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Neuroinflammation as a therapeutic target in Huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani H.Palpagama Center for Brain Research and Department of Anatomy and Medical imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George Huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. Huntington's disease(HD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： Huntington inflammation Medicine

Adjuvant therapy for gastric cancer:Current and future directions

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World Journal of Gastroenterology 2014年第38期20卷 13718-13727页

作者： Marcus Foo Trevor Leong Division of Radiation Oncology and cancer imaging and cancer imaging Peter MacCallum Cancer Centre University of Melbourne

The management of gastric cancer continues to evolve. Whilst surgery alone is effective when tumours present early,a large proportion of patients are diagnosed with loco-regionally advanced disease,resulting in high locoregional and distant relapse rates,with subsequent poor survival. Early attempts at improving outcomes following resection were disappointing;however,randomized trials have now established either post-operative chemoradiotherapy(INT0116) or peri-operative chemotherapy as standard adjuvant therapies in the Western world. There remain,however,significant differences in the approach to management between the West and East. In Asia,where there is the highest incidence of gastric cancer,extended resection followed by adjuvant chemotherapy represents the standard of care. This review discusses current standard adjuvant therapy in gastric adenocarcinoma,as well as recent and ongoing trials investigating novel(neo)adjuvant approaches,which hope to build on the successes of previous studies.

关键词： Adjuvant Gastric Stomach cancer Chemoradiation Chemoradiotherapy Chemotherapy Peri-operative Neo-adjuvant

Advances in computed tomography and magnetic resonance imaging of hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第1期22卷 205-220页

作者： Tiffany Hennedige Sudhakar K Venkatesh Department of Oncologic imaging National Cancer Centre Department of Radiology Mayo Clinic

Hepatocellular carcinoma(HCC)is the most common primary liver *** is important for establishing a diagnosis of HCC and early diagnosis is imperative as several potentially curative treatments are available when HCC is *** occurs in a stepwise manner on a background of chronic liver disease or cirrhosis wherein multiple genes are altered resulting in a range of cirrhosisassociated *** progression is related to increased cellularity,neovascularity and size of the *** understanding of the stepwise progression may aid in early *** and multiphase contrast-enhanced computed tomography and magnetic resonance imaging still form the cornerstone in the diagnosis of *** overview of the current diagnostic standards of HCC in accordance to the more common practicing guidelines and their differences will be *** features contribute to diagnostic confidence and has been incorporated into the more recent Liver imaging Reporting and Data *** use of hepatocyte-specific contrast agents is increasing and gradually changing the standard of diagnosis of HCC;the most significant benefit being the lack of uptake in the hepatocyte phase in the earlier stages of HCC *** outline of supplementary techniques in the imaging of HCC will also be reviewed.

关键词： Hepatocellular carcinoma Computedtomography Magnetic resonance imaging Contrastagent Cirrhosis Ancillary features

On a New Diffeomorphic Multi-Modality Image Registration Model and Its Convergent Gauss-Newton Solver

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Journal of Mathematical Research with Applications 2019年第6期39卷 633-656页

作者： Daoping ZHANG Anis THELJANI Ke CHEN epsrc Liverpool centre for Mathematics in Healthcare Centre for Mathematical Imaging Techniques and Department of Mathematical Sciences The University of Liverpool

In this work, we propose a new variational model for multi-modal image registration and present an efficient numerical implementation. The model minimizes a new functional based on using reformulated normalized gradients of the images as the fidelity term and higher-order derivatives as the regularizer. A key feature of the model is its ability of guaranteeing a diffeomorphic transformation which is achieved by a control term motivated by the quasi-conformal map and Beltrami coefficient. The existence of the solution of this model is established. To solve the model numerically, we design a Gauss-Newton method to solve the resulting discrete optimization problem and prove its convergence; a multilevel technique is employed to speed up the initialization and avoid likely local minima of the underlying functional. Finally, numerical experiments demonstrate that this new model can deliver good performances for multi-modal image registration and simultaneously generate an accurate diffeomorphic transformation.

关键词： Multi-modal image registration variational model diffeomorphic transformation

SMILE soft X-ray Imager flight model CCD370 pre-flight device characterisation

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Earth and Planetary Physics 2024年第1期8卷 25-38页

作者： S.Parsons D.J.Hall O.Hetherington T.W.Buggey T.Arnold M.W.J.Hubbard A.Holland centre for Electronic imaging the Open UniversityMilton KeynesMK76AAUK

Throughout the SMILE mission the satellite will be bombarded by radiation which gradually damages the focal plane devices and degrades their *** order to understand the changes of the CCD370s within the soft X-ray Imager,an initial characterisation of the devices has been carried out to give a baseline performance *** CCDs have been characterised,the two flight devices and the flight spa *** has been carried out at the Open University in a bespo ke cleanroom measure ment *** results show that there is a cluster of bright pixels in the flight spa re which increases in size with tempe *** at the nominal ope rating tempe rature(-120℃) it is within the procure ment ***,the devices meet the specifications when ope rating at -120℃ in 6 × 6 binned frame transfer science *** se rial charge transfer inefficiency degrades with temperature in full frame *** any charge losses are recovered when binning/frame transfer is implemented.

关键词： CCD soft X-ray imager characterisation SMILE

Predictive models for mild cognitive impairment to Alzheimer's disease conversion

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Neural Regeneration Research 2021年第9期16卷 1766-1767页

作者： Konstantina Skolariki Graciella Muniz Terrera Samuel O.Danso Bioinformatics and Human Electrophysiology Laboratory Ionian UniversityCorfuGreece centre for Dementia Prevention University of EdinburghUK Division of Neuroimaging Centre for Clinical Brain Sciences and Edinburgh ImagingUniversity of EdinburghScotlandUK

Alzheimer's disease(AD) is an irreversible and progressive neurodegenerative disease as well as the most common form of dementia. It usually affects the older population, but early onset AD is still possible(Ritchie e... 详细信息

关键词： Alzheimer al. impairment

Application of radiomics and artificial intelligence in lung cancer immunotherapy: a guide and hurdles from clinical trials

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Journal of cancer Metastasis and Treatment 2023年第1期9卷 94-111页

作者： Xiaorong Wu Andreas Polychronis Lung cancer Unit Mount Vernon Cancer CentreLondon HA62RNUK

Immunotherapy has shown promising results with improved progression-free survival and overall survival in lung ***,novel immunotherapy could generate atypical response patterns,which is a big challenge for traditional imaging ***,combined with artificial intelligence(AI),represents new quantitative methodologies that could serve as an additional imaging biomarker to predict immunotherapy benefits and assess responses to assist oncologists in decision-making in lung cancer *** paper aims to review the latest advancement of AI-based radiomics applied to lung cancer patients receiving immunotherapy,focusing on the fundamentals of these approaches and commonly used *** also address the hurdles in the AI and radiomic analysis pipeline to guide clinicians in approaching this new concept.

关键词： Radiomics artificial intelligence lung cancer immunotherapy

Successes and challenges in non-destructive testing of aircraft composite structures

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Chinese Journal of Aeronautics 2020年第3期33卷 771-791页

作者： Hossein TOWSYFYAN Ander BIGURI Richard BOARDMAN Thomas BLUMENSATH Institute of Sound and Vibration Research(ISVR) University of SouthamptonSouthampton SO171BJUK μ-VIS X-Ray imaging centre University of SouthamptonSouthampton SO171BJUK

Composite materials are increasingly used in the aerospace *** fully realise the weight saving potential along with superior mechanical properties that composites offer in safety critical applications,reliable Non-Destructive Testing(NDT)methods are required to prevent catastrophic *** paper will review the state of the art in the field and point to highlight the success and challenges that different NDT methods are faced to evaluate the integrity of critical aerospace *** focus will be on advanced certificated NDT methods for damage detection and characterization in composite laminates for use in the aircraft primary and secondary structures.

关键词： Acoustic emission Aircraft composite structures Eddy Current Testing Infra-Red Thermography Laser Shearography Non-Destructive Testing(NDT) Ultrasonic testing X-ray radiography and tomography

imaging assessment after SBRT for hepatocellular carcinoma

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Hepatoma Research 2020年第7期6卷 78-85页

作者： Connie Yip Tiffany Priyanthi Hennedige Gary JRCook Vicky Goh Radiation Oncology National Cancer Centre SingaporeSingapore 169610Singapore Oncologic imaging National Cancer Centre SingaporeSingapore 169610Singapore cancer imaging King’s College LondonLondon WC2R 2LSUnited Kingdom

The use of stereotactic body radiotherapy(SBRT)in hepatocellular carcinoma(HCC)has increased over the past few ***,accurate evaluation of post-SBRT treatment response is essential to avoid over-treatment of responders as well as missing the opportunity to salvage *** are some intricate imaging differences after liver SBRT compared to those observed after conventional fractionated radiotherapy and other locoregional *** aim to review the imaging changes that occur following SBRT for HCC and their potential clinical implications.

关键词： imaging liver stereotactic body radiotherapy hepatocellular carcinoma