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Unified deep learning model for predicting fundus fluorescein angiography image from fundus structure image

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Journal of Innovative Optical Health sciences 2024年第3期17卷 105-113页

作者： Yiwei Chen Yi He Hong Ye Lina Xing Xin Zhang Guohua Shi Jiangsu key laboratory of medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163P.R.China School of biomedical engineering(suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of China Hefei 230026P.R.China Center for Excellence in Brain Science and Intelligence technology Chinese Academy of SciencesShanghai 200031P.R.China

The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image *** comprises estimating FFA from fundus camera imaging,single-phase FFA from scanning laser ophthalmoscopy(SLO),and three-phase FFA also from *** many deep learning models are available,a single model can only perform one or two of these prediction *** accomplish three prediction tasks using a unified method,we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial *** three prediction tasks are processed as follows:data preparation,network training under FFA supervision,and FFA image prediction from fundus structure images on a test *** comparing the FFA images predicted by our model,pix2pix,and CycleGAN,we demonstrate the remarkable progress achieved by our *** high performance of our model is validated in terms of the peak signal-to-noise ratio,structural similarity index,and mean squared error.

关键词： Fundus fluorescein angiography image fundus structure image image translation unified deep learning model generative adversarial networks

Thiol-Disulfide Exchange Coordinates the Release of Nitric Oxide and Dexamethasone for Synergistic Regulation of Intestinal Microenvironment in Colitis

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Research 2024年第2期6卷 285-300页

作者： Junna Lu Tongfei Shi Chengxin Shi Fangman Chen Chao Yang Xiaochun Xie Zheng Wang He Shen Jiaqi Xu Kam W.Leong Dan Shao School of biomedical sciences and engineering South China University of TechnologyGuangzhou International CampusGuangzhouGuangdong 510006China National engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangdong 510006China Department of Plastic and Aesthetic Center The First Affliated Hospital of Zhejiang UniversityHangzhou 310000China Department of biomedical engineering Columbia UniversityNew YorkNY 10027USA School of Medicine South China University of TechnologyGuangzhouGuangdong 510006China cas key laboratory of Nano-bio Interface Suzhou Institute of Nano-Tech and NanoBionicsChinese Academy of SciencesSuzhou 215123China cas key laboratory for biomedical Efects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Guangdong Provincial key laboratory of biomedical engineering South China University of TechnologyGuangzhou 510006China key laboratory of biomedical Materials and engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China

The cell-specific functions of nitric oxide(NO)in the intestinal microenvironment orchestrate its therapeutic effects in ulcerative *** most biomaterials show promise by eliciting the characteristics of NO,the insufficient storage,burst release,and pro-inflammatory side effects of NO remain as ***,we report the development of thiol-disulfide hybrid mesoporous organosilica nanoparticles(MONs)that improve the storage and sustained release of NO,broadening the therapeutic window of NO-based therapy against *** tailored NO-storing nanomaterials coordinated the release of NO and the immunoregulator dexamethasone(Dex)in the intestinal microenvironment,specifically integrating the alleviation of oxidative stress in enterocytes and the reversal of NO-exacerbated macrophage ***,such a synchronous operation was achieved by a self-motivated process wherein the thiyl radicals produced by NO release cleaved the disulfide bonds to degrade the matrix and release Dex via thiol-disulfide ***,the MON-mediated combination of NO and Dex greatly ameliorated intractable colitis compared with 5-aminosalicylic acid,even after delayed ***,our results reveal a key contribution of synergistic modulation of the intestinal microenvironment in NO-based colitis therapy and introduce thiol-disulfide hybrid nanotherapeutics for the management of inflammatory diseases and cancer.

关键词： sustained release disulfide

Ensemble Attention Guided Multi-SEANet Trained with Curriculum Learning for Noninvasive Prediction of Gleason Grade Groups from MRI

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Journal of Shanghai Jiaotong university(Science) 2024年第1期29卷 109-119页

作者：沈傲胡冀苏金鹏飞周志勇钱旭升郑毅包婕王希明戴亚康 School of Computer Science and technology Changchun University of Science and TechnologyChangchun 130022China suzhou institute of biomedical engineering and technology Chinese Academy of SciencesSuzhou 215163JiangsuChina School of biomedical engineering(SooChow) University of Science and Technology of ChinaSuzhou 215163JiangsuChina Department of Radiology The First Afiliated Hospital of Soochow UniversitySuzhou 215006JiangsuChina

The Gleason grade group(GG)is an important basis for assessing the malignancy of prostate can-cer,but it requires invasive biopsy to obtain *** noninvasively evaluate GG,an automatic prediction method is proposed based on multi-scale convolutional neural network of the ensemble attention module trained with curriculum ***,a lesion-attention map based on the image of the region of interest is proposed in combination with the bottleneck attention module to make the network more focus on the lesion ***,the feature pyramid network is combined to make the network better learn the multi-scale information of the lesion ***,in the network training,a curriculum based on the consistency gap between the visual evaluation and the pathological grade is proposed,which further improves the prediction performance of the ***-perimental results show that the proposed method is better than the traditional network model in predicting GG *** quadratic weighted Kappa is 0.4711 and the positive predictive value for predicting clinically significant cancer is 0.9369.

关键词： prostate cancer Gleason grade groups(GGs) bi-parametric magnetic resonance imaging deep learn-ing curriculum learning

Tumor-targeted self-assembled micelles reducing PD-L1 expression combined with ICIs to enhance chemo-immunotherapy of TNBC

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chinese Chemical Letters 2024年第2期35卷 305-310页

作者： Hongda Zhu Kai Ma Rui Ruan Chaobo Yang Aqin Yan Jing Li Qi Yu Hongmei Sun Mingxing Liu Hongmei Zheng Jing Gao Xiaofang Guan Zhu Dai Yao Sun Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province) Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of TechnologyWuhan 430068China Hubei Cancer Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079China National key laboratory of Green Pesticide College of ChemistryCentral China Normal UniversityWuhan 430079China key laboratory of medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China key laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science Ministry of EducationQingdao University of Science and TechnologyQingdao 266000China

Immune checkpoint inhibitors(ICIs)therapy targeting programmed cell death ligand 1(PD-L1)and programmed death protein 1(PD-1)had exhibited significant clinical benefits for cancer treatment such as triple negative breast cancer(TNBC).However,the relatively low anti-tumor immune response rate and ICIs drug resistance highlight the necessity of developing ICIs combination therapy strategies to improve the anti-tumor effect of ***,the immunomodulator epigallocatechin gallate palmitate(PEGCG)and the immunoadjuvant metformin(MET)self-assembled into tumor-targeted micelles via hydrogen bond and electrostatic interaction,which encapsulated the therapeutic agents doxorubicin(DOX)-loaded PEGCG-MET micelles(PMD)and combined with ICIs(anti-PD-1 antibody)as therapeutic strategy to reduce the endogenous expression of PD-L1 and improve the tumor immunosuppressive *** results presented that PMD integrated chemotherapy and immunotherapy to enhance antitumor efficacy in vitro and in vivo,compared with DOX or anti-PD-1 antibody for the therapy of *** micelles might be a potential candidate,which could remedy the shortcomings of antibody-based ICIs and provide synergistic effect to enhance the antitumor effects of ICIs in tumor therapy.

关键词： Immunotherapy Tumor-targeted Self-assembled micelles Metformin Reducing PD-L1 expression TNBC

Enhanced charge collection of AgNWs-based top electrode to realize high-performance, all-solution processed organic solar cells

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Science China Chemistry 2024年第10期67卷 3347-3356页

作者： Juanyong Wan Yang Chen Weijie Chen Jinfeng Xia Guang Zeng Jianlei Cao Chuang Jin Yunxiu Shen Xiaoxiao Wu Haiyang Chen Junyuan Ding Xue-mei Ou Yaowen Li Yongfang Li laboratory of Advanced Optoelectronic Materials Suzhou Key Laboratory of Novel Semiconductor-Optoelectronics Materials and DevicesCollege of ChemistryChemical Engineering and Materials ScienceSoochow University Jiangsu Sidike New Materials Science and technology Co. Ltd. Jiangsu key laboratory of Advanced Negative Carbon Technologies Soochow University State and Local Joint engineering laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationCollege of ChemistryChemical Engineering and Materials ScienceSoochow University Beijing National laboratory for Molecular sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of Sciences

All-solution processed organic solar cells are the ultimate aim of printable photovoltaics, but their electrical losses arising from poor contact of top electrodes greatly limit efficiency improvement. To solve the problem, a solution-processed hybrid top electrode was constructed using silver nanowires(AgNWs) as the skeleton and ZnO nanoparticles(ZnO-NPs) as the *** constructing the skeleton, a spin-rinsing treatment was first used to reduce the amount of the residual insulating polyvinylpyrrolidone wrapped around the AgNWs to promote intimate contact among the AgNWs in the skeleton. Then, the ZnO-NPs matrix was deposited onto the AgNWs skeleton, bridging the AgNWs skeleton with the underlayer ZnO-NPs electron transporting layer(ETL). The underlayer ZnO-NPs ETL can also induce the growth of the ZnO-NPs matrix to minimize lattice mismatch, which creates additional transport channels from the ETL to the AgNWs skeleton for charge collection. As a result,the obtained electrode significantly enhances the electrical contact in the device, thus delivering record power conversion efficiencies of 16.04% and 14.54% for rigid and flexible all-solution processed OSCs, respectively.

关键词： solution-processed top electrode organic solar cells AgNWs electrical contact

Scalable synthesis of lipid nanoparticles for nucleic acid drug delivery using an isometric channel-size enlarging strategy

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Nano Research 2024年第4期17卷 2899-2907页

作者： Zesen Ma Haiyang Tong Sijin Lin Li Zhou Demeng Sun Baoqing Li Changlin Tian Jiaru Chu Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230027China key laboratory of Precision Scientific Instrumentation of Anhui Higher Education institutes University of Science and Technology of ChinaHefei 230027China Science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230026China Anhui Provincial key laboratory of High Field Magnetic Resonance Imaging High Magnetic Field LaboratoryHefei Institute of Physical ScienceChinese Academy of SciencesHefei 230031China Anhui Provincial engineering laboratory of Peptide Drugs University of Science and Technology of ChinaHefei 230027China School of biomedical engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaSuzhou 215127China

Lipid nanoparticles(LNPs)have emerged as highly effective delivery systems for nucleic acid-based ***,the broad clinical translation of LNP-based drugs is hampered by the lack of robust and scalable synthesis techniques that can consistently produce formulations from early development to clinical *** this work,we proposed a method to achieve scalable synthesis of LNPs by scaling inertial microfluidic mixers isometrically in three ***,a theoretical predictive method,which controls the mixing time to be equal across different chips,is developed to ensure consistent particle size and size distribution of the synthesized *** loaded with small interfering RNA(siRNA)were synthesized at different flow rates,exhibiting consistent physical properties,including particle size,size distribution and encapsulation *** work provides a practical approach for scalable synthesis of LNPs consistently,offering the potential to accelerate the transition of nucleic acid drug development into clinical application.

关键词： lipid nanoparticles nucleic acid delivery microfluidics scalable synthesis consistent particle size

Dynamic asymmetric mechanical responsive carbon nanotube fiber for ionic logic gate

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chinese Chemical Letters 2024年第6期35卷 249-253页

作者： Pei Cao Yilan Wang Lejian Yu Miao Wang Liming Zhao Xu Hou State key laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation laboratory for sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China The Higher Educational key laboratory for biomedical engineering of Fujian Province Department of BiomaterialsResearch Center of Biomedical Engineering of XiamenCollege of MaterialsXiamen UniversityXiamen 361005China key laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China institute of Artificial Intelligence Xiamen UniversityXiamen 361005China Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China engineering Research Center of Electrochemical Technologies of Ministry of Education Xiamen UniversityXiamen 361005China

Inspired by biological ion channels,numerous artificial asymmetric ion channels have been synthesized to facilitate the fabrication of ionic ***,the creation of biomimetic asymmetric ion channels necessitates expensive scientific apparatus and intricate material processing procedures,which constrains its advancement within the realm of ionic *** this study,we have devised dynamic asymmetric ion channels with mechanical responsiveness by combining polymers of varying elastic modulus along the longitudinal axis of carbon nanotube fiber(CNTF).The ion rectification can be modulated via the disparate response of CNTF-based ion channels to mechanical *** have effectively employed these asymmetric ion channels with mechanical sensitivity in the design of a logic gate device,achieving logic operations such as“AND”and“OR”.The conception of these dynamic asymmetric ion channels with mechanical sensitivity offers a straightforward,cost-effective,and versatile approach for generating ion channels,highlighting their potential application in intricate,highly integrated ionic circuits.

关键词： Carbon nanotubes fibers Mechanical response Rectification effect Ionic logic gate

Multi-Field Analysis and Experimental Verification on Piezoelectric Valve-Less Pumps Actuated by Centrifugal Force

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chinese Journal of Mechanical engineering 2017年第4期30卷 1032-1043页

作者： Yu-Ting Ma Zhi-Guo Pei Zhong-Xiang Chen cas key Lab of bio-medical diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China

A piezoelectric centrifugal pump was developed previously to overcome the low frequency responses of piezoelectric pumps with check valves and liquid reflux of conventional valveless piezoelectric pumps. However, the electro-mechanical-fluidic analysis on this pump has not been done. Therefore, multi-field analysis and experimen- tal verification on piezoelectrically actuated centrifugal valveless pumps are conducted for liquid transport appli- cations. The valveless pump consists of two piezoelectric sheets and a metal tube with piezoelectric elements pushing the metal tube to swing at the first bending resonant fre- quency. The centrifugal force generated by the swinging motion will force the liquid out of the metal tube. The governing equations for the solid and fluid domains are established, and the coupling relations of the mechanical, electrical and fluid fields are described. The bending res- onant frequency and bending mode in solid domain are discussed, and the liquid flow rate, velocity profile, and gauge pressure are investigated in fluid domain. The working frequency and flow rate concerning different components sizes are analyzed and verified through experiments to guide the pump design. A fabricated pro- totype with an outer diameter of 2.2 mm and a length of 80 mm produced the largest flow rate of 13.8 mL/min at backpressure of 0.8 kPa with driving voltage of 80 Vpp. Bysolving the electro-mechanical-fluidic coupling problem, the model developed can provide theoretical guidance on the optimization of centrifugal valveless pump characters.

关键词： Valveless pump Centrifugal force Piezoelectric pump Multi-field analysis

An ultrasensitive aptasensor for prostate specific antigen assay based on Exonuclease T-aided cyclic cleavage

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Science China Chemistry 2018年第4期61卷 393-396页

作者： Guangxing Liu Tian Zhang Yuguo Tang Peng Miao cas key laboratory of bio-medical diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China University of Science and technology of China Hefei 230026China

An ultrasensitive electrochemical aptasensor is presented for prostate specific antigen(PSA) detection. DNA tetrahedronaptamer is designed, which not only facilitates the molecular self-assembly events,but also improves the recognition efficiency between PSA and aptamer sequence on the electrode interface. The DNA conformation on top of DNA tetrahedron changes accordingly, which can be further digested by Exonuclease T(Exo T), a type of single-strand specific nuclease. Electrochemical species are removed synchronously and the initial PSA level can thus be determined. A linear range from 0.5 pg mL^(-1) to50 ng mL^(-1) is achieved with the limit of detection(LOD) as low as 0.15 pg mL^(-1). Moreover, this proposed method is highly selective and is successfully applied to determine PSA in human serum samples.

关键词： prostate specific antigen aptamer DNA tetrahedron Exonuclease T square wave voltammetry.