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Impact of PRRSV on activation and viability of antigen presenting cells

World Journal of Virology 2013年第4期2卷 146-151页

作者： Irene M Rodríguez-Gómez Jaime Gómez-Laguna Librado Carrasco Department of Anatomy and Comparative Pathology University of Córdoba14071 Córdoba Spain cicap-food research centre Pozoblanco 14400 Córdoba Spain

Porcine reproductive and respiratory syndrome(PRRS) is one of the most important diseases of swine industry. The causal agent, PRRS-virus(PRRSV), is able to evade the host immune response and survive in the organism causing transient infections. Despite all scientific efforts, there are still some gaps in the knowledge of the pathogenesis of this disease. Antigen presenting cells(APCs), as initiators of the immune response, are located in the first line of defense against microorganisms, and are responsible for antigen recognition, processing and presentation. Dendritic cells(DCs) are the main type of APC involved in antigen presentation and they are susceptible to PRRSV infection. Thus, PRRSV replication in DCs may trigger off different mechanisms to impair the onset of a host effective immune response against the virus. On the one side, PRRSV may impair the basic functions of DCs by regulating the expression of major histocompatibility complex class Ⅱ and CD80/86. Other strategy followed by the virus is the induction of cell death of APCs by apoptosis, necrosis or both of them. The impairment and/or cell death ofAPCs could lead to a failure in the onset of an efficient immune response, as long as cells could not properly activate T cells. Future aspects to take into account are also discussed in this review.

关键词： Porcine reproductive and respiratory syndrome Antigen presenting cells Dendritic cells Immune response Major histocompatibility complex classⅡ CD80/86 Cell death Apoptosis

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