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Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent

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World Journal of Gastroenterology 2007年第16期13卷 2312-2318页

作者： S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel chu de la Conception Marseille 13005 France chu Saint-Antoine Paris France chu Saint-Eloi Montpellier France chu Hautepierre Strasbourg France chu Lyon-Sud Pierre-Bénite France chu Dijon France chu timone Marseille France Hpital Trousseau Paris France chu Nord Marseille 13005 France Laboratoire Luxembourgeois d’Immunopathologie Esch-sur-Alzette Luxembourg. Services de gastro-entérologie et pédiatrie France

AIM： Anti-Saccharomyces anti-nuclear associated cerevisiae antibodies （ASCA）, anti-neutrophil antibodies （NANA） and antibodies to exocrine pancreas （PAB）, are serological tools for discriminating Crohn＇s disease （CrD） and ulcerative colitis （UC）. Like CrD, coeliac disease （COD） is an inflammatory bowel disease （IBD） associated with （auto） antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS： Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence （IIF）. RESULTS： ASCA＋/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active *** were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION： ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value.

关键词： Inflammatory bowel disease Coeliac disease Anti-Saccharomyces cerevisiae antibodies Anti-neutrophil cytoplasmic antibodies Anti-pancreatic antibodies

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Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

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Cellular & Molecular Immunology 2021年第11期18卷 1290-1304页

作者： Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier Aix Marseille University CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance chu Bordeaux Service d’Hématologie Clinique et de Thérapie CellulaireBordeauxFrance Bordeaux University BordeauxFrance Institut National de la Santéet de la Recherche Médicale U1035BordeauxFrance APHM Hôpital de la TimoneMarseille-ImmunopôleMarseilleFrance Établissement Français du Sang Nouvelle Aquitaine BordeauxFrance Innate Pharma Research Laboratories Innate PharmaMarseilleFrance

Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor *** human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and *** the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone *** analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological *** profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell *** marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate.

关键词： NK cells scRNASeq AML

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Barcelona clinic liver cancer nomogram and others staging/scoring systems in a French hepatocellular carcinoma cohort

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World Journal of Gastroenterology 2017年第14期23卷 2545-2555页

作者： Xavier Adhoute Guillaume Pénaranda Jean Luc Raoul Julien Edeline Jean-Frédéric Blanc Bernard Pol Manuela Campanile HervéPerrierO livier Bayle Olivier Monnet Patrick Beaurain Cyril Muller Paul Castellani Yves Patrice Le Treut Jean Pierre Bronowicki Marc Bourlière Department of Hepato-Gastroenterology Hopital Saint-Joseph Marseille Alpha Bio Laboratory Marseille Department of Hepato-Gastroenterology and Digestive Oncology Institut Paoli-Calmette Marseille Department of Hepato-Gastroenterology and Digestive Oncology Centre Eugène Marquis Rennes Department of Hepato-Gastroenterology Centre Hospitalo-Universitaire Saint-AndréBordeaux Department of Hepatobiliary Surgery Hopital Saint-Joseph Marseille Department of Radiology Hopital Saint-Joseph Marseille Department of Hepatobiliary Surgery Centre Hospitalo-Universitaire Timone Marseille Department of Hepato-Gastroenterology Centre Hospitalo-Universitaire de Nancy INSERM U954 Universitéde LorraineCHU de NancyVandoeuvre les Nancy

AIM To compare the performances of the Barcelona clinic liver cancer(BCLC) nomogram and others systems(BCLC, HKLC, CLIP, NIACE) for survival prediction in a large hepatocellular carcinoma(HCC) French *** Data were collected retrospectively from 01/2007 to 12/2013 in five French centers. Newly diagnosed HCC patients were analyzed. The discriminatory ability, homogeneity ability, prognostic stratification ability Akaike information criterion(AIC) and C-index were compared among scoring systems. RESULTS The cohort included 1102 patients, mostly men, median age 68 [60-74] years with cirrhosis(81%), child-Pugh A(73%), alcohol-related(41%), HCV-related(27%). HCC were multinodular(59%) and vascular invasion was present in 41% of cases. At time of HCC diagnosis BCLC stages were A(17%), B(16%), C(60%) and D(7%). First line HCC treatment was curative in 23.5%, palliative in 59.5%, BSC in 17% of our population. Median OS was 10.8 mo [4.9-28.0]. Each system distinguished different survival prognosis groups(P < 0.0001). The nomogram had the highest discriminatory ability, the highest C-index value. NIACE score had the lowest AIC value. The nomogram distinguished sixteen different prognosis groups. By classifying unifocal large HCC into tumor burden 1, the nomogram was less powerful. CONCLUSION In this French cohort, the BCLC nomogram and the NIACE score provided the best prognostic information, but the NIACE could even help treatment strategies.

关键词： Barcelona clinical liver cancer Hong kong liver cancer NIACE CLIP Hepatocellular carcinoma

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French Spine Surgery Society guidelines for management of spinal surgeries during COVID-19 pandemic

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World Journal of Clinical Cases 2020年第10期8卷 1756-1762页

作者： Solène Prost Yann Philippe Charles Jérome Allain Jean-Luc Barat Henri d'Astorg Manuel Delhaye Chistophe Eap Fahed Zairi Pierre Guigui Brice Ilharreborde Jean Meyblum Jean-Charles Le Huec Nicolas Lonjon Guillaume Lot Olivier Hamel Guillaume Riouallon Stéphane Litrico Patrick Tropiano Benjamin Blondel Aix-Marseille Université APHMCNRSISMCHU TimoneUnitéde Chirurgie RachidienneMarseille 13005France Service de Chirurgie du Rachis Hopitaux Universitaires de StrasbourgStrasbourg 67200France Institut Parisien du dos Paris 75005France Service de Neurochirurgie Hopital privéClairval-Ramsay santéMarseille 13009France Unitéde Chirurgie du Rachis Centre Orthopédique SantyLyon 69008France Centre Francilien du dos Versailles 78000France chu Reims Hopital Maison BlancheNeurochirurgieReims 51100France Hopital PrivéLe Bois Ramsay Santé Lille 59000France Hopital Européen Georges-Pompidou HEGP Paris 75015France Service de Chirurgie Orthopédique Pédiatrique CHU Robert DebréAPHPUniversitéde ParisParis 75019France Service de Chirurgie Orthopédique Groupe Hospitalier Paris Saint-JosephParis 75014France Polyclinique Bordeaux Nord Aquitaine Bordeaux 33300France Service de Neurochirurgie Hopital Gui de ChauliacMontpellier 34090France Hopital-Fondation Rothschild Service de NeurochirurgieParis 75019France Clinique Des Cèdres Service de Neurochirurgie Chateau D’AlliezCornebarrieu 31700France Hopital Paris Saint-Joseph Paris 75014France Unitéde Chirurgie Rachidienne Hopital Pasteur 2CHU de NiceNice 06001France

Since the outbreak of coronavirus disease 2019(COVID-19)in December 2019 in China,various measures have been adopted in order to attenuate the impact of the virus on the *** regard to spine surgery,French physicians are devoted to take place in the national plan against COVID-19,the French Spine Surgery Society therefore decided to elaborate specific guidelines for management of spinal disorders during COVID-19 pandemic in order to prioritize management of patients.A three levels stratification was elaborated with Level I:Urgent surgical indications,Level II:Surgical indications associated to a potential loss of chance for the patient and Level III:Non-urgent surgical *** also report French experience in a COVID-19 cluster region illustrated by two clinical *** hope that the guidelines formulated by the French Spine Surgery Society and the experience of spine surgeons from a cluster region will be helpful in order optimizing the management of patients with urgent spinal conditions during the pandemic.

关键词： COVID-19 Spine Surgery Guidelines Organization Cluster region

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胸内囊性血管淋巴管瘤:一种罕见的与婴儿急性细支气管炎的诊断极其相似的疾病

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 11-11页

作者： Bosdure E. Mates M. Mely L. J.C.Dubus 朱新菊 U.de Médecine Infantile CHU Timone-Enfants 13385 Marseille Cedex 05 France

Hemolymphangiomais a benign malformation of the lymphatic *** localisation is the most *** localisation is rare, but may be life-threatening because of airway *** report on a four-month-old boy who presented, in a context of epidemics, with clinical signs of acute bronchiolitis requiring mechanical ventilation for several *** X-rays showed an important mediastinal mass with airways *** was evoked on CT-scan aspects and confirmed by *** allowed complete resolution, but dysphonia and oropharyngeal disorders persisted for several *** rare congenitalmalformation is reviewed.

关键词：急性细支气管炎内囊性淋巴管瘤淋巴导管发声困难组织学检查口咽部先天性畸形功能失调外科手术

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脑肿瘤如何改变脑功能的连接性?一项脑磁图描记术研究

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世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 4-4页

作者： Bartolomei F Bosma I Klein M. 周永 Department of Clinical Neurophysiology and Epileptology CHU Timone 264 rue Saint-Pierre 13012 Marseille FranceDr.

Objective: This study was undertaken to test the hypothesis that brain tumors interfere with normal brain function by disrupting functional connectivity of brain networks. Methods: Functional connectivity was assessed by computing the synchronization likelihood in a broad band (0.5- 60Hz)or in the gamma band (30- 60Hz) between all pairwise combinations of magnetoencephalography signals. Magnetoencephalography recordings were made at rest in 17 brain tumor patients and 15 healthy control subjects. For a given threshold of synchronization likelihood values, graphs of the suprathreshold connections between each magnetoencephalography channel and the others channels were built. Results: In some regions, a variable number of channels without connectivity (missing connective points) at this threshold was found. The number of missing connective points was higher in patients with brain tumors than in control subjects (p < 0.0001, broad and gamma band) and was higher for left-sided than right-sided tumors (p = 0.008, broad band; p < 0.0001, gamma band). Individual results analysis indicates that the majority of brain tumor patients display several regions with missing connective point alterations in the affected and in the contralateral hemisphere. Interpretation: Our findings suggest that brain tumors induce a loss of functional connectivity that affects multiple brain regions, and that left side brain tumors have the more severe consequences in this respect.

关键词：脑磁图描记术脑功能脑肿瘤连接肿瘤患者宽频带不同数量患者表现同步化伽玛

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广泛性焦虑障碍量表(GAD-7)在中国癫痫患者中的检验

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癫痫杂志 2016年第5期2卷 469-469页

作者：童馨安东梅 McGonigal A Park SP 周东四川大学华西医院神经内科成都610041 Aix Marseille Université InsermINS UMR_S 1106CHU TimoneService de Neurophysiologie CliniqueAssistance Publique des H?pitaux de MarseilleMarseille 13005France Department of Neurology School of MedicineKyungpook National UniversityDaeguSouth Korea

背景癫痫患者中合并焦虑障碍的比例约11%~50%,远高于未患癫痫者.合并焦虑的癫痫患者会出现更多抗癫痫药物(AEDs)副作用和更多认知困难,生活质量更差,发作控制也更差,有着更高的自杀风险、更高的住院率,和更重的经济负担.对癫痫合并焦虑... 详细信息

背景癫痫患者中合并焦虑障碍的比例约11%~50%,远高于未患癫痫者.合并焦虑的癫痫患者会出现更多抗癫痫药物(AEDs)副作用和更多认知困难,生活质量更差,发作控制也更差,有着更高的自杀风险、更高的住院率,和更重的经济负担.对癫痫合并焦虑的早期诊断和适当管理对于提高患者生活质量至关重要.广泛性焦虑障碍量表(Generalized anxiety disorder-7,GAD-7)是一种筛工具,用于在初级保健患者中筛查广泛性焦虑障碍.

关键词：检验药物抗癫痫患者癫痫障碍量表

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Factors associated with DAA virological treatment failure and resistance-associated substitutions description in HIV/HCV coinfected patients

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World Journal of Hepatology 2018年第11期10卷 856-866页

作者： Dominique Salmon Pascale Trimoulet Camille Gilbert Caroline Solas Eva Lafourcade Julie Chas Lionel Piroth Karine Lacombe Christine Katlama Gilles Peytavin Hugues Aumaitre Laurent Alric Franoois Boué Philippe Morlat Isabelle Poizot-Martin Eric Billaud Eric Rosenthal Alissa Naqvi Patrick Miailhes Firouzé Bani-Sadr Laure Esterle Patrizia Carrieri Franoois Dabis Philippe Sogni Linda Wittkop 无 Assistance Publique des Hopitaux de Paris Hopitaux Universitaires Paris CentreHopital Hotel DieuUnitédes Maladies infectieuses et tropicalesParis 75004France Université Paris Descartes Sorbonne Paris CitéParis 75006France Trimoulet CHU de BordeauxHopital PellegrinLaboratoire de VirologieBordeaux 33000France Trimoulet CNRS-UMR 5234Microbiologie fondamentale et PathogénicitéUniversitéde BordeauxBordeaux 3000France Philippe Morlat Laure EsterleFrancois DabisLinda WittkopUniv.BordeauxISPEDInsermBordeaux Population Health Research Centerteam MORPH3EUSUMR 1219CIC-EC 1401Bordeaux F-33000France APHM Hopital La TimoneLaboratoire de Pharmacocinétique et ToxicologieMarseille 13005France Centre Hospitalier Universitaire de Dijon Département d'InfectiologieDijon cedex 21079France INSERM-CIC 1342 Universitéde Bourgogne Dijon 21000France Assistance Publique des Hopitaux de Paris GHUEP site Saint-AntoineServices Maladies infectieuses et tropicalesParis 75011France UniversitéPierre et Marie Curie UMR S1136Institut Pierre Louis d' Epidémiologie et de SantéPubliqueParis 75646France UniversitéParis-Sorbonne Paris 75005France Assistance Publique des Hopitaux de Paris Hopital PitiéSalpêtrière Services Maladies infectieuses et tropicalesParis 75013France Assistance Publique des Hopitaux de Paris Hopital Bichat-Claude BernardLaboratoire de PharmacologieParis 75877France IAME UMR 1137Sorbonne Paris CitéINSERMUniversitéParis DiderotParis 75890France Centre Hospitalier de Perpignan Service Maladies infectieuses et tropicalesPerpignan 66000Franc Centre Hospitalier Universitaire de Toulouse Hopital PurpanService Médecine interne-Pole DigestifToulouse 31300France UMR 152 IRD UniversitéToulouseⅢ Paul SabatierToulouse 31330France Hopital Antoine-Béclère Assistance Publique des Hopitaux de ParisUniversitéParis SudService Médecine interne et immunologieClamart 92140France Centre Hospitalier Universitaire de Bordeaux Service de médecine interneHopital Saint-AndréBordeaux 33000France Uni

AIMTo describe factors associated with treatment failure and frequency of resistance-associated substitutions （RAS）.METHODSHuman immunodefciency virus （HIV）/hepatitis C virus （HCV） coinfected patients starting a first direct-acting antiviral （DAA） regimen before February 2016 and included in the French ANRS CO13 HEPAVIH cohort were eligible. Failure was defned as：（1） non-response [HCV-RNA remained detectable during treatment, at end of treatment （EOT）]; and （2） relapse （HCV-RNA suppressed at EOT but detectable thereafter）. Sequencing analysis was performed to describe prevalence of drug class-specifc RAS. Factors associated with failure were determined using logistic regression *** 559 patients, 77% had suppressed plasmaHIV-RNA 〈 50 copies/mL at DAA treatment initiation41% were cirrhotic, and 68% were HCV treatmentexperienced. Virological treatment failures occurred in22 patients and were mainly relapses （17, 77%） thenundefined failures （3, 14%） and non-responses （29%）. Mean treatment duration was 16 wk overall. Posttreatment NS3, NS5A or NS5B RAS were detected in10/14 patients with samples available for sequencinganalysis. After adjustment for age, sex, ribavirin useHCV genotype and treatment duration, low platelecount was the only factor signifcantly associated with ahigher risk of failure （OR： 6.5; 95%CI： 1.8-22.6）. CONCLUSIONOnly 3.9% HIV-HCV coinfected patients failed DAAregimens and RAS were found in 70% of those failingLow platelet count was independently associated withvirological failure.

关键词： Human immunodeficiency virus Hepatitis C virus Direct-acting antiviral Treatment virological failure Resistant associated mutations

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