nuciferine

Evaluation of the safety and efficiency of cytotoxic T cell therapy sensitized by tumor antigens original from T-ALL-iPSC in vivo

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Cancer Innovation 2024年第1期3卷 50-60页

作者： Weiran Li Meiling Zhou Lu Wang Liying Huang Xuemei Chen Xizhuo Sun Tao Liu Department of Tumor Immunotherapy Shenzhen Luohu People's HospitalThe Third Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongChina Cell quality Testing Laboratory of Shenzhen Luohu Hospital Group ShenzhenGuangdongChina

Background:Since RNA sequencing has shown that induced pluripotent stem cells(iPSCs)share a common antigen profile with tumor cells,cancer vaccines that focus on iPSCs have made promising progress in recent ***,we showed that iPSCs derived from leukemic cells of patients with primary T cell acute lymphoblastic leukemia(T-ALL)have a gene expression profile similar to that of T-ALL cell ***:Mice with T-ALL were treated with dendritic and T(DC-T)cells loaded with intact and complete antigens from T-ALL-derived iPSCs(T-ALL-iPSCs).We evaluated the safety and antitumor efficiency of autologous tumor-derived iPSC antigens by flow cytometry,cytokine release assay,acute toxicity experiments,long-term toxicity experiments,and other ***:Our results indicate that complete tumor antigens from T-ALL-iPSCs could inhibit the growth of inoculated tumors in immunocompromised mice without causing acute and long-term ***:T-ALL-iPSC-based treatment is safe and can be used as a potential strategy for leukemia immunotherapy.

关键词： adoptive cell therapy drug safety evaluation IPSCs T-ALL

Fermented calcium butyrate supplementation in post-peak laying hens improved ovarian function and tibia quality through the“gut-bone” axis

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Metagenomic insights into responses of microbial population and key functional genes to fulvic acid during partial nitritation

Animal Nutrition 2024年第1期16卷 350-362页

作者： Huaiyong Zhang Yongshuai Wang Yilu Wang Bin Wei Leilei Wang Minh Tu Nguyen Xiangyun Lv Yanqun Huang Wen Chen College of Animal Science and Technology Key Laboratory of Animal Biochemistry and NutritionMinistry of AgricultureHenan Agricultural University Laboratory for Animal Nutrition and Animal Product quality Department of Animal Sciences and Aquatic EcologyGhent University Department of Agriculture and Forestry Hue University Charoen Pokphand Group Co. Ltd.

The compromised egg quality and leg abnormality during the end of the laying cycle(after 40 weeks)have been leading to poor animal welfare and substantial economic losses. Therefore, the effects of fermented calcium(Ca) butyrate, produced by fermentation by Clostridium butyricum, on production,eggshell quality, and tibial property of hens were explored. A total of 192 Hy-line brown laying hens at50-week-old were assigned to a basal diet or the basal diet with 300 mg/kg of the fermented Ca butyrate from 50 to 58 weeks of age. Each treatment had 6 replicates with 16 hens each. The diet supplemented with 300 mg/kg fermented Ca butyrate notably increased egg weight, ovarian follicle number, and eggshell strength(P = 0.072) as compared to the basal diet, which were associated with cytokine secretion, toll-like receptor signaling pathways, and intestinal immunity based on the RNA-seq data from the granulosa. Dietary Ca butyrate inclusion decreased the expression of ileal tumor necrosis factor-alpha and serum pro-inflammatory cytokine concentration, as well as increased the content of serum immunoglobulin A when compared to the basal diet(both P 0.05). In addition, the diet with fermented Ca butyrate reduced the number of osteoclasts in the proximal tibia and the level of C-terminal cross-linked telopeptide of type I collagen, a bone resorption marker(P < 0.05), whereas it tended to increase the concentration of the procollagen type I N-terminal propeptide that reflects bone formation marker in serum. Moreover, the layers fed fermented Ca butyrate diets possessed higher(P < 0.05) bone area and trabecular number of the proximal tibia, yield load, and ultimate load than those that consumed basal diets. Collectively, dietary fermented Ca butyrate supplementa

关键词： Fermented Ca butyrate Ovarian property Tibia metabolism Layer

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Journal of Environmental Sciences 2023年第2期124卷 952-962页

作者： Li Zhang Shuang Lan Quanhao Dou Shiwei Hao Yueping Wang Xiaoxuan Wang Ruoyan Zhang Yongzhen Peng Jiachun Yang National Engineering Laboratory for Advanced Municipal Wastewater treatment and Reuse Technology Key Laboratory of Beijing for Water Quality Science and Water Environment Recovery EngineeringBeijing University of TechnologyBeijing 100124China Shuifa Shandong water Development Group Co.Ltd. Shandong 274200China

The long-term impact of fulvic acid(FA)on partial nitritation(PN)systemwas initially examined in this *** obtained results revealed that the FA lower than 50 mg/L had negligible effect on the nitrite accumulation rate(NAR nearly 100%)and ammonium removal rate(ARR 56.85%),while FA over 50 mg/L decreased ARR from 56.85%to 0.7%.Sludge characteristics analysis found that appropriate FA(treatment of FA-containing sewage.

关键词： Partial nitritation Fulvic acid Microbial community Functional genes Metagenomic

Application Effect of External Diaphragm Pacemaker Combined with Active Respiratory Circulation Technology in Pulmonary Rehabilitation of Perioperative Lung Cancer Patients

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Journal of Cancer Therapy 2024年第4期15卷 190-200页

作者： Linjuan Zeng Gaoyang Duan Dandan Liu Heping Wu Cancer Prevention and treatment Center Department of Thoracic Surgery Sun Yat-sen University Guangzhou China

Aim: To explore the application effect of external diaphragm pacemaker combined with active respiratory circulation technology in pulmonary rehabilitation of perioperative lung cancer patients. Methods: A total of 98 lung cancer patients admitted to our hospital from April 2020 to November 2021 were selected as the observation objects, and then divided into a control group and an observation group using the random number table method, with 49 cases in each group. The control group received routine admission guidance and active respiratory circulation training, while the observation group was supplemented with external diaphragm pacemaker on the basis of the control group. The intervention effect was evaluated by blood gas indicators, pulmonary function indicators, diaphragm function indicators, sputum comfort degree, and activity tolerance indicators before and after intervention. Results: Before intervention, there were no significant differences in blood gas analysis indicators, pulmonary function indicators, diaphragm function indicators, sputum comfort degree, and activity tolerance indicators between the two groups (P > 0.05). After intervention, the improvement degree of the above indicators in the observation group was higher than that in the control group (P quality of life of patients.

关键词： The Extracorporeal Diaphragm Pacemaker Active Breathing and Circulation Training Lung Cancer Diaphragmatic Mobility Pulmonary Function