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Initial Experience of NIR-II Fluorescence Imaging-Guided Surgery in Foot and Ankle Surgery

Engineering 2024年第9期40卷 19-27页

作者： Xiaoxiao Fan Jie Yang Huwei Ni Qiming Xia Xiaolong Liu Tianxiang Wu Lin Li Paras N.Prasad Chao Liu Hui Lin Jun Qian Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Centre for Optical and Electromagnetic Research&International Research Center for Advanced Photonics College of Optical Science and EngineeringZhejiang UniversityHangzhou 310058China Department of Orthopedics Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Institute for Lasers Photonicsand BiophotonicsDepartment of ChemistryState University of New YorkBuffaloNY 14260-3000USA Zhejiang Engineering Research Center of Cognitive Healthcare Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310027China

Optical imaging in the second near-infrared(NIR-II;900-1880 nm)window is currently a popular research topic in the field of biomedical *** study aimed to explore the application value of NIR-II fluorescence imaging in foot and ankle surgeries.A lab-established NIR-II fluorescence surgical navigation system was developed and used to navigate foot and ankle surgeries which enabled obtaining more high-spatial-frequency information and a higher signal-to-background ratio(SBR)in NIR-II fluorescence images compared to NIR-I fluorescence images;our result demonstrates that NIR-II imaging could provide higher-contrast and larger-depth images to *** types of clinical application scenarios(diabetic foot,calcaneal fracture,and lower extremity trauma)were included in this *** the NIR-II fluorescence imaging technique,we observed the ischemic region in the diabetic foot before morphological alterations,accurately determined the boundary of the ischemic region in the surgical incision,and fully assessed the blood supply condition of the ***-II fluorescence imaging can help surgeons precisely judge surgical margins,detect ischemic lesions early,and dynamically trace the perfusion *** believe that portable and reliable NIR-II fluorescence imaging equipment and additional functional fluorescent probes can play crucial roles in precision surgery.

关键词： Second near-infrared fluorescence imaging Foot and ankle surgery Indocyanine green Imaging-guided surgery

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Principal axes of M-DOF structures PartⅡ:Dynamic loading

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Earthquake Engineering and Engineering Vibration 2003年第1期2卷 39-50页

作者： Zach Liang GeorgeC.Lee Department of Civil Structural and Environmental Engineering University at BuffaloState University of New YorkBuffaloNew YorkUSA Research Associate Professor Multidisciplinary Center for Earthquake Engineering Research University at BuffaloState University of New YorkBuffaloNew YorkUSA Samuel P.Capen Professor of Engineering

This paper is the second in a two-part series that discusses the principal axes of M-DOF structures subjected to static and dynamic *** primary purpose of this series is to understand the magnitude of the dynamie response of structures to enable better design of structures and response modification devices/*** idealized design condi- tions,the structural responses are obtained by using single directinn input ground motions in the direction of the intended response modification devices/systems,and by assuming that the responses of the structure is deconpleable in three mutual- ly perpendicular *** standard practice has been applied to both new and retrofitted structures using various seis- mic protective *** limited information is available on the effects of neglecting the impact of directional couplings (cross effects of which torsion is a component)of the dynamic response of *** order to quantify such effects,it is necessary to examine the principal axes of structures under both static and dynamic *** this twn-part series,the first paper is concerned with static loading,which provides definitions and fundamental formulations,with the conclusion that cross effects of a statically loaded M-DOF structure resulting from the lack of principal axes are of insignificant magnitude. However,under dynamic or earthquake loading,a relatively small amount of energy transferred across perpendicular direc- tions is accumulated,which may result in significant enlargement of the structural *** paper deals with a formu- lation to define the principal axes of M-DOF structures under dynamic loading and develops quantitative measures to identify cross effects resuhing from the non-existence of principal axes.

关键词： principal axes of M-DOF structures structural response couplings cross effect theoretical base dynamic loading peak response estimation

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Deletion of IFT20 in early stage T lymphocyte differentiation inhibits the development of col agen-induced arthritis

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Bone Research 2014年第4期2卷 241-251页

作者： Xue Yuan Lee Ann Garrett-Sinha Debanjan Sarkar Shuying Yang Department of Oral Biology School of Dental MedicineUniversity at BuffaloThe State University of New YorkBuffaloNY 14214USA Department of Biochemistry School of Medicine and Biomedical SciencesUniversity at BuffaloThe State University of New YorkBuffaloNY 14203USA Laboratory for Biomaterials and Regenerative Therapeutics Department of Biomedical EngineeringUniversity at BuffaloThe State University of New YorkBuffaloNY 14260-2050USA Developmental Genomics Group New York State Center of Excellence in Bioinformatics and Life SciencesUniversity at BuffaloThe State University of New YorkBuffaloNY 14203USA

IFT20 is the smallest member of the intraflagellar transport protein（IFT） complex B. It is involved in cilia formation. Studies of IFT20 have been confined to ciliated cells. Recently, IFT20 was found to be also expressed in non-ciliated T cells and have functions in immune synapse formation and signaling in vitro. However, how IFT20 regulates T-cell development and activation in vivo is still unknown. We deleted the IFT20 gene in early and later stages of T-cell development by crossing IFT20flox/flox（IFT20f/f） mice with Lck-Cre and CD4-Cre transgenic mice, and investigated the role of IFT20 in T-cell maturation and in the development of T cell-mediated collagen-induced arthritis（CIA）. We found that both Lck-Cre/IFT20f/f and CD4-Cre/IFT20f/f mice were indistinguishable from their wild-type littermates in body size, as well as in the morphology and weight of the spleen and thymus. However, the number of CD4- and CD8-positive cells was significantly lower in thymus and spleen in Lck-Cre/IFT20f/f mice. Meanwhile, the incidence and severity of CIA symptoms were significantly decreased, and inflammation in the paw was significantly inhibited in Lck-Cre/IFT20f/f mice compared to Lck-Cre/IFT201/1littermates. Deletion IFT20 in more mature T cells of CD4-Cre/IFT20f/f mice had only mild effects on the development of T cells and CIA. The expression of IL-1b, IL-6 and TGF-b1 were significantly downregulated in the paw of Lck-Cre/IFT20f/f mice, but just slight decreased in CD4-Cre/IFT20f/f mice. These results demonstrate that deletion of IFT20 in the early stage of T-cell development inhibited CIA development through regulating T-cell development and the expression of critical cytokines.

关键词： INTRAFLAGELLAR TRANSPORT IFT NF-KAPPA-B RHEUMATOID-ARTHRITIS CELL DEVELOPMENT PRIMARY CILIUM KINESIN-II MICE EXPRESSION COMPLEX PROTEINS

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Randomization of Q_(p) spaces on the unit ball of C^(n)

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Science China Mathematics 2005年第Z1期48卷 306-317页

作者： LI Bo & OUYANG Caiheng Department of Mathematics, State University of New York at buffalo, buffalo, NY 14260, USA Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China Department of Mathematics State University of New York at Buffalo Buffalo USA Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan China

In this paper, we study the random power series of several complex variables,and give some sufficient conditions for random power series to belong to Qp and Qp,0spaces by means of their characterizations of Carleson m... 详细信息

关键词： random power series, function spaces, the unit ball.

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Modulated orientation-sensitive terahertz spectroscopy

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Photonics Research 2016年第3期4卷 1-8页

作者： Rohit Singh Deepu Koshy George Chejin Bae K.A.Niessen A.G.Markelz Department of Physics and Astronomy Depauw University Department of Physics Virginia Tech Department of Electrical Engineering University at Buffalo Department of Physics University at Buffalo

Intramolecular vibrations of large macromolecules reside in the terahertz range. In particular, protein vibrations are closely spaced in frequency, resulting in a nearly continuous vibrational density of states. This density of vibrations interferes with the identification of specific absorption lines and their subsequent association with specific functional motions. This challenge is compounded with the absorption being dominated by the solvent and local relaxational motions. A strategy for removing the isotropic relaxational loss and isolating specific vibrations is to use aligned samples and polarization-sensitive measurements. Here, we demonstrate a technique to rapidly attain the anisotropic resonant absorbance using terahertz time domain spectroscopy and a spinning sample. The technique, modulated orientation-sensitive terahertz spectroscopy(MOSTS), has a nonzero signal only for anisotropic samples, as demonstrated by a comparison between a silicon wafer and a wire grid polarizer. For sucrose and oxalic acid molecular crystals, the MOSTS response is in agreement with modeled results for the intermolecular vibrations. Further, we demonstrate that, even in the presence of a large relaxational background, MOSTS isolates underlying vibrational resonances.

关键词： THz Modulated orientation-sensitive terahertz spectroscopy

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Toll of Mental Disorders: TLR-Mediated Function of the Innate Immune System

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Neuroscience Bulletin 2019年第4期35卷 771-774页

作者： Jian-Feng Liu Ruyan Wu Jun-Xu Li Department of Pharmacology and Toxicology University at Buffalo Buffalo NY 14214 USA School of Medicine Yangzhou University Yangzhou 225000 China

Mental disorder is defined as a syndrome characterized by clinically significant disturbance in an individual’s cognition, emotion, or behavior that reflects a dysfunction in the psychological, biological, or develop... 详细信息

关键词： Mental Disorders TLR-Mediated Function Innate Immune System

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Spectral and fragility evaluations of retrofitted structures through strength reduction and enhanced damping

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Earthquake Engineering and Engineering Vibration 2009年第1期8卷 115-125页

作者： Gian Paolo Cimellaro Hwasung Roh Alessandro De Stefano Department of Structural & Geotechnical Engineering (DISTR) Polytechnic of Turin Turin Italy Department of Civil Structural & Environmental Engineering University at Buffalo The State University of New York Buffalo USA

A retrofit procedure for existing buildings called the ＂weakening and damping technique＂（WED） is presented in this paper. Weakening of structures can limit the maximum response accelerations during severe ground motions, but leads to an increase in the displacements or inter-story drifts. Added damping by using viscous dampers, on the other hand, reduces the inter-story drifts and has no significant effect on total accelerations, when structures behave inelastically. The weakening and damping technique addresses the two main causes for both structural and nonstructural damage in structures. The weakening retrofit is particularly suitable for structures that have overstressed components and weak brittle components. In this paper, the advantages of the WeD are verified by nonlinear dynamic analysis and simplified spectral approach that has been modified to fit structures with additional damping devices. A hospital structure located in the San Fernando Valley in California is selected as a case study. The results from both analyses show that the retrofit solution is feasible to reduce both structural acceleration and displacement. A sensitivity analysis is also carried out to evaluate the effectiveness of the retrofitting method using different combinations of performance thresholds in accelerations and displacements through fragility analysis.

关键词： weakening damping retrofit inelastic spectral response fragility analysis nonlinear dynamic analysis

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Bioorthogonal chemistry:a covalent strategy for the study of biological systems

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Science China Chemistry 2010年第1期53卷 61-70页

作者： LIM Reyna K.V. Department of Chemistry State University of New York at Buffalo

The development of genetically encoded,wavelength-tunable fluorescent proteins has provided a powerful imaging tool to the study of protein dynamics and functions in cellular and organismal ***,many biological functions are not directly encoded in the protein primary sequence,e.g.,dynamic regulation afforded by protein posttranslational modifications such as *** meet this challenge,an emerging field of bioorthogonal chemistry has promised to offer a versatile strategy to selectively label a biomolecule of interest and track their dynamic regulations in its native *** strategy has been successfully applied to the studies of all classes of biomolecules in living systems,including proteins,nucleic acids,carbohydrates,and *** the incorporation of a bioorthogonal reporter site-selectively into a biomolecule through either genetic or metabolic approaches has been well established,the development of bioorthogonal reactions that allow fast ligation of exogenous chemical probes with the bioorthogonal reporter in living systems remains in its early ***,we review the recent development of bioorthogonal reactions and their applications in various biological systems,with a detailed discussion about our own work―the development of the tetrazole-based,photoinducible 1,3-dipolar cycloaddition reaction.

关键词： bioorthogonal reaction proteins biotechnology 1 3-dipolar cycloaddition click chemistry tetrazole

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An off-and-towards-equilibrium strategy for vibrational control of structures

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Earthquake Engineering and Engineering Vibration 2006年第2期5卷 195-203页

作者：杨润林童迈周锡元闫维明刘锡荟 Department of Civil Engineering Civil & Environment Engineering School University of Science and Technology Beijing national Center for Earthquake Engineering Research SUNY at Buffalo 109 Red Jacket Quad. Buffalo NY 14261 USA Professor School of Architecture and Civil Engineering Beijing University of Technology Electronic Information Center Ministry of Information Industry

Traditional control strategies have difficulty handling nonlinear behavior of structures, time variable features and parameter uncertainties of structural control systems under seismic excitation. An off-and-towardsequilibrium （OTE） strategy combined with fuzzy control is presented in this paper to overcome these difficulties. According to the OTE strategy, the control force is designed from the viewpoint of a mechanical relationship between the motions of the structure, the exciting force and the control force. The advantage of the OTE strategy is that it can be used for a variety of control systems. In order to evaluate the performance of the proposed strategy, the seismic performance of a three-story shear building with an Active Tendon System （ATS） using a Fuzzy Logic Controller （FLC） is studied. The main advantage of the fuzzy controller is its inherent robustness and ability to handle any nonlinear behavior of structures. However, there are no design guidelines to set up the corresponding control rule table for a FLC. Based on the proposed strategy for the FLC, a control rule table associated with the building under study is developed, which then allows formation of a detailed algorithm. The results obtained in this study show that the proposed strategy performs slightly better than the linear quadratic regulator （LQR） strategy, while possessing several advantages over the LQR controller. Consequently, the feasibility and validity of the proposed strategy are verified.

关键词： structural vibration control control strategy off-and-towards-equilibrium control fuzzy control seismicexcitation active tendon system

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Review of Remotely Sensed Imagery Classification Patterns Based on Object-oriented Image Analysis

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Chinese Geographical Science 2006年第3期16卷 282-288页

作者： LIU Yongxue LI Manchun MAO Liang XU Feifei HUANG Shuo School of Geographic and Oceanographic Sciences Nanjing University Nanjing 210093 China Department of Geography State University of New York at Buffalo Buffalo NY 14261 USA

With the wide use of high-resolution remotely sensed imagery, the object-oriented remotely sensed informa- tion classification pattern has been intensively studied. Starting with the definition of object-oriented remotely sensed information classification pattern and a literature review of related research progress, this paper sums up 4 developing phases of object-oriented classification pattern during the past 20 years. Then, we discuss the three aspects of method- ology in detail, namely remotely sensed imagery segmentation, feature analysis and feature selection, and classification rule generation, through comparing them with remotely sensed information classification method based on per-pixel. At last, this paper presents several points that need to be paid attention to in the future studies on object-oriented RS in- formation classification pattern: 1) developing robust and highly effective image segmentation algorithm for multi-spectral RS imagery; 2) improving the feature-set including edge, spatial-adjacent and temporal characteristics; 3) discussing the classification rule generation classifier based on the decision tree; 4) presenting evaluation methods for classification result by object-oriented classification pattern.

关键词： object-oriented image analysis remote sensing classification pattern

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