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可生物降解纳米药物通过重塑肿瘤微环境和调节能量代谢高效治疗结直肠癌

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Science China Materials 2024年第1期67卷 331-342页

作者：张绍鹏张昊宋沛哲曹悦李伟王大广王樱蕙张洪杰 Department of Gastrocolorectal Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry(CIAC)Chinese Academy of Sciences(CAS)Changchun 130022China Department of Neurosurgery The First Hospital of Jilin UniversityChangchun 130021China Department of Chemistry Tsinghua UniversityBeijing 100084China

顺铂(CDDP)是治疗结直肠癌的常用化疗药物,但其存在清除快、耐药和靶向性差等问题.同时,缺氧、高水平谷胱甘肽和快速能量代谢等复杂的肿瘤微环境,也是导致化疗疗效不理想的原因之一.本文首先在沸石咪唑框架上负载CDDP,而后在表面包裹二... 详细信息

顺铂(CDDP)是治疗结直肠癌的常用化疗药物,但其存在清除快、耐药和靶向性差等问题.同时,缺氧、高水平谷胱甘肽和快速能量代谢等复杂的肿瘤微环境,也是导致化疗疗效不理想的原因之一.本文首先在沸石咪唑框架上负载CDDP,而后在表面包裹二氧化锰外壳,最后以透明质酸(HA)作为靶向分子进行修饰,成功构建了一种肿瘤微环境响应型纳米平台(ZIF-90@CDDP@MnO_(2)@HA),实现了化疗、化学动力学疗法和饥饿疗法的联合治疗.肿瘤微环境响应性药物释放大大提高了化疗的疗效.MnO_(2)外壳一方面会消耗谷胱甘肽(GSH)以抑制CDDP解毒和活性氧(ROS)清除,同时,释放的Mn2+可实现化学动力治疗.另一方面,MnO_(2)通过原位氧气生成下调低氧诱导转录因子1α的表达,不仅能提高化疗耐受性,还能通过下调己糖激酶2和葡萄糖转运蛋白1的表达,抑制有氧糖酵解,进一步促进饥饿疗法.此外,ZIF-90释放的Zn2+会造成线粒体损伤,进一步抑制三磷酸腺苷(ATP)的产生,从而加强饥饿疗法.这种协同治疗策略在体外和体内均表现出良好的抗肿瘤效果,为结直肠癌联合治疗开辟了一条新途径.

关键词：肿瘤微环境葡萄糖转运蛋白1 线粒体损伤 CDDP 有氧糖酵解抗肿瘤效果化疗疗效结直肠癌

Augmented reality system to assist inexperienced pool players

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Computational Visual Media 2016年第2期2卷 183-193页

作者： L.Sousa R.Alves J.M.F.Rodrigues LARSy S and Institute of Engineering University of the Algarve LARSy S CIAC and Institute of Engineering University of the Algarve

Pool and billiards are amongst a family of games played on a table with six pockets along the rails. This paper presents an augmented reality tool designed to assist unskilled or amateur players of such games. The system is based on a projector and a Kinect 2 sensor placed above the table, acquiring and processing the game on-the-fly. By using depth information and detecting the table's rails(borders),the balls' positions, the cue direction, and the strike of the ball, computations predict the resulting balls' trajectories after the shot is played. These results—trajectories, visual effects, and menus—are visually output by the projector, making them visible on the snooker table. The system achieves a shot prediction accuracy of 98% when no bouncing occurs.

关键词： computer vision augmented reality(AR) Kinect pool game

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Preface

Preface

Multifunctional core/satellite polydopamine@Nd^3＋- sensitized upconversion nanocomposite： A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy

2013年中国智能自动化学术会议

作者： Zengqi Sun Chair of ciac2013

The 2013 Chinese Intelligent Automation Conference(ciac2013) was Sponsored by Intelligent Automation Committee,Chinese Association of Automation and organized by Yangzhou University in Yangzhou,Jiangsu Province,China;23-25, August,*** objective of ciac2013 was to provide a platform for researchers,engineers,academicians as well as industrial professionals from all

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Nano Research 2017年第10期10卷 3434-3446页

作者： Xing Ding Jianhua Liu Dapeng Liu Junqi Li Fan Wang Leijiao Li Yinghui Wang Shuyan Song Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry (CIAC) Chinese Academy of Sciences (CAS) Changchun 130022 China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 China Department of Radiology the Second Hospital of Jilin University Changchun 130041 China

Significant attenuation and overheating, caused by the absorption of the excitation band （980 nm） in water, are the major obstacles in the in vivo application of lanthanide-doped upconversion nanoparticles （UCNPs）. Therefore, appropriately- structured Nd3^＋-doped UCNPs with 808 nm excitation could be a promising alternative. Herein, we developed core-shell-shell structured Nd3^＋-sensitized UCNPs as imaging agents, and decorated them onto the surface of polydopamine （PDA） to construct a novel multifunctional core/satellite nanotheranostic （PDA@UCNPs） for in vivo imaging guidance photothermal therapy using single 808 nm laser irradiation. The core-shell-shell structured design enabled outstanding upconversion luminescence properties and strong X-ray attenuation, thereby making the nanocomposites potential candidates for excellent upconversion luminescence/computed tomography dual modal imaging. In addition, the PDA core not only provides high photothermal conversion efficiency and outstanding antitumor effect, but also endows the platform with robust biocompatibility owing to its natural features. Therefore, this multifunctional nanocomposite could be a promising theranostic in future oncotherapy, with high therapeutic effectiveness but low side effects. This study would stimulate interest in designing bio- application-compatible multifunctional nanocomposites, especially for cancer diagnosis and treatment in vivo.

关键词： Nd^3+-sensitized upconversion nanopartides dual-modality imaging photothermal therapy multifunctional theranostic platform biocompatibility

Boosting Chemodynamic Therapy by the Synergistic Eect of Co-Catalyze and Photothermal Eect Triggered by the Second Near-Infrared Light

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Nano-Micro Letters 2020年第12期 322-334页

作者： Songtao Zhang Longhai Jin Jianhua Liu Yang Liu Tianqi Zhang Ying Zhao Na Yin Rui Niu Xiaoqing Li Dongzhi Xue Shuyan Song Yinghui Wang Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry (CIAC) Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences Department of Radiology The Second Hospital of Jilin University Department of Chemistry Tsinghua University

In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction（i.e., chemodynamic therapy, CDT） has been attracted more attentions in recent years, the limited Fenton reaction e ciency is the important obstacle to further application in clinic. Herein, we synthesized novel Fe O/MoS;nanocomposites modified by bovine serum albumin（Fe O/MoS;-BSA） with boosted Fenton reaction e ciency by the synergistic e ect of co-catalyze and photothermal e ect of MoS;nanosheets triggered by the second near-infrared（NIR II） light. In the tumor microenvironments, the MoS;nanosheets not only can accelerate the conversion of Fe;ions to Fe;ions by Mo;ions on their surface to improve Fenton reaction e ciency, but also endow Fe O/MoS;-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy（PTT）. Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly e cient CDT.

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Boosting Chemodynamic Therapy by the Synergistic Effect of Co‑Catalyze and Photothermal Effect Triggered by the Second Near‑Infrared Light

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Nano-Micro Letters 2020年第12期12卷 318-330页

作者： Songtao Zhang Longhai Jin Jianhua Liu Yang Liu Tianqi Zhang Ying Zhao Na Yin Rui Niu Xiaoqing Li Dongzhi Xue Shuyan Song Yinghui Wang Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry(CIAC)Chinese Academy of Sciences(CAS)Changchun 130022People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Department of Chemistry Tsinghua UniversityBeijing 100084People’s Republic of China Department of Radiology The Second Hospital of Jilin UniversityChangchun 130041People’s Republic of China

In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction(i.e.,chemodynamic therapy,CDT)has been attracted more attentions in recent years,the limited Fenton reaction efficiency is the important obstacle to further application in ***,we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin(FeO/MoS2-BSA)with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared(NIR II)*** the tumor microenvironments,the MoS2 nanosheets not only can accelerate the conversion of Fe3+ions to Fe2+ions by Mo4+ions on their surface to improve Fenton reaction efficiency,but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy(PTT).Consequently,benefiting from the synergetic-enhanced CDT/PTT,the tumors are eradicated completely in *** work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

关键词： Chemodynamic therapy Fenton reaction Co-catalysis Photothermal effect NIR II biowindows

A nanotheranostic agent based on Nd^(3+)-doped YVO_(4) with blood-brain-barrier permeability for NIR-Ⅱ fluorescence imaging/magnetic resonance imaging and boosted sonodynamic therapy of orthotopic glioma

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Light(Science & Applications) 2022年第6期11卷 1088-1097页

作者： Zhijia Lv Longhai Jin Yue Cao Hao Zhang Dongzhi Xue Na Yin Tianqi Zhang Yinghui Wang Jianhua Liu Xiaogang Liu Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry(CIAC)Chinese Academy of Sciences130022 ChangchunChina University of Science and Technology of China 230026 HefeiAnhuiChina Ganjiang Innovation Academy Chinese Academy of Sciences341000 GanzhouJiangxiChina Department of Radiology The Second Hospital of Jilin University130041 ChangchunChina Department of Neurosurgery The First Hospital of Jilin University130041 ChangchunChina Department of Chemistry National University of SingaporeSingapore 117543Singapore Department of Chemistry Tsinghua University100084 BeijingChina

The specific diagnosis and treatment of gliomas is a primary challenge in clinic due to their high invasiveness and blood-brain barrier(BBB)*** is highly desirable to find a multifunctional agent with good BBB penetration for precise ***,we design and construct a core-shell structured nanotheranostic agent(YVO_(4):Nd^(3+)-HMME@MnO_(2)-LF,marked as YHM)with YVO_(4)∶Nd^(3+) particles as the core and MnO_(2) nanosheets as the *** hematoporphyrinmonomethyl ether(HMME)and lactoferrin(LF)were further loaded and modified on the surface,giving it a good ability to cross the BBB,near-infrared fluorescence imaging in the second window(NIR-Ⅱ)/magnetic resonance imaging(MRI)bimodality,and highly efficient sonodynamic therapy(SDT)of orthotopic *** YVO_(4):Nd^(3+)(25%)core exhibited good NIR-Ⅱ fluorescence properties,enabling YHM to act as promising probes for NIR-Ⅱ fluorescence imaging of vessels and orthotopic ***_(2) shell can not only provide O2 in the tumor microenvironments(TME)to significantly improve the healing efficacy of SDT,but also release Mn^(2+) ions to achieve T1-weight MRI in ***-invasive SDT can effectively restrain tumor *** work not only demonstrates that multifunctional YHM is promising for diagnosis and treatment of orthotopic glioma,but also provides insights into exploring the theranostic agents based on rare earth-doped yttrium vanadate nanoparticles.

关键词： diagnosis agent barrier

Targeting Ageing Disease Related Quadruplex and Amyloid Aggregation and Their Applications

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Targeting Ageing Disease Related Quadruplex and Amyloid Aggr...

第十一届全国化学生物学学术会议

作者： Zhi Du Yuhuan Sun Xinping Liu 曲晓刚 Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry (CIAC)Chinese Academy of Sciences 中科院长春应用化学研究所

Many biological important processes are related to the conformation and assembly state of specific gene,involved proteins and *** this report,we summarize our recent research progress in this field and focus on Alzhei... 详细信息

关键词： metal complex supramolecular complex G-quardruplex amyloid

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类似先天性感染的遗传综合征

世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 58-59页

作者： Sanchis A. Cerver L. Bataller A. M.L. Martnez-Fras 宁亮 ciac Instituto de Salud Carlos III Pabelln 6Sinesio Delgado 6 Madrid 28029 Spain Dr.

Genetic syndromes that mimic congenital infection are important to recognize b ecause of the associated risk of recurrence. We describe two brothers born to consanguineous parents with clini cal features suggestive of intrauterine infection but with negative serologic in vestigations. Our observations suggest that Aicardi-Goutiéres syndrome (AGS) a nd pseudo-TORCH syndrome likely represent the same disorder.

关键词：先天性感染同胞兄弟宫内感染 TORCH 血清学