检索结果-南通市图书馆

Medical management of victims contaminated with radionuclides after a “dirty bomb” attack

Military Medical Research 2019年第1期6卷 13-22页

作者： Alexis Rump Benjamin Becker Stefan Eder Andreas Lamkowski Michael Abend Matthias Port bundeswehr institute of radiobiology

A wide spectrum of scenarios may lead to radiation incidents and the liberation of radioactive material. In the case of a terrorist attack by a "dirty bomb", there is a risk of mechanical and thermal trauma, external irradiation, superficial contamination and incorporation of radioactive material. The first treatment priority must be given to the care of trauma patients with life-threatening injuries, as the health effects of radiation occur with latency. Radionuclide incorporation will lead to a longer-lasting irradiation from inside the body, associated with a higher risk of stochastic radiation effects(e.g., occurrence of tumors) in the long run. It must be expected that victims with potentially incorporated radionuclides will far outnumber trauma patients. The elimination of radionuclides can be enhanced by the administration of decorporation agents such as(Ca) Diethylenetriaminepentaacetic acid(DTPA) or Prussian blue,reducing the radiological burden of the body. There is still no consensus whether decorporation treatment should be started immediately based only on a suspicion of radionuclide incorporation("urgent approach") or if the results of internal dosimetry confirming the necessity of a treatment should be awaited, accepting the delay caused by the measurements and computations("precautionary approach"). As the therapeutic effectiveness may be substantially decreased if treatment initiation is delayed only by several days, depending on the radionuclide, the physicochemical properties of the compounds involved and the route of absorption, we favor an "urgent approach" from a medical point of view. In doubt, it seems justified to treat victims by precaution, as the adverse effects of the medication seem minimal. However, in the case of a high number of victims, an "urgent treatment approach" may require a large number of daily doses of antidotes, and therefore, adequate investments in preparedness and antidote stockpiling are necessary.

关键词： Medical NRBC protection Radiological emergency Dirty bomb Combined injuries Radionuclide incorporation Decorporation therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparing for a “dirty bomb” attack: The optimum mix of medical countermeasure resources

引用

Military Medical Research 2021年第3期8卷 336-351页

作者： Alexis Rump Patrick Ostheim Stefan Eder Cornelius Hermann Michael Abend Matthias Port bundeswehr institute of radiobiology Neuherberg Str.n80937 MunichGermany

Background: In radiological emergencies with radionuclide incorporation, decorporation treatment is particularly effective if started early. Treating all people potentially contaminated("urgent treatment") may require large antidote stockpiles. An efficacious way to reduce antidote requirements is by using radioactivity screening equipment. We analyzed the suitability of such equipment for triage purposes and determined the most efficient mix of screening units and antidote daily ***: The committed effective doses corresponding to activities within the detection limits of monitoring portals and mobile whole-body counters were used to assess their usefulness as triage tools. To determine the optimal resource mix, we departed from a large-scale scenario(60,000 victims) and based on purchase prices of antidotes and screening equipment in Germany, we calculated efficiencies of different combinations of medical countermeasure resources by data envelopment analysis. Cost-effectiveness was expressed as the costs per life year saved and compared to risk reduction opportunities in other sectors of society as well as the values of a statistical ***: Monitoring portals are adequate instruments for a sensitive triage after cesium-137 exposure with a high screening throughput. For the detection of americium-241 whole-body counters with a lower daily screening capacity per unit are needed. Assuming that 1% of the potentially contaminated patients actually need decorporation treatment, an efficient resource mix includes 6 monitoring portals and 25 mobile whole-body counters. The optimum mix depends on price discounts and in particular the fraction of victims actually needing treatment. The costeffectiveness of preparedness for a "dirty bomb" attack is less than for common health care, but costs for a life year saved are less than for many risk-reduction interventions in the environmental ***: To achieve economic efficiency a high daily screening ca

关键词： Radiological emergency Dirty bomb Medical countermeasures Radionuclide incorporation Decorporation treatment Screening Efficiency Data envelopment analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Estimation of radiation-induced health hazards from a“dirty bomb”attack with radiocesium under different assault and rescue conditions

引用

Military Medical Research 2022年第1期9卷 106-125页

作者： Alexis Rump Stefan Eder Cornelius Hermann Andreas Lamkowski Patrick Ostheim Michael Abend Matthias Port bundeswehr institute of radiobiology Neuherberg Str.1180937 MunichGermany

In the case of a terrorist attack by a“dirty bomb”,blast injuries,external irradiation and the incorporation of radioactivity are to be *** from information about the radiological attack scenario with cesium-137 in the *** Scenario Planning Guide,we estimated the radiological doses *** calculations were performed for a smaller plume size and a detonation in a *** conditions as described in the ***,the committed effective dose amounted to a maximum of 848 mSv,even for very unfavorable *** bone marrow equivalent doses are insufcient to induce acute radiation sickness(ARS).In the case of a smaller plume size,the ARS threshold may be exceeded in some *** a subway bombing,doses are much higher and the occurrence of ARS should be *** health hazards from a dirty bomb attack will depend on the location and the explosive *** derived Haddon matrix indicates that preparing for such an event includes education of all the medical staff about radiation effects,the time lines of radiation damages and the treatment *** determinants of the outcome include rapid evacuation even from difficult locations,the availability of a specific triage tool to rapidly identify victims at risk for ARS,the availability of an antidote stockpile and dedicated hospital beds to treat seriously irradiated victims.

关键词： Medical NRBC protection Terrorism Radiological emergency Dirty bomb Combined injuries Triage Acute radiation sickness Radionuclide incorporation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pharmacological treatment of inhalation injury after nuclear or radiological incidents: The Chinese and German approach

引用

Military Medical Research 2019年第2期6卷 159-169页

作者： Tian-Tian Yan Guo-An Lin Min-Jie Wang Andreas Lamkowski Matthias Port Alexis Rump Military Burn Center the990th Hospital of the Joint Logistics SupportForces of Chinese PLA(the159th Hospital of Chinese PLA)Zhumadian463000HenanChina bundeswehr institute of radiobiology MunichGermany

Inhalation injury is often associated with burns and significantly increases morbidity and mortality. The main toxic components of fire smoke are carbon monoxide, hydrogen cyanide, and irritants. In the case of an incident at a nuclear power plant or recycling facility associated with fire, smoke may also contain radioactive material. Medical treatments may vary in different countries, and in this paper, we discuss the similarities and differences in the treatments between China and Germany. Carbon monoxide poisoning is treated by 100% oxygen administration and,if available, hyperbaric oxygenation in China as well as in Germany. In addition, antidotes binding the cyanide ions and relieving the respiratory chain are important. Methemoglobin-forming agents(e.g., nitrites, dimethylaminophenol)or hydroxocobalamin(Vitamin B12) are options. The metabolic elimination of cyanide may be enhanced by sodium thiosulfate. In China, sodium nitrite with sodium thiosulfate is the most common combination. The use of dimethylaminophenol instead of sodium nitrite is typical for Germany, and hydroxocobalamin is considered the antidote of choice if available in cases of cyanide intoxications by fire smoke inhalation as it does not further reduce oxygen transport capacity. Systematic prophylactic use of corticosteroids to prevent toxic pulmonary edema is not recommended in China or Germany. Stable iodine is indicated in the case of radioiodine exposure and must be administered within several hours to be effective. The decorporation of metal radionuclides is possible with Ca(DTPA)or Prussian blue that should be given as soon as possible. These medications are used in both countries, but it seems that Ca(DTPA) is administered at lower dosages in China. Although the details of the treatment of inhalation injury and radionuclide(s) decorporation may vary, the general therapeutic strategy is very similar in China and Germany.

关键词： Fire smoke Inhalation injury Carbon monoxide Cyanide Radionuclide incorporation Decorporation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of KTJT-1,an early-maturity mutant of sweet sorghum acquired by carbon ions irradiation

引用

Nuclear Science and Techniques 2014年第2期25卷 47-50页

作者：董喜存李文建 radiobiology Department Institute of Modern PhysicsChinese Academy of Sciences

Sweet sorghum has the potential of becoming a useful energy *** early-maturity mutant of sweet sorghum,KFJT-1,was obtained by carbon ions irradiation of KFJT-CK,a wild *** this paper,we evaluate the mutant from the length and fresh weight of radicle and leaves after seed germination,the growth rate at the elongation stage,and the internodal parameters under field trail *** results showed that the seedling growth of KFJT-1 was inhibited by carbon ions irradiation,and the leaf length,the fresh weight of radicle and leaves from KFJT-1 decreased by 15.32%,76.27%,and 27.08%than those of KFJT-CK,***,the growth rate of KFJT-1 on July 12,July 27 and August 1 increased by 16.19%,59.28%and26.87%,respectively,compared with the *** stalk diameter,total biomass yield and sugar content of KFJT-1 was higher than those of KFJT-CK,despite that the plant height of KFJT-1 was significantly less than KFJT-CK(P < 0.05).In addition,KFJT-1 differed from KFJT-CK in the internodal length,weight and sugar *** conclusion,the early-maturity mutant of KFJT-1 will be a promising variety for sweet sorghum industrialization in Gansu province,China.

关键词：早熟突变甜高粱碳离子离子辐照评价收购节间长度能源作物

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein lysine crotonylation in cellular processions and disease associations

引用

Genes & Diseases 2024年第5期11卷 219-235页

作者： Hongling Zhao Yang Han Pingkun Zhou Hua Guan Shanshan Gao Beijing Key Laboratory for radiobiology Beijing Institute of Radiation MedicineBeijing 100850China

Protein lysine crotonylation(Kcr)is one conserved form of posttranslational modifications of proteins,which plays an important role in a series of cellular physiological and pathological *** e-amino groups are the primary sites of such modification,resulting in four-carbon planar lysine crotonylation that is structurally and functionally distinct from the acetylation of these *** levels of Kcr modifications have been identified on both histone and non-histone *** present review offers an update on the research progression regarding protein Kcr modifications in biomedical contexts and provides a discussion of the mechanisms whereby Kcr modification governs a range of biological *** addition,given the importance of protein Kcr modification in disease onset and progression,the potential viability of Kcr regulators as therapeutic targets is elucidated.

关键词： Cell biology Disease Lysine crotonylation Posttranslational modification Therapeutic target

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

INDEPENDENT AND SYNERGIC INHIBITION OF VERAPAMIL AND ELECTRIC BEAM RADIATION ON CLONOGENIC GROWTH IN K562 AND K562/ADM CELL LINES IN VITRO

引用

Chinese Journal of Cancer Research 1995年第1期7卷 24-27页

作者：谢佐福沈世仁 Department of radiobiology Tumor Research Institute Fujian Provincial Tumor Hospital Fuzhou

It was first reported here that verupamil(VP) and electric beam radiation(EBR) were capable of inhibiting,independently or synergically,clonogenic growth in two kinds of K562 cell lines, adriamycin(ADM)-sensitive and ADM-resistant(K562/S and K562/ADM).Results showed that clonogenic rate(CGR) decreased by 3%-99.9% in the prasence of dependent dose-ADM(3.8μg/ml) in K562/ADM cell lines,while treated with 0.5μM-6μM of *** was capable of potentiating radiosensitivity in K562/S and K562/ADM cell lines,whether before or after exposure of them to electric beam radiation,and significantly reduced CGR in these kinds of cell lines(P<0.01).

关键词： Verapamil Radiation K562 cell line K562/ADM cell line.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Developmental Toxicity in Mice Following Paternal Exposure to Di-N-Butyl-Phthalate (DBP)

引用

Biomedical and Environmental Sciences 2011年第5期24卷 569-578页

作者： Malgorzata M.DOBRZY SKA Ewa J.TYRKIEL Krzysztof A.PACHOCKI Department of Radiation Protection and radiobiology National Institute of Public Health-National Institute of Hygiene00-791 WarsawPoland Department of Environmental Toxicology National Institute of Public Health-National Institute of Hygiene00-791 WarsawPoland

Objective The aim of the present study was to investigate the effects of paternal Di‐N‐butyl‐phthalate （DBP） exposure pre‐ and postnatally on F1 generation offspring,and prenatally on F2 generation *** Male mice were exposed to either 500 mg/kg or 2 000 mg/kg of DBP for 8 weeks,and mated with non‐exposed ***‐quarters of the females were sacrificed a day prior to parturition,and examined for the number of living and dead implantations,and incidence of gross *** from the remaining females were assessed for developmental markers,growth parameters,as well as sperm quantity and *** There were no changes in the fertility of parents and in intrauterine development of the *** of DBP‐exposed males demonstrated growth‐*** paternal exposure to 500 mg/kg bw of DBP,there were almost twice the number of males than females born in the F1 generation.F1 generation females had a 2.5‐day delay in vaginal *** exposure to 2 000 mg/kg bw of DBP increased the incidence of sperm head malformations in F1 generation males;however,there were no changes in the fertility and viability of foetuses in the F2 *** Paternal DBP exposure may disturb the sex ratio of the offspring,delay female sexual maturation,and deteriorate the sperm quality of F1 generation males.

关键词： Di‐n‐butyl phthalate Paternal exposure Pre‐ and postnatal effects Male‐mediated developmental toxicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comethylation of p16 and MGMT genes in colorectal carcinoma:Correlation with clinicopathological features and prognostic value

引用

World Journal of Gastroenterology 2007年第8期13卷 1187-1194页

作者： Koviljka Krtolica Milena Krajnovic Slavica Usaj-Knezevic Dragan Babic Dusan Jovanovic Bogomir Dimitrijevic Laboratory for radiobiology and Molecular Genetics Institute of Nuclear Sciences "Vinca" P. O. BOX 522 Belgrade Serbia institute of Oncology Sremska KamenicaSerbia institute for Medical Statistics of Medical University BelgradeSerbia

AIM: To investigate the significance of p16 and O6- methylguanine-DNA methyltransferase (MGMT) genes promoter hypermethylation and K-ras mutations on colorectal tumorigenesis and progression. METHODS: p16 and MGMT methylation status was examined on 47 tumor samples, and K-ras mutational status was examined on 85 tumor samples. For methylation analysis, a methylation specific PCR (MS-PCR) method was used. RESULTS: p16 and MGMT promoter methylation was found in 51% (24/47) and 43% (20/47) of CRCs, respectively, and the K-ras mutation was found in 44% (37/85) of CRCs. Comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease within a two-year period of observation. Only 27% of patients with simultaneous p 16 and MGMT methylation showed the detectible occurrence of metastasis and/or death, compared to 67% of patients without double methylation or with no methylation (3/11 vs 22/33, P < 0.05, χ2-test). In addition, p16 and MGMT comethylation showed a trend toward an association with longer survival in patients with CRCs (35.5 ± 6.0 mo vs 23.1 ± 3.2 mo, P = 0.072, Log-rank test). Progression of the disease within a two-year period was observed in 66% of patients carrying the K-ras mutation, compared to only 19% of patients with wild type K-ras (29/44 vs 7/37, P < 0.001, χ2-test). The presence of the K-ras mutation significantly correlated to shortened overall survival (20.0 ± 1.9 mo vs 37.0 ± 1.8 mo, P < 0.001, Log-rank test). The comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease even when K-ras mutations were included in the analysis as an independent variable. CONCLUSION: Our data suggest that comethylation of promoters of p 16 and MGMT genes could have a prognostic value in patients with CRC. Specifically, concurrent methylation of both genes correlates with better prognosis.

关键词： Colorectal carcinoma DNA methylation p16 MGMT K-ras mutation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microalgae Improve the Photosynthetic Performance of Rice Seedlings(Oryza sativa L.)under Physiological Conditions and Cadmium Stress

引用

Phyton-International Journal of Experimental Botany 2022年第7期91卷 1365-1380页

作者： Ekaterina Yotsova Martin Stefanov Georgi Rashkov Margarita Kouzmanova Anelia Dobrikova Emilia Apostolova institute of Biophysics and Biomedical Engineering Bulgarian Academy of SciencesSofiaBulgaria Department of Biophysics and radiobiology Biological FacultySofia UniversitySofiaBulgaria

The aim of this study was to assess the impact of the microalgae Chlorella vulgaris on the rice seedlings at physiological conditions and under cadmium(Cd)*** examined the effects of *** in the nutrient solution on rice seedlings grown hydroponically in the presence and the absence of 150μM CdCl2,using the low(77 K)temperature and pulse amplitude modulated(PAM)chlorophyll fluorescence,P700 photooxidation measurements,photochemical activities of both photosystems,kinetic parameters of oxygen evolution,oxidative stress markers(MDA,H_(2)O_(2) and proline),pigment content,growth parameters and Cd *** revealed that the application *** not only stimulates growth and improves the functions of photosynthetic apparatus under physiological conditions,but also reduces the toxic effect of Cd on rice ***,the presence of the green microalgae in the nutrient solution of the rice seedlings during Cd exposure,signifi-cantly improved the growth,photochemical activities of both photosystems,the kinetic parameters of the oxygen-evolving reactions,pigment content and decreased lipid peroxidation,H_(2)O_(2) and proline *** showed that the alleviation of Cd-induced effects in rice seedlings is a result of the Cd sorption by microalgae,as well as the reduced Cd accumulation in the roots and its translocation from the roots to the shoots.

关键词： Chlorella vulgaris growth parameters low temperature chlorophyll fluorescence PAM chlorophyll fluorescence photosynthesis rice stress markers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：