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Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat Alessandra Tempio Barbara Bardoni Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

MARIE:One-Stage Object Detection Mechanism for Real-Time Identifying of Firearms

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 279-298页

作者： Diana Abi-Nader Hassan Harb Ali Jaber Ali Mansour Christophe Osswald Nour Mostafa Chamseddine Zaki Computer Science Department Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering and Technology American University of the Middle EastEgaila54200Kuwait Lab-STICC CNRS UMR 6285ENSTA-BretagneBrest29200France

Security and safety remain paramount concerns for both governments and individuals *** today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to ***,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent *** advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying *** paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection *** SSD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction *** experimental results demonstrate that this modified SSD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy *** these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.

关键词： Firearm and gun detection single shot multi-box detector deep learning one-stage detector MobileNet inception convolutional neural network

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

FLOWABILITY INDEX OF STORED BULK FOOD PRODUCTS

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FLOWABILITY INDEX OF STORED BULK FOOD PRODUCTS

Rapid prototyping of a polymer MEMS dropletdispenser by laser-assisted 3D printing

The Second International Conference on Measurement and Control of Granular Materials

作者： Minh Phong LUONG cnrs 317 Laboratoire de Mécanique des Solides Ecole Polytechnique91128 PalaiseauFrance

Silo storage of bulk solid materials generates an unsual class of both structural and functional failure problems,resulting often from an incomplete understanding of the rheology of the stored products,A realistic knowledge of their mechanical behaviour should permit a better evaluation of loads and stresses on the silo *** paper proposes a rheological characterization of some granular food products on different stress paths using the conventional triaxial *** characteristic state concept or disaggregation threshold of the granular structure reveals to be quite suitable and even indispensible for examining the mechanical behaviour and the flowability of the stored bulk materials.

关键词： silo storage bulk materials characteristic threshold arching flowability index

来源： cnki会议评论

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Microsystems & Nanoengineering 2023年第4期9卷 211-221页

作者： Rémi Courson Oleksii Bratash Ali Maziz CloéDesmet Ricardo Alvarado Meza Loïc Leroy Elodie Engel Arnaud Buhot Laurent Malaquin Thierry Leïchlé LAAS-cnrs Universitéde ToulouseCNRS31400 ToulouseFrance UniversitéGrenoble Alpes CNRSCEAIRIGSyMMES38000 GrenobleFrance Georgia Tech−cnrs International Research Laboratory AtlantaGA 30332USA

In this work, we introduce a polymer version of a previously developed silicon MEMS drop deposition tool for surfacefunctionalization that consists of a microcantilever integrating an open fluidic channel and a reservoir. The device isfabricated by laser stereolithography, which offers the advantages of low-cost and fast prototyping. Additionally,thanks to the ability to process multiple materials, a magnetic base is incorporated into the cantilever for convenienthandling and attachment to the holder of a robotized stage used for spotting. Droplets with diameters ranging from∼50 μm to ∼300 μm are printed upon direct contact of the cantilever tip with the surface to pattern. Liquid loading isachieved by fully immersing the cantilever into a reservoir drop, where a single load results in the deposition of morethan 200 droplets. The influences of the size and shape of the cantilever tip and the reservoir on the printing outcomeare studied. As a proof-of-concept of the biofunctionalization capability of this 3D printed droplet dispenser,microarrays of oligonucleotides and antibodies displaying high specificity and no cross-contamination are fabricated,and droplets are deposited at the tip of an optical fiber bundle.

关键词： cantilever reservoir printing

Synthesis of two-dimensional lead sheets by spark discharge in liquid nitrogen

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Particuology 2018年第5期16卷 152-159页

作者： Ahmad Hamdan Hiba Kabbara Cedric Noel Jaafar Ghanbaja Abdelkrim Redjaimia Thierry Belmonte Universite de Lorraine lnstitutJean tamourUMR CNRS 7198Nancy F-54042France cnrs lnstitutJean LamourUMR CNRS 7198Nancy F-54042France

A simple method to synthesise hexagonal lead sheets,which belong to the class of two-dimensional materials,is *** objects are collected on a substrate located under two lead electrodes, between which nanosecond-pulsed spark discharges are ignited in liquid *** hexagonal sheets are single crystals produced by gas phase *** nitrogen completely evaporates,the sheets change to PbO2by oxidation in *** oxidation process induces stress that pleats the uppermost sheets or open cracks at the *** thickness of the individual objects typically varies from 4to *** the number of discharges is more than about 2000,in addition to sheets,two types of PbO2 sticks start to form:bundles composed of nanosticks (length 5p.m and diameter 50nm)and isolated sticks (length 20μm and diameter 500nm).These new nanostructures mainly form because of the way the discharge erodes the lead ***,anisotropic erosion driven by the orientation of the crystallographic planes of the lead crystals produces octahedra and nanosticks,and the nanosticks grow on the electrode surfaces as discharge *** about 2000discharges,the nanosticks are sufficiently long that they can be easily broken,probably by mechanical stress,and they fall onto the underlying substrate.

关键词： Discharge in hquids Plasma-surface interaction Nanopamcles Liquid nitrogen Lead

Selecting and optimal sizing of hybridized energy storage systems for tidal energy integration into power grid

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Journal of Modern Power Systems and Clean Energy 2019年第1期7卷 113-122页

作者： Seifeddine BEN ELGHALI Rachid OUTBIB Mohamed BENBOUZID LIS-UMR cnrs 7020 University of Aix-Marseille UMR cnrs 6027 IRDL University of Brest Shanghai Maritime University

The high penetration of renewable energy systems with fluctuating power generation into the electric grids affects considerably the electric power quality and supply ***, energy storage resources are used to deal with the challenges imposed by power variability and demand-supply *** main focus of this paper is to investigate the appropriate storage technologies and the capacity needed for a successful tidal power ***, a simplified sizing method, integrating an energy management strategy, is *** method allows the selection of the adequate storage technologies and determines the required least-cost storage capacity by considering their technological limits associated with different power *** optimal solutions given by the multi-objective evolutionary algorithm are presented and analyzed.

关键词： Tidal energy Energy storage system Optimal sizing Selection

Process conditions for preparing well-defined nano- and microparticles as delivery systems of alkyl gallates

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Particuology 2019年第3期17卷 105-116页

作者： Asma Chebil Denis Funfschilling Jean-Luc Six Cécile Nouvel Alain Durand Michèle Léonard Universite de Lorraine CNRS LCPM F-54000 Nancy France Universite de Lorraine CNRS LRGP F-54000 Nancy France Universite de Strasbourg CNRS ICube F-67000 Strasbourg France

Dextran-covered poly(D,L-lactide) (PLA) nano-and microparticles were prepared using an emulsion/solvent evaporation (or diffusion) process for the encapsulation of alkyl gallates (AGs).In the first step,a solution of PLA and AG in ethyl acetate was emulsified to give an aqueous phase containing a hydrophobically modified dextran,which acted as a *** second step involved solvent evaporation or *** emulsification conditions were varied,which allowed for the preparation of nanoand microparticle suspensions covering a wide range of surface-average particle diameters from 0.1 μm (sonication) to 500 μm (stirring with a magnetic bar),with narrow and reproducible size *** microfluidic emulsification in a flow-focusing system led to well-defined microparticles,in the 10-50 μm *** loaded with octyl gallate (OG) and nonyl gallate (NG) were obtained using the three processes,and we showed that the encapsulation efficiency of OG and NG varied significantly depending on the emulsification *** effect of particle size on the mechanism of in vitro release of encapsulated AGs was *** kinetics of release were controlled either by Fickian diffusion within the solid core or swelling and hydrolytic degradation of the PLA matrix,depending on the pH of the external medium.

关键词： Emulsion/solvent evaporation Dextran Poly(D.L-lactide) Encapsulation Release Alkyl gallate

Multicomponent flow modeling

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Science China Mathematics 2012年第1期55卷 285-308页

作者： GIOVANGIGLI Vincent CMAP-cnrs Ecole

We present multicomponent flow models derived from the kinetic theory of gases and investigate the symmetric hyperbolic-parabolic structure of the resulting system of partial differential *** address the Cauchy problem for smooth solutions as well as the existence of deflagration waves,also termed anchored *** further discuss related models which have a similar hyperbolic-parabolic structure,notably the SaintVenant system with a temperature equation as well as the equations governing chemical equilibrium *** next investigate multicomponent ionized and magnetized flow models with anisotropic transport fluxes which have a different mathematical *** finally discuss numerical algorithms specifically devoted to complex chemistry flows,in particular the evaluation of multicomponent transport properties,as well as the impact of multicomponent transport.

关键词： multicomponent reactive flow Cauchy problem deflagration wave multicomponent transport

Paralinearization of the Dirichlet-Neumann operator and applications to progressive gravity waves Dedicated to the NSFC-cnrs Chinese-French summer institute on fluid mechanics in 2010

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Science China Mathematics 2012年第2期55卷 207-220页

作者： ALAZARD Thomas DMAet cnrs UMR 8553 Ecole Normale Supdrieure 45 rue d＇Ulm 75005 Paris France

This note presents a paradifferential approach to the analysis of the water waves equations.

关键词： incompressible Euler equation free surface paradifferential calculus