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Helicobacter pylori gamma-glutamyl transpeptidase and its pathogenic role

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World Journal of Gastroenterology 2014年第3期20卷 630-638页

作者： Vittorio Ricci Maria Giannouli Marco Romano Raffaele Zarrilli Department of Molecular Medicine Human Physiology SectionUniversity of Pavia Medical School Department of Public Health Hygiene SectionUniversity of Naples "Federico Ⅱ" Department of Clinical and Experimental Medicine Chair of GastroenterologySecond University of Naples ceinge biotecnologie avanzate

Helicobacter pylori(***)gamma-glutamyl transpeptidase(GGT)is a bacterial virulence factor that converts glutamine into glutamate and ammonia,and converts glutathione into glutamate and *** GGT causes glutamine and glutathione consumption in the host cells,ammonia production and reactive oxygen species *** products induce cell-cycle arrest,apoptosis,and necrosis in gastric epithelial *** GGT may also inhibit apoptosis and induce gastric epithelial cell proliferation through the induction of cyclooxygenase-2,epidermal growth factor-related peptides,inducible nitric oxide synthase and *** GGT induces immune tolerance through the inhibition of T cell-mediated immunity and dendritic cell *** effect of GGT on *** colonization and gastric persistence are also discussed.

关键词： Helicobacter pylori Gamma-glutamyl transpeptidase Bacterial virulence factor Gastric epithelial cell damage T cell-mediated immunity

Hereditary gastrointestinal polyposis: Diagnosis, genetic test and risk assessment

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Open Journal of Genetics 2013年第2期3卷 50-58页

作者： Marina De Rosa Francesca Duraturo Raffaella Liccardo Paola Izzo Dipartimento di Medicina Molecolare e biotecnologie Mediche and ceinge biotecnologie avanzate Università di Napoli Federico II Naples Italy

Colorectal cancer (CRC) is the second cause of cancer deaths, with over 1 million new cases estimated every year. Familial adenomatous polyposis, MUTYH-associated polyposis and hamartomatous polyposis are inherited syndromes that account for 2%-5% of all colon cancer. The mutated genes responsible for the vast majority of these disorders, are now known (MLH1, MSH2, MSH6, PMS2, APC, MYH, LKB1, SMAD4, BMPR1A, and PTEN) and specific mutations have been identified. Molecular caracterization of inherited CRCs allows pre-symptomatic diagnosis identifying at-risk individuals and improving cancer surveillance. Adenomatous polyposis includes familial adenomatous polyposis (FAP), attenuated FAP (AFAP), and MUTYH-associated polyposis (MAP). Hamartomatous polyposis comprises Peutz-Jeghers syndrome (PJS), juvenile polyposis syndrome (JPS) and “PTEN hamartoma tumour syndrome” (PHTS). MAP is an autosomal recessive condition, while all other disorders are inherited in an autosomal dominant manner. Differential dyagnosis could be very difficult between syndromes because of their phenotypic variability. Attenuated FAP, MAP and Lynch syndrome could be all associated with fewer numbers of adenomas (3-10 polyps), nevertheless, each syndrome has distinct cancer risks, characteristic clinical features, and separate genetic etiologies. Thus, differential diagnosis is essential for correct management of the specific disease. In our laboratory we set up a methodology for genetic tests of the colorectal polyposis syndrome. In these reviews we summarize the literature data and our experience about diagnosis, genetic tests and cancer risk assesment associated with colorectal polyposis. According to literature data, in our experience, there is a portion of analyzing patients that remain without identified mutation, after molecular screening of the specific gene involved in the pathogenesis of the disease. Since the sensibility of used techniques, such as DHPLC, MLPA and sequencing, is now very h

关键词： Familial Adenomatous Polyposis (FAP) MUTYH-Associated Polyposis (MAP) Peutz-Jeghers Syndrome (PJS) PTEN Hamartoma Tumour Syndrome (PHTS)

The physiological polyphosphate as a healing biomaterial for chronic wounds:Crucial roles of its antibacterial and unique metabolic energy supplying properties

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Journal of Materials Science & Technology 2023年第4期135卷 170-185页

作者： Werner E.G.Müller Hadrian Schepler Meik Neufurth Shunfeng Wang Veronica Ferrucci Massimo Zollo Rongwei Tan Heinz C.Schröder Xiaohong Wang ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry University Medical Center of the Johannes Gutenberg UniversityDuesbergweg 6Mainz D-55128Germany Department of Dermatology University Clinic MainzLangenbeckstr.1Mainz D-55131Germany Dipartimento di Medicina Molecolare e biotecnologie Mediche Universitàdegli Studi di Napoli Federico IIVia Sergio Pansini 5Naples 80131Italy ceinge biotecnologie avanzate Francesco Salvatore Via G.Salvatore 486Naples 80145Italy Shenzhen Lando Biomaterials Co. Ltd.Shenzhen 518107China

Insufficient metabolic energy,in the form of adenosine triphosphate(ATP),and bacterial infections are among the main causes for the development of chronic *** we showed that the physi-ological inorganic polymer polyphosphate(polyP)massively accelerates wound healing both in animals(diabetic mice)and,when incorporated into mats,in patients with chronic ***,we focused on a hydrogel-based gel formulation,supplemented with both soluble sodium polyP(Na-polyP)and amor-phous calcium polyP nanoparticles(Ca-polyP-NP).Exposure of human epidermal keratinocytes to the gel caused a significant increase in extracellular ATP level,an effect that was even enhanced when Na-polyP was combined with ***,it is shown that the added polyP in the gel is converted into a coacervate,leading to encapsulation and killing of *** data on human chronic wounds showed that the administration of hydrogel leads to the complete closure of these *** analysis of biopsies showed an increased granulation of the wounds and an enhanced microvessel *** results indicate that the polyP hydrogel,due to its properties to entrap bacteria and generate metabolic energy,is a very promising formulation for a new therapy for chronic wounds.

关键词： Inorganic polyphosphate Nanoparticles Hydrogel Coacervate Human chronic wounds Antibacterial activity Metabolic energy

Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis

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World Journal of Gastroenterology 2013年第46期19卷 8659-8670页

作者： Martina Galatola Erasmo Miele Caterina Strisciuglio Lorella Paparo Daniela Rega Paolo Delrio Francesca Duraturo Massimo Martinelli Giovanni Battista Rossi Annamaria Staiano Paola Izzo Marina De Rosa Department of Molecular Medicine and Medical Biotechnology and ceinge biotecnologie avanzate University of Naples"FedericoⅡ" Department of Translational Medical Sciences Section of PediatricsUniversity of Naples"FedericoⅡ" Colorectal Surgical Oncology-Abdominal Oncology Department Istituto Nazionale per lo studio e la cura dei tumori"Fondazione Giovanni Pascale"IRCCS-80131 NaplesItaly Endoscopy Unit Istituto Nazionale per lo studio e la cura dei tumori"Fondazione Giovanni Pascale"IRCCS-80131 NaplesItaly

AIM: To investigated the molecular cause of very early-onset ulcerative colitis (UC) in an 18-mo-old affected child.

关键词： Inflammatory bowel disease, Ulcerative colitis, Interleukin 10 receptors, Tumour necrosis factor α receptors, Beta catenin

Awake laparoscopic cholecystectomy:A case report and review of literature

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World Journal of Clinical Cases 2023年第13期11卷 3002-3009页

作者： Chiara Mazzone Maria Sofia Iacopo Sarvà Giorgia Litrico Andrea Maria Luca Di Stefano Gaetano La Greca Saverio Latteri Dipartimento di Scienze Mediche Chirurgiche e Tecnologie Avanzate"G.F.Ingrassia"Universitàdegli Studi di CataniaCatania 95123Italy

BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most widely practiced surgical procedures in abdominal *** undergo LC during general anaesthesia;however,in recent years,several studies have suggested the ability to perform LC in patients who are *** report a case of awake LC and a literature *** SUMMARY A 69-year-old patient with severe pulmonary disease affected by cholelithiasis was scheduled for LC under regional *** first performed peridural anaesthesia at the T8-T9 level and then spinal anaesthesia at the T12-L1 *** procedure was managed in total comfort for both the patient and the *** intra-abdominal pressure was 8 *** patient remained stable throughout the procedure,and the postoperative course was *** Evidence has warranted the safe use of spinal and epidural anaesthesia,with minimal side effects easily managed with *** anaesthesia in selected patients may provide some advantages over general anaesthesia,such as no airway manipulation,maintenance of spontaneous breathing,effective postoperative analgesia,less nausea and vomiting,and early ***,this technique for LC is not widely used in Europe;this is the first case reported in Italy in the *** anaesthesia is feasible and safe in performing some types of laparoscopic *** studies should be carried out to introduce this type of anaesthesia in routine clinical practice.

关键词： Laparoscopic cholecystectomy Awake surgery Awake laparoscopy Gallstone disease Regional anaesthesia Spinal anesthesia Case report

Metastatic tumors to the stomach: Clinical and endoscopicfeatures

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World Journal of Gastroenterology 2006年第45期12卷 7326-7328页

作者： Giovanni D De Palma Stefania Masone Maria Rega Immacolata Simeoli Mario Donisi Pietro Addeo Loredana Iannone Vincenzo Pilone Giovanni Persico Centro per l'Innovazione Tecnologica in Chirurgia Dipartimento di Chirurgia Generale Oncologica e Tecnologie Avanzate. Università degli Studi di Napoli Federico II Facoltà di Medicina e Chirurgia Napoli Italy Centro per l’Innovazione Tecnologica in Chirurgia Dipartimento di Chirurgia Generale Oncologica e Tecnologie Avanzate. Università degli Studi di Napoli Federico II Facoltà di Medicina e Chirurgia Napoli Italy

AIM: To evaluate the clinical and endoscopic patterns in a large series of patients with metastatic tumors in the stomach. METHODS: A total of 64 patients with gastric meta- stases from solid malignant tumors were retros- pectively examined between 1990 and 2005. The clinicopathological findings were reviewed along with tumor characteristics such as endoscopic pattern, location, size and origin of the primary sites. RESULTS: Common indications for endoscopy were anemia, bleeding and epigastric pain. Metastases presented as solitary (62.5%) or multiple (37.5%) tumors were mainly located in the middle or upper third of stomach. The main primary metastatic tumors were from breast and lung cancer and malignant melanoma. CONCLUSION: As the prognosis of cancer patients has been improving gradually, gastrointestinal (GI) metastases will be encountered more often. Endoscopic examinations should be conducted carefully in patients with malignancies, and endoscopic biopsies and information on the patient’s clinical history are useful for correct diagnosis of gastric metastases.

关键词： Stomach Metastatic tumors Clinical findings Pathology Endoscopy

Actively bleeding Dieulafoy's lesion of the small bowel identified by capsule endoscopy and treated by push enteroscopy

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World Journal of Gastroenterology 2006年第24期12卷 3936-3937页

作者： Giovanni D De Palma Francesco Patrone Maria Rega Immacolata Simeoli Stefania Masone Giovanni Persico Centro per l'Innovazione Tecnologica in Chirurgia-Dipartimento di Chirurgia Generale Oncologica e Tecnologie avanzate Universita degli Studi di Napoli Federico Ⅱ Facoltà di Medicina e ChirurgiaNapoliItaly

Dieulafoy＇s lesion is an unusual cause of recurrent GI bleeding. This report describes a case of actively bleeding Dieulafoy＇s lesion of the small bowel in which the diagnosis was made by capsule endoscopy, followed by treatment with the use of push enteroscopy. The case illustrates that capsule endoscopy and enteroscopy are highly complementary in patients with small bowel diseases.

关键词： Dieulafoy's lesion GI hemorrhage Smallbowel Capsule endoscopy Push enteroscopy

Endoscopic management of intragastric penetrated adjustable gastric band for morbid obesity

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World Journal of Gastroenterology 2006年第25期12卷 4098-4100页

作者： Giovanni D De Palma Antonio Formato Vincenzo Pilone Maria Rega Maria Elena Giuliano Immacolata Simeoli Pietro Forestieri Centro per l'Innovazione Tecnologica in Chirurgia (ITC)-Dipartimento di Chirurgia Generale Oncologica e Tecnologie avanzate.Università degli Studi di Napoli Federico Ⅱ Facoltà di Medicina e Chirurgia NapoliItaly

This report describes a case of successful endoscopic management of intragastric penetrated adjustable gastric band in a patient with morbid obesity. The favorable course of the case described here demonstrates that adjustable gastric bands in the process of migration need not be removed surgically in patients who are asymptomatic.

关键词： Morbid obesity Adjustable gastric band Complications Endoscopy Endoscopic therapy

Conventional colonoscopy and magnified chromoendoscopy for the endoscopic histological prediction of diminutive colorectal polyps: A single operator study

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World Journal of Gastroenterology 2006年第15期12卷 2402-2405页

作者： Giovanni D De Palma Maria Rega Stefania Masone Marcello Persico Saverio Siciliano Pietro Addeo Giovanni Persico Centro di Eccellenza per 1'Innovazione Tecnologica in Chirurgia Dipartimento di Chirurgia Generale e Tecnologie avanzate Università degli Studi di Napoli Federico ⅡFacoltà di Medicina e ChirurgiaNapoliItaly

AIM： To accurately differentiate the adenomatous from the non-adenomatous polyps by colonoscopy. METHODS： All lesions detected by colonoscopy were first diagnosed using the conventional view followed by chromoendoscopy with magnification. The diagnosis at each step was recorded consecutively. All polyps were completely removed endoscopically for histological evaluation. The accuracy rate of each type of endoscopic diagnosis was evaluated, using histological findings as gold standard. RESULTS： A total of 240 lesions were identified, of which 158 （65.8%） were non-neoplastic and 82 （34.2%） were adenomatous. The overall diagnostic accuracy of conventional view, and chromoendoscopy with magnification was 76.3% （183/240） and 95.4% （229/240）, respectively （P〈 0.001） CONCLUSION： The combination of colonoscopy and magnified chromoendoscopy is the most reliable nonbiopsy method for distinguishing the non-neoplastic from the neoplastic lesions.

关键词： Colorectal polyps Colonoscopy Chromoendoscopy Magnifying endoscopy