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Chemical constituents and pharmacological effects of Lonicerae japonicae

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Asian Journal of Traditional Medicines 2024年第1期19卷 34-45页

作者： Yunpeng Yang Dan Tian Yibo Wang Yi’an Shi Yuntian Xing Yu Chen School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China Shenyang Hoper group Co. LtdShenyang 110122China national health commission Key Laboratory of Parasitic Disease Control and Prevention Jiangsu Provincial Key Laboratory on Parasite and Vector Control TechnologyJiangsu Provincial Medical Key LaboratoryJiangsu Institute of Parasitic DiseasesWuxi 214064China

Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of *** consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to chemical composition and pharmacological *** articles show that *** has a wide range of pharmacological activities,including antiviral,anti-tumor,and antioxidant *** activities have important applications in the pharmaceutical,food,and fragrance *** review focuses on the chemical composition and pharmacological effects of ***,which is of great significance to the development of new drugs and therapeutic methods.

关键词： Lonicerae japonicae chemical composition pharmacological activity

An Improving national Economy and a Positive Start for the 14th Five-Year Plan

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Qiu Shi 2022年第2期14卷 26-36页

作者： Ning Jizhe the national Development and Reform commission the cpc leadership group of the national Bureau of Statistics

The year of 2021 marked milestones in the history of the Communist Party of China(cpc)and the People’s Republic of China,and it was a year of special importance in our country s *** year,we continued to lead the world in economic development and our handling of the Covid-19 *** realized in full our major economic and social development goals,took new strides toward building a new development dynamic,and made new achievements in high-quality development,all of which got the 14th Five-Year Plan off to a good start.

关键词： continued goals Communist

Stable Economic Recovery and New Development Opportunities

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Qiu Shi 2020年第5期12卷 24-32页

作者： Ning Jizhe national Development and Reform commission CPC Leadership Groupthe National Bureau of Statistics

The sudden Covid-19 outbreak earlier this year has had an unprecedented impact,bringing a sharp increase in the risks and challenges faced by *** with this severe and complex situation,under the strong leadership of the cpc Central Committee with Xi Jinping at its core,the whole country has worked together to overcome difficulties by quickly launching an all-out people’s war against the *** region and sector has conscientiously implemented the decisions of the cpc Central Committee and the State Council to resolutely curb the spread of the disease。

关键词： bringing overcome Recovery

Stress Echocardiography for Chronic Coronary Syndrome:Clinical Practice Guidelines(2023)

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Journal of Geriatric Cardiology 2024年第5期21卷 475-505页

作者： Peng-Fei ZHANG Jia-Wei TIAN Tian-Gang ZHU Jue-Fei WU Xiao-Ping LENG Yi WANG Meng-Meng LI Xin-Hao LI Qian-Qian WANG Xiao-Peng FENG Jia-Yan LV Li-Xue YIN Yun ZHANG Mei ZHANG Chinese Society of Echocardiography,Superficial Tissue and Vascular group of Chinese Society of Ultrasound in Medicine,Ultrasound Professional Committee of Chinese Medicine Education Association State Key Laboratory for Innovation and Transformation of Luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinanChina The Second Affiliated Hospital of Harbin Medical University HaerbinChina Peking University People's Hospital BeijingChina Sichuan Province People's Hospital ChengduChina Nanfang Hospital Southern Medical UniversityGuangzhouChina Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijingChina 不详

In the context of the People's Republic of China,coronary artery disease(CAD)presents a sig-nificant clinical challenge,with over 11.3 mil-lion patients ***,the diagnos-is of CAD has predominantly relied on invasive coronary angiography.[1]However,recent advances in clinical research have revealed a notable trend:a substantial 82% of patients subjected to such invas-ive diagnostics do not necessitate interventional therapy.

关键词： coronary clinical patients

Steroidal scaffold decorations in Solanum alkaloid biosynthesis

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Molecular Plant 2024年第8期17卷 1236-1254页

作者： Rosalind Lucier Mohamed O.Kamileen Yoko Nakamura Sofiia Serediuk Ranjit Barbole Jens Wurlitzer Maritta Kunert Sarah Heinicke Sarah E.O'Connor Prashant D.Sonawane Department of Natural Product Biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Research group Biosynthesis and NMR Max Planck Institute for Chemical Ecology07745 JenaGermany Biochemical Sciences Division CSIR-National Chemical LaboratoryPune 411008MaharashtraIndia

Steroidal glycoalkaloids(SGAs)are specialized metabolites produced by hundreds of Solanum species,including important vegetable crops such as tomato,potato,and *** it has been known that SGAs play important roles in defense in plants and“anti-nutritional"effects(e.g.,toxicity and bitterness)to humans,many of these molecules have documented anti-cancer,anti-microbial,antiinflammatory,anti-viral,and anti-pyretic *** these,α-solasonine andα-solamargine isolated from black nightshade(Solanum nigrum)are reported to have potent anti-tumor,anti-proliferative,and anti-inflammatory ***,α-solasonine andα-solamargine,along with the core steroidal aglycone solasodine,are the most widespread SGAs produced among the Solanum ***,it is still unknown how plants synthesize these bioactive steroidal *** comparative metabolomictranscriptome-guided approach,biosynthetic logic,combinatorial expression in Nicotiana benthamiana,and functional recombinant enzyme assays,here we report the discovery of 12 enzymes from *** that converts the starting cholesterol precursorto solasodine aglycone,and the downstreamα-solasonine,α-solamargine,and malonyl-solamargine SGA *** further identified six enzymes from cultivated eggplant that catalyze the production ofα-solasonine,α-solamargine,and malonyl-solamargine SGAs from solasodine aglycone via glycosylation and atypical malonylation *** work provides the gene tool box and platform for engineering the production of high-value,steroidal bioactive molecules inheterologoushosts usingsyntheticbiology.

关键词： steroidal glycoalkaloids Solanum biosynthetic pathway α-solamargine malonyl-solamargine specialized metabolites

Traditional Chinese Medicine:Leveraging Unique Strengths and Applications to Benefit People’s health in New Ways

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Qiu Shi 2020年第5期12卷 40-48页

作者： Yu Yanhong Yu Wenming national health commission cpc leadership group of the national Administration of Traditional Chinese Medicine national Administration of Traditional Chinese Medicine

On June 6,2020,President Xi Jinping delivered a keynote address at a symposium of experts and scholars in which he emphasized that the simultaneous and integrated use of Chinese and Western medicine has been a major highlight of the fight against the Covid-19 epidemic,as well as a vivid representation of how traditional Chinese medicine(TCM)has been carried forward through the preservation of effective practices and the development of new *** gave full affirmation to the contributions that TCM has made in epidemic prevention and control from an overall strategic perspective on the health and safety of the people,and put forward important plans for taking full advantage of the discipline’s unique strengths and applications.

关键词： prevention fir strategic

Magnetic resonance imaging of knees:a novel approach to predict recombinant human growth hormone therapy response in short-stature children in late puberty

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World Journal of Pediatrics 2024年第7期20卷 723-734页

作者： Xi Bai Zhi‑Bo Zhou Xiao‑Yuan Guo Yi‑Ling He Yue‑Lun Zhang Feng‑Dan Wang Feng Feng Hong‑Bo Yang Shi Chen Feng‑Ying Gong Hui‑Juan Zhu Hui Pan Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Key Laboratory of Endocrinology of national health commission Department of EndocrinologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina

Background There is no appropriate tool to predict recombinant human growth hormone(rhGH)response before therapy initiation in short-stature children in late *** current study aimed to explore the associations between magnetic resonance imaging(MRI)stages of the knee growth plates and rhGH response in short-stature children in late *** In this prospective cohort study,short-stature children in late puberty were treated with rhGH and followed up for 6 *** proposed a novel knee MRI staging system according to the growth plate states of distal femurs or proximal tibias and divided the participants into three groups:unclosed growth plate group,marginally closed growth plate group,and nearly closed growth plate *** primary outcomes were height gain and growth velocity(GV),which were assessed three months *** Fifty participants were enrolled,including 23 boys and 27 *** and height gain after 6 months of rhGH therapy decreased successively in the three groups with an increased degree of growth plate fusion,especially when grouped by proximal tibias(GV_(1-3 mon)from 9.38 to 6.08 to 4.56 cm/year,GV_(4-6 mon)from 6.75 to 4.92 to 3.25 cm/year,and height gain from 4.03 to 2.75 to 1.95 cm,all Pgrouped by proximal tibias(all P<0.01).Conclusion The MRI staging method is expected to be an effective tool for predicting rhGH response before therapy initiation in short-stature children in late puberty.

关键词： Growth hormone Growth velocity Late puberty Magnetic resonance imaging Short stature

The Chinese Economy Starts the Year Off Strong with Overall Stability Exceeding Expectations

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Qiu Shi 2019年第2期11卷 105-116页

作者： Ning Jizhe the national Development and Reform commission and the National Bureau of Statistics and the Bureau’s CPC Leadership Group

In the first quarter of 2019, despite complex and daunting conditions both at home and abroad, China continued to uphold the core principle of progress amidst stability. We remained committed to the new development philosophy, resolutely promoted high-quality growth by focusing on furthering structural reform on the supply side, and continued to fight the three critical battles against potential risks, poverty, and pollution. Thanks to these efforts, ChinaJs economic performance has maintained overall stability and exceeded expectations.

关键词： Chinese Economy Starts Overall Stability Exceeding Expectations

The Value of Chinas Economic Growth in the First Half of 2019

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Qiu Shi 2019年第3期11卷 113-123页

作者： Ning jizhe the national Development and Reform commission the national Bureau of Statistics、Bureau’s cpc leadership group

In the first half of this year,China's economy grew by 6.3%and continued to operate within a reasonable *** wellbeing improved continuously,transformation and upgrading progressed steadily,the stamina of development continued to strengthen,and new progress was made toward high-quality growth,thereby laying sound foundations for meeting this year's economic and social development *** growth rate of 6.3%did not come easily,but was achieved despite decelerating global economic and trade growth and mounting downward pressure on China’s economy.

关键词： continued thereby mount