检索结果-南通市图书馆

Unusual outcome of in utero infection and subsequent postnatal super-infection with different PCV2b strains

Virologica Sinica 2014年第3期29卷 176-182页

作者： Dipongkor Saha Uladzimir U.Karniychuk Liping Huang Marc Geldhof Merijn Vanhee David J.Lefebvre Peter Meerts Richard Ducatelle Jan V.Doorsselaere Hans J.Nauwynck Laboratory of Virology Department of Virology Parasitology and Immunology Faculty of Veterinary Medicine Ghent UniversityBelgium Brain Tumor Research Center Department of Molecular Neurosurgery Harvard Medical School and Massachusetts General Hospital 185 Cambridge StreetBoston MA-02114 USA Division of Experimental Therapeutics Toronto General Hospital Research Institute University Health NetworkToronto Canada Division of Swine Infectious Diseases Harbin Veterinary Research Institute The Chinese Academy of Agricultural Sciences Department of Health Care and Biotechnology KATHO Catholic University College of South-West FlandersBelgium coda-cerva Groeselenberg 99 1180 Ukkel Belgium Ablynx nv Technologiepark 219052 Zwijnaarde Belgium Department of Pathology Bacteriology and Poultry Diseases Faculty of Veterinary Medicine Ghent UniversityBelgium

VC2002, isolated from postweaning multisystemic wasting syndrome(PMWS)-affected pig, is a mixture of two porcine circovirus genotype 2b(PCV2b) viruses, K2 and K39. Preliminary experiments disclosed short-term adverse effects of K39, but not K2, on porcine foetuses. These findings led to the hypothesis that infection of immuno-incompetent foetuses with K2 confers a status of immunotolerance, and postnatal super-infection with K39 triggers PMWS. To explore this hypothesis, nine 55-day-old foetuses were inoculated in utero(three with K2-104.3TCID50, three with K39-104.3TCID50 and three with medium), and foeto-pathogenicity examined. At 21 days post-inoculation(dpi), K2 did not induce pathology, whereas pathological effects of K39 were evident. Twenty-four 45-day-old foetuses were subsequently inoculated to examine the long-term effect of K2, including six with K2-high dose-104.3TCID50, six with K2-low dose-102.3TCID50 and 12 mock-inoculated controls. Both doses resulted in five mummified foetuses and one live-born piglet each(69dpi). K2 was recovered from all mummies. K2 and K2-specific antibodies were not detected in serum of the two live-born piglets at birth, indicating full control of K2 infection. The K2-low dose-infected piglet was immunostimulated at day 2, but not the K2-high dose-infected piglet. Both non-stimulated and stimulated K2-infected piglets were super-inoculated with K39 at day 6 or 8(taken as 0 days post super-inoculation). Low viral replication was observed in the non-stimulated K2-K39 piglet(up to 103.3 TCID50/g; identified as K39). In contrast, viral replication was extremely high in the stimulated K2-K39 piglet(up to 105.6TCID50/g) and identified as K2, indicating that K2 infection is controlled during foetal life, but emerges after birth upon immunostimulation. However, none of the piglets showed any signs of PMWS.

关键词：感染生后断奶后多系统衰竭综合征猪圆环病毒品系 PMWS 免疫耐受病毒复制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

向北之光——来自芬兰的首饰

引用

艺术与设计 2019年第6期8卷 104-107页

作者：祝青无不详 coda MUSEUM

芬兰,北欧洲五国之一,在这个国度的中部,成千上万的湖泊与广袤的森林是其两种标志性的景色。精神之花似乎难以繁茂于酷寒冷峻。事实是,芬兰在20世纪前几乎没有一家美术馆或博物馆。

关键词：芬兰人

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新型显示产业回顾与展望

新型显示产业回顾与展望

引用

2019·中国显示行业供应链技术和市场对接交流会“第二届（2018 年度）中国新型显示产业链发展贡献奖”表彰大会

作者：胡春明中国光学光电子行业协会液晶分会(coda)

＜正＞～～

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Clinical and Epidemiological Evolution of Sheep Pox in Morocco

引用

Journal of Agricultural Science and Technology(A) 2019年第2期9卷 103-113页

作者： Sara Lafar Khalil Zro Andy Haegeman Mounir Khayli Kris De Clercq Renaud Lancelot My Mustapha Ennaji Laboratory of Virology Microbiology and Quality/Eco-Toxicology and BiodiversityFaculty of Sciences and Techniques of MohammediaHassan II University of CasablancaBP 146Mohammedia 20650Morocco Diagnosis Research and Development UnitBiological and Pharmaceutical Production CompanyBIOPHARMABP 4569Rabat 10000Morocco Vesicular and Exotic Diseases Unit Virology DepartmentCODA-CERVAGroeselenberg 99Brussels 1180Belgium National Office of Health and Food Products Security ONSSARabat 10000Morocco CIRAD Baillarguet International Campus 34398Montpellier Cedex 5France

Sheep pox is an infectious viral disease that affects specifically sheep and it is caused by the Capripoxvirus *** clinical signs include fever,diarrhea,difficulty breathing,nodules,lung lesions and *** Morocco,the 2010 epidemic of sheep pox was characterized by the emergence of a nodular form of the *** local strain was isolated and the analysis of affected animals was positively confirmed by virus isolation and real-time polymerase chain reaction(RT-PCR).The epidemiological analysis of 911 data records showed that the virus is endemic in the country;an average of 350 cases per year with an epizootic evolution was observed in *** incidence varies depending on provinces and the disease appears confined to the central and the eastern regions of the country where a very intensive sheep breeding activity is taking *** statistical analysis showed that there is a positive correlation between the endemicity and the significant factor of the rural market(p=0.006).The annual average morbidity and mortality rates were 2.96%(1.26%to 4.32%)and 0.71%(0.41%to 0.94%),*** clinical findings associated to the epidemiological data analysis confirmed the presence of sheep pox in its nodular form and suggest that new pathogenic strains may have been introduced from *** purpose of this work was to provide a better description of the spatiotemporal evolution of sheep pox disease based on some epidemiological indicators and to put forward plausible hypotheses regarding the emergence of the virus in order to implement an adequate control strategy.

关键词： Sheep pox Capripoxvirus epidemiology clinical signs virus isolation RT-PCR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：