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A secondary bile acid from microbiota metabolism attenuates ileitis and bile acid reduction in subclinical necrotic enteritis in chickens

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Journal of Animal Science and Biotechnology 2020年第3期11卷 767-776页

作者： Mohit Bansal Ying Fu Bilal Alrubaye Mussie Abraha Ayidh Almansour Anamika Gupta Rohana Liyanage Hong Wang Billy Hargis Xiaolun Sun Center of Excellence for Poultry Science University of Arkansas1260 W Maple St.O409FayettevilleAR 72701USA cemb University of ArkansasFayettevilleAR 72701USA Department of Chemistry University of ArkansasFayettevilleAR 72701USA.

Background:Clostridium perfringens-induced chicken necrotic enteritis(NE)is responsible for substantial economic losses worldwide ***,as a result of antibiotic growth promoter prohibition,the prevalence of NE in chickens has *** study was aimed to reduce NE through titrating dietary deoxycholic acid(DCA)as an effective antimicrobial *** and methods:Day-old broiler chicks were assigned to six groups and fed diets supplemented with 0(basal diet),0.8,1.0 and 1.5 g/kg(on top of basal diet)*** birds were challenged with Eimeria maxima(20,000 oocysts/bird)at d 18 and ***(109 CFU/bird per day)at d 23,24,and 25 to induce *** birds were sacrificed at d 26 when ileal tissue and digesta were collected for analyzing histopathology,mRNA accumulation and *** colonization by real-time PCR,targeted metabolomics of bile acids,fluorescence in situ hybridization(FISH),or terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)***:At the cellular level,birds infected with *** and *** developed subclinical NE and showed shortening villi,crypt hyperplasia and immune cell infiltration in *** DCA alleviated the NE-induced ileal inflammation in a dose-dependent manner compared to NE control *** with the increased histopathological scores,subclinical NE birds suffered body weight gain reduction compared to the uninfected birds,an effect attenuated with increased doses of dietary *** the molecular level,the highest dose of DCA at 1.5 g/kg reduced *** luminal colonization compared to NE birds using PCR and ***,the dietary DCA reduced subclinical NE-induced intestinal inflammatory gene expression and cell apoptosis using PCR and TUNEL *** further examining ileal bile acid pool through targeted metabolomics,subclinical NE reduced the total bile acid level in ileal digesta compared to uninfected ***,dietary DCA increased total

关键词： Bile acid Chicken Clostridium perfringens Deoxycholic acid Intestinal inflammation Necrotic enteritis

Risk Assessment and Biosafety Studies of Transgenic Bt Rice （Oryza sativa L.）

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Journal of Agricultural Science and Technology 2010年第4期4卷 1-9页

作者： N. Muhammad Mahmood-ur-Rahman A. A. Shahid T. Husnain and S. Riazuddin National Center of Excellence in Molecular Biology （cemb） 87-West Canal Bank Road University of the Punjab Lahore 53 700Pakistan

Transgenic crops having alien genes from different sources are getting popularity. A Rice （Oryza sativa L.） containing gene from Bacillus thuringiensis, a soil bacterium, was assessed to study the potential risks of transgenic plants on environment. The crop was found resistant to target insect pests. Rice variety Basmati-370 transformed with two insecticidal genes, crylAc and cry2A, was grown under field conditions for several years. Data were collected at different stages of the plant growth. Fate of Cry protein in soil, effect of Bt protein on non-target insects, risks of vertical and horizontal gene flow were evaluated. No potential hazard was found at all levels. Bt protein was unstable and degraded significantly in soil within 30 days after harvesting the crop. No harmful effects were found on non-target insects （insects other than order lepidoptera）. Maximum gene flow of 0.02% was observed at close spacing and no evidence of horizontal gene transfer to Rhizobium spp. was found. In conclusion, the transgenic rice plants transformed with Bt genes have no harmful effects on the environment.

关键词： Bacillus thuringiensis transgenic Bt rice (Oryza sativa L.) vertical gene flow horizontal gene transfer non-target insects genetically modified crops.

HIV/AIDs Risk Perception and Sexual Behavior among Commercial Female Sex Worker in Thailand

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World Journal of AIDS 2022年第3期12卷 141-155页

作者： Phrutthinun Surit Sukkid Yasothornsrikul Ratchanee Mitkitti Facuty of Medical Science and Centre of Excellence in Medical Biotechnology (cemb) Naresuan University Phitsanulok Thailand School of Nursing Mae Fah Luang University Chiangrai Thailand

Background: Commercial female sex workers (CFSWs) are considered a high-risk group for HIV/AIDs. The prevalence of HIV/AIDs trends to increase among those groups also in Thailand. An adequate perception of the degree to which one is at risk of having HIV is necessary for behavioral change and of safe behaviors. HIV/AIDs risk perception among CFSWs was needed to reduce HIV/AIDs infection. Methods: A cross-sectional study was conducted among 141 CFSWs in Bangkok, Thailand. Participants were selected using convenient and purposive sampling methods for January to October 2019. Self-access questionnaire was used for collecting data with the reliability testing of 0.82. Logistic regression employed to identify adjusted odd ratio between demographic data, sexual behaviors and HIV/AIDs risk perception, p-value less than 0.05 was considered statistically significant. Results: 51.77% of CFSWs perceived themselves at high risk for HIV/AIDs infection. Most CFSWs reported that they did not consistently use condom (57.45%), factors associated with perception risk of HIV/AIDs including education level (adjusted OR = 2.23, 95% CI = 1.07 - 4.54), knowledge of HIV and STDs (adjusted OR = 3.65 and 3.22. 95% CI = 1.89 - 3.91), Condom use (adjusted OR = 2.56, 95% CI = 1.05 - 2.90) years engaged in sex work, age of initiating in sex work, frequency of sex work in the last month and unplanned sex work were significant with risk perception of HIV/AIDs (adjusted OR = 3.33, 2.71, 2.67, 2.56 and 95% CI = 1.99 - 3.84, 1.72 - 3.32, 1.29 - 3.12, 1.05 - 2.78 respectively), and had HIV/STDs test (adjusted OR = 3.22, 95% CI = 2.11 - 3.95). Other used illicit drugs by injection, smoking and alcohol consumption had a strong association with the high perception of HIV/AIDs among CFSWs. Conclusion: Majority of CFSWs with risky sexual behaviors had a high HIV/AIDs risk perception. Effective educational programmes are necessary to enable CFSWs to correctly assess their own HIV/AIDs risk and change risk b

关键词： Commercial Female Sex Workers HIV/AIDs Prevalence Sexually Transmitted Infection Epidemiology

Zika virus: Is Pakistan next?

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Asian Pacific Journal of Tropical Medicine 2018年第7期11卷 451-452页

作者： Braira Wahid Amjad Ali Shazia Rafique Muhammad Idrees Genome Centre for Molecular Based Diagnostics and Research Cl-25 Block B Al-Sudais Plaza Abdalian Cooperative Society Centre for Applied Molecular Biology (CAMB) 87-West Canal Bank Road Thokar Niaz Baig University of the Punjab Division of Molecular Virology and Diagnostics Center of Excellence in Molecular Biology (cemb) 87-West Canal Bank Road Thokar Niaz Baig University of the Punjab Vice Chancellor Hazara University Mansehra

Dear editor,Zika virus(ZIKV)crisis,which caught Brazil in 2015,heralded the rapid spread throughout Americas and has imparted catastrophic devastation to human population in the form of severe

关键词： Aedes ZIKV Microcephaly Deaths

Application of Capture and Recapture Method for Estimating the Population Size of Men Who Have Sex with Men in Chiang Mai, Thailand

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World Journal of AIDS 2016年第4期6卷 197-204页

作者： Phrutthinun Surit Ning Zheng He Yi Xiaojing Yu Watcharee Srithong Saisiri Mirasena Wutthichai Jariya Faculty of Medical Science Naresuan University Phitsanulok Thailand Center of Excellence in Medical Biotechnology (cemb) Phitsanulok Thailand Shanghai Municipal Center for Disease Control & Prevention Shanghai China Faculty of Public Health Naresuan University Phitsanulok Thailand

Background: Men who have sex with men (MSM) are highly vulnerable to HIV infection, but this population can be particularly difficult to reach in Thailand. This study aimed to estimate the number of MSM in Chiang Mai Thailand, in order to plan HIV control and prevention. Methods: The total of 348 potential MSM were identified at eight contact locations, including two public parks, two bars, two massage parlors and two pubs in Chiang Mai. Trained 16 research enumerators and 16 enumerators were trained to extend a recruitment of brooches to MSM. The MSMs were captured one week apart. A record was kept of when, where and by whom the invitation was extended and received, and of refusals. The total estimate of MSM was derived from capture-recapture calculation. Results: The total MSM in Chiang Mai Thailand estimated by capture and recapture method was 733 (95%CI = 480 - 948) or the estimate was 7.3% (95%CI = 7.1% - 14.1%). Conclusions: Capture and recapture method can be used to enumerate and provide accurate and reliable estimates of the MSM population in any area, provided that certain conditions are controlled. MSM who are engaged in personal community represent a sizeable population who urgently need to be targeted by HIV and STDs prevention strategies.

关键词： MSM HIV Capture and Recapture Thailand

Risk Factors Affecting Condom Use among Royal Thai Army Conscripts in Thailand

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World Journal of AIDS 2017年第2期7卷 92-105页

作者： Phrutthinun Surit Wutthichai Jariya Ning Zheng He Yi Xiaojing Yu Watcharee Srithong Saisiri Mirasena Faculty of Medical Science Naresuan University Phitsanulok Thailand Center of Excellence in Medical Biotechnology (cemb) Naresuan University Phitsanulok Thailand Faculty of Public Health Naresuan University Phitsanulok Thailand Shanghai Municipal Center for Disease Control & Prevention Shanghai China

The study was conducted to explore factors associated with condom use of young Thai men conscripts. Methods: A cross-sectional study was conducted. Participants were 159 conscripts in second year who served in the Royal Thai Army by lottery method. Demographic data, sexual history including condom use, HIV and STDs and knowledge were collected using a self-administered questionnaire. Logistic regression was used to analyze the data. Results: Condom use at the last sex was 41.18% of the conscripts aged 20 - 27 years and secondary school education completed of 74.2%. 25.78% had experience with drugs used but injection was rare (6.9%). Age at the first sex was reported lowest at 11 years, 9.4% reported first sex with men and 21.38% were married. The participants have sexual history (last six months) with female only of 83.2%, male only of 4.1% and both of 14.6%. Among these only 12.6% reported every time of condom use and 19.5% never used condom. Older age, higher education, drinking alcohol, drugs use and higher knowledge were associated with condom use with statistical significance. Conclusions: Condom use among male Thai conscripts was low. Education and a condom use program are urgently needed to prevent future spread of HIV and STDs.

关键词： Conscript Condom AIDs Sexually Transmitted Diseases Thailand

SCREENING AND MOLECULAR CHARACTERIZATION OF FUNGI CAPABLE OF LACCASE PRODUCTION FROM DIFFERENT FOREST ECOSYSTEMS OF MICHOACAN STATE,MEXICO

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SCREENING AND MOLECULAR CHARACTERIZATION OF FUNGI CAPABLE OF...