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Role of calcium-activated potassium currents in CNP-induced relaxation of gastric antral circular smooth muscle in guinea pigs

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World Journal of Gastroenterology 2003年第9期9卷 2054-2059页

作者： Hui-ShuGuo Zheng-XuCai Hai-FengZheng Xiang-LanLi Yi-FengCui Zuo-YuWang Wen-XieXu Sang-JinLee Young--ChuiKim DepartmentofPhysiology CollegeofMedicine.YanbianUnivemityYanji133000JilinProvinceChina CenterofExperiment AffiliatedHosoitalofCollegeofMedicineYanbianUniversityYanji133000JilinprovinceChina DepartmentofPhysiology CollegeofMedicineChungbukNationalUniversityCheo-ngjuChungbuk361-763Korea

AIM: To investigate ion channel mechanism in CNP-induced relaxation of gastric circular smooth muscle in guinea ***: Spontaneous contraction of gastric smooth muscle was recorded by a four -channel physiograph. The whole cell patch-clamp technique was used to record calciumactivated potassium currents and membrane potential in the gastric myocytes isolated by ***: C-type natriuretic peptide (CNP) markedly inhibited the spontaneous contraction in a dose-dependent manner in gastric circular smooth muscle in guinea ***83583, an inhibitor of guanylate cyclase, weakened CNPinduced inhibition on spontaneous contraction but Zaparinast, an inhibitor of cGMP sensitive phosphoesterase,potentiated CNP-induced inhibition in gastric circular smooth muscles. The inhibitory effects of CNP on spontaneous contraction were blocked by tetrathylammonium (TEA), a nonselective potassium channel blocker. CNP hyperpolarized membrane potential from -60.0 mV±2.0 mV to -68.3 meV±3.0 mV in a single gastric myocyte. CNP increased calcium-activated potassium currents (Ik(ca)) in a dose-dependent manner in gastric circular myocytes. CNP also increased the spontaneously transient outward currents (STOCs). Ly83583 partly blocked CNP-induced increase of calcium-activated potassium currents, but Zaparinast potented the ***: CNP inhibits spontaneous contraction, and potassium channel may be involved in the process in gastric circular smooth musde of guinea pigs. CNP-induced increase of Ik(ca) is mediated by a cGMP dependent pathway.

关键词：钙钾 C型促尿钠排泄缩氨酸胃窦环形平滑肌细胞

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Vitamin D supplementation for autoimmune hepatitis: A need for further investigation

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World Journal of Hepatology 2022年第1期14卷 295-299页

作者： Consolato M Sergi Anatomic Pathology Division Children’s Hospital of Eastern Ontario(CHEO)University of OttawaOttawa K1H 8L1ONCanada

Autoimmune hepatitis is a chronic liver disease harboring an autoimmune basis and progressive *** still obscurity in etiology and pathogenesis,some evidence supports the importance of sustaining the immune *** D is a lipo-soluble vitamin,which has been identified as decreased in our *** is often due to the daily habit change and decrease of individual sun exposure due to the increase of the ultraviolet-induced potential melanocytic ***,we emphasize the importance of vitamin D supplementation in patients affected with liver disease.

关键词： Vitamin D Autoimmune hepatitis Supplementation Immunostimulants Liver

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Microarray analysis of gene expression in the liver of transgenic mouse model of HCV infection

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Advances in Bioscience and Biotechnology 2012年第8期3卷 1151-1159页

作者： Masoud Ghorbani Turaya Naas Catalina Soare Rashmi Kothary Francisco Diaz-Mitoma Division of Virology Children’s Hospital of Eastern Ontario (CHEO) Ottawa Canada Infectious Disease and Vaccine Research Centre Children’s Hospital of Eastern Ontario research institute Ottawa Canada

Background: The molecular interactions of hepatitis C virus (HCV) with hepatic tissue have yet to be completely elucidated and understood. The purpose of this study was to compare differential gene expression patterns in the livers of non-transgenic and transgenic mouse model expressing HCV structural proteins Core, Envelope 1 (E1) and Envelope 2 (E2) using complementary DNA (cDNA) microarrays. Results: Total RNA extracted from the livers of HCV transgenic and non-transgenic mice was analyzed with cDNA microarray and differentially expressed genes confirmed by real-time RT-PCR. Relative expression ratios of individual genes were determined by comparing hybridization of Cy5-labelled cDNA from transgenic mouse livers and Cy3-labelled cDNA from non-transgenic mouse livers. The spot array images were quantified using QuantArray software and the outlier spots was normalized and filtered using five different criteria. 15,297 genes were analyzed using three different analytical methods. Depending on these methods, twenty-one genes were found to be differentially expressed at a statistically significant level. From these, 6 genes had a consistent differential expression. Several genes were directly involved in lipid metabolism and lipid β-oxidation. 5-azacytidine induced gene 2 (AZ2), which is involved in the methylation of genes was down regulated in HCV transgenic mice. Altered transcript levels of these 6 genes were confirmed by real-time RT-PCR analysis. Conclusion: Interactions between HCV and hepatocytes not only involve lipid metabolism and redox balance, but this interaction may also influence DNA methylation, indicating a potential association with the development of hepatocellular carcinoma.

关键词： Microarray HCV Hepatocellular Carcinoma

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Levels and correlates of 24-hour movement behaviors among South Koreans:Results from the Korea National Health and Nutrition Examination Surveys,2014 and 2015

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Journal of Sport and Health Science 2019年第4期8卷 376-385页

作者： Eun-Young,Lee Valerie Carson Justin Y.Jeon John C.Spence Mark S.Tremblay School of Kinesiology and Health Studies Queen's UniversityKingston ON K7L 2N9Canada Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmonton AB T6G 2H9Canada Department of Sport Industry Faculty of Education SciencesYonsei UniversitySeoul 03722Republic of Korea Healthy Active Living and Obesity(HALO)Research Group CHEO Research InstituteOttawa ON KIH 8L1Canada

*** study aimed to examine the levels and correlates of 24-h movement behaviors(i.e.,physical activity,sedentary time,and sleep),and different patterns of these behaviors in a nationally representative sample of South Koreans aged 12 years and *** study also aimed to examine the sociodemographic correlates of 24?h movement behaviors stratified by age ***-reported,repeated cross-sectional data from 10,708 participants in the 2014 and 2015 Korea National Health and Nutrition Examination surveys were *** variables included moderate-to-vigorous intensity physical activity,muscular strengthening exercises,walking,active transportation,sedentary time,and *** variables included age,sex,household income,area of residence,and education *** statistics by sex and age as well as general linear models by age group were *** proportions of individuals meeting the moderate-to-vigorous intensity physical activity,muscular strengthening exercises,and sleep guidelines were,respectively,21.6%,22.1%,and 32.5%in male youth;6.9%,4.5%,and 22.8%in female youth;55.5%,30.8%,and 54.0%in male adults;48.8%,14.4%,and 57.6%in female adults;44.0%,30.6%,and 45.5%in male older adults;and 29.5%,8.9%,and 37.3%in female older *** proportions of individuals showing the most ideal combinations of 24-h movement behaviors were only 3.2%in youth,0.4%in adults,and 0 in older ***,older age,female sex,or living in metro Seoul were associated with unfavorable patterns of 24-h movement behaviors across different age ***,the associations of income and education with movement behaviors were mixed across age ***,the proportion of South Koreans with a healthy 24-h movement behavior pattern is *** sociodemographic correlates of different types of 24-h movement behaviors should be considered when designing targeted interventions for the promotion of healthy active living for

关键词： 24-h movement behavior Behavioral epidemiology Guideline adherence Health behavior surveillance

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Olympic Games and 24-hour movement behaviors:A match worth making

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Journal of Sport and Health Science 2024年第6期13卷 728-731页

作者： Mark S.Tremblay Nicholas Kuzik Markus J.Duncan Diego Augusto Santos Silva cheo Research Institute OttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Federal University of Santa Catarina FlorianopolisSanta Catarina 88040-900Brazil

*** The Olympic motto,"Faster,Higher,Stronger-Together",represents the pursuit of athletic excellence,united as a global community."Excellence,respect and friendship"are the Olympic *** the motto and values are multifaceted and holistic in nature,and all-encompassing in their reach while recognizing no single entity rises above the ***,these foundational statements anchor the Olympic movement in its quest to build a better world through sport.

关键词： movement Together pursuit

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Prevalence of meeting 24-Hour Movement Guidelines from pre-school to adolescence: A systematic review and meta-analysis including 387,437 participants and 23 countries

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Journal of Sport and Health Science 2022年第4期11卷 427-437页

作者： Miguel Angel Tapia-Serrano Javier Sevil-Serrano Pedro Antonio Sanchez-Miguel Jose Francisco Lopez-Gil Mark STremblay Antonio Garcıa-Hermoso Department of Didactics of Musical Plastic and Body ExpressionFaculty of Teaching TrainingUniversity of ExtremaduraAvenida de la UniversidadS/NCaceres 10071Spain Department of Physical Activity and Sport Faculty of Sport ScienceUniversity of Murcia(UM)San Javier 30720Spain Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario(CHEO)Research InstituteOttawaON K1H 8L1Canada Navarrabiomed Public University of Navarra(UPNA)Health Research Institute of Navarra(IdiSNA)Navarra Hospital Complex(CHN)Pamplona 310008Spaia

Background:Meeting the 24-Hour Movement Guidelines(physical activity,screen time,and sleep duration) has been associated with positive health ***,there are no previous meta-analyses that have examined the overall adherence to the 24-Hour Movement Guidelines from pre-school to adolescence across the ***,the main purpose of this systematic review and meta-analysis was to examine the overall(non)adherence to the 24-Hour Movement Guidelines among preschoolers,children,and adolescents ***:Four electronic databases(MEDLINE,Scopus,Web of Science,and Cochrane Database of Systematic Reviews) were searched for quantitative studies published in Spanish and English between January 2016 and May *** that were conducted with apparently healthy participants and reported the overall(non)adherence to the 24-Hour Movement Guidelines in preschoolers and/or children and/or adolescents were ***:Sixty-three studies comprising 387,437 individuals(51% girls) aged 3-18 years from 23 countries were ***,7.12%(95%confidence interval(95%CI):6.45%-7.78%) of youth met all three 24-Hour Movement Guidelines,and 19.21%(95%CI:16.73%-21.69%)met none of the 3 *** sex,adherence to all recommendations was significantly lower in girls(3.75%,95%CI:3.23%-4.27%) than in boys(6.89%,95%CI:5.89%-7.89%)(p <0.001).However,there were no sex differences regarding adherence to any of the 3 individual recommendations(girls,15.66%,95%CI:8.40%-22.92%;boys,12.95%,95%CI:6.57%-19.33%).In terms of age group,adherence to the 3 recommendations was 11.26%(95%CI:8.68%-13.84%),10.31%(95%CI:7.49%-13.12%),and 2.68%(95%CI:1.78%-3.58%) in preschoolers,children,and adolescents,***,8.81%(95%CI:5.97%-11.64%) of preschoolers,15.57%(95%CI:11.60%-19.54%) of children,and 28.59%(95%CI:22.42%-34.75%) of adolescents did not meet any of the *** America was the region with the lowest adherence(all:2.93%;none:3

关键词： Exercise Lifestyle Movement behaviors Sedentary behaviors Youth

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Towards precision 24-hour movement behavior recommendations—The next new paradigm?

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Journal of Sport and Health Science 2024年第6期13卷 743-748页

作者： Mark S.Tremblay Markus J.Duncan Nicholas Kuzik Diego Augusto Santos Silva Valerie Carson cheo Research Institute OttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Federal University of Santa Catarina Santa Catarina 88040900Brazil Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmontonAB T6G 2H9Canada

*** The importance of physical activity(PA)for health is unequivocal.^(1)Accordingly,population-based recommendations for exercise,and more recently public health guidelines for PA,have been developed and released by authoritative groups for many decades.^(2)Such guidelines emerged with leadership from the exercise physiology discipline and were rooted in,and loyal to,the importance of moderate-to-vigorous intensity PA(MVPA)or exercise.

关键词： movement behavior exercise

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Quality improvement in pediatric inflammatory bowel disease: Moving forward to improve outcomes

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World Journal of Gastroenterology 2013年第38期19卷 6367-6374页

作者： Pauline Quach Geoffrey C Nguyen Eric I Benchimol cheo IBD Centre Division of GastroenterologyHepatology and NutritionChildren’s Hospital of Eastern OntarioOttawa K1H 8L1Canada Institute for Clinical Evaluative Sciences Ottawa K1Y 4E9Canada Zane Cohen Center for Digestive Research Division of GastroenterologyMount Sinai HospitalToronto M5T 3L9Canada Department of Medicine University of TorontoToronto M5S 2J7Canada Departments of Pediatrics Epidemiology and Community MedicineUniversity of OttawaOttawa K1H 8M5Canada

In recent years,pediatric health care has embraced the concept of quality improvement to improve patient *** quality improvement efforts are implemented,network collaboration(where multiple centers and practices implement standardized programs)is a popular *** a collaborative network,improvement in the conduct of structural,process and outcome quality measures can lead to improvements in overall health,and benchmarks can be used to assess and compare *** this review article,we provided an overview of the quality improvement movement and the role of quality indicators in this *** reviewed current quality improvement efforts in pediatric inflammatory bowel disease (IBD),as well as other pediatric chronic *** discussed the need to standardize the development of quality indicators used in quality improvement networks to assess medical care,and the validation techniques which can be used to ensure that process indicators result in improved outcomes of clinical *** aimed to assess current quality improvement efforts in pediatric IBD and other diseases,such as childhood asthma,childhood arthritis,and neonatal *** doing so,we hope to learn from their successes and failures and to move the field forward for future improvements in the care provided to children with IBD.

关键词： Inflammatory bowel disease Colitis Ulcerative Crohn’s disease Child Adolescent Quality of health care Review

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Associations between meeting 24-hour movement guidelines and quality of life among children and adolescents with autism spectrum disorder

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Journal of Sport and Health Science 2023年第1期12卷 73-86页

作者： Chuidan Kong Aiguo Chen Sebastian Ludyga Fabian Herold Sean Healy Mengxian Zhao Alyx Taylor Notger G.Muller Arthur F.Kramer Sitong Chen Mark S.Tremblay Liye Zou Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen 518061China College of Physical Education Yangzhou UniversityYangzhou 225127China Department of Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland Research Group Degenerative and Chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam 14476Germany Community Health Academic Group School of NursingPsychotherapy and Community HealthDublin City UniversityDublin 9Ireland School of Rehabilitation Sport and PsychologyAECC University CollegeBournemouthBH52DFUK Research Group Neuroprotection German Center for Neurodegenerative Diseases(DZNE)Magdeburg 39120Germany Center for Behavioral Brain Sciences(CBBS) Magdeburg 39118Germany Center for Cognitive and Brain Health Northeastern UniversityBostonMA 02115USA Beckman Institute University of Illinois at Urbana-ChampaignChampaignIL 61820USA Institute for Health and Sport Victoria UniversityMelbourne 8001Australia Healthy Active Living and Obesity Research Group CHEO Research InstituteOttawaOntario K1H8L1Canada Department of Pediatrics University of OttawaOttawaOntario K1N 6N5Canada

Background:The Canadian 24-hour movement behavior(24-HMB)guidelines suggest that a limited amount of screen time use,an adequate level of physical activity(PA),and sufficient sleep duration are beneficial for ensuring and optimizing the health and quality of life(QoL)of children and ***,this topic has yet to be examined for children and adolescents with autism spectrum disorder(ASD)*** aim of this cross-sectional observational study was to examine the associations between meeting 24-HMB guidelines and several QoLrelated indicators among a national sample of American children and adolescents with ***:Data were taken from the 2020 *** Survey of Children’s Health ***(n=956)aged 617 years and currently diagnosed with ASD were *** exposure of interest was adherence to the 24-HMB *** were QoL indicators,including learning interest/curiosity,repeating grades,adaptive ability,victimization by bullying,and behavioral *** variables were described with unweighted sample counts and weighted ***,sex,race,preterm birth status,medication,behavioral treatment,household poverty level,and the educational level of the primary caregivers were included as *** ratio(OR)and 95%confidence interval(95%CI)were used to present the strength of association between adherence to 24-HMB guidelines and QoL-related ***:Overall,452 participants(45.34%)met 1 of the 3 recommendations,216(22.65%)met 2 recommendations,whereas only 39 participants(5.04%)met all 3 *** with meeting none of the recommendations,meeting both sleep duration and PA recommendations(OR=3.92,95%CI:1.639.48,p<0.001)or all 3 recommendations(OR=2.11,95%CI:1.034.35,p=0.04)was associated with higher odds of showing learning interest/*** both screen time and PA recommendations(OR=0.15,95%CI:0.040.61,p<0.05)or both sleep duration and PA recommendations(OR=0.24,95

关键词： 24-hour movement guidelines Autism spectrum disorder Physical activity Quality of life

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Comparison of pediatric ventriculoperitoneal shunt infections arising in antibiotic-impregnated and standard catheters:a multicenter observational study

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World Journal of Pediatric Surgery 2023年第3期6卷 196-199页

作者： Joan Robinson Archana Balamohan Michelle Barton Marie-Astrid Lefebvre Ahmed Almadani Dolores Freire Alastair McAlpine Jocelyn Srigley Patrick Passarelli John Bradley Dele Davies Gwenn Skar Isabelle Viel-Theriault Sarah Khan Rupeena Purewal Nicole LeSaux Jennifer Bowes Michael Hawkes 无 Department of Pediatrics University of AlbertaEdmontonAlbertaCanada University of Arkansas for Medical Sciences Little RockArkansasUSA Arkansas Children's Hospital Little RockArkansasUSA Western University LondonOntarioCanada McGill University Faculty of Medicine MontrealQuebecCanada Umm Al-Qura University MakkahSaudi Arabia University of Alberta EdmontonAlbertaCanada The University of British Columbia VancouverBritish ColumbiaCanada Pediatrics Rady Children's Hospital San DiegoSan DiegoCaliforniaUSA Arnot Ogden Medical Center ElmiraNew YorkUSA Rady Children's Hospital San Diego San DiegoCaliforniaUSA Pediatrics University of Nebraska Medical CenterOmahaNebraskaUSA University of Nebraska Medical Center OmahaNebraskaUSA Laval University QuebecQuebecCanada McMaster University HamiltonOntarioCanada University of Saskatchewan SaskatoonSaskatchewanCanada cheo OttawaOntarioCanada for the Pediatric Investigators Collaborative Network on Infections in Canada(PICNIC)

Antibiotic-impregnated ventricular shunt catheters(AIVSCs)with 0.15%clindamycin and 0.054%rifampin are commonly used to prevent ventriculo-peritoneal(VP)shunt *** approved by the United States Food and Drug Administration in 2003(https://***/file/general/***),they have antimicrobial activity documented for minimum 31 days(https://***/cdrh_docs/pdf11/***).These antibiotics were chosen as they cover the majority of Staphylococcus aureus and may provide some activity against coagulase negative staphylococci.1 These normal skin flora account for the majority of VP shunt *** the largest randomized controlled trial(RCT)to date,AIVSCs significantly reduced the risk of infection compared with standard shunts(cause-specific hazard ratio(HR)0.38).2 This effect was mainly due to a reduction in staphylococcal infections;the number of gram-negative infections was similar in both *** studies3–5 and a meta-analysis6 in children support the findings of this *** objective of this study was to examine the spectrum of pathogens,time to infection,and outcomes with AIVSCs vs standard shunts.

关键词： shunt infections peritoneal

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