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Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine

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chinese Chemical Letters 2010年第2期21卷 155-158页

作者： Yuan, Lei Wang, Jin Hui Sun, Tie Min Shenyang pharmaceut univ Sch Pharmaceut Engn Shenyang 110016 Peoples R China Shenyang pharmaceut univ Sch Traditt Chinese Mat Med Shenyang 110016 Peoples R China

All stereoisomers of asperphenamate 1a and patriscabratine 2a were achieved with a high yield,and total synthesis of 2a is firstly described *** absolute configuration of patriscabratine was determined as(S,S).The compounds 1a-d and 2a-d have been tested by MTT assay in T47D,MDA-MB231,HL60,Hela and SGC-7901 cell lines in *** them,the(R,S) stereoisomer shows the strongest anticancer effects,while the(S,R) shows the weakest one.

关键词： N N -substituted phenylalanine-phenylalaninol ester Asperphenamate Patriscabratine Total synthesis Anticancer activity

A New Enolate Furostanoside from Asparagus Filicinus

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chinese Chemical Letters 2000年第9期11卷 793-794页

作者： Xiao Dong CONG Wen Cai YE Chun Tao CHE Department of Pharmacohnosy China pharmaceutical university Nanjing 210009 Department of Phytochemistry China pharmaceutical university Nanjing 210009 School of chinese Medicine The chinese university of Hong Kon China pharmaceut univ Dept Pharmacognosy Nanjing 210009 Peoples R China China pharmaceut univ Dept Phytochem Nanjing 210009 Peoples R China chinese univ Hong Kong Sch Chinese Med Hong Kong Hong Kong Peoples R China

A new enolate derivative of furostanol glycoside, named asparagusin A, was isolated from the roots of Asparagus filicinus and established as 3-O-beta-D-xylopyranosyl(1-->4)-beta-D-glucopyranosyl (25S)-furost-20(22)-ene-3 beta, 26-diol 26-O-beta-D-glucopyranoside (1) by spectroscopic and chemical methods. Asparagusin A (1) exhibited a cytotoxic activity effect on PC12 cells.

关键词： Asparagus filicinus Liliaceae furostanol glycoside asparagusin A cytotoxic activity

A practical synthesis of sarpogrelate hydrochloride and in vitro platelet aggregation inhibitory activities of its analogues

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chinese Chemical Letters 2010年第3期21卷 287-289页

作者： Chen, Guo Hua Wang, Sheng Wu, Fei Hua China pharmaceut univ Dept Med Chem Nanjing 210009 Peoples R China China pharmaceut univ Dept Pharmacol Chinese Mat Med Nanjing 210038 Peoples R China

A convenient approach for the preparation of sarpogrelate hydrochloride was *** series of sarpogrelate hydrochloride analogues were designed and synthesized in order to improve their platelet aggregation inhibitory activities, biological tests suggested that these compounds have platelet aggregation inhibitory activities to some extent.

关键词： Sarpogrelate hydrochloride Platelet aggregation inhibitor Synthesis

A NEW BICOUMARIN FROM PLEUROSPERMUM RIVULORUM (DIELS)

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chinese Chemical Letters 1995年第5期6卷 385-386页

作者： Xiao, YQ Liu, XH Baba, K Taniguchi, M chinese Acad Tradit chinese Med Inst Chinese Meteria Med Beijing 100700 Peoples R China Osaka univ pharmaceut Sci Osaka 580 Japan

From the BtOAc extract of the underground parts of Pleurospermum rivulorum (Diels), a new bicoumarin, rivulobirin was isolated along with eight known furocoumarins.

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Two new taraxastane-type triterpenoids from the fruit of Cicuta virosa *** latisecta Celak

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chinese Chemical Letters 2010年第3期21卷 317-321页

作者： Li, Zhen Lin Qian, Shi Hui Pu, She Ban Jiangsu Acad Tradit chinese Med Nanjing 210028 Peoples R China China pharmaceut univ Nanjing 210038 Peoples R China

Two new taraxastane-type triterpenoids,20-taraxastene-3β,12β,16β-triol 1 and 3β-feruloyloxy-20-taraxastene-16β,28-diol 2, were isolated from the fruit of Cicuta virosa *** latisecta *** structures were elucidated... 详细信息

关键词： Cicuta virosa L.var latisecta Celak Cicuta Triterpene 20-Taraxastene-3β 12β 16β-triol 3β-Feruloyloxy-20-taraxastene-16β 28-diol

Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents

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chinese Chemical Letters 2010年第4期21卷 381-384页

作者： He, Li Qin Liu, Jing Yin, Deng Ke Zhang, Yi Hua Wang, Xiao Shan China pharmaceut univ Ctr Drug Discovery Nanjing 210009 Peoples R China Anhui univ Tradit chinese Med Anhui Key Lab Modernized Chinese Mat Med Hefei 230031 Anhui Peoples R China

A series of furoxan-based nitric oxide-releasing matrine derivatives(10a-f) were *** biological evaluation showed that compounds 10a,10b,10e and 10f had stronger cytotoxic activities than 5-fluorouracil against human ... 详细信息

关键词： Matrine Furoxan Anti-tumor activity HepG2

A New Glycoside from Erigeron Breviscapus

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chinese Chemical Letters 1999年第2期10卷 125-126页

作者： Wei Dong ZHANG De Yun KONG Hui Ting LI Gen Jin YANG(Department of Traditional chinese Medicine. Shanghai Institute ofpharmaceutical Industry. 1320 Beijing Road (w.), Shanghai 200040) Shanghai Inst pharmaceut Ind Dept Tradit Chinese Med Shanghai 200040 Peoples R China

Erigeside I was isolated from Erigeron breviscapus. The structure elucidation and H-1. C-13 NMR. assignments were achieved by spectroscopic method.

关键词： Erigeron breviscapus compositae erigeside I

Studies on the synthesis and antifungal activity of thiochromanone derivatives

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chinese Chemical Letters 1997年第11期8卷 939-942页

作者： Lin FANG Chum GUO Qi Bing ZHANG (Department of pharmaceutics, Shenyang pharmaceutical university, Shenyang 110015) Shenyang pharmaceut univ Dept Pharmaceut Shenyang 110015 Peoples R China

In this paper nine New Mannich bases of 6-fluoro-thiochromanone and eight new 3-substituted-6.8-dichloro thiochromanones were synthesized and their structures were confirmed by IR, H-1-NMR and elementary analysis. Mos... 详细信息

关键词： ppm IR Studies on the synthesis and antifungal activity of thiochromanone derivatives NH

Identification of the Metabolite of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in Rat Bile by LC/MS and LC/NMR

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chinese Chemical Letters 1997年第6期8卷 515-518页

作者： Feng, NP Zhang, ZX An, DK Huang, WL Wang, GJ Han, XW Bao, XH CHINA pharmaceut univ NANJING 210009PEOPLES R CHINA chinese ACAD SCI DALIAN INST CHEM PHYSDALIAN 116023PEOPLES R CHINA

The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile. A metabolite and unchanged CTHB were found in the bile. C... 详细信息

关键词： MS LC tetrahydroberberine chloride in Rat Bile by LC/MS and LC/NMR Chlorbenzyl Identification of the Metabolite of 7