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Structural and Interfacial effects on Drug Release Kinetics of Liquid‑Based Fibrous Catheter

Advanced Fiber Materials 2022年第6期4卷 1645-1655页

作者： Chunyan Wang Yaqi Hou Xingyi Wang Weijun Li Yunmao Zhang Shuli Wang Jing Zheng Xu Hou College of Chemistry and Chemical Engineering State Key Laboratory of Physical Chemistry of Solid SurfacesXiamen UniversityXiamen 361005China Collaborative Innovation Center of Chemistry for Energy Materials Xiamen UniversityXiamen 361005China Department of Electronic Science Fujian Engineering Research Center for Solid‑State LightingSchool of Electronic Science and EngineeringXiamen UniversityXiamen 361005China College of Physical Science and Technology Xiamen UniversityXiamen 361005China

Catheterization is indispensable in the field of modern ***,catheter-related thrombosis and infections almost inevitably occur during the process,and as drugs can only be administered at the end of catheter,auxiliary strategies are required for successful *** these intractable limitations,a type of self-adaptive,anti-coagulate liquidbased fibrous catheter has been *** importantly,it has positional drug release property that traditional catheters desperately need but couldn’t *** enlightening,the feasibility and performance of the positional drug release have only been demonstrated by fluorescents,the specific drug release kinetics remains unknown for adaptation to application ***,we systematically investigate the structural and interfacial effects of drug molecules and fibrous matrixes on drug release kinetics in a liquid-based fibrous *** calculations and experiments demonstrate that oleophilic and hydrophilic molecules release slowly due to a dissolution-diffusion *** molecules,however,will significantly affect the gating performance by affecting the interfacial stability,hence they release quickly with emulsifying the gating *** the significant impact of molecular properties and interfacial effects,matrix pore size also has a slight influence that molecules release faster in bigger *** this study,the liquid-based fibrous catheter may step further toward practical applications including chemotherapy,haemodialysis,angiography,*** overcome the existing catheter-related limitations.

关键词： Liquid-based materials Electrospinning fibrous materials Catheter Drug release

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