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Stem cell transplantation in cerebrovascular accidents:A global bibliometric analysis(2000-2023)

World Journal of Stem Cells 2024年第9期16卷 832-841页

作者： Jad El Masri Ahmad Afyouni Maya Ghazi Karim Hamideh Israe Moubayed Abdo Jurjus Hanine Haidar Ruzanna Petrosyan Pascale Salameh Hassan Hosseini École Doctorale Sciences de la Vie et de la santé UniversitéParis-Est CréteilCréteil 94010France INSERM U955-E01 Institut Mondor de Recherche BiomédicaleUniversitéParis-Est CréteilCréteil 94000France Faculty of Medical Sciences Lebanese UniversityBeirut 1533Lebanon department of Anatomy Cell Biology and Physiological SciencesFaculty of MedicineAmerican University of BeirutBeirut 1107Lebanon department of Neurology Faculty of MedicineLebanese American UniversityBeirut 1102Lebanon department of Pathology Faculty of MedicineLebanese American UniversityBeirut 1102Lebanon Faculty of Pharmacy Lebanese UniversityBeirut 1102Lebanon Faculty of Medicine Lebanese American UniversityBeirut 1102Lebanon department of Primary Care and Population Health University of Nicosia Medical SchoolNicosia 2408Cyprus Institut National de santéPublique d'Épidémiologie Clinique et de Toxicologie-Liban Beirut 1103Lebanon department of Neurology Henri Mondor HospitalAP-HPCréteil 94000France

BACKGROUND Cerebrovascular accident(CVA)is a major global contributor to death and *** part of its medical management,researchers have recognized the importance of promising neuroprotective strategies,where stem cell transplantation(SCT)is thought to confer advantages via trophic and neuroprotective *** To evaluate the current state of research on SCT in patients with CVA,assess key trends and highlight literature *** PubMed was screened for SCT in CVA-related articles in October 2023,for each country during the period between 2000 and *** the World Bank data,total population and gross domestic product were collected for ***_1.6.19 was used to create the VOS figure using the results of the same *** and tables were obtained using Microsoft Office *** A total of 6923 studies were identified on SCT in CVA,making 0.03%of all published studies ***,68%were conducted in high-income countries,with a significant focus on mesenchymal stem *** journal“Stroke”featured the largest share of these articles,with mesenchymal SCT having the highest rate of inclusion,followed by hematopoietic *** time,there has been a noticeable shift from in vitro studies,which assess stem cell proliferation and neurogenesis,to in vivo studies aimed at evaluating efficacy and ***,the number of reviews increased along this *** This bibliometric analysis provides a comprehensive guide for physicians and researchers in the field through an objective overview of research activity,and highlights both current trends and *** a potential therapeutic role in CVA,more research is needed in the future to focus on different aspects of SCT,aiming to reach a better treatment strategy and improve life quality in patients.

关键词： Bibliometric analysis PubMed Stem cell transplantation Cerebrovascular accidents Stroke

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Impact of Anemia on Mortality and Nutritional Recovery among Hospitalized Severely Malnourished Children in Burkina Faso

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Open Journal of Pediatrics 2014年第1期4卷 115-120页

作者： Léon G. Blaise Savadogo Ivone Zoetaba Bernard Ilboudo Maurice Kinda Philipe Donnen Centre de Réhabilitation Nutritionnelle Ouagadougou Burkina Faso cr3 Politiques et Systèmes de Santé Santé Internationale Ecole de Santé Publique Université Libre de Bruxelles Bruxelles Belgique department of Epidemiology and Public Health Child and Mother Health Nutrition and Survival Unit Institut Supérieur des Sciences de la Santé Université Polytechnique de Bobo Dioulasso Bobo Dioulasso Burkina Faso

This study aimed to analyze the impact of anemia on mortality rate and nutritional recovery, during severely malnourished inpatient treatment. Material and Methods: This was a retrospective cohort study conducted from data of severely malnourished children hospitalized at a feeding the rapeutic center. Pearson’s Chi square test, General linear model, Mortality relatives risks, Kaplan-Meir survival curves have been used. Results: At admission, 85.3% of included malnourished children had anemia (Hb ≤ 11 g/dl) and 10.6% severe anemic (Hb 6 g/dl). Mortality rate did not differed significantly from severely malnourished children with anemia (12.4%) and without anemia (22.2%), p = 0.12. Kaplan Meir survival curves did not differed significantly between the two groups, (p Log Rank = 0.11). From admission to discharge, anthropometric Z-scores means evolution did not differed significantly between severely malnourished children with and without anemia at admission. But anthropometric Z-scores means evolution differed significantly within each group’s subjects: WHZ (between groups: p = 0.74;within subjects: p 0.001), and WAZ (between groups: p = 0.54;within subjects: p 0.001). Conclusion: With a strong respect of current recommendation of anemia treatment of inpatient severely malnutrition management, there is no increased mortality rate in SAM anemic group;and nutritional recovery is significant within subjects of SAM anemic and non anemic children, without difference between groups.

关键词： Anemia Mortality Nutritional Recovery Severely Malnourished Children

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Maternal Mortality Risk Factors in Regional Hospital of Burkina Faso

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Open Journal of Epidemiology 2014年第2期4卷 57-62页

作者： Léon G. Blaise Savadogo Aminata Zombra Cécile Tamini Maurice Kinda Philipe Donnen Centre Hospitalier Régional Banfora Burkina Faso cr3—politiques et systèmes de santé—santé Internationale School of Public Health Université Libre de Bruxelles Bruxelles Belgique department of Epidemiology and Public Health—Child and Mother Health Nutrition and Survival Unit—Institut Supérieur des Sciences de la Santé Université Polytechnique Bobo Dioulasso Burkina Faso Ecole National de santé Publique Bobo Dioulasso Burkina Faso

Individual causes and community determinants are synergic in maternal death occurrence. This study aimed to identify maternal mortality risk factors in a regional hospital. Material and Methods: This was a retrospective cohort study from data of 1807 hospitalized women. To identify maternal mortality risks factors, mortality hazard ratio (HR CI95%) has been calculated in univariate analysis and Cox proportional hazard model. Results: During hospitalization, 30 maternal deaths occurred. From Cox regression, adjusted mortality HR confirmed that women age older than 35 (HR = 2.5, CI95%: [1.2-5.7] and younger than 19 (HR = 3.02, CI95%: [1.5-6.7]);distance to hospital ≥10 Km (HR = 4.1, CI95%: [1.8-9.4];multiple deliveries (HR = 2.4, CI95%: [1.1-7.3]), less ante natal care (3 visits) (HR = 3.03, CI95%: [0.97-9.48]);obstetrical maternal mortality directs causes (HR = 2.31, CI95%: [1.7-6.21]) and emergently reference (HR = 3.5, CI95%: [1.8-8.32]) were maternal mortality risk factors. Conclusion: In this regional hospital of low income country, identified maternal mortality factors are related to women socio-economic determinants and quality prenatal or obstetric care access. Interventions to reduce maternal mortality rate should be conducted within both household and women socio-economic status development and in maternal health and obstetric care strengthening.

关键词： Maternal Mortality Risk Factors Regional Hospital Burkina Faso

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Characteristics of Severely Anemic Pregnant Women and Perinatal Outcomes in Banfora Regional Hospital, Burkina Faso: An Epidemiological Study

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Open Journal of Obstetrics and Gynecology 2014年第5期4卷 234-238页

作者： Léon G. Blaise Savadogo Ouédraogo Salimata Cécile Tamini Maurice Kinda Philipe Donnen Centre Hospitalier Régional de Banfora Banfora Burkina Faso cr3 politiques et systèmes de santé Santé Internationale Ecole de Santé Publique Université Libre de Bruxelles Bruxelles Belgique department of Epidemiology and Public Health Child and Mother Health Nutrition and Survival Unit Institut Supérieur des Sciences de la Santé Université Polytechnique de Bobo Dioulasso Bobo Dioulasso Burkina Faso Ecole National de santé Publique Bobo Dioulasso Burkina Faso

Severe anemia during pregnancy remains an acute maternal health problem in low income countries and its management is a challenge. This study aimed to analyze the characteristics of hospitalized pregnant women with severe anemia and issue of the management in a regional hospital of a low income country. Material and Methods: This was a retrospective descriptive study from January 1, 2007 to december 31, 2008, at a regional hospital maternity. Data of the 283 pregnancy severe anemia cases have been analyzed using usual Pearson’s Chi square test or Fisher’s exact test. Results: Of the 283 women with pregnancy severe anemia, 98% were illiterate, 98% were household women;majority were in the third trimester (64%);41% had no previous delivery;49% did not had antenatal care. There were no statistics association between hemoglobin values stage and gestational age, gravidity and parity. During the hospitalization, from the 283 women with pregnancy severe anemia, deliveries occurred on 22.6%;abortion on 1%. From the 64 deliveries, 45.3% were alive preterm birth, 20.3% preterm stillbirth, 25.0% at term birth and 9.4% at term stillbirth. Between the 45 alive babies, 91% were low birth weight. In global, from the 283 women, mortality rate was 2.8%. Conclusion:?Severe anemia during pregnancy results in maternal mortality, preterm, low birth and stillbirth even between hospitalized women. As most of the pregnancy anemia risk factors are chronic poverty related factors, intervention must be focused on prevention including health pregnant women iron supplementation and adequate nutritional diet promoting at both health facilities and community level.

关键词： Pregnancy Severe Anemia Regional Hospital Burkina Faso

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Socioeconomic Indices Performance for HIV Diagnostic on Severely Malnourished Children in Burkina Faso

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World Journal of AIDS 2014年第1期4卷 99-106页

作者： Léon G. Blaise Savadogo Philippe Donnen Michèle Dramaix cr2-Epidemiology-Biostatistics-Clinical Research School of Public Health Université Libre de Bruxelles Bruxelles Belgique cr3-politiques et systèmes de santé Santé Internationale School of Public Health Université Libre de Bruxelles Bruxelles Belgique department of Epidemiology and Public Health Child and Mother Health Nutrition and Survival UnitInstitut Supérieur des Sciences de la Santé Bobo Dioulasso Burkina Faso cr2-Epidemiology-Biostatistics-Clinical Research School of Public Health Université Libre de Bruxelles Bruxelles Belgique

Children living with HIV should be diagnosed as early as possible and linked to antiretroviral treatment. The costs of HIV virological testing, individual and social implications of the disease require critical quality of the medical approach to diagnostic strategy. Socioeconomic data can be used to refine the medical decision. The objective of this analysis was to determine informative capacity of socioeconomic indices in the diagnosis and approach of HIV in severely malnourished children using receiver operating characteristic (ROC) curves. Materials and Methods: This was a test performance analysis conducted from data of severely malnourished children at an inpatient feeding therapeutic center in Ouagadougou. Anthropometric and social indices have been used as tests;their sensitivity, specificity and predictive values have been calculated. ROC curves and areas under curves were obtained. Medical decision aid scheme has been validated from severely malnourished children data. Results: Socioeconomic indices showed high performance to discriminate severely malnourished HIV infected and uninfected children, with high area under ROC curves. The medical decision aid scheme specificity reached 97.6% with predictive values close to 85%. Conclusion: This approach can help for expanding ART for children in low income countries and achieve the maximum ART benefits in child socioeconomic kneed context.

关键词： Socioeconomic Indices Test Performance HIV Severely Malnourished Children

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Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients

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World Journal of Gastroenterology 2006年第45期12卷 7319-7325页

作者： Thomas decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux Service d'Hépatologie et de Gastroentérologie AP-HP Hpital Henri Mondor Créteil Unité INSERM 581 France Département de santé Publique AP-HP Hpital Henri Mondor Créteil France Service d’Hépatologie Hpital Jean Minjoz Besanon France Service de Transplantation Hpital HautefeuilleStrasbourg France Service de Chirurgie Digestive Hpital L’Ar-chet 2 Nice France Service d’Hépatologie AP-HP Hpital Beau-jon Clichy France Service d’Hépatologie et de Gastroentéro-logie H?pital Pellegrin Bordeaux France Service de Chirurgie Digestive Hpital Edouard Herriot Lyon France Service de Chirurgie Digestive Hpital Ponchaillou Rennes France Service de Chirurgie Digestive AP-HP HpitalCochin Paris France Service de Chirurgie Digestive Hpital laConception Marseille France Service de Chirurgie Digestive Hpital de laCroix Rousse Lyon France Fédération Médico-Chirurgicale deMaladies de l’Appareil Digestif Hpital Saint-Eloi MontpellierFrance Service d’Hépatologie et de Gastroentérologie H?pital Claude Huriez Lille France Service d’Hépatologie AP-HP Hpital SAntoine Paris France Service de Chirurgie Générale et Digestive APHP Hopital Henri Mondor Créteil France

AIM： To assess pre-orthotopic liver transplantation （OLT） factors that could be evaluated pre-operatively or controlled post-operatively associated with hepatocellular carcinoma （HCC） recurrence and disease-free survival after liver transplantation （LT）.MetHODS： Four hundred and twelve patients transplanted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to identify independent predictors of recurrence. RESULTS： Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were： presence of cirrhosis （P = 0.001）, etiology of liver disease （P = 0.03）, α fetoprotein level （〈 200, 200 to 2000, or 〉 2000; P 〈 0.0001）, y-GT activity （N, N to 2N or 〉 2N; P = 0.02）, the number of nodules （1, 2-3 or ≥ 4; P = 0.02）, maximal diameter of the largest nodule （〈 3 cm, 3 to 5 cm or 〉 5 cm; P 〈 0.0001）, the sum of the diameter of the nodules （〈 3 cm, 3 to 5 cm, 5 to 10 cm or 〉10 cm; P 〈 0.0001）, bilobar location （P = 0.01）, preoperative portal thrombosis （P 〈 0.0001）, peri-operative treatment of the tumor （P = 0.002） and chemoembolization （P = 0.03）, tumor differentiation （P = 0.01）, initial type of calcineurin inhibitor （P = 0.003）, the use of antilymphocyte antibodies （P = 0.02）, rejection episodes （P = 0.003） and period of LT （P 〈 0.0001）. By multivariate analysis, 6 variables were independently associated with HCC recurrence： maximal diameter of the largest nodule （P 〈 0.0001）, time of LT （P 〈 0.0001）, tumor differentiation （P 〈 0.0001）, use of anti-lymphocyte antibody （ATG） or anti-CD3 antibody （OKT3）（P = 0.005）, preoperative portal thrombosis （P = 0.06） and the number of nodules （P = 0.06）. CONCLUSION： This study identifies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recur

关键词： Immunosuppression Hepatocellular carcinoma Tumor differentiation Liver transplantation

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Herpes Simplex Virus Type 2 (HSV-2) and HTLV-1 &2 among Female Sex Workers in Ouagadougou, Burkina Faso

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Open Journal of Medical Microbiology 2022年第2期12卷 56-69页

作者： Henri Gautier Ouédraogo Dinanibè Kambiré Tani Sagna Tegwinde Rebeca Compaore Oumarou Ouédraogo Abdou Azaque Zouré Serge Théophile Soubeiga Sylvie Zida Danielle Belemsaga/Yugbaré Samadoulougou Benoît Cesaire Odette Ky-Zerbo Yves Traoré Nicolas Barro Seni Kouanda Institut de Recherche en Sciences de la santé (IRSS) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso Sécrétariat Permanent du Conseil National de Lutte contre le Sida et les Infections Sexuellement Transmissibles (SP/CNLS-IST) Ouagadougou Burkina Faso Unité de Formation et de Recherche en Sciences de la santé (UFR-SDS) Université Joseph Ki Zerbo Ouagadougou Burkina Faso

Background: Herpes Simplex Virus type-2 (HSV-2) infection is one of the most common worldwide sexually transmitted and female sex workers are most at risk for these infections. Beside HSV-2, Human T-lymphotropic virus (HTLV) is one of these infections with a high risk of sexual transmission. HTLV-1 causes T-cell leukaemia and myelopathy. Little is known about the HSV-2, HTLV-1 and HTLV-2 infections among female sex workers in West Africa in general, and particularly in Burkina Faso. The aim of this study aimed to estimate HSV-2 and HTLV-1/2 seroprevalence among female sex workers, in Ouagadougou in order to inform HIV prevention programs. Methods: Archived sera samples of a biological and behavioral cross-sectional study among female sex workers (FSWs) in Ouagadougou were tested for HSV-2 and HTLV-1/2. Sera samples collected from February to May 2013 were previously tested for HIV and syphilis and stored with participants’ additional consent for further infection testing. Antibodies against HSV-2 and HTLV-1/2 detection tests were performed using Enzyme-Linked Immuno-Sorbent Assay (ELISA) methods. Results: HSV-2 seroprevalence was approximately 75.7% (95% CI: 70.8-79.9) among FSWs. It ranged from 69.3% among FSWs under 24 years of age, to 88.5% among those who were at least 30 years old. Furthermore, HSV-2 seroprevalence was high among FSW with no formal education (87.7%) and decreased significantly among those with at least primary education (76.0%) and others with secondary education and above (64.9%). Regarding HTLV-1/2, 11.2% (95% CI: 8.3 - 15.1) of FSWs were positive. By age group, 11.8% were positive among FSWs under 25 years of age;15.2% among those 25 to 29 years of age, and 5.8% among those over 30 years of age. Conclusion: HSV-2 and HTLV-1&2 infections are common among FSWs, which confirms the need for effective and preventive interventions such as sex education and early screening.

关键词： HSV-2 HTLV-1/2 Seroprevalence Female Sex Workers FSWs

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Redefining pandemic preparedness:Multidisciplinary insights from the CERP modelling workshop in infectious diseases,workshop report

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Infectious Disease Modelling 2024年第2期9卷 501-518页

作者： Marta C.Nunes Edward Thommes Holger Fröhlich Antoine Flahault Julien Arino Marc Baguelin Matthew Biggerstaff Gaston Bizel-Bizellot Rebecca Borchering Giacomo Cacciapaglia Simon Cauchemez Alex Barbier--Chebbah Carsten Claussen Christine Choirat Monica Cojocaru Catherine Commaille-Chapus Chitin Hon Jude Kong Nicolas Lambert Katharina B.Lauer Thorsten Lehr Cédric Mahe Vincent Marechal Adel Mebarki Seyed Moghadas Rene Niehus Lulla Opatowski Francesco Parino Gery Pruvost Andreas Schuppert Rodolphe Thiébaut Andrea Thomas-Bachli Cecile Viboud Jianhong Wu Pascal crépey Pascalcrepey Center of Excellence in Respiratory Pathogens(CERP) Hospices Civils de Lyon(HCL)and Centre International de Recherche en Infectiologie(CIRI)Équipe SantéPubliqueÉpidémiologie etÉcologieÉvolutive des Maladies Infectieuses(PHE3ID)Inserm U1111CNRS UMR5308ENS de LyonUniversitéClaude Bernard Lyon 1LyonFrance South African Medical Research Council Vaccines&Infectious Diseases Analytics Research UnitFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa New Products and Innovation(NPI) Sanofi Vaccines(Global)TorontoOntarioCanada department of Mathematics and Statistics University of GuelphGuelphOntarioCanada Fraunhofer Institute for Algorithms and Scientific Computing(SCAI) Department of BioinformaticsSchloss BirlinghovenSankt AugustinGermany University of Bonn Bonn-Aachen International Center for IT(b-it)BonnGermany Institute of Global Health Faculty of MedicineUniversity of GenevaGenevaSwitzerland and Swiss School of Public HealthZürichSwitzerland department of Mathematics University of ManitobaWinnipegManitobaCanada MRC Centre for Global Infectious Disease Analysis School of Public HealthImperial College LondonLondonUK Centre for Mathematical Modelling of Infectious Diseases Department of Infectious Disease EpidemiologyLondon School of Hygiene&Tropical MedicineLondonUK National Center for Immunization and Respiratory Diseases(NCIRD) US Centers for Disease Control and Prevention(CDC)AtlantaGAUSA departement of Computational Biology Departement of Global HealthInstitut PasteurParisFrance Institut de Physique des deux Infinis de Lyon(IP2I) UMR5822IN2P3/CNRSUniversitéClaude Bernard Lyon 1VilleurbanneFrance Mathematical Modelling of Infectious Diseases Unit Institut PasteurUniversitéParis CitéUMR2000 CNRSParisFrance decision and Bayesian Computation Institut PasteurUniversitéParis CitéCNRS UMR 3571France Fraunhofer-Institute for Translational Medicine and Pharmacology HamburgGermany Institute of Global Health Faculty of MedicineUniversity of

In July 2023,the Center of Excellence in Respiratory Pathogens organized a two-day workshop on infectious diseases modelling and the lessons learnt from the Covid-19 *** report summarizes the rich discussions that occurred during the *** workshop participants discussed multisource data integration and highlighted the benefits of combining traditional surveillance with more novel data sources like mobility data,social media,and wastewater *** advancements were noted in the development of predictive models,with examples from various countries showcasing the use of machine learning and artificial intelligence in detecting and monitoring disease *** role of open collaboration between various stakeholders in modelling was stressed,advocating for the continuation of such partnerships beyond the pandemic.A major gap identified was the absence of a common international framework for data sharing,which is crucial for global pandemic ***,the workshop underscored the need for robust,adaptable modelling frameworks and the integration of different data sources and collaboration across sectors,as key elements in enhancing future pandemic response and preparedness.

关键词： Modelling Covid-19 Infectious diseases Pandemic preparedness Workshop

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Acute lung injury in mechanically ventilated patients with epidermal necrolysis:an exposed-unexposed retrospective cohort study

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Burns & Trauma 2020年第1期8卷 30-33页

作者： S.Lalevée J.Catano S.Ingen-Housz-Oro M.Surenaud J.Tran Van Nhieu F.Schlemmer I.Bendib A.Mekontso-dessap S.Hue N.de Prost Service de dermatologie AP-HPhoital Henri MondorCréteilFrance UniversitéParis Est créteil INSERM U955IMRBF-94010 CréteilFrance Service de Médecine Intensive Réanimation Hoitaux Universitaires Henri MondorAssistance Publique-Hoitaux de ParisCréteil Cedex 94010France EA7379 EpidermE UPECCréteilFrance Centre de référence des dermatoses bulleuses toxiques et toxidermies graves TOXIBUL CréteilFrance Service d’Anatomopathologie AP-HPhoital Henri MondorCréteilFrance Unitéde Pneumologie Service de Médecine Intensive RéanimationHoitaux Universitaires Henri MondorAssistance Publique-Hoitaux de ParisCréteil Cedex 94010France Groupe de Recherche Clinique CARMAS Facultéde Santéde CréteilUniversitéParis Est CréteilCréteil Cedex 94010France AP-HP Département d’Hématologie et d’Immunologie biologiquesGroupe hospitalouniversitaire Chenevier MondorAssistance Publique-Hoitaux de Paris F-94010 CréteilFrance

To the Editor,During the acute phase of epidermal necrolysis(EN,including Stevens-Johnson syndrome and toxic epidermal necrolysis),mucosal lesions involving the tracheo-bronchial tract have been reported[1,2]and approximately one in four EN patients develop acute respiratory failure and require endotracheal intubation and mechanical ventilation(MV)support[3].Asymptomatic respiratory sequelae may be detected on pulmonary function tests after the acute phase in as much as 50%of EN patients,possibly related to pulmonary lesions that occurred at the acute phase[4].

关键词： acute patients respiratory

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长余辉纳米探针的光学性质调控及其在生物分析中的应用

长余辉纳米探针的光学性质调控及其在生物分析中的应用

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第十届全国化学生物学学术会议

作者：刘英帅 Daniel Scherman Cyrille Richard 西南大学材料与能源学部 Unité de Technologies Chimiques et Biologiques pour la santé

长余辉发光材料是指物质在激发光照射时可将能量储存起来,在停止激发后仍能够持续发光的一类光致发光材料。长余辉发光探针与传统有机荧光染料、量子点和上转换纳米探针等不同,在复杂的生物分析体系中它可有效避免激发光导致的背景信号... 详细信息

长余辉发光材料是指物质在激发光照射时可将能量储存起来,在停止激发后仍能够持续发光的一类光致发光材料。长余辉发光探针与传统有机荧光染料、量子点和上转换纳米探针等不同,在复杂的生物分析体系中它可有效避免激发光导致的背景信号的干扰,大大提高检测的信噪比[1,2]。尽管如此,与传统的光学探针相比长余辉探针发光效率较低,极大地限制了其生物传感与分析领域的应用[3]。本工作创新性地通过液相化学掺杂的方式开发出一种简单、有效地增强长余辉纳米探针Zn Ga2O4:cr（ZGO:cr）发光性能的方法。并通过改变激发光的波长;改变溶剂和掺杂分子的特性;调整表面包被层的厚度等因素对H2O2增强长余辉发光性能的机理进行了详细探讨。基于H2O2诱导的发光增强效应,本工作应用长余辉纳米材料作为探针构建了一种细胞表面聚糖表达谱的分析方法和一种简单、灵敏的免疫分析方法。上述方法将特异性分子识别和化学掺杂介导的信号增强有机结合起来,克服了探针本身信号弱的缺陷,同时信号检测时该探针不需要原位激发,避免了容器和生物样品的背景信号,大大提高了检测的信噪比和灵敏度。另外,本方法不需要对长余辉发光探针做任何功能化修饰,避免了复杂、耗时、低效率的探针修饰,有效提高了检测的便捷性和可靠性。本工作为长余辉发光纳米探针的余辉效应调控以及在体外生物传感与生物分析领域开辟了一条新途径。

关键词：长余辉材料信号增强细胞表面聚糖免疫分析

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