检索结果-南通市图书馆

Towards a blood ecosystem approach to dissect systemic diseases

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第7期67卷 1528-1531页

作者： Hong Wang Tao Cheng State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell EcosystemNational Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin institutes of Health Science Tianjin 301600China

Systemic diseases,in contrast to localized ailments,exert widespread effects and can impact the entire *** of systemic diseases encompass autoimmune disorders,infectious diseases,metabolic disorders,and chronic conditions like *** diseases often entail intricate interactions among diverse organs,tissues,and physiological systems,influenced by a myriad of factors.

关键词： diseases organs autoimmune

Climate-driven changes in drought metrics across the Yellow River Basin based on Coupled Model Intercomparison Project Phase 6

在线全文

学校读者我要写书评

暂无评论

Journal of Geographical Sciences 2024年第9期34卷 1841-1856页

作者： LIU Jiayuan LIU Xianfeng LIANG Juan FENG Yu School of Geography and Tourist Shaanxi Normal UniversityXi'an 710119China Ningbo institute of Digital Twin Eastern Institute for Advanced StudyNingbo 315200ZhejiangChina

Recent climate change has accelerated the global hydrological cycle, substantially affecting drought metrics such as drought duration and drought propagation;however, knowledge of drought patterns in these metrics remains limited. Here, we aimed to address the evolution and influencing factors of major drought metrics under past and future climate scenarios within the Yellow River Basin(YRB) based on Coupled Model Intercomparison Project Phase 6(CMIP6). Accordingly, we investigated the changes in drought duration for meteorological drought and agricultural drought across the YRB and identified the variability in drought propagation time from meteorological drought to agricultural drought by using a standardized precipitation/soil moisture index and run theory. Meteorological and agricultural drought duration, and propagation time, increased from 1850 to 2014, decreased significantly from 2015 to 2100 with change trends of –0.0027, –0.0197, and –0.002 month/year, respectively. Drought duration had a negative sensitivity to humidification, and agricultural drought was more sensitive than meteorological drought. Propagation time exhibited a greater sensitivity to meteorological humidification than agricultural humidification. The results also suggest that precipitation, evapotranspiration, and soil moisture are the main drivers of drought metric changes, with air temperature and crop cover exhibiting a strong indirect effect on drought metrics in the YRB. Decreased propagation time from meteorological to agricultural drought and decreased duration provide evidence for the accelerated occurrence and increased impact of drought, highlighting the importance of a more comprehensive understanding of drought metric changes under rapid climate change.

关键词： drought duration drought propagation climate change humidification Yellow River Basin CMIP6

Robust Correlation Clustering Problem with Locally Bounded Disagreements

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2024年第1期29卷 66-75页

作者： Sai Ji Min Li Mei Liang Zhenning Zhang institute of Mathematics Hebei University of TechnologyTianjin 300401China School of Mathematics and Statistics Shandong Normal UniversityJinan 250358China College of Statistics and Data Science Beijing University of TechnologyBeijing 100124China Department of Operations research and Information Engineering Beijing University of TechnologyBeijing 100124China

Min-max disagreements are an important generalization of the correlation clustering problem(CorCP).It can be defined as *** a marked complete graph G=(V,E),each edge in the graph is marked by a positive label"+"or a negative label"_"based on the similarity of the connected *** goal is to find a clustering C of vertices V,so as to minimize the number of disagreements at the vertex with the most ***,the disagreements are the positive cut edges and the negative non-cut edges produced by clustering *** paper considers two robust min-max disagreements:min-max disagreements with outliers and min-max disagreements with *** parameter δ∈(0,1/14),we first provide a threshold-based iterative clustering algorithm based on LP-rounding technique,which is a(1/δ,7/(1-14δ))-bi-criteria approximation algorithm for both the min-max disagreements with outliers and the min-max disagreements with outliers on one-sided complete bipartite ***,we verify that the above algorithm can achieve an approximation ratio of 21 for min-max disagreements with penalties when we set parameter δ=1/21.

关键词： min-max disagreements outliers penalties approximation algorithm LP-rounding

Microstructure transformations and improving wear resistance of austenitic stainless steel additively fabricated by arc-based DED process

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第8期38卷 194-204页

作者： Ashish Yadav Manu Srivastava Prashant K.Jain Sandeep Rathee Hybrid Additive Manufacturing Laboratory Mechanical Engineering DepartmentPDPM Indian Institute of Information TechnologyDesign&ManufacturingJabalpur482005Madhya PradeshIndia FFF Laboratory Mechanical Engineering DepartmentPDPM Indian Institute of Information TechnologyDesign&ManufacturingJabalpur482005Madhya PradeshIndia Department of Mechanical Engineering National Institute of TechnologySrinagarIndia

In this study, austenitic stainless steel(ASS) was additively fabricated by an arc-based direct energy deposition(DED) technique. Macrostructure, microstructure, mechanical characteristics at different spatial orientations(0°, 90°, and 45°), and wear characteristics were evaluated at the deposited structure top, middle, and bottom regions. Results show that austenite(γ) and delta-ferrite(δ) phases make up most of the microstructure of additively fabricated SS316LSi steel. Within γ matrix, δ phase is dispersed both(within and along) grain boundaries, exhibiting a fine vermicular morphology. The bottom, middle,and top regions of WAAM deposited ASS exhibit similar values to those of wrought SS316L in the tensile and impact test findings. Notably, a drop in hardness values is observed as build height increases. During SEM examinations of fractured surfaces from tensile specimen, closed dimples were observed, indicating good ductility of as-built structure. Wear test findings show signs of mild oxidation and usual adhesive wear. By depositing a mechanically mixed composite layer, an increase in the oxidation percentage was discovered to facilitate healing of worn surfaces. The findings of this study will help in design, production and renovation of products/components that are prone to wear. WAAM-deposited ASS has remarkable strength and ability to withstand impacts;it can be used in the production of armour plates for defence applications, mainly military vehicles and aircraft.

关键词： Metal additive deposition Defence applications Arc-based DED Characterization Wear behaviour Fractography

Development of SNP parentage assignment techniques in the yellowfin seabream Acanthopagrus latus

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2024年第2期43卷 151-155页

作者： Hongbo Zhao Liangmin Huang Jing Zhang Songyuan You Qingmin Zeng Xiande Liu Fisheries College of Jimei University Xiamen 361021China Key Laboratory of Healthy Mariculture for the East China Sea Ministry of Agriculture and Rural AffairsXiamen 361021China Bureau of Agriculture and Rural Affairs of Wudang District Guiyang CityGuizhou ProvinceGuiyang 550018China Fisheries research institute of Fujian Xiamen 361000China

Acanthopagrus latus is an essential aquaculture species on the south coast of ***,there is a lack of systematic breeding of ***,which considerably limits the sustainable development of *** a result,genetic improvements are urgently needed to breed new strains of *** with rapid growth and strong resistance to *** selective breeding,it is necessary to estimate the genetic parameters of the target trait,which in turn depends on an accurate disentangled pedigree for the selective ***,it is necessary to establish the parentage assignment technique for *** this study,95 individuals selected from their parents and their 14 families were used as experimental *** were developed by genome resequencing,and highly polymorphic SNPs were screened on the basis of optimized filtering parameters.A total of 14392738 SNPs were discovered and 205 SNPs were selected for parentage assignment using the CERVUS *** the model where the gender of the parents is known,the assignment success rate is 98.61%for the male parent,97.22%for the female parent,and 95.83%for the parent *** the model where the gender of the parents is unknown,the assignment success rate is 100%for a single parent and 90.28%for the parent *** results of this study were expected to serve as a reference for the breeding of new varieties of ***.

关键词： Acanthopagrus latus parentage assignment SNP Genome re-sequencing

Seeing is believing: observation of migrasomes

在线全文

学校读者我要写书评

暂无评论

Biophysics Reports 2024年第2期10卷 67-81页

作者： Yuwei Huang Li Yu School of Basic Medical Sciences Translational Medicine Institute Xi'an Jiaotong University State Key Laboratory of Membrane Biology Tsinghua University-Peking University Joint Center for Life SciencesBeijing Frontier Research Center for Biological Structure School of Life Sciences Tsinghua University

Migrasomes are a novel type of cell organelle that form on the retraction fibers at the rear of migrating cells. In recent years, numerous studies have unveiled the mechanisms of migrasome formation and have highlighted significant roles of migrasomes in both physiological and pathological *** upon the strategies outlined in published works and our own research experiences, we have compiled a comprehensive set of protocols for observing migrasomes. These step-by-step instructions encompass various aspects such as cell culture, labeling, imaging, in vitro reconstitution, and statistical analysis. We believe that these protocols serve as a valuable resource for researchers exploring migrasome biology.

关键词： Imaging Labeling Migrasome In vitro reconstitution

Strategies for Applying LED Lights in Night Space Lighting for Bridges

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of World Architecture 2024年第3期8卷 57-62页

作者： Yingling Dai Qinghua Zhao China Merchants Chongqing Communications Technology research&Design institute Co. LTD.Chongqing 400067China

LED lights have been widely used in urban night space lighting in recent years as they are small,energy-saving,and *** article explores the use of LEDs in bridge night space lighting and their application *** aim is to offer valuable insights and references for urban planners and bridge lighting designers in *** advancing the application of LED technology in bridge night lighting,the goal is to enhance the city’s nighttime ambiance,making the bridge an iconic landmark and a defining feature of the city.

关键词： Bridge night space lighting LED application Color band and gradient Artistic value Online publication:July 11,2024

Nanoscale Reorganization of Glutamate Receptors Underlies Synaptic Plasticity and Pathology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第6期40卷 840-844页

作者： Jia-Hui Chen Ai-Hui Tang Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research Center and Biomedical Sciences and Health Laboratory of Anhui ProvinceUniversity of Science and Technology of ChinaHefei230027China institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei230088China

Excitatory synapses serve as the primary sites for information transmission between neurons in the *** work over the past decades has identified and revealed multiple compositions and functions of the synaptic proteome in the postsynaptic density(PSD),including receptors,scaffold proteins,and signaling molecules,which work together to ensure stable and effective synaptic transmission.

关键词： Receptor scale Glutamate

Wedelolactone attenuates sepsis-associated acute liver injury by regulating the macrophage M1/M2 polarization balance through the PI3K/AKT/NF-κB signalling pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine research 2024年第11期9卷 1-11页

作者： Wang-Ting Li Jin-Yi Chen Shao-Jie Huang Dong-Mei Hu Xing-Ru Tao Fei Mu Jing-Yi Zhao Chao Guo Jia-Lin Duan Jing-Wen Wang Department of Pharmacology Shaanxi University of Chinese MedicineXianyang 712046China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710032China institute of Medical research Northwestern Polytechnical UniversityXi’an 710032China.

Background:Liver injury caused by sepsis seriously impairs the normal physiology of the ***(WED)has an obvious anti-inflammatory effect against liver damage caused by various ***,further research is needed to determine if WED might mitigate acute liver damage linked to sepsis by influencing macrophage ***:We first assessed the effect of WED on lipopolysaccharides-triggered liver injury by biochemistry assay and tissue *** factors were assessed using the ELISA *** expression of Cluster of Differentiation 86(CD86)and Cluster of Differentiation 206(CD206)was measured by immunofluorescence *** protein levels of inducible nitric oxide sythase(iNOS),Arginase 1(Arg-1),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),PI3K phosphorylation(p-PI3K),AKT phosphorylation(p-AKT),inhibitor of kappa B kinase(IKK),inhibitor of kappa B(IκB),and nuclear factor kappa-B(NF-κB)p65 were quantified by western blot ***:WED decreased the level of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and malondialdehyde,and increased the activity of superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX).Moreover,WED exerted effective anti-inflammatory effects by decreasing the level of Tumor necrosis factor-α(TNF-α)and Interleukin 6(IL-6)and increasing the level of Interleukin 10(IL-10)in serum and *** not only decreased CD86 and iNOS expression but also increased CD206 and Arg-1 *** also downregulated the increased expression of PI3K,AKT,p-PI3K,p-AKT,IKK,and NF-κB p65 induced by lipopolysaccharides,while up-regulated the decreased expression of Iκ***,LY294002 with WED decreased the expression of protein PI3K,AKT,p-PI3K,p-AKT,IKK and NF-κB p65,and raised the expression of IκBα.Conclusion:Wedelolactone could attenuate sepsis-associated acute liver injury,and its mechanism may be associated with balancing pro-inflammatory and anti-inflamm

关键词： Wedelactone sepsis liver injury macrophage polarization PI3K/AKT/NF-κB