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A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

Oncology Research 2024年第5期32卷 849-875页

作者： NILAM BHUSARE MAUSHMI KUMAR Somaiya Institute for Research&consultancy Somaiya Vidyavihar UniversityVidyavihar(East)Mumbai400077India

Glioblastoma,the most aggressive form of brain tumor,poses significant challenges in terms of treatment success and patient *** treatment modalities for glioblastoma include radiation therapy,surgical intervention,and ***,the median survival rate remains dishearteningly low at 12–15 *** of the major obstacles in treating glioblastoma is the recurrence of tumors,making chemotherapy the primary approach for secondary glioma ***,the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance ***,considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing targeted *** tackle glioma,numerous studies have examined kinase-downstream signaling pathways such as *** targeting specific signaling pathways,heterocyclic compounds have demonstrated efficacy in glioma ***,key kinases including phosphatidylinositol 3-kinase(PI3K),serine/threonine kinase,cytoplasmic tyrosine kinase(CTK),receptor tyrosine kinase(RTK)and lipid kinase(LK)have been considered for *** pathways play crucial roles in drug effectiveness in glioma *** compounds,encompassing pyrimidine,thiazole,quinazoline,imidazole,indole,acridone,triazine,and other derivatives,have shown promising results in targeting these *** part of this review,we propose exploring novel structures with low toxicity and high potency for glioma *** development of these compounds should strive to overcome multidrug resistance mechanisms and efficiently penetrate the blood-brain *** optimizing the chemical properties and designing compounds with enhanced drug-like characteristics,we can maximize their therapeutic value and minimize adverse *** the complex nature of glioblastoma,these novel structures should be rigorously tested and e

关键词： Glioblastoma Kinase pathway Pyrimidine Quinazoline Heterocycles

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Distributed Resource Allocation in Dispersed Computing Environment Based on UAV Track Inspection in Urban Rail Transit

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Computers, Materials & Continua 2024年第7期80卷 643-660页

作者： Tong Gan Shuo Dong Shiyou Wang Jiaxin Li Division of Consulting Beijing Metro Consultancy Corporation Ltd.Beijing100037China Department of Computer and Communication Engineering University of Science and Technology BeijingBeijing100083China

With the rapid development of urban rail transit,the existing track detection has some problems such as low efficiency and insufficient detection coverage,so an intelligent and automatic track detectionmethod based onUAV is urgently needed to avoid major safety *** the same time,the geographical distribution of IoT devices results in the inefficient use of the significant computing potential held by a large number of *** a result,the Dispersed Computing(DCOMP)architecture enables collaborative computing between devices in the Internet of Everything(IoE),promotes low-latency and efficient cross-wide applications,and meets users’growing needs for computing performance and service *** paper focuses on examining the resource allocation challenge within a dispersed computing environment that utilizes UAV inspection ***,the system takes into account both resource constraints and computational constraints and transforms the optimization problem into an energy minimization problem with computational *** Markov Decision Process(MDP)model is employed to capture the connection between the dispersed computing resource allocation strategy and the system ***,a method based on Double Deep Q-Network(DDQN)is introduced to derive the optimal ***,an experience replay mechanism is implemented to tackle the issue of increasing *** experimental simulations validate the efficacy of the method across various scenarios.

关键词： UAV track inspection dispersed computing resource allocation deep reinforcement learning Markov decision process

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Radiative Blood-Based Hybrid Copper-Graphene Nanoliquid Flows along a Source-Heated Leaning Cylinder

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1017-1037页

作者： Siti Nur Ainsyah Ghani Noor Fadiya Mohd Noor Institute of Mathematical Sciences Faculty of ScienceUniversiti MalayaKuala Lumpur50603Malaysia Center for Data Analytics consultancy&Services(UM-CDACS) Faculty of ScienceUniversiti MalayaKuala Lumpur50603Malaysia

Variant graphene,graphene oxides(GO),and graphene nanoplatelets(GNP)dispersed in blood-based copper(Cu)nanoliquids over a leaning permeable cylinder are the focus of this *** forms of graphene are highly beneficial in the biological and medical fields for cancer therapy,anti-infection measures,and drug *** non-Newtonian Sutterby(blood-based)hybrid nanoliquid flows are generalized within the context of the Tiwari-Das model to simulate the effects of radiation and heating *** governing partial differential equations are reformulated into a nonlinear set of ordinary differential equations using similar transformational *** equations are then transformed into boundary value problems through a shooting technique,followed by the implementation of the bvp4c tool in *** influences of various parameters on the model’s nondimensional velocity and temperature profiles,reduced skin friction,and reduced Nusselt number are presented for detailed *** results indicated that Cu-GNP/blood and Cu-GO/blood hybrid nanofluids exhibit the lowest and highest velocity distributions,respectively,for increased nanoparticles volume fraction,curvature parameter,Sutterby fluid parameter,Hartmann number,and wall permeability ***,opposite trends are observed for the temperature distribution for all considered parameters,except the mixed convection *** in the reduced skin friction magnitude and the reduced Nusselt number with higher values of graphene/GO/GNP nanoparticle volume fraction are also ***,GNP is identified as the superior heat conductor,with an average increase of approximately 5%and a peak of 7.8%in the reduced Nusselt number compared to graphene and GO nanoparticles in the Cu/blood nanofluids.

关键词： Hybrid nanofluid sutterby fluid tiwari-das model thermal radiation graphene graphene oxides graphene nanoplatelets

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气体流量和喷嘴直径对鼓泡塔内气泡大小和形状分布的影响

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Transactions of Nonferrous Metals Society of China 2024年第5期34卷 1710-1720页

作者：闫红杰张河杨刘柳 Thomas ZIEGENHEIN 周萍中南大学能源科学与工程学院长沙410083 TIV consultancy 7th Pl Road 131285281 TempeArizonaUnited States

通过高速摄影结合图像处理算法,研究气体流量和喷嘴直径对气泡尺寸和纵横比分布的影响。结果表明,在所有喷嘴直径下,气泡当量直径的概率密度呈现双峰分布,其中第一个峰值接近直径为1.5~2 mm的小气泡区域,另一个峰值位于较大的气泡区域... 详细信息

通过高速摄影结合图像处理算法,研究气体流量和喷嘴直径对气泡尺寸和纵横比分布的影响。结果表明,在所有喷嘴直径下,气泡当量直径的概率密度呈现双峰分布,其中第一个峰值接近直径为1.5~2 mm的小气泡区域,另一个峰值位于较大的气泡区域。将气体流量从0.1 L/min增加到0.2 L/min会导致大气泡的概率密度更高,表明气泡聚并现象普遍存在。当气体流量增加至1.2L/min时,峰值对应的气泡直径变小,并且气泡破裂占主导地位。对于直径为1~2 mm的气泡,形状受气体流量的影响较小,而3~9 mm的气泡在所有气体流量下气泡纵横比概率密度分布的峰值均位于纵横比E=0.5处。Iguchi和Chihara提出的模型能更好地预测气泡脱离直径随气体流量的增大的变化。

关键词：气泡尺寸分布气泡直径气泡纵横比气体流量喷嘴直径鼓泡塔

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Artificial Intelligence for Global Health: Difficulties and Challenges: A Narrative Review

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Open Journal of Epidemiology 2024年第1期14卷 122-130页

作者： Nazia S. Sadat Maryam S. Shuttari Mir Sadat-Ali Department of Applied Nutrition University of New England Portland USA Department of US consultancy for Applied Research Lombard USA Department of Haifa Medical Center AlKhobar Saudi Arabia

Global health (GH) aims to improve healthcare for all people on the planet and eradicate all avoidable diseases and deaths. The inception of Artificial Intelligence (AI) is innovating healthcare practices and improving patient outcomes by shuffling enormous volumes of health data—from health records and clinical studies to genetic information analyzing it much faster than humans. AI also helps in the improvement of medical imaging and medical diagnosis. There is an increased optimism regarding the use of applications of AI locally but can these facets be translated globally in the advancement and delivery of healthcare with the help of AI. At present majority of AI developments and applications in health care provide to the needs of developed countries and there is little effort to develop programs which could help to improve healthcare delivery globally. We performed this narrative review to assess the difficulties and discrepancies in implementing AI in global health delivery and find ways to improve.

关键词： Artificial Intelligence Global Health Implementation Pitfalls

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Critical movement of large rocks in currents and waves

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International Journal of Sediment Research 2019年第4期34卷 387-398页

作者： L.C.van Rijn LVR-Sediment consultancy

Cobbles, boulders, and rocks often are used in a bed protection layer near a structure to protect the underlying sand bed against erosion by combined current and waves. The design of a bed protection layer consisting of loose rocks(rubble mound) requires knowledge of the stability and movement(as bed load) of very coarse materials. If some movement(or damage) is acceptable, the rock diameter can be designed to be smaller. This paper addresses the stability and movement of very coarse materials(cobbles, boulders, and rocks) based on the concept of the critical Shields mobility number. It is shown that the bed load transport of large cobbles, boulders, and rocks can be described by the equations of Meyer-Peter and Mueller(MPM) and Cheng. Both are valid for relatively small Shields mobility *** and general equations for the design of a bed protection layer(including some permissible damage)in conditions with a current with or without waves are proposed based on the Shields mobility parameter and the bed load transport equation of Cheng. Laboratory and field data of critical velocities for pebbles, cobbles, boulders, and rocks have been analyzed and compared to the computed results of the proposed equations. Practical applications are given to demonstrate the general applicability of the proposed equations.

关键词： Rock stability Bed protection Critical movement Bed load transport Rocks

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抗生素在动物生产中的应用将给人类健康带来怎样的冲击

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农村养殖技术（新兽医） 2006年第3期 26-28页

作者： Robin J, bywater 邹华（译编） bywater consultancy Clungunford Shropshire UK

该文讲到：在人类医学中，抗生素耐药性是一个日益严重的问题，并且人们普遍认为这种耐药性主要源于治疗人类疾病时大量使用抗菌药物。但是在动物使用抗生素，尤其是使用抗生素生长促进剂（AGPs）是否也会导致人类对抗生素的耐药性，该... 详细信息

该文讲到：在人类医学中，抗生素耐药性是一个日益严重的问题，并且人们普遍认为这种耐药性主要源于治疗人类疾病时大量使用抗菌药物。但是在动物使用抗生素，尤其是使用抗生素生长促进剂（AGPs）是否也会导致人类对抗生素的耐药性，该问题正在引起人们的关注，并且引发了激烈的讨论。

关键词：抗生素耐药性人类健康动物生产抗生素生长促进剂应用人类医学抗菌药物人类疾病动物使用

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How will biomining be applied in future?

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中国有色金属学会会刊：英文版 2008年第6期18卷 1302-1310页

作者： C.L.BRIERLEY Brierley consultancy LLC P.O.Box 630012Highlands Ranch

这篇论文在全世界考察商业 biomining 操作的当前的地位，识别作为一种处理技术驾驶 biomining 的选择的因素，描述挑战到利用这些革新，并且与 biomining 的未来的讨论得出结论。Biomining 商业地用设计垃圾场，堆和搅动的坦克被使用... 详细信息

这篇论文在全世界考察商业 biomining 操作的当前的地位，识别作为一种处理技术驾驶 biomining 的选择的因素，描述挑战到利用这些革新，并且与 biomining 的未来的讨论得出结论。Biomining 商业地用设计垃圾场，堆和搅动的坦克被使用。克服阴沉的费用的技术挑战，处理在矿的低档，低质量、复杂的矿石和利用存在大写的投资要求微生物引起的活动和创新工程的更好的理解。克服 biomining 广告挑战必要改进采矿 company/biomining 改革者合作和知识产权控制。

关键词：生物采矿生物浸取应用技术研究

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Integrated “Generate, Make, and Test” for Formulated Products using Knowledge Graphs

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Data Intelligence 2021年第3期3卷 340-375页

作者： Sagar Sunkle Deepak Jain Krati Saxena Ashwini Patil Tushita Singh Beena Rai Vinay Kulkarni Tata consultancy Services Research Pune MaharashtraIndia411013

In the multi-billion dollar formulated product industry, state of the art continues to rely heavily on experts during the "generate, make and test" steps of formulation design. We propose automation aids to each step with a knowledge graph of relevant information as the central artifact. The generate step usually focuses on coming up with new recipes for intended formulation. We propose to aid the experts who generally carry out this step manually by providing a recommendation system and a templating system on top of the knowledge graph. Using the former, the expert can create a recipe from scratch using historical formulations and related data. With the latter, the expert starts with a recipe template created by our system and substitutes the requisite constituents to form a recipe. In the current state of practice, the three steps mentioned above operate in a fragmented manner wherein observations from one step do not aid other steps in a streamlined manner. Instead of manually operated labs for the make and test steps, we assume automated or robotic labs and in-silico testing, respectively. Using two formulations, namely face cream and an exterior coating, we show how the knowledge graph may help integrate and streamline the communication between the generate, the make, and the test steps. Our initial exploration shows considerable promise.

关键词： Formulated product design Formulation recommendation Formulation template Robotic labs In-silico testing Integrated generate-make-test

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Investigation of MS and Anti-segregation Process HSS Flat Broaching Tools

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厦门大学学报（自然科学版） 2002年第S1期41卷 106-107页

作者： Mohammed Sarwar Industrial Research & consultancy Centre

An investigation has been carried out to compare th e cutting performance and tool life evaluation of high speed steel broach samp les. The comparison has been done between conventional M2 and Anti-Segregation Process (ASP) ASP53 and ASP30 high speed steel broach samples. The ASP53 was a development material. The cutting performance was evaluated by measuring the c utting forces and calculating the specific cutting energy, an indicator of cutti ng performance. As the roughness of the machined surface is an important criter ion in the evaluation of performance of a tool, the surface roughness of the workpiece was studied as a function of undeformed chip thickness. The workpiec e material was 150M36 alloy steel used in manufacture of automobile engines. Th e performance tests were conducted at two cutting speeds, which were 0 7 m/min and 10.5 m/min respectively. This allowed a better understanding of the effect of cutting speed on tool performance. The wear tests were performed at a cuttin g speed on 10.5 m/min. The cutting edges of ASP broach samples were finer compared to that of M2. Ther e was no practical difference in the cutting forces and the specific cutting ene rgy while cutting with MS, ASP30 and ASP53 broach samples. The ASP30 and ASP53 tools have a better surface roughness on the machined surface than that of M2 at both cutting speeds. The ASP30 gave 2.25 times the life and an improved surfac e finish compared to M2 steel. The ASP53 gave 1.3 times the life of M2 steel. These results should prove useful to the tool designer and manufacturing enginee r.

关键词： Investigation of MS and Anti-segregation Process HSS Flat Broaching Tools MS

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