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Citation analysis of the scientific publications of Britton chance in ISI citation indexes

Journal of Innovative Optical Health Sciences 2014年第2期7卷 129-142页

作者： Lin Z.Li Loet Leydesdorff Shoko Nioka Nannan Sun Eugene Garfield Departiment of Radiology PerelmanSchool of Medicine University of Penn.syluaninPhiladelphiaPA 19104USA briton chance laboratory of Redoa imaging Johnson Research FoundationDepartment of Biochemistryand BiophysicsPereiman School of Medicine University of Penn syluaniaPhiladelphiaPA 19104USA University of Amsterdam Amsterdam School of Communications research(ASCoR) Netherlands briton chance Center for Biomedical Photonics Wuhan National laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074P.R.China Inste for Scientific Informationo-Thomson Reuters Philadelphia PA 19180USA

Britton chance was a pioneer in many scientifc fields such as enzymatic reaction kinetis,bioenergetics,metabolism,in vivo NMr,and *** an engineer,physical chemist,physicist,physiologist,biophysicist,biochemist,innovator and educator,he had worked indiversifed fields over extended periods bet ween 1926 until his death in 2010,at the age of *** to illustrate his scientific career and great impact on research from a new perspective,weemploy scientometric analysis tools to analyze the publications of Britton chance with datadownloaded from the ISI Citation Indexes in April *** included articles,reviews andproceding papers but excluded meeting *** total,we obtained 1023 publication recordswith 1236 authors in 266 joumals with 17,114 citations from 1945 to *** show the annualpublications and citations that Britton chance received from 1945 to 2013,and generate HistCitemaps on the basis of the global citations(GCS)and local(sel)citations(LCS)to show thecitation relationships among the top-30 publications of Britton *** and the development of physical methods to probe it appear to be the commecting thread of the lifelongresearch of Britton ***,we generate the joumal map and co-authorship maptoshow the broad scope of research topics and collaborators and the high impacts of the scientificoeuvre of Britton chance ranging from physics,engineering,chemistry and biology to medicine.

关键词： Scientometric analysis impact Hist Cite citation tree metabolism mitochondria.

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3D imaging of the mitochondrial redox state of rathearts under normal and fasting conditions

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 60-69页

作者： He N.Xu Rong Zhou Lily Moon Min Feng Lin Z.Li Department of Radiology Universityof PennsyluaniaPhilade lphia PA 19104USA briton chance laboratory of redor imaging johnson research foundation Department of Biochemistry and Biophysics University of Pennsyluania Philade lphiaPA 19104USA Institute of Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104USA

The heart requires continuous ATP availability that is generated in the *** using the cell culture and perfiused organ models have been carried out to investigate thebiochemistry in the mitochondria in response to a change in substrate supply,mitochondrialbioenergetics of heart under normal feed or fasting conditions has not been studied at the tissuelevel with a sub-millimeter spatial resolution either in vivo or er *** of many food-derived metabolites to generate ATP in the mitochondria is realized through the NADH/NAD+couple acting as a central electron *** employed the chance redox scanner thelow-temperat ure fluorescence scanner to image the three-dimensional(3D)spatial distribution of themitochondrial redox states in heart tissues of rats under normai feeding or an overnight star-vation for 14.5 *** consecutive sections of each heart were imaged to map three redoxindices,i.e,NADH,oxidized favoproteins Fp,including flavin adenine dinucleotide(FAD)andthe redox ratio NADH/*** imaging results revealed the micro-heterogeneity and the spatial distribution of these redox *** quantitative analysis showed that in the fasted hearts thestandard deviation of both NADH and Fp,ie.,SD NADH and SDFp,significantly decreasedwith a p value of 0.032 and 0.045,respectively,indicating that the hearts become relatively morehomogeneous after *** fasted hearts contained 28.6%less NADH(p=0.038).No *** change in Fp was foumnd(p=0.4).The NADH/Fp ratio decreased with a marginalP value(0.076).The decreased NADH im the fasted hearts is consistent with the cardiac celsreliance of fatty acids consumption for energy metabolism when glucose becomes *** o bservation of N ADH decrease induced by dietary restriction in the heart at tissuelevel has not been reported to our best *** chance redox scanner demonstrated thefeasibility of 3D imaging of the mitochondrial redox st ate in the heart and

关键词： Mitochondion metabolism bioenergetics cardiomyocyte NADH flavoproteins Fp FAD caloric restriction food deprivation.

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