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Hypothalamic circuits and aging:keeping the circadian clock updated

Neural Regeneration research 2024年第9期19卷 1919-1928页

作者： Rosa Vázquez-Lizarraga Lucia Mendoza-Viveros Carolina Cid-Castro Sareni Ruiz-Montoya Erick Carreño-Vázquez Ricardo Orozco-Solis instituto Nacional de Medicina Genómica(INMEGEN) México CityMéxico Centro de Investigacíon sobre el Envejecimiento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of life.Studies on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian derangements.The circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during aging.Given the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy aging.Intranasal brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalamus intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis

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Elevation transition of aquatic insects closely matches a thermal feature in the Yungas of Northwestern Argentina

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Journal of Mountain Science 2024年第2期21卷 433-448页

作者： Alexandra BUITRAGO-GUACANAME Carlos MOLINERI Andrés LIRA-NORIEGA Daniel Andrés DOS SANTOS Neotropical Biodiversity Institute(CONICET-UNT) UNT-DomesHorco Molle S/N4107 TucumánArgentina conacyt research fellow Network of Advanced Molecular StudiesInstitute of Ecology A.COld Road to Coatepec 351El HayaCP 91073XalapaVeracruzMexico Biostatistics Chair Faculty of Natural Sciences and IMLNational University of TucumánSan Miguel de TucumánMiguel Lillo 2054000 TucumánArgentina

Temperature is a key factor that shapes the distribution of organisms.Having knowledge about how species respond to temperature is relevant to devise strategies for addressing the impacts of climate change.Aquatic insects are particularly vulnerable to climate change,yet there is still much to learn about their ecology and distribution.In the Yungas ecoregion of Northwestern Argentina,cold-and warm-adapted species of the orders Ephemeroptera,Plecoptera,and Trichoptera(EPT)are segregated by elevation.We modeled the ecological niche of South American EPT species in this region using available data and projected their potential distribution in geographic space.Species were grouped based on their ecogeographic similarity,and we analyzed their replacement pattern along elevation gradients,focusing on the ecotone where opposing thermal preferences converge.Along this interface,we identified critical points where the combined incidence of cold and warm assemblages maximizes,indicating a significant transition zone.We found that the Montane Cloud Forest holds the interface,with a particularly greater suitability at its lower boundary.The main axis of the interface runs in a N-S direction and falls between 14°C-16°C mean annual isotherms.The probability of a particular location within a basin being classified as part of the interface increases as Kira’s warmth index approaches a score around 150.Understanding the interface is critical for defining the thermal limits of species distribution and designing biomonitoring programs.Changes in the location of thermal constants related to mountainous ecotones may cause vertical displacement of aquatic insects and vegetation communities.We have recognized significant temperature thresholds that serve as indicators of suitability for the interface.As global warming is anticipated to shift these indicators,we suggest using them to monitor the imprints of climate change on mountain ecosystems.

关键词： Austral Yungas Ecological Niche Model Ephemeroptera Kira’s warmth index Plecoptera Trichoptera

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Dynamical study of varicella-zoster virus model in sense of Mittag-Leffler kernel

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International Journal of Biomathematics 2024年第3期17卷 153-183页

作者： Qura Tul Ain Aziz Khan Thabet Abdeljawad J.F.Gomez-Aguilar Saleem Riaz department of Mathematics Guizhou University GuiyangGuizhou 550025P.R.China department of Mathematics and Sciences Prince Sultan University P.O.Bor 66833 11586 RiyadhSaudi Arabia department of Medical research China Medical University Taichung 40402Taiwan conacyt-Tecnologico Nacional de Mécico/CENIdeT Interior Internado Palmira S/N Col.Palmira C.P.62490CuernavacaMorelosMécico IConsejo Academico Universidad Virtual CNCIMonterreyMécico School of Automation Northwestern Polytechnical University 170072 Xian P.R.China

The primary varicella-zoster virus(VzV)infection that causes chickenpox(also known as varicella),spreads quickly among people and,in severe circumstances,can cause to fever and encephalitis.In this paper,the Mittag-Leffler fractional operator is used to examine the mathematical representation of the vzV.Five fractional-order differential equations are created in terms of the disease's dynamical analysis such as S:Susceptible,V:Vaccinated,E:Exposed,I:Infectious and R:Recovered.We derive the existence criterion,positive solution,Hyers-Ulam stability,and boundedness of results in order to examine the suggested fractional-order model's wellposedness.Finally,some numerical examples for the VzV model of various fractional orders are shown with the aid of the generalized Adams-Bashforth-Moulton approach to show the viability of the obtained results.

关键词： Varicella-zoster virus model Hyers-Ulam stability ABC fractional operator Schauder fix point theory numerical analysis

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Abundance of White-fronted Parrots and diet of an urban parrot assemblage(Aves:Psittaciformes)in a green Neotropical city

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Avian research 2022年第1期13卷 36-42页

作者： CristelAlvarez-Castillo Ian MacGregor-Fors Stefan LArriaga-Weiss Claudio Mota-Vargas Diego Santiago-Alarcon Biología y Conservación de Vertebrados Instituto de EcologíaA.C.-CONACYTXalapaMexico Biological and Environmental Sciences University of HelsinkiLahtiFinland División Académica de Ciencias Biológicas Universidad Juárez Autónoma de TabascoVillahermosaMexico Biología Evolutiva Instituto de EcologíaA.C.-CONACYTXalapaMexico department of Integrative Biology University of South FloridaTampaUSA

Urban ecosystems are evolutionarily recent novel environments acting as biodiversity filters.Psittacidae birds are considered successful urban adapters mainly due to their generalist feeding and opportunistic behavior,allowing them to occupy environments from cold temperate to dry xeric areas.Therefore,it is important to understand how these species interact in the urban environment.We studied the interannual(2013–2016)abundance of the White-fronted Parrot(Amazona albifrons)in the Neotropical cities of Xalapa and Coatepec,in Central Veracruz,México.Additionally,we studied the feeding ecology during 13 months of 6 parrot species detected in the city of Xalapa.The abundance of the White-fronted Parrot was significantly higher in Xalapa than in Coatepec,and it was homogeneous across years.Non-native plants represented 30–41%of Psittacidae diets in Xalapa,where seeds were the most commonly consumed resource.We recorded the highest Psittacidae species richness and highest diet overlap among species by the end of the dry season(April–May).The White-fronted Parrot had the highest plant richness in its diet,followed by the Monk Parakeet(Myiopsitta monachus)and the Green Parakeet(Psittacara holochlorus);yet,the White-fronted Parrot had a specialized diet dominated by two plant species(Grevillea robusta and Ficus aurea).The diet overlap among the three above-mentioned parrot species was not significantly different to a null model,where the White-fronted Parrot and the Monk Parakeet overlapped during the months of February,April,June,and September.The White-fronted Parrot is an urban adapter that has successfully expanded its geographic range via natural means and by human activities.The invasive Monk Parakeet is currently restricted to one park in Xalapa,and it has remained in that stage for many years(i.e.,pre-expansion phase).Exotic plant species in Xalapa represent∼55%of the woody vegetation,some of which have longer flowering and fruiting periods that may have aided the successful establishment of parrot species in urb

关键词： Biological invasions Feeding ecology Population biology Psittacidae Urban ecology

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Consolidation of AA 7075-2 wt% ZrO2 Composite Powders by Severe Plastic deformation via ECAP

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Acta Metallurgica Sinica(English Letters) 2016年第10期29卷 895-901页

作者： S. E. Hernandez-Martinez J. J. Cruz-Rivera R. Martinez-Sanchez C. G. Garay-Reyes J. A. Mufioz-Bolanos J. M. Cabrera J.L.Hernández-Rivera instituto de metalurgia Universidad Autonoma de San Luis Potosi Sierra Leona 550 78210 San Luis Potosi Mexico Centro de Investigacion en Materiales Avanzados (CIMAV) Miguel de Cervantes 120 31109 Chihuahua Mexico departamento de Ciencia de Materiales e Ingenieria Metalurgica Universitat Politecnica de Catalunya Av Diagonal 647 08028 Barcelona Spain Fundacion CTM Centro Tecnologico Plaza de la Ciencia 208243 Manresa Spain conacyt research fellow-instituto de metalurgia Universidad Autonoma de San Luis Potosi- Sierra Leona 550 78210 San Luis Potosf Mexico

The powders of the AA 7075-ZRO2 were mixed by mechanical milling, but it was found that the system presents a few disadvantages when processed by conventional sintering and hot extrusion, since intermetallic phases between ZrO2 particles and alloying elements were formed. Equal channel angular pressing （ECAP） processing was proposed as an alternative method to consolidate the composite where there is no intermetallic formation. The analysis of the ECAP process showed that the intermediate temperature （220℃） produced a higher consolidation level than conventional sintering and hot extrusion （400 and 500℃, respectively）. This fact was supported by relative density analysis. In the case of the sintered and hot-extruded sample, the relative density exhibited a value of 0.95, while ECAP sample showed a value of 0.98. Hardness values show that microstructural refinement obtained during mechanical milling was preserved during ECAP processing even when it was carded out at 220℃.

关键词： Metal matrix composites （MMCs） Powder consolidation Severe plastic deformation （SPD）

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Morphological and mineralogical characterizations of oolitic iron ore in the Exi region, China

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International Journal of Minerals,Metallurgy and Materials 2013年第2期20卷 113-118页

作者： Shao-xian Song Ernesto Fabian Campos-Toro Yi-min Zhang Alejandro Lopez-Valdivieso School of Resources and Environmental Engineering Wuhan University of Technology instituto de metalurgia Universidad Autonoma de San Luis Potosi

The morphological and mineralogical characterizations of a Chinese oolitic iron ore （Exi deposit） were studied by scanning electron microscopy and energy-dispersive X-ray spectroscopy in this work. It is shown that the Exi ore is mainly composed of hematite, quartz, apatite, and chlorite. The hematite is present as the oolitic layers and in the spaces between the aggregated ooids; quartz exists as granular particles in the spaces and as nucleuses in ooids; the harmful mineral, apatite, is associated with hematite as the oolitic layers, fine dissemination, granular particles in the spaces, and nucleuses in ooids. From the viewpoint of mineral beneficiation, it is hard to separate apatite and chlorite but easy to separate quartz from hematite in the Exi iron ore in recovering the iron values.

关键词： iron ores mineralogy morphology scanning electron microscopy

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The short form of the SUR1 and its functional implications in the damaged brain

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Neural Regeneration research 2022年第3期17卷 488-496页

作者： Iván Alquisiras-Burgos Javier Franco-Pérez Moisés Rubio-Osornio Penélope Aguilera Laboratorio de Patología Vascular Cerebral Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio de Formación Reticular Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio Experimental de Enfermedades Neurodegenerativas Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico.

Sulfonylurea receptor(SUR) belongs to the adenosine 5′-triphosphate(ATP)-binding cassette(ABC) transporter family;however,SUR is associated with ion channels and acts as a regulatory subunit determining the opening or closing of the pore.Abcc8 and Abcc9 genes code for the proteins SUR1 and SUR2,respectively.The SUR1 transcript encodes a protein of 1582 amino acids with a mass around 140–177 k Da expressed in the pancreas,brain,heart,and other tissues.It is well known that SUR1 assembles with Kir6.2 and TRPM4 to establish K_(ATP) channels and non-selective cation channels,respectively.Abbc8 and 9 are alternatively spliced,and the resulting transcripts encode different isoforms of SUR1 and SUR2,which have been detected by different experimental strategies.Interestingly,the use of binding assays to sulfonylureas and Western blotting has allowed the detection of shorter forms of SUR(-65 k Da).Identity of the SUR1 variants has not been clarified,and some authors have suggested that the shorter forms are unspecific.However,immunoprecipitation assays have shown that SUR2 short forms are part of a functional channel even coexisting with the typical forms of the receptor in the heart.This evidence confirms that the structure of the short forms of the SURs is fully functional and does not lose the ability to interact with the channels.Since structural changes in short forms of SUR modify its affinity to ATP,regulation of its expression might represent an advantage in pathologies where ATP concentrations decrease and a therapeutic target to induce neuroprotection.Remarkably,the expression of SUR1 variants might be induced by conditions associated to the decrease of energetic substrates in the brain(e.***.during stroke and epilepsy).In this review,we want to contribute to the knowledge of SUR1 complexity by analyzing evidence that shows the existence of short SUR1 variants and its possible implications in brain function.

关键词： brain edema epilepsy Parkinson's disease stroke sulfonylurea receptor 1 SUR1 traumatic brain injury TRPM4

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Slime coating of kaolinite on chalcopyrite in saline water flotation

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International Journal of Minerals,Metallurgy and Materials 2018年第5期25卷 481-488页

作者： Zhi-li Li Feng Rao Shao-xian Song Yan-mei Li Wen-biao Liu conacyt instituto de Investigación en metalurgiay Materiales Universidad Michoacana de San Nicolás de Hidalgo School of Resources and Environmental Engineering Wuhan University of Technology departamento de Ingeniería en Minas Metalurgia y GeologíaUniversidad de Guanajuato Faculty of Land and Resource Engineering Kunming University of Science and Technology

In saline water flotation, the salinity can cause a distinguishable slime coating of clay minerals on chalcopyrite particles through its effect on their electrical double layers in aqueous solutions. In this work, kaolinite was used as a representative clay mineral for studying slime coating during chalcopyrite flotation. The flotation of chalcopyrite in the presence and absence of kaolinite in tap water, seawater, and gypsum-saturated water and the stability of chalcopyrite and kaolinite particles in slurries are presented. Zeta-potential distributions and scanning electron microscopy images were used to characterize and explain the different slime coating degrees and the different flotation performances. Kaolinite particles induced slime coating on chalcopyrite surfaces and reduced chalcopyrite floatability to the greatest extent when the p H value was in the alkaline range. At 0.24 wt% of kaolinite, the chalcopyrite floatability was depressed by more than 10% at alkaline p H levels in tap water. Salinity in seawater and gypsum-saturated water compressed the electrical double layers and resulted in extensive slime coating.

关键词： chalcopyrite clay minerals saline water flotation slime coating stability

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Surgical and nutritional interventions for endometrial receptivity:A case report and review of literature

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World Journal of Clinical Cases 2022年第33期10卷 12295-12304页

作者： Dinorah Hernández-Melchor Cecilia Palafox-Gómez Ivan Madrazo Ginna Ortiz America Padilla-Viveros Esther López-Bayghen Science Technology and Society ProgramCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMéxico City 07360CDMXMéxico Clinical research Instituto Regenera SCMéxico City 05320CDMXMéxico departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMéxico City 07360CDMXMéxico Investigación Clínica Instituto de Infertilidad y Genética México SCINGENESMéxico City 05320CDMXMéxico departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMéxico

BACKGROUND Polycystic ovary syndrome(PCOS)is an endocrine disease that combines metabolic,reproductive,and psychological dysfunctions.Ovulation disorders and impaired endometrial receptivity in PCOS can cause infertility.Insulin resistance(IR)is a pathological state of inadequate response to insulin that affects reproduction in PCOS,as damage caused by IR at the endometrial level becomes an obstacle for embryo implantation.Reversing IR resulted in spontaneous pregnancies in PCOS patients,indicating that metabolic corrections improve endometrial dysfunctions.Mesenchymal stem-cell treatment has also corrected endometrial quality and lead to pregnancies in patients with Asherman’s syndrome.We propose a combination of nutritional intervention with the surgical placement of stem cells to improve endometrial quality to achieve pregnancy in a PCOS patient undergoing in vitro fertilization(IVF)treatment.CASE SUMMARY After two failed IVF cycles,a metabolic intervention,consisting of a ketogenic diet with daily consumption of 50 g of carbohydrates(CH),was indicated until pregnancy.Metabolic Syndrome was assessed using the Harmonizing definition(3 of 5 pathologies:Central obesity,hypertension,hyperglycemia,hypertriglyceridemia,and dyslipidemia),and the Homeostatic Model Assessment of IR(HOMA-IR)was used to measure the level of IR.Once IR improved,endometrial quality improved.However,two day 5-thawed embryos(euploid,donated oocyte–partner's sperm)failed to implant,suggesting endometrial quality improvement was insufficient.Therefore,transmyometrial implantation of mesenchymal stem cells from the stromal vascular fraction of adipose tissue was performed to enrich the endometrial stem cell niche.Minimal endometrial mean thickness for embryo transfer(6.9 mm)was achieved three months after stem cell treatment and continuous dietary control of IR.Two euploid-day 5-thawed embryos(donated oocyte–partner's sperm)were transferred,and embryo implantation was confirmed on day 14 byβ-hCG serum levels.Currently,a 37 wk baby girl is born.

关键词： Polycystic ovarian syndrome Insulin resistance Nutritional intervention Endometrial quality Stem cell treatment Case report

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Natural sediment at a dam and its inorganic materials as adsorbents of praseodymium(Pr(Ⅲ))

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International Journal of Sediment research 2023年第4期38卷 566-575页

作者： Melania Jiménez-Reyes Jaime Jiménez-Becerril Marcos Solache-Ríos Perla Tatiana Almazán-Sánchez departamento de Química Instituto Nacional de Investigaciones Nucleares Carretera México-Toluca S/N CONACy T-instituto Nacional de Investigaciones Nucleares

The sediment deposited behind a dam(DS) and its inorganic materials(IM-DS) were characterized and used for the removal of praseodymium(Pr) from aqueous solutions. Quartz, albite, and kaolinite were found in the sediment by X-ray diffraction. Kinetic data fit well to a pseudo second-order model, the equilibrium time for DS and IM-DS was 2 h and 3 min, respectively, and the adsorption capacity was higher for Pr/DS(qe= 4.91 mg/g) than for Pr/IM-DS(qe= 3.01 mg/g) in these conditions. Pr/DS and Pr/IM-DS data isotherms were in agreement with the Langmuir-Freundlich model and the maximum adsorption capacities were 4.95 and 4.01 mg/g, respectively. Both processes are exothermic(enthalpy change, ΔH0=-22.8 and-21.8 k J/mol for DS and IM-DS, respectively), the increase of the randomness is small, and the feasibility and spontaneity are low. Praseodymium was desorbed by ethylenediaminetetraacetic acid disodium(EDTA-Na2), sodium chloride, nitric, citric, and humic acids solutions, and one hundred percent of praseodymium was desorbed by the EDTA-Na2solution. The Pr2(EDTA)3(praseodymium ethylenediaminetetraacetate) complex was completely desorbed from both materials(DS and IM-DS). Distribution coefficients(KD) depend upon praseodymium concentration,temperature, p H, and the kind of adsorbent. Chemical reactions of praseodymium with kaolinite and iron minerals could explain the adsorption.

关键词： Praseodymium Sediment Adsorption process parameters desorption

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