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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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The implication of neurovascular unit signaling in controlling the subtle balance between injury and repair following ischemic stroke

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Neural Regeneration Research 2016年第6期11卷 914-915页

作者： Ayman El Ali Neuroscience Axis CHU de Québec Research Center (CHUL) department of Psychiatry and Neuroscience Faculty of Medicine Laval University

Neurovascular unit（NVU）：Brain microvasculature has a close structural and functional relationship with brain parenchyma,an aspect governed by the NVU（Hermann and El Ali,2012）.The concept of it was introduced by t... 详细信息

关键词： subtle implication repair microglia governed signaling giving inevitably attempt astrocyte

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Innate and adaptive immune responses toward nanomedicines

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Acta Pharmaceutica Sinica B 2021年第4期11卷 852-870页

作者： Iara Maíra de Oliveira Viana Sabrina Roussel Joan defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand Laboratory of Pharmaceutical Technology(FarmaTec) Federal University of GoiásGoiás 74605-220Brazil Faculty of Pharmacy UniversitéLaval and CHU de Québec-UniversitéLaval Research CenterQuébec G1V 4G2Canada department of Medicine Faculty of MedicineUniversitéLaval and CHU de Québec-UniversitéLaval Research CenterQuébec G1V 4G2Canada

Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological *** work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more *** nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond *** parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented *** rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune *** review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions.

关键词： Cancer immunotherapy mRNA vaccine Complement activation Macrophage In vivo clearance Anti-PEG antibody Nanoparticle mRNA-1273 BNT162b2 Immunology

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Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer

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Journal of Molecular Cell Biology 2015年第6期7卷 568-579页

作者： Xiaoqiang Wang Catherine Gérard Jean-Francois Thériault Donald Poirier Charles J.Doillon Sheng-Xiang Lin Laboratory of Molecular Endocrinology and Oncology Centre Hospitalier Universitaire de Québec Research Center(CHULCHU)and Laval UniversityQuébec CityQuebecG1V4G2Canada

17β-hydroxysteroid dehydrogenase(17β-HSD)type 1 is known as a critical target to block the final step of estrogen production in estrogen-dependent breast *** confirmation of the role of dyhydroxytestosterone(DHT)in counteracting estrogeninduced cell growth prompted us to study the reductive 17β-HSD type 7(17β-HSD7),which activates estrone while markedly *** role ofDHTin breast cancer cell proliferation isdemonstratedby its independent suppression of cell growthin the presence of a physiological concentration of estradiol(E2).Moreover,an integral analysis of a large number of clinical samples in Oncomine datasets demonstrated the overexpression of 17β-HSD7 in breast *** of 17β-HSD7 in breast cancer cells resulted in a lower level of E2 and a higher level of DHT,successively induced regulation of cyclinD1,p21,Bcl-2,and Bik,consequently arrested cell cycle in the G0/G1 phase,and triggered apoptosis and auto-downregulation feedback of the *** inhibition led to significant shrinkage of xenograft tumors with decreased cancer cell density and reduced 17β-HSD7 *** plasma E2 and elevated plasma DHT levels were also ***,the dual functional 17β-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of E2 *** aconceptual advance on the general belief that the major role of this enzyme is in cholesterol metabolism.

关键词： 17β-hydroxysteroid dehydrogenase type 7 breast cancer xenograft tumor steroid enzyme inhibition

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A microfluidic approach for development of hybrid collagen-chitosan extracellular matrix-like membranes for on-chip cell cultures

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Journal of Materials Science & Technology 2021年第4期63卷 54-61页

作者： Erica Rosella Nan Jia Diego Mantovani Jesse Greener Laboratory Department of ChemistryLaval UniversityQuébecQCCanada Laboratory of Biomaterials and Bioengineering CRC-1Dept.Min-Met-Materials Eng&CHU de QuebecResearch CenterLaval UniversityQuébecQCCanada chu de quebec Research Centre Laval University10 rue de l’EspinayQuébecQC G1L 3L5Canada

To advance organ-on-a-chip development and other areas befitting from physiologically-relevant biomembranes,a microfluidic platform is presented for synthesis of biomembranes during gelation and investigation into their role as extracellular matrix *** this work,high-throughput studies of collagen,chitosan,and collagen-chitosan hybrid biomembranes were carried out to characterize and compare key properties as a function of the applied hydrodynamic conditions during ***,depending on the biopolymer material used,varying flow conditions during biomembrane gelation caused width,uniformity,and swelling ratio to be differently affected and ***,cell viability studies of seeded fibroblasts were conducted,thus showing the potential for biological applications.

关键词： matrix swelling showing

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Follicle-stimulating hormone(FSH)levels prior to prostatectomy are not related to long-term oncologic or cardiovascular outcomes for men with prostate cancer

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Asian Journal of Andrology 2022年第1期24卷 21-25页

作者： Kassim Kourbanhoussen France-Hélène Joncas Christopher JD Wallis Hélène Hovington Francois Dagenais Yves Fradet Chantal Guillemette Louis Lacombe Paul Toren department of Surgery Faculty of MedicineUniversitéLavalCHU de Québec Research CenterOncology DivisionQuebec City G1R3S1Canada department of Urology Vanderbilt University Medical CenterNashvilleTN 37232USA Institut universitaire Cardiologie et Pneumologie de québec Quebec City G1V 4G5Canada Faculty of Pharmacy UniversitéLavalCHU de Québec Research CenterQuebec City G1V 4G2Canada

Prior research suggests a link between circulating levels of follicle-stimulating hormone(FSH)and prostate cancer *** levels may also explain some of the observed differences in cardiovascular events among men treated with gonadotropin-releasing hormone(GnRH)antagonists compared to GnRH *** study evaluates the association between preoperative FSH and long-term cardiovascular and oncologic outcomes in a cohort of men with long follow-up after radical *** performed a cohort study utilizing an institutional biobank with annotated clinical *** levels were measured from cryopreserved plasma and compared with sex steroids previously measured from the same *** in oncologic outcomes between tertiles of FSH levels were compared using adjusted cox regression *** adverse cardiovascular events(MACE)were similarly assessed using hospital admission diagnostic codes.A total of 492 patients were included,with a median follow-up of 13.1(interquartile range:8.9–15.9)*** sulfate(DHEA-S)levels,but not other androgens,negatively correlated with FSH levels on linear regression analysis(P=0.03).There was no association between FSH tertile and outcomes of biochemical recurrence,time to castrate-resistant prostate cancer,or time to *** were identified in 50 patients(10.2%),with a mean time to first event of 8.8 *** association with FSH tertile and occurrence of MACE was *** results do not suggest that preoperative FSH levels are significantly associated with oncologic outcomes among prostate cancer patients treated with radical prostatectomy,nor do these levels appear to be predictors of long-term cardiovascular risk.

关键词： cardiovascular events follicle-stimulating hormone prostate cancer recurrence

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New pharmacological approaches against chronic bowel and bladder problems in paralytics

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World Journal of Critical Care Medicine 2016年第1期5卷 1-6页

作者： Pierre A Guertin department of Psychiatry and Neurosciences Laval University laval university Medical Center (chu de québec - chul)

Spinal cord injury(SCI) leads generally to an irreversible loss of sensory functions and voluntary motor control below injury level. Cures that could repair SCI and/or restore voluntary walking have not been yet developed nor commercialized. Beyond the well-known loss of walking capabilities, most SCI patients experience also a plethora of motor problems and health concerns including specific bladder and bowel dysfunctions. Indeed, chronic constipation and urinary retention, two significant life-threatening complications, are typically found in patients suffering of traumatic(e.g., falls or car accidents) or non-traumatic SCI(e.g., multiple sclerosis, spinal tumors). Secondary health concerns associated with these dysfunctions include hemorrhoids, abdominal distention, altered visceral sensitivity, hydronephrosis, kidney failure, urinary tract infections, sepsis and, in some cases, cardiac arrest. Consequently, individuals with chronic SCI are forced to regularly seek emergency and critical care treatments when some of these conditions occur or become intolerable. Increasing evidence supports the existence of a novel experimental approach that may be capable of preventing the occurrence or severity of bladder and bowel problems. Indeed, recent findings in animal models of SCI have revealed that, despite paraplegia or tetraplegia, it remains possible to elicit episodes of micturition and defecation by acting pharmacologically or electrically upon specialized lumbosacral neuronal networks, namely the spinal or sacral micturition center(SMC) and lumbosacral defecation center(LDC). Daily activation of SMC and LDC neurons could potentially become, new classes of minimally invasive treatments(i.e., if orally active) against these dysfunctions and their many lifethreatening complications.

关键词： Prevention of intensive care problems quality of care Temporary recovery of vital functions Micturition defecation Spinal networks Central pattern generators

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New avenues for reducing intensive care needs in patients with chronic spinal cord injury

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World Journal of Critical Care Medicine 2016年第4期5卷 201-203页

作者： Pierre A Guertin department of Psychiatry and Neurosciences Laval University laval university Medical Center (chu de québec - chul)

Relatively soon after their accident, patients suffering a spinal cord injury(SCI) begin generally experiencing the development of significant, often life-threatening secondary complications. Many of which are associated with chronic physical inactivity-related immune function problems and increasing susceptibility to infection that repeatedly requires intensive care treatment. Therapies capable of repairing the spinal cord or restoring ambulation would normally prevent many of these problems but, as of now, there is no cure for SCI. Thus, management strategies and antibiotics remain the standard of care although antimicrobial resistance constitutes a significant challenge for patients with chronic SCI facing recurrent infections of the urinary tract and respiratory systems. Identifying alternative therapies capable of safe and potent actions upon these serious health concerns should therefore be considered a priority. This editorial presents some of the novel approaches currently in development for the prevention of specific infections after SCI. Among them, brain-permeable small molecule therapeutics acting centrally on spinal cord circuits that can augment respiratory capabilities or bladder functions. If eventually approved by regulatory authorities, some of these new avenues may potentially become clinically-relevant therapies capable of indirectly preventing the occurrence and/or severity of these lifethreatening complications in people with paraplegic or tetraplegic injuries.

关键词： Prevention of intensive care problems quality of care Temporary recovery of vital functions Micturition Spinal networks Central pattern generators

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Considerations for the clinical use of stem cells in genitourinary regenerative medicine

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World Journal of Stem Cells 2021年第10期13卷 1480-1512页

作者： Christophe Caneparo Luis Sorroza-Martinez Stéphane Chabaud Julie Fradette Stéphane Bolduc Centre de Recherche en Organogénèse Expérimentale de l'universitélaval/LOEX Centre de Recherche du CHU de Québec-UniversitéLavalAxe Médecine RégénératriceQuebec G1J1Z4Canada department of Surgery Faculty of MedicineUniversitéLavalQuebec G1V0A6Canada

The genitourinary tract can be affected by several pathologies which require repair or replacement to recover biological *** therapeutic strategies are challenged by a growing shortage of adequate ***,new options must be considered for the treatment of patients,with the use of stem cells(SCs)being *** different strategies can be derived from stem cell use:Cell therapy and tissue therapy,mainly through tissue *** recent advances using these approaches are described in this review,with a focus on stromal/mesenchymal cells found in adipose ***,the accessibility,high yield at harvest as well as anti-fibrotic,immunomodulatory and proangiogenic properties make adipose-derived stromal/SCs promising alternatives to the therapies currently offered to ***,an innovative technique allowing tissue reconstruction without exogenous material,the self-assembly approach,will be *** advances,more studies are needed to translate such approaches from the bench to clinics in *** the 21st century,cell and tissue therapies based on SCs are certainly the future of genitourinary regenerative medicine.

关键词： Genitourinary tract Cell therapy Tissue engineering Stem cells

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Ultrastretchable and wearable conductive multifilament enabled by buckled polypyrrole structure in parallel

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npj Flexible Electronics 2022年第1期6卷 419-429页

作者： Yimeng Li Yaya Gao Lizhen Lan Qian Zhang Leqian Wei Mengqi Shan Lamei Guo Fujun Wang Jifu Mao Ze Zhang Lu Wang Key Laboratory of Textile Science&Technology of Ministry of Education and College of Textiles Donghua UniversityShanghai 201620China Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology Donghua UniversityShanghai 201620China Département de chirurgie Facultéde médecineUniversitéLavalAxe médecine régénératriceCentre de recherche du CHU de Québec-UniversitéLavalQuébec(QC)G1V 0A6Canada

Stretchable conductive fibers have attracted much attention due to their potential use in wearable ***,the ultrahigh strain insensitive conductivity is hindered by mechanical mismatch in Young’s modulus and failure of stretchable structures under large *** challenge is addressed with a conductive and elastic multifilament made of the polyurethane monofilaments that are surface-coated with buckled polypyrrole(PPy)of which flexibility is improved by sodium *** parallel conductive monofilaments with PPy buckling on surface reduce the influence of cracks in the conductive coating on the overall conductivity,displaying an ultra-high strain insensitive behavior(quality factor Q=10.9).Remarkably,various complex forms of wearable electronic textiles made by this conductive multifilament maintain the strain-insensitive behavior of the original multifilament,even upon the large deformation of human *** multifilament with wrinkled PPy has attractive advantages in the application of super-stretched wearable electronic devices.

关键词： conductive polypyrrole conductivity

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