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Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field

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Zoological Research 2024年第3期45卷 478-490页

作者： Han-Xiao Chen Xin-Yu Wang Biao Yu Chuan-Lin Feng Guo-Feng Cheng Lei Zhang Jun-Jun Wang Ying Wang Ruo-Wen Guo Xin-Miao Ji Wen-Jing Xie Wei-Li Chen Chao Song Xin Zhang cas key laboratory of high magnetic field and ion beam physical biology High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230026China Institutes of physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China

Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in *** predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late *** the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery *** the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte ***,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially ***,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP *** note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

关键词： Acetaminophen Acute liver injury Static magnetic fields Oxidative stress DNA synthesis

Effects of 3.7 T-24.5 T high magnetic fields on tumor-bearing mice

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Chinese Physics B 2018年第11期27卷 649-658页

作者： Xiaofei Tian Ze Wang Lei Zhang Chuanying Xi Li Pi Ziping Qi Qingyou Lu Xin Zhang high magnetic field laboratory Key Laboratory of High Magnetic Field and Ion Beam Physical Biology Hefci Institutes of Physical Science Chinese Academy of Sciences Hefei 230031 China Institute of physical Science and Information Technology Anhui University Hefei 230601 China Hefei National laboratory for physical Sciences at Microscale University of Science and Technology of China Hefei 230026 China Anhui Province key laboratory of Condensed Matter Physics at Extreme Conditions Hefei 230031 China

Since high magnetic field（MF） intensity can improve the image quality and reduce magnetic resonance imaging（MRI） acquisition time, the field intensity of MRIs has continued to increase over the past few decades. Although MRIs in most current hospitals are 0.5 T–3 T, there are preclinical studies have been carried out using 9.4 T MRI, and engineers are also putting efforts on building MRIs with even higher MFs. However, the accompanied safety issue of high-field MRIs is an emergent question to address before their clinical applications. In the meantime, the static magnetic field（SMF） has been shown to inhibit tumor growth in previous studies. Here, we investigated both the safety issue and the anti-tumor potentials of 3.7 T–24.5 T SMFs on GIST-T1 gastrointestinal stromal tumor-bearing nude mice. We followed up the mice three weeks after their exposure to high SMF and found that none of the mice died or had severe organ damage, except for slightly decreased food intake, weight gain, and liver function. Moreover, the tumor growth was inhibited by 3.7 T–24.5 T SMFs（up to ～54%）. It is interesting that the effects are more dependent on MF gradient than intensities, and for the same gradient and intensity, mice responded differently to hypogravity and hypergravity conditions. Therefore, our study not only demonstrated the safeness of high SMFs up to 24.5 T on mice but also revealed their anti-tumor potentials in the future.

关键词： static magnetic field (SMF) high magnetic field (MF) tumor magnetic field gradient

NMR and biochemical characterization of the interaction between FGFR1 juxtamembrane domain and phospholipids Dedicated to Professor Chaohui Ye on the occasion of his 80th birthday

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magnetic Resonance Letters 2022年第4期2卷 205-213页

作者： Yunyan Li Yong Liu Huiqin Zhang Zhen Wang Maosen Ruan Jiarong Wang Jing Yang Bo Wu Junfeng Wang high magnetic field laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230026China Institutes of physical Science and Information Technology Anhui UniversityHefei230601China Anhui University Hefei230039China

Fibroblast growth factor receptors(FGFRs)play an important role in the regulation of cell proliferation,migration and differentiation,while the juxtamembrane domain(JMD)of FGFRs is the key in mediating these transmembrane signal transduction ***,we expressed and purified the JMD(398K-470R)of FGFR1 with the presence of transmembrane domain(377I-397Y).The results from nuclear magnetic resonance(NMR)chemical shift analysis demonstrate that the main structure of JMD is ***,the N-terminus of JMD was observed to form a short a-helix upon introducing negatively charged lipid 1,2-dioleoyl-sn-glycero-3-phospho-L-serine(DOPS)into its membrane mimic ***,the N-terminus of JMD interacts with FRS2a,which is a substrate 2a of ***,we propose a model that FGFR1-JMD may interact with FRS2a and negatively charged lipids *** study provides a new understanding on the role of the JMD of FGFRs.

关键词： Fibroblast growth factor receptors(FGFRs) Juxtamembrane domain FGFR substrate 2a Negatively charged lipid Secondary structure transition Nuclear magnetic resonance(NMR) Protein-lipid interaction

Microwave awakening the n-π^(*) electronic transition in highly crystalline polymeric carbon nitride nanosheets for photocatalytic hydrogen generation

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Journal of Energy Chemistry 2022年第2期31卷 541-547页

作者： Xiangang Lin Haiwei Du Daochuan Jiang Peng Zhang Zhiwu Yu Hong Bi Yupeng Yuan School of Chemistry and Chemical Engineering Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized MaterialsAnhui UniversityHefei 230601AnhuiChina key laboratory of Structure and Functional Regulation of Hybrid Materials(Anhui University) Ministry of EducationHefei 230601AnhuiChina high magnetic field laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031AnhuiChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina

The n-π^(*) electronic transition in polymeric carbon nitride(PCN)can remarkably harvest visible light,which thus potentially promotes the photocatalytic hydrogen H2 ***,awaking the n-π^(*) lectronic transition has proven to be a grand ***,we reported on the awakening of n-π^(*) electronic transition by microwave thermolysis of urea pellet,which yielded the PCN with absorption edge of 600 nm,near 140 nm red-shift from 460 nm of pristine *** n-π^(*) electronic transition endows PCN with an increased photocata lytic H_(2) generation,with a highest H_(2) rate of 61.7μmol h^(-1) under visible light exposure,which is near 6 times higher than that by using the PCN from the thermolysis of urea pellets in an electric furnace(10.6μmol h^(-1)).Furthermore,the n-π^(*) transition in PCN leads to the longest wavelength of 535 nm that can initiate H2 generation,remarkably longer than the absorption edge of pristine PCN(460 nm).This work manifests the advantages of microwave sintering route to awaken the n-π^(*) electronic transition in PCN for an increased photocata lytic performance.

关键词： Polymeric carbon nitride Microwave n-π^(*)electronic transition Hydrogen

Nanocarbon-based electrode materials applied for supercapacitors

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Rare Metals 2022年第12期41卷 3957-3975页

作者： Yu-Xiang Yang Kang-Kang Ge Sajid ur Rehman Hong Bi School of Chemistry and Chemical Engineering School of Materials Science and EngineeringAnhui UniversityHefei 230601China CIRIMAT UMR CNRS 5085UniversitéPaul Sabatier ToulouseⅢToulouse 31062France cas key laboratory of high magnetic field and ion beam physical biology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

As one of the promising energy storage and conversion systems,supercapacitors(SCs)are highly favored owing to their high power density and good service *** all the key components of supercapacitor devices,the design and investigation of electrode materials play an essential role in determining the whole electrochemical charge storage ***,nanocarbon-based materials(e.g.,graphene,carbon dots,graphene quantum dots,etc.)have been widely used as SC electrode materials because of their good physical structure and chemical properties,providing a new route to further improve the energy density and life span of ***,we review the latest progress of nanocarbon-based materials(including nanocarbon and nanocarbon-based composite materials)as electrode materials in SCs *** recent progress of carbon dots,graphene,carbon nanotubes,and other nanocarbon materials electrodes is summarized,while the capacitance and energy density of the above nanocarbon electrodes still need to be ***,the preparation and performance of nanocarbonbased composite electrodes comprising transition metal oxides,conductive polymer,and metal-organic framework derived porous carbon are ***,we outline major challenges and propose some ideas on building better nanocarbon-based SC electrodes.

关键词： Supercapacitor(SC) Nanocarbon Electrode materials Carbon dots Nanocarbon-based composite

Recent progress on surface chemistryⅡ:Property and characterization

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Chinese Chemical Letters 2025年第1期36卷 8-57页

作者： Xin Li Zhen Xu Donglei Bu Jinming Cai Huamei Chen Qi Chen Ting Chen Fang Cheng Lifeng Chi Wenjie Dong Zhenchao Dong Shixuan Du Qitang Fan Xing Fan Qiang Fu Song Gao Jing Guo Weijun Guo Yang He Shimin Hou Ying Jiang Huihui Kong Baojun Li Dengyuan Li Jie Li Qing Li Ruoning Li Shuying Li Yuxuan Lin Mengxi Liu Peinian Liu Yanyan Liu Jingtao Lü Chuanxu Ma Haoyang Pan JinLiang Pan Minghu Pan Xiaohui Qiu Ziyong Shen Qiang Sun Shijing Tan Bing Wang Dong Wang Li Wang Lili Wang Tao Wang Xiang Wang Xingyue Wang Xueyan Wang Yansong Wang Yu Wang Kai Wu Wei Xu Na Xue Linghao Yan Fan Yang Zhiyong Yang Chi Zhang Xue Zhang Yang Zhang Yao Zhang Xiong Zhou Junfa Zhu Yajie Zhang Feixue Gao Yongfeng Wang Center for Carbon-based Electronics and key laboratory for the Physics and Chemistry of Nanodevices School of ElectronicsPeking UniversityBeijing 100871China Spin-X Institute School of MicroelectronicsSouth China University of TechnologyGuangzhou 511442China School of Materials and Energy Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage DevicesGuangdong University of TechnologyGuangzhou 510006China Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China i-Lab CAS Key Laboratory of Nanophotonic Materials and DevicesSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China cas key laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of SciencesBeijing 100190China State key laboratory for Organic Electronics and Information Displays&Jiangsu key laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing University of Posts and TelecommunicationsNanjing 210023China Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Hefei National Research Center for physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Institute of Physics&University of Chinese Academy of Sciences Beijing 100190China State key laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemistry Beijing Normal UniversityBeijing 100875China Beijing National laboratory for Molecular Sciences(BNLMS) College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China School

Surface with well-defined components and structures possesses unique electronic,magnetic,optical and chemical *** a result,surface chemistry research plays a crucial role in various fields such as catalysis,energy,materials,quantum,and *** science mainly investigates the correspondence between surface property and *** probe microscopy(SPM)techniques are important tools to characterize surface properties because of the capability of atomic-scale imaging,spectroscopy and manipulation at the single-atom *** this review,we summarize recent advances in surface electronic,magnetic and optical properties characterized mainly by SPM-based *** focus on elucidating theπ-magnetism in graphene-based nanostructures,construction of spin qubits on surfaces,topology properties of surface organic structures,STM-based light emission,tip-enhanced Raman spectroscopy and integration of machine learning in SPM studies.

关键词： Surface chemistry Scanning probe microscopy π-Magnetism Spin qubits Tip-enhanced Raman spectroscopy

Application of magnetotactic bacteria as engineering microrobots:higher delivery efficiency of antitumor medicine

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Chinese Chemical Letters 2024年第10期35卷 139-146页

作者： Jing Zhang Charles Wang Yaoyao Zhang Haining Xia Yujuan Wang Kun Ma junfeng Wang high magnetic field laboratory CAS Key Laboratory of High Magnetic Field and lon Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China University of California San DiegoLa JollaCA 92093United States International Magnetobiology Frontier Research Center Hefei 230031China

For a significant duration,enhancing the efficacy of cancer therapy has remained a critical *** bacteria(MTB),often likened to micro-robots,hold substantial promise as a drug delivery ***,classified as anaerobic,aquatic,and gram-negative microorganisms,exhibit remarkable motility and precise control over their internal biomineralization *** unique ability results in the formation of magnetic nanoparticles arranged along filamentous structures in a catenary fashion,enclosed within a *** bacteria possess distinctive biochemical properties that facilitate their precise positioning within complex *** harnessing these biochemical attributes,MTB could potentially offer substantial advantages in the realm of cancer *** article reviews the drug delivery capabilities of MTB in tumor treatment and explores various applications based on their inherent *** objective is to provide a comprehensive understanding of MTB-driven drug delivery and stimulate innovative insights in this field.

关键词： Magnetotactic bacteria Engineering microrobot Tumor treatment Drug delivery Bioconjugation

Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine

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Science China Chemistry 2023年第9期66卷 2492-2512页

作者： Yuan Gao Shuangqing Liu Hui Liu Haiyan Ge Meng Zhang Chunyu Zhao Yufang Gong Xinyu Zhang Chao Wang Xiao Sun Zhengyan Wu School of Chemistry and Pharmaceutical Engineering Medical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250000China key laboratory of high magnetic field and ion beam physical biology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

Nanomedicine has become an important development direction of modern medicine, and provides a new way for cancer theranostics. To extend the superior physicochemical property of nanomedicine and enhance their role in cancer theranostics,various strategies have been proposed. Among them, the introduction of oxygen vacancies can enhance the separation of electron-hole pairs and improve the nanomaterials' catalytic activity, which is beneficial for cancer diagnosis and treatment. This review briefly summarized the formation mechanism and preparation methods of various oxygen vacancy nanomaterials. Then,the effect and application of various oxygen vacancy nanomaterials, such as iron, manganese, titanium, zinc, bismuth, tungsten,cerium, and molybdenum-based nanomaterials in enhancing cancer theranostics were highlighted. At last, the prospect and challenges of oxygen vacancy nanomaterials were discussed. This review provided an overview of the relevant information on oxygen vacancy in cancer theranostics, and further promoted the development of cancer nanomedicine.

关键词： oxygen vacancy electron-hole pairs nanomedicine catalytic therapy cancer theranostics

Intermittent F-actin Perturbations by magnetic fields Inhibit Breast Cancer Metastasis

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Research 2023年第4期2023卷 321-335页

作者： Xinmiao Ji Xiaofei Tian Shuang Feng Lei Zhang Junjun Wang Ruowen Guo Yiming Zhu Xin Yu Yongsen Zhang Haifeng Du Vitalii Zablotskii Xin Zhang high magnetic field laboratory of cas(CHMFL) CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHFIPSHefeiAnhui 230031P.R China Institutes of physical Science and Information Technology Anhui UniversityHefeiAnhui230601P.R.China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230031P.R China Institute of Physics of the Czech Academy of Sciences PragueCzech Republic International Magnetobiology Frontier Research Center Science IslandHefei 230031P.R.China.

F-actin(filamentous actin)has been shown to be sensitive to mechanical stimuli and play critical roles in cell attachment,migration,and cancer metastasis,but there are very limited ways to perturb F-actin dynamics with low cell *** field is a noninvasive and reversible physical tool that can easily penetrate cells and human ***,we show that 0.1/0.4-T 4.2-Hz moderate-intensity low-frequency rotating magnetic field-induced electric field could directly decrease F-actin formation in vitro and in vivo,which results in decreased breast cancer cell migration,invasion,and ***,lowfrequency rotating magnetic fields generated significantly different effects on F-actin in breast cancer *** cells,including F-actin number and their recovery after magnetic field *** an intermittent treatment modality,low-frequency rotating magnetic fields could significantly reduce mouse breast cancer metastasis,prolong mouse survival by 31.5 to 46.0%(Pphysical ***,our work demonstrates that low-frequency rotating magnetic fields not only can be used as a research tool to perturb F-actin but also can inhibit breast cancer metastasis through F-actin modulation while having minimum effects on normal cells,which reveals their potential to be developed as temporal-controlled,noninvasive,and high-penetration physical treatments for metastatic cancer.

关键词： metastasis invasion cancer