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ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 2024年第6期19卷 100971页

作者： Ercelik, Melis Tekin, Cagla Gurbuz, Melisa Tuncbilekli, Yagmur Dogan, Hazal Yilmaz Mutlu, Busra Eser, Pinar Tezcan, Gulcin Parin, Fatma Nur Yildirim, Kenan Sarihan, Mehmet Akpinar, Gurler Kasap, Murat Bekar, Ahmet Kocaeli, Hasan Taskapilioglu, Mevlut Ozgur Aksoy, Secil Ak Ozpar, Rifat Hakyemez, Bahattin Tunca, Berrin bursa Uludag univ Fac Med Dept Med Biol Bursa Turkiye bursa Uludag univ Fac Med Dept Neurosurg Bursa Turkiye bursa tech univ Dept Met & Mat Engn Bursa Turkiye bursa tech univ Cent Res Lab Bursa Turkiye bursa Uludag univ Fac Dent Dept Fundamental Sci Bursa Turkiye bursa tech univ Fac Engn & Nat Sci Dept Polymer Mat Engn Bursa Turkiye Kocaeli univ Dept Med Biol Prote Lab Kocaeli Turkiye Istanbul Yeni Yuzyil univ Fac Med Dept Neurosurg Istanbul Turkiye bursa Uludag univ Inegol Vocat Sch Bursa Turkiye bursa Uludag univ Fac Med Dept Radiol Bursa Turkiye

Total resection of glioblastoma (GB) tumors is nearly impossible, and systemic administration of temozolomide (TMZ) is often inadequate. This study presents a hybrid layered composite nanofiber mesh (LHN) designed for localized treatment in GB tumor bed. The LHN, consisting of polyvinyl alcohol and core-shell polylactic acid layers, was loaded with TMZ and rutin. In vitro analysis revealed that LHNTMZ and LHNrutin decelerated epithelial-mesenchymal transition and growth of stem-like cells, while the combination, LHNTMZ+rutin, significantly reduced sphere size compared to untreated and LHNTMZ-treated cells (P university. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/)

关键词： Glioblastoma Local treatment Temozolomide Rutin Hybrid layered composite nanofiber web

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Study on the hydrogen absorption properties of a YGdTbDyHo rare-earth high-entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 127-135页

作者： Tongyue Li Ziliang Xie Wenjiao Zhou Huan Tong Dawen Yang Anjia Zhang Yuan Wu Xiping Song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Whole Win(Beijing)Materials Sci.&tech.Co. Ltd.Beijing 100083China

This study investigated the microstructure and hydrogen absorption properties of a rare-earth high-entropy alloy(HEA),*** indicated that the YGdTbDyHo alloy had a microstructure of equiaxed grains,with the alloy elements distributed *** hydrogen absorption,the phase structure of the HEA changed from a solid solution with an hexagonal-close-packed(HCP)structure to a high-entropy hydride with an faced-centered-cubic(FCC)structure without any secondary phase *** alloy demonstrated a maximum hydrogen storage capacity of 2.33 H/M(hydrogen atom/metal atom)at 723 K,with an enthalpy change(ΔH)of-141.09 kJ·mol^(-1)and an entropy change(ΔS)of-119.14 J·mol^(-1)·K^(-1).The kinetic mechanism of hydrogen absorption was hydride nucleation and growth,with an apparent activation energy(E_(a))of 20.90 kJ·mol^(-1).Without any activation,the YGdTbDyHo alloy could absorb hydrogen quickly(180 s at 923 K)with nearly no incubation period *** reason for the obtained value of 2.33 H/M was that the hydrogen atoms occupied both tetrahedral and octahedral *** results demonstrate the potential application of HEAs as a high-capacity hydrogen storage material with a large H/M ratio,which can be used in the deuterium storage field.

关键词： rare-earth high-entropy alloy hydrogen absorption capacity pressure–composition–temperature curves kinetics

A breakthrough of printable mesoscopic perovskite solar cells

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Science China Materials 2025年第01期 307-308页

作者： Zhiyi Yao Zhijun Ning School of Physical Science and technology Shanghai Tech University

High-performance solar cells based on low-cost wet coating methods are the much-anticipated technology for the next generation of photovoltaics. Perovskite solar cells (PSCs) provide a fascinating choice because their...

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STUDY AND APPLICATION OF SILLIMANITE FLOTATION AGENTS

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Journal of Wuhan university of technology(Materials Science) 1994年第1期9卷 83-88页

作者：方和平罗亚田 Wuhan univ of tech China

This paper, starting from the study on the surface elec-tric-property differences between sillimanite in some Chinese mine and its main inter grown silicates, detailedly inquires into the mixing function of fatty acids and hydrocarbon sulfonic acids collecting agents on sillimanite and based on this finds the optimum agent-blending system , so that it is possible to realize the efficient separation of sillimanite , mica and quartz. Through the single flotation closed-circuit experiment of hard-to -be-sepa-rated ores with hair-like corpuscles embedded, the authors have successively separated out the sillimanite concentration (A12O3 56. 31% ; Fe2O31. 07% ; TiO2 1. 0% ; alkalis 0. 2% )from the raw ores (sillimanite 15% ; A12O3 19. 92% ; Fe2O31. 90% i TiO2 3% ; alkalis 0. 2%) and obtained the silli-manite flotation recovery as high as 70% .

关键词： sillimanite quartz mica flotation flotation agents

NEW DEVELOPMENT IN THE PROCESSING OF KAOLIN IN CHINA

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Journal of Wuhan university of technology(Materials Science) 1994年第1期9卷 98-103页

作者：袁继祖龚文琪夏惠芳 Wuhan univ of tech China

: To meet the increasingly higher requirements on the quali-ty of kaolins from the industries of paper, ceramics, rubber and plastics, etc. , the processing of kaolins in China has undergone remarkable develop-ment in recent years. This article reports the new achievements in tech-niques , processes and equipment in flotation, selective flocculation, high gradient magnetic separation and classification of altrafines in the process-ing of kaolins in China. The comprehensive utilization of kaolins is also re-ported.

关键词： kaolin processing flotation flocculation mag-netic separation leaching

CURE OF PREPOLYMER BASED ON METHYL METHACRYLATE/STYRENE AND OPTICAL PROPERTY AND HYDROTHRMAL STABILITY OF TRANSPARENT FIBRE—REINFORCED THERMOPLASTIC COPOLYMER COMPOSITES

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Journal of Wuhan university of technology(Materials Science) 1994年第2期9卷 42-49页

作者：赵方鸣郁轶澄刘雄亚 Wuhan univ of tech China

: Copolymers used for transparent fibre glass-reinforced thermoplastic composite -were prepared from methyl methacrylate (.MMA) and styrene (St). Composites containing 20~25 ivt% glass fibre and 0. 7 mm in thickness had an overall optical transmission of 88 ~90%. The gel time and cure time of the prepolymers from MM A and St decreased markedly ivith addition of tiie two linear unsaturated polyesters (.LUPE) and curing process of composite laminate became controlling easily-The effect of the concentration of LUPE on thermal stability of copolymers 晅he optical properties and the hydrothermal sta-bility of composites was investigated by comparing with those of trans-parent unsaturated composites .

关键词： transparent fibre composites MM A styrene copoly-mer cure hydrothermul stability

SYNERGISTIC ACTIVATION OF CHELATING AGENT ON XANTHATE DURING THE FLOTATION OF REFRACTORY COPPER OXIDIZED ORES

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Journal of Wuhan university of technology(Materials Science) 1994年第1期9卷 89-97页

作者：徐晓军刘邦瑞 Wuhan univ of tech China

For realizing the effective flotation of refractory copper ox-idized ores and developing the activation-flotation theory , the influences of nine different organic chelating agents on xanthate collection pcnver and its adsorption characteristics ivere studied in the flotation of malachite and chrysocolla representatively selected by means of XPS,IR, absorbed quanti-ty measurements and flotation *** easily-dissolved malachite flotation , a small amount of chelating agent can obviously enhance xanthate collecting power and make malachite floated easily , and so reduces the consumption of xanthate. For hard-dis-晄olved chrysocolla, chelating agent is able to increase its recovery to 90% , but the chelating agent consumption is high. Chelating agent and xanthate can produce synergistic adsorptions, which follmv Freundlich's adsorption equation on malachite and Chrysocolla surfaces. The high chemical activity of chelating agent and its synergistic activation on xanthate are the key to improving xanthate collection poiver. The synergistic activation of chelat-ing agent on xanthate on melachite surfaces is clearly stronger than on chrysocolla surfaces. According to experimental results, it can be thought that the synergistic activation results from the synergistic complexation of chelating agent and xanthate with copper ions to form biligand-tribasic co-ordination complex.

关键词： organic chelating agent copper oxidized ores activa-tion flotation malachite chrysocolla

Investigation of Sintered Maraging Steels

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Journal of Materials Science & technology 2001年第1期17卷 47-48页

作者： S. Chtchegolikhina Far Eastern State technical university, Vladivostok, Russia Far Eastern State tech univ Vladivostok Russia

Processing of five grades of sintered maraging steels containing 13% Cr, 9% Ni, 1% Ti and different quantities of Mo, Co is described. Variations of ageing temperatures and ageing holding times had resulted in choosing optimum regime of ageing f T=550℃, T=2.5 h. It allowed to receive mechanical properties of these steels like to them for compact steels; UTS=1200 MPa, EL=5.3%, RA=7%, and Charpy impact =1445 kJ/m2. X-ray analysis had shown phases Fe7Mo6, Fe2Mo in steels containing Co and decreasing of the period 'of or-phase lattice in these steels after ageing.

关键词： Investigation of Sintered Maraging Steels

STUDY ON THE SURFACE ELECTRIC CHARACTERISTICS OF FLAKE GRAPHITE AND THE MECHANISM OF ABSORPTION MEDICAMENT

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Journal of Wuhan university of technology(Materials Science) 1994年第1期9卷 35-38页

作者：方和平 Wuhan univ of tech China

It is of important significance to make studies on the sur-face electric characteristics of flake graphite and their variation law for strengthening the floatation of flake *** this paper, DPM type microelectrophoresis apparatus is used to de-termine the surface Zeta-potential of flake graphite pure mineral, study the affection of pulp pH value, seueral kinds of inorganic salt ions and anion surface activation agent (petroleum sodium sulfonate ) on flake graphite surface Zeta-potential,and explore the surface absorption charac-teristics of *** floatation experiment of flake graphite pure mineral shows that both the petroleum sodium sulfonate and inorganic salt can strengthen the conventional floatation of flake graphite. The surface characteristic varia-tion caused by them is also an important factor to promote graphite floata-tion.

关键词： graphite surface electric charactorictics floata- tion medicament