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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina cas key laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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The new face of iron oxide nanoparticles: the bullets targeting tumor microenvironment for cancer therapy

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Science Bulletin 2016年第23期61卷 1788-1790页

作者： Jinxia Li Feng Zhao Chunying Chen cas key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences cas key laboratory for biomedical effects of nanomaterials and nanosafety National Center for Nanoscience and Technology

Ferumoxytol, an iron replacement product in clinic practices, is an agent of superparamagnetic iron oxide nanoparticles coated with polyglucose sorbitol carboxymethylether. It is approved for the intravenous therapy o... 详细信息

关键词：铁纳米粒子肿瘤治疗氧化微环境子弹缺铁性贫血临床实践替代产品

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Analytical methods for nano-bio interface interactions

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Science China Chemistry 2016年第11期59卷 1467-1478页

作者： Jing Wang Waseem Akthar Quershi Yiye Li Jianxun Xu Guangjun Nie cas key laboratory for biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology

Knowledge on the interactions between engineered nanomaterials(ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano-bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface characterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level.

关键词： engineered nanomaterial nano-bio interface nano-bio interaction analytical methods protein corona synchrotron radiation

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Nanotechnology in the programmed cell therapy:nowhere to escape of cancer

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Science Bulletin 2016年第1期61卷 45-47页

作者： Jinxia Li Yuliang Zhao cas key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences cas key laboratory for biomedical effects of nanomaterials and nanosafety National Center for Nanosciences and Technology

For lymphomas,the transport of chemotherapeutic drugs usually meets physical barriers to the lymph nodes where disseminated tumor cells frequently *** new findings show that autologous T cells as live vectors combined with nanotechnology-based drug delivery can provide a novel opportunity for the improved chemotherapy toward lymphomas.

关键词：纳米技术细胞疗法程序性癌症化疗药物肿瘤细胞淋巴瘤淋巴结

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KLVFF peptide functionalized nanoparticles capture Aβ_(42) by co-assembly for decreasing cytotoxicity

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Chinese Chemical Letters 2018年第12期29卷 1811-1814页

作者： Peipei Yang Chao Yang Kuo Zhang Lei Wang Hao Wang cas Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology (NCNST)

The accumulation of extracellular senile plagues of amyloid β-proteins(Aβ) in the patient brain is one of most important facture in Alzheimer’s disease(AD), which is resulted from abnormal self-assembly of Aβpeptide. Nanoparticles show greatly potential for therapeutic studies due to the sophisticated surface which can mimic the functionality of protein. Herein, we design the bis(pyrene)-Lys-Leu-Val-Phe-PheGly-poly ethylene glycol(BP-KLVFFGPEG) based nanoparticles, which capture Aβthrough recognition and co-assembly of KLVFF. The resulting co-assemblies show different morphologies, such as large aggregates, nanoparticles and nanofibers corresponding to the different length chain of PEG, leading to different capture efficiencies. The co-assembly strategy shows a decrease of cytotoxicity, potentially for AD treatment.

关键词： Co-assembly Morphology Capture Nanoparticles Aβ

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Protein corona in vivo: dynamic complement proteins-mediated opsonization and immune modulation

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Science Bulletin 2017年第14期62卷 976-977页

作者： Rong Cai Chunying Chen cas key laboratory for biomedical effects of nanomaterials and nanosafety & cas Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China

It has been well-established that blood biomolecules deposit on the surface of nanoparticles forming a protein rich layer,known as‘‘protein corona',which directly interacts with and is recognized by *** interactions play a critical role in affecting nanoparticle biological properties,including biodistribution[1],pathophysiology[2],and therapeutic efficacy[3].The compositions of protein corona undergo dynamic exchange in vivo and are

关键词：蛋白质免疫调节调理作用介导补体啤酒体内纳米颗粒

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Probing the interaction at nano-bio interface using synchrotron radiation-based analytical techniques

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Science China Chemistry 2015年第5期58卷 768-779页

作者： Bing Wang Weiyue Feng Zhifang Chai Yuliang Zhao cas key laboratory for biomedical effects of nanomaterials and nanosafety cas key laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy Physics Chinese Academy of Sciences

Understanding the interactions of nanomaterials(NMs) with biomolecules, organelles, cells, and organic tissues at the nano-bio interface can offer important information for their uptake, distribution, translocation, metabolism and degradation in vitro and in vivo, which can help to precisely tune and design "smart" NMs for biomedical applications. However, probing the interactions at the nano-bio interface, which generally requires dedicated analytical methods and tools, is remarkably complicated due to the dynamically changed nature of the nano-bio interface. Because of the advantages of high spatial resolution, high sensitivity, excellent accuracy, low matrix effects and non-destructiveness, synchrotron radiation(SR)-based analytical techniques have become extremely valuable tools. Herein, we present a comprehensive overview of SR-based techniques for the visualized study of NMs at cellular and subcellular interfaces and their transformation in vitro; the exploration of biodistribution, translocation, metabolism and degradation of NMs in vivo; and clarification of the molecular mechanisms of NMs' reactions with biomolecules. Rapid development of advanced light source means that in situ, real-time analysis of NMs at the nano-bio interface will be achieved.

关键词： nano-bio interface synchrotron-radiation-based analytical techniques interaction

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Precise design of nanomedicines: perspectives for cancer treatment

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National Science Review 2019年第6期6卷 1107-1110页

作者： Jing Wang Yiye Li Guangjun Nie Yuliang Zhao cas key laboratory for biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology University of Chinese Academy of Sciences

Nanomedicine is a field in which nanomaterials and nanotechnology are applied to improve or create medications. Combining knowledge in various disciplines including nanoscience, biological science, advanced materials and pharmacy, the current interests in nanomedicine mainly focus on exploiting nanomaterials for drug delivery in order

关键词： Precise design of nanomedicines perspectives for cancer treatment

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Nanomaterial libraries and model organisms for rapid high-content analysis of nanosafety

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National Science Review 2018年第3期5卷 365-388页

作者： Yiye Li Jing Wang Feng Zhao Bing Bai Guangjun Nie André E.Nel Yuliang Zhao cas key laboratory for biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology cas key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Division of Nano Medicine Department of Medicine and California Nano Systems Institute University of California

Safety analysis of engineered nanomaterials(ENMs) presents a formidable challenge regarding environmental health and safety, due to their complicated and diverse physicochemical *** large amounts of data have been published regarding the potential hazards of these materials, we still lack a comprehensive strategy for their safety assessment, which generates a huge workload in decision-making. Thus, an integrated approach is urgently required by government, industry, academia and all others who deal with the safe implementation of nanomaterials on their way to the marketplace. The rapid emergence and sheer number of new nanomaterials with novel properties demands rapid and high-content screening(HCS), which could be performed on multiple materials to assess their safety and generate large data sets for integrated decision-making. With this approach, we have to consider reducing and replacing the commonly used rodent models, which are expensive, time-consuming, and not amenable to high-throughput screening and analysis. In this review, we present a ‘Library Integration Approach’ for high-content safety analysis relevant to the ENMs. We propose the integration of compositional and property-based ENM libraries for HCS of cells and biologically relevant organisms to be screened for mechanistic biomarkers that can be used to generate data for HCS and decision analysis. This systematic approach integrates the use of material and biological libraries, automated HCS and high-content data analysis to provide predictions about the environmental impact of large numbers of ENMs in various categories. This integrated approach also allows the safer design of ENMs, which is relevant to the implementation of nanotechnology solutions in the pharmaceutical industry.

关键词： analysis method nanosafety assessment library integration approach high-content screening nanomaterials

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Multifunctional nanoparticle systems for combined chemo- and photothermal cancer therapy

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Frontiers of Materials Science 2013年第2期7卷 118-128页

作者： Hai WANG Yu-Liang ZHAO Guang-Jun NIE cas key laboratory for biomedical effects of nanomaterials & nanosafety National Center for Nanoscience and Technology (NCNST) 11 Beiyitiao Zhongguancun Beijing 100190 China cas key laboratory for biomedical effects of nanomaterials & nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

Hyperthermia has long been considered as an adjuvant therapy for treating various diseases. Cancer treatment exploiting hyperthermia shows great clinical potential for a wide range of tumors. Importantly, the efficacy of hyperthermal therapy has recently been enhanced by the development of functional nanomaterials. The unique physicochemical properties of nanomaterials afford the specific localization of hyperthermia to primary tumors and early-stage cancers. In particular, due to their high rate of light-to-heat conversion and their capacity to be activated by tissue-penetrating electromagnetic radiation, near-infrared （NIR） light-absorbing plasmonic nanomaterials have attracted considerable attention as candidates for noninvasive photothermal therapy. The purpose of this article is to provide a overview on the current development in multifunctional nanomaterials capable of combined hyperthermia-chemotherapy delivery.

关键词： combination therapy multifunctional nanoparticle drug delivery hyperthermia photothermal therapy

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