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Effects of Cold Spells on Mortality — Ningbo City, Zhejiang Province, China, 2014–2018

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China cdc weekly 2022年第16期4卷 342-346,I0002页

作者： Hejia Song Yonghong Li Yibin Cheng Yushu Huang Rui Zhang Xiaoyuan Yao China cdc Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina

Summary What is already known about this topic?In recent years,climate change may lead to an increase in cold spells in the middle latitudes,and there is a positive correlation between cold spells and population *** is added by this report?The acute response period and the vulnerable population were identified under the optimal definition of cold spells,and the mortality burden caused by cold spells were *** are the implications for public health practice?This research would provide evidence on the acute mortality effects of cold spells in southern ***,vulnerable populations,especially the elderly,should take timely measures to reduce the health damage caused by cold spells,especially in the first week after cold waves.

关键词： Ningbo China. measures

Y-chromosomal STR haplotypes in Chinese Tuvans in the Altay region

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Y-chromosomal STR haplotypes in Chinese Tuvans in the Altay ...

First report of human infection by Rhodoplanes sp.,Alphaproteobacteria in China

中国的遗传学研究——遗传学进步推动中国西部经济与社会发展——2011年中国遗传学会大会

作者： Yeerhazi Zaerhumaer Center for Disease Control and Prevention(cdc)

Allele and haplotype frequencies of 12 Y-chromosomal short tandem repeats(STRs) included in the PowerPlex Y Systems(Promega) were determined in a sample of 150 unrelated healthy male individuals of Chinese Tuvans living in the Altay region of Xinjiang Uygut Autonomous *** frequencies and gene diversity for each Y-STR locus were determined The observed haplotype diversity value was *** present results can be used as Chinese Tuvan genetic information resources in routine population study and forensic analysis.

关键词： Y chromosomal STR haplotype Chinese Tuvans population data

来源： cnki会议评论

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Asian Pacific Journal of Tropical Medicine 2011年第3期4卷 248-250页

作者： Zhang LJ Wang GQ Yu HL Wang J Wang SW Jia Y Yu YY Xu JG Department of Rickettsiology National Institute of Communicable Disease Control and PreventionChina CDC Department of Infectious Diseases Peking University First Hospital Department of Infectious Diseases Peking UniversityFirst Hospital

We isolated a novel strain of Alphaproteobacteria from a patient,who had medical history of chronic rhinitis for more than twenty years and recently experienced local skin abscess and ulcer. He eventually died of multiple organ failure due to multi-antibiotics *** identified the microorganism by 16SrRNA sequencing and found that it belonged to the genus Rhodoplanes. It was named as Rhodoplanes *** *** is resumed that Rhodoplanes *** ZLJ-0 might be an emerging human pathogen involving in unknown febrile conditions and could cause local infection of any tissues or *** diagnosis of febrile patients should be conducted in clinical practice and research on emerging pathogens of Alphaproteobacteria should be performed to determine the epidemiology,clinical symptoms and pathogenic features of these pathogens.

关键词： Rhodoplanes sp. Infection Alphaproteobacteria Isolation Pathogen

Oxidative Damage to BV2 Cells by Trichloroacetic Acid:Protective Role of Boron via the p53 Pathway

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Biomedical and Environmental Sciences 2022年第7期35卷 657-662页

作者： WANG Chong HUANG Wei LI Li WANG Chao SHI Ying TANG Song GU Wen XU Yong Jun ZHANG Li Xia ZHANG Ming DUAN Lian ZHAO Kang Feng China cdc Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China The Afffiliated Shunde Hospital of Guangzhou Medical University Foshan 528315GuangzhouChina

This study aimed to investigate the neurotoxicity induced by trichloroacetic acid(TCA)and the possible protective mechanisms of boron(B).Mouse BV2 cells were treated with TCA(0,0.39,0.78,1.56,3.12,6.25,or 12.5 mmol/L)and B(0,7.8,15.6,31.25,62.5,125,500,or 1,000 mmol/L)for 3 h and 24 h,***,reactive oxygen species,and supernatant proinflammatory cytokine and protein levels were analyzed after 24 h of combined *** the dose-dependent decrease in the cellular viability,it clearly increased after B supplementation(P<0.05).Moreover,B decreased oxidative damage,and significantly down-regulated IL-6 levels and up-regulated TNF-βproduction(P<0.05).B also decreased apoptosis via the p53 *** present findings indicated that TCA may induce oxidative damage,whereas B mitigates these adverse effects by decreasing cell apoptosis.

关键词： BV2 protective damage

Natural killer cells are activated and play a protective role against ZIKA virus infection in mice

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Science Bulletin 2017年第14期62卷 982-984页

作者： Xuefeng Duan Shihua Li Gary Wong Dongfang Wang Haoyu Wang Jiao Lu Yuhai Bi Xuancheng Lu Yi Shi Jinghua Yan Min Fang George Fu Gao CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Health Sciences Anhui University Laboratory Animal Center Chinese Center for Disease Control and Prevention (China CDC) International College University of Chinese Academy of Sciences National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention (China CDC) Savaid Medical School University of Chinese Academy of Sciences Research Network of Immunity and Health (RNIH) Beijing Institutes of Life Science Chinese Academy of Sciences

Zika virus(ZIKV)is a mosquito-borne Flavivirus that was responsible for an epidemic in the Americas during 2015–2016[1].ZIKV infections in adults have been linked to Guillain-Barrésyndrome[2,3],as well as abnormalities such as abortion,stillbirth,and microcephaly in some cases[4].In addition,we have reported that ZIKV infect testicular stem-like peritubular

关键词：病毒感染细胞活性保护作用杀伤自然小鼠对齐

Isolated Cases of Plague--Inner Mongolia-Beijing, 2019

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China cdc weekly 2019年第1期1卷 13-16页

作者： Yumeng Wang Lei Zhou Mengguang Fan Quanyi Wang Jianyun Li Qun Li Zijian Feng George FGao Cheng Xu Lijuan Chen Wei Li Yanping Zhang National Institute for Communicable Disease Control and Prevention China CDCChangpingBeijingChina State Key Laboratory of Infectious Disease Prevention and Control BeijingChina Chinese Center for Disease Control and Prevention BeijingChina General Center for Disease Control and Prevention of Inner Mongolia Autonomous Region HohhotChina Beijing Center for Disease Control and Prevention BeijingChina The Base for Control and Prevention of Plague and Brucellosis China CDCBaicheng CityJilin ProvinceChina.

What is already known about this topic?Plague is an acute infectious disease caused by Yersinia pestis(***)and is primarily transmitted by *** can be infected by bites of bacterium-bearing fleas or direct contact with diseased or dead plagueinfected *** 2004,the last human plague case was reported in Inner Mongolia Autonomous Region due to skinning a dead *** is added by this report?This is the first case of pneumonic plague imported into a major city since the founding of the People's Republic of *** primary pneumonic plague cases(Patients A and B)found in residents of Inner Mongolia were confirmed in Beijing on November 12,*** case(Patient C)of *** was identified as bubonic plague on November *** A most likely became infected from aerosol exposure to infective droplets while digging on his farm,located in an Meriones unguiculatus(***)natural plague *** B became infected from contact with Patient A(her husband).Patient C became infected after skinning a dead *** was no epidemiological relationship between the Patient A/B and Patient *** are the implications for public health practice?When epizootic plague is detected,local health-care providers and the public should be alerted about any possible *** education efforts should focus on promoting personal protection measures.

关键词： acute founding likely

Changes in HIV-1 Subtypes/Sub-Subtypes,and Transmitted Drug Resistance Among ART-Naïve HIV-Infected Individuals—China,2004–2022

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China cdc weekly 2023年第30期5卷 664-671,I0010-I0012页

作者： Xiu Liu Dong Wang Jing Hu Chang Song Lingjie Liao Yi Feng Dan Li Hui Xing Yuhua Ruan State Key Laboratory of Infectious Disease Prevention and Control(SKLID) National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina.

Introduction:The efficacy of treatment and clinical outcomes may be jeopardized by factors such as transmitted drug resistance(TDR)and the genetic diversity of the human immunodeficiency virus type 1(HIV-1).This comprehensive study aims to examine the alterations in HIV-1 subtypes or sub-subtypes and TDR among Chinese individuals,who have been diagnosed with HIV infection and are previously untreated with antiretroviral therapy(ART),across the span of 2004 to ***:Sequences of the HIV-1 pol gene region were obtained from ART-naïve HIV-positive individuals across 31 provincial-level administrative divisions between 2004 and *** predict susceptibility to 12 antiretroviral drugs,the research utilized the Stanford HIV Drug Resistance *** Cochran-Armitage trend test facilitated the analysis of changes in HIV-1 subtype/sub-subtype prevalence and *** analysis was conducted in alignment with the progression of the National Free Antiretroviral Treatment Program’s stages between 2004 and ***:Among the 57,902 ART-naïve individuals infected with HIV,there was a notable decline in the prevalence of CRF01_AE,B,and C from 37.3%,24.1%,and 1.3%respectively in 2004–2007 to 29.4%,7.3%,and 0.2%respectively in 2020–***,a significant increase was observed in the proportions of CRF07_BC,CRF08_BC,CRF55_01B,other CRFs,and URFs,from 24.1%,11.5%,0.1%,0.4%,and 0.9%respectively in 2004–2007 to 40.8%,11.5%,3.8%,3.7%,and 2.8%respectively in 2020–2022(all P<0.001 for trend).The prevalence of TDR to overall,non-nucleoside reverse transcriptase inhibitor(NNRTI),efavirenz,and nevirapine also significantly increased from 2.6%,1.8%,1.6%,and 1.8%respectively in 2004–2007 to 7.8%,6.7%,6.3%,and 6.7%respectively in 2020–2022(all P<0.001 for trend).However,there were no meaningful changes in the TDR prevalence of nucleoside reverse transcriptase inhibitor and protease ***,in 2020–2022,the overall TDR prevalence exceeded 15%in ***

关键词： prevalence alterations drugs

Effect of 80.55 MeV//u^(12)C^(6+) Ions on Radiosensitivity and Cell Cycle of Human Hepatoma Cell Lines

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Plasma Science and Technology 2008年第2期10卷 245-249页

作者：魏巍李文建郭传玲荆西刚金晓东苏旭 Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China National Institute for Radiological Protection China CDC Beijing 100088 China

In this paper, the relationship between radiosensitivity, cell cycle alteration and the change of apoptosis in different human hepatoma cell lines irradiated by heavy ions were studied with the aim of building up the base data for clinical therapy. Exponentially growing hepatoma cell lines were irradiated by 80.55 MeV/u12C6＋ ions at a dose of 0 Gy, 0.5 Gy, 1 Gy, 2 Gy, 4 Gy and 8 Gy. The radiosensitivity was assessed by means of the colony-forming assay. The DNA content, the percentage of each cell-cycle phase and the apoptosis rate were obtained with flow cytometry methods. After the irradiation, the SF2 （survival fraction at 2 gray） of SMMC-7721 cells were evidently lower than that of HepG2 cells. The S phase arrest, G2/M phase arrest delay and the apoptosis in the two hepatoma cell lines varied with the increase of the dose and repair time. The heavy ions could obviously kill the human hepatoma cell lines. Compared to HepG2 cells, SMMC-7721 cells were more radiosensitive to 12C^6＋ ions.

关键词： heavy ions human hepatoma cell lines radiosensitivity cell cycle cell apoptosis

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中华医学杂志(英文版) 2024年第22期137卷 2726-2733页

作者： Xu Huaiyue Wang Qing Zhu Huanhuan Zhang Yayi Ma Runmei Ban Jie Liu Yiting Chen Chen Li Tiantian Department of Environmental Health Risk Assessment China CDC Key Laboratory of Environment and Population Health National Institute of Environmental Health Chinese Center for Disease Control and Prevention Beijing China School of Geomatics and Marine Information Jiangsu Ocean University Lianyungang Jiangsu China

Background: Substantial progress in air pollution control has brought considerable health benefits in China, but little is known about the spatio-temporal trends of economic burden from air pollution. This study aimed to explore their spatio-temporal features of disease burden from air pollution in China to provide policy recommendations for efficiently reducing the air pollution and related disease burden in an era of a growing ***: Using the Global Burden of Disease method and willingness to pay method, we estimated fine particulate matter (PM2.5) and/or ozone (O3) related premature mortality and its economic burden across China, and explored their spatio-temporal trends between 2005 and ***: In 2017, we estimated that the premature mortality and economic burden related to the two pollutants were RMB 0.94 million (68.49 per 100,000) and 1170.31 billion yuan (1.41% of the national gross domestic product [GDP]), respectively. From 2005 to 2017, the total premature mortality was decreasing with the air quality improvement, but the economic burden was increasing along with the economic growth. And the economic growth has contributed more to the growth of economic costs than the economic burden decrease brought by the air quality improvement. The premature mortality and economic burden from O3 in the total loss from the two pollutants was substantially lower than that of PM2.5, but it was rapidly growing. The O3-contribution was highest in the Yangtze River Delta region, the Fen-Wei Plain region, and some western regions. The proportion of economic burden from PM2.5 and O3 to GDP significantly declined from 2005 to 2017 and showed a decreasing trend pattern from northeast to ***: The disease burden from O3 is lower than that of PM2.5, the O3-contribution has a significantly increasing trend with the growth of economy and O3 concentration.

关键词： Fine particulate matter Ozone Long-term mortality Willingness to pay Economic burden Spatio-temporal trends Air quality