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浙江普利斐特生产基地一期组团

建筑学报 2020年第7期 56-59页

作者：朱培栋沈晓峰王雨非龚悦陈智航谢道清周剑丰建华黄国华孙啸宇洪洋金煜庭刘甲蔡肖愚史建国刘茉然陈威龙顾传杰李上阳金剑波苏陈娟汤睿娴无不详 GLA建筑设计 gad·line+studio 存在建筑

1从水池望向西侧员工宿舍2从下沉水径望向对外服务车间次入口(摄影:简直建筑-空间摄影)3生活服务中心与下沉水径(摄影:简直建筑-空间摄影)4串联各功能体量的山径5从无尘车间通向食堂的山径6生活服务中心与庭院-叠石理水(摄影:简直建筑-... 详细信息

1从水池望向西侧员工宿舍2从下沉水径望向对外服务车间次入口(摄影:简直建筑-空间摄影)3生活服务中心与下沉水径(摄影:简直建筑-空间摄影)4串联各功能体量的山径5从无尘车间通向食堂的山径6生活服务中心与庭院-叠石理水(摄影:简直建筑-空间摄影)。

关键词：生活服务中心员工宿舍叠石理水对外服务组团食堂庭院下沉

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乌克兰Cirlce line设计办公室

现代装饰 2016年第6期 58-67页

作者： Kate Kuzmenko Elizabeth Gundych Olga Vodko Alexander Angelovskiy 姜敏华 Circle line Intenors

这是一家来自乌克兰的室内设计公司Circle line为自己量身设计打造的办公室,改建自当地的一座老工业建筑。由于原有建筑结构比较独特,拥有较高的层高和开窗,窗台之间的距离有两米多,导致人在里面很不舒服,难以很好欣赏窗外的景色,考虑... 详细信息

这是一家来自乌克兰的室内设计公司Circle line为自己量身设计打造的办公室,改建自当地的一座老工业建筑。由于原有建筑结构比较独特,拥有较高的层高和开窗,窗台之间的距离有两米多,导致人在里面很不舒服,难以很好欣赏窗外的景色,考虑这一特点,设计师顺势采用了一种＂屋中屋＂的设计方案。

关键词：室内设计 line 乌克兰办公室工业建筑结构比较设计师开窗

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深厚软土桥梁桩基荷载传递特性及沉降控制效果研究

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中国铁道科学 2012年第4期33卷 13-19页

作者： Xin, Xuezhong Wei, Limin He, Qun Hangzhou-Ningbo Passenger Dedicated line Co. Ltd. Hangzhou Zhejiang 310009 China School of Civil Engineering Central South University Changsha Hunan 410075 China

通过杭甬铁路客运专线柯桥特大桥单桩静载试验,桩身应变、桩身压缩量及桥墩沉降的测试,研究深厚软土地区桥梁桩基的荷载传递特性及沉降控制效果。结果表明:桩侧摩阻力先于桩端阻力发挥作用;尽管桩端置于强风化凝灰质砂岩上,但在试验荷载... 详细信息

通过杭甬铁路客运专线柯桥特大桥单桩静载试验,桩身应变、桩身压缩量及桥墩沉降的测试,研究深厚软土地区桥梁桩基的荷载传递特性及沉降控制效果。结果表明:桩侧摩阻力先于桩端阻力发挥作用;尽管桩端置于强风化凝灰质砂岩上,但在试验荷载下2根超长试验桩的端承比均小于1.5%,桩的承载特性表现为摩擦桩的性质;单桩静载试验实测的桩身压缩量占桩顶沉降量的85%以上;桥墩浇筑完成后经过753d的沉降观测,2个试验墩实测沉降量分别为3.00和3.41mm,其中,无砟轨道铺设后300d的实测沉降分别为0.11和0.25mm,表明在深厚软土地区采用超长钻孔灌注桩控制桥梁基础沉降的效果显著。

关键词：桥梁桩基深厚软土超长钻孔灌注桩单桩静载试验荷载传递特性桩身变形沉降控制

Energy and carbon performance of urban buildings using metamodeling variable importance techniques

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Building Simulation 2021年第3期14卷 535-547页

作者： Yunliang Liu Wei Tian Xiang Zhou School of Mechanical Engineering Tongji UniversityShanghai 200092China Tianjin Key Laboratory of Integrated Design and On-line Monitoring for Light Industry&Food Machinery and Equipment College of Mechanical EngineeringTianjin University of Science and TechnologyTianjin 300222China Tianjin International Joint Research and Development Center of Low-Carbon Green Process Equipment Tianjin 300222China

Global urbanization causes more environmental stresses in cities and energy efficiency is one of major concerns for urban *** variable importance techniques have been widely used in building energy analysis to determine key factors influencing building energy *** of these applications,however,use only one type of variable importance ***,this paper proposes a procedure of conducting two types of variable importance analysis(predictive and variance-based)to determine robust and effective energy saving measures in urban *** two variable importance methods belong to metamodeling techniques,which can significantly reduce computational cost of building energy simulation models for urban *** predictive importance analysis is based on the prediction errors of metamodels to obtain importance rankings of inputs,while the variance-based variable importance can explore non-linear effects and interactions among input variables based on variance *** campus buildings are used to demonstrate the application of the method proposed to explore characteristic of heating energy,cooling energy,electricity,and carbon emissions of *** results indicate that the combination of two types of metamodeling variable importance analysis can provide fast and robust analysis to improve energy efficiency of urban *** carbon emissions can be reduced approximately 30%after using a few of effective energy efficiency measures and more aggressive measures can lead to the 60%of reduction of carbon ***,this research demonstrates the application of parallel computing to expedite building energy analysis in urban environment since more multi-core computers become increasingly available.

关键词： urban buildings variable importance metamodeling energy performance carbon emissions

Obesity, metabolic syndrome and diabetic retinopathy: Beyond hyperglycemia

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World Journal of Diabetes 2017年第7期8卷 317-329页

作者： Osinakachukwu Mbata Nada Fawzy Abo El-Magd Azza Bahram El-Remessy Program in Clinical and Experimental Therapeutics College of Pharmacy University of Georgia Medical College of Georgia/University of Georgia Medical Partnership Department of Biochemistry Faculty of Pharmacy Mansoura University Augusta Biomedical Research Corporation Charlie Norwood VA Medical Center Research Service Line

Diabetic retinopathy(DR) is the most feared ocular manifestation of diabetes. DR is characterized by progressive retinal damage that may eventually result in blindness. Clinically, this blindness is caused by progressive damage to the retinal microvasculature, which leads to ischemia, retinal swelling, and neovascularization. Retinopathy is associated with both type 1 and type 2 diabetes, with DR being the leading cause of new onset blindness in United States adults. Despite this strong association with diabetes, it must be noted that the development of retinopathy lesions is multifactorial and may occur in individuals without an established history of diabetes. Metabolic syndrome is a multifactorial condition of central obesity, hypertriglyceridemia, dyslipidemia, hypertension, fasting hyperglycemia, and insulin resistance. Although several studies examined the individual components observed in the metabolic syndrome in relation to the development of DR, there is conflicting data as to the association of the metabolic syndrome with the development of retinopathy lesions in nondiabetic subjects. This review will summarize the current literature on the evidence of the metabolic syndrome on retinopathy in subjects with and without an established history of diabetes. This review will also discuss some of the mechanisms through which metabolic syndrome can contribute to the development of retinopathy.

关键词： Diabetic retinopathy Diabetes Metabolic syndrome Oxidative stress Inflammation Insulin resistance

办公园区与生活园区——城市公共空间的商业开发与运营

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建筑实践 2020年第3期 90-97页

作者：孟凡浩 gad·line+studio

依现在的发展来看,"工作场所"不再是单纯的"办公建筑",您怎样看待此类空间的新变化、新趋势?当下的时代创新日新月异,技术革命使办公空间模式自然地发生新变化。最早的"工作场所"或许只是一张桌子、一块画布,后续分工细化产生了新的职业... 详细信息

依现在的发展来看,"工作场所"不再是单纯的"办公建筑",您怎样看待此类空间的新变化、新趋势?当下的时代创新日新月异,技术革命使办公空间模式自然地发生新变化。最早的"工作场所"或许只是一张桌子、一块画布,后续分工细化产生了新的职业,催生出集聚在一个空间办公的需求。办公空间逐步发展成信息与物质大规模生产的场所,同时劳动密集型产业对应需要大尺度流水线办公空间。现今,移动办公、视频会议等工作模式流行起来,改变了人与人之间的距离

关键词： office 公园区生活园区城市公共空间

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Gad line +,用建筑尊重自然

艺术与设计 2019年第8期8卷 76-81页

作者：宗澍坤无不详 Gad line + Studio

Dezeen互联网杂志在成功举办了首届大奖(Dezeen Award)活动后,2019年如期地开始了新的一届评选;就在7月的第二周,入围名单中的中国设计团队和作品涵盖了“年度建筑师”、“年度新锐建筑设计团队”、“年度新锐室内设计团队”、“家具设... 详细信息

Dezeen互联网杂志在成功举办了首届大奖(Dezeen Award)活动后,2019年如期地开始了新的一届评选;就在7月的第二周,入围名单中的中国设计团队和作品涵盖了“年度建筑师”、“年度新锐建筑设计团队”、“年度新锐室内设计团队”、“家具设计”、“产品设计”、“文化类建筑”、“再生改造类建筑”等二十余个分类奖项。

关键词：建筑师尊重自然 Gad 建筑设计室内设计家具设计产品设计互联网

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灰水利用的契机--对境外水域的探寻与思考

景观设计学（中英文） 2018年第1期6卷 139-147页

作者：托马斯.尼德律斯特陆小璇孙一鹤 Landscape Architect (Switzerland) 35 line Street Cambridge MA 02138 USA

干旱地区约占陆地总面积的41%,承载着全球三分之一的人口,更有多个特大城市坐落其中,以丰富的矿产和肥沃的土壤创造了每年数十亿美元的经济收入。然而,持续的人口增长与不断变化的降水量造成了水资源的严重短缺。为在维持当地经济稳定... 详细信息

干旱地区约占陆地总面积的41%,承载着全球三分之一的人口,更有多个特大城市坐落其中,以丰富的矿产和肥沃的土壤创造了每年数十亿美元的经济收入。然而,持续的人口增长与不断变化的降水量造成了水资源的严重短缺。为在维持当地经济稳定发展的同时有效进行人口增长的预测,世界各地的政府纷纷将水-能网络扩展到境外流域中。作为由哈佛大学查尔斯·艾略特旅行奖学金资助的比较设计研究项目的一部分,本文探讨了全球范围内的水资源短缺问题。项目研究了旱灾对干旱地区的影响,记录了不同区域水系统的特征,概述了大型水利工程对社会经济与社会生态的影响。通过呈现这些过程,本文从景观设计学的角度探讨了当前的水资源议题,通过强调灰水的重要性而将视野从"水之稀缺"向"水之充沛"转变。为印证这一具有社会和经济复杂性的构想,该项目通过国际案例研究探讨了中央集控下跨境调水的缺陷以及地方分控下灰水收集及利用的潜力。为应对水资源短缺的问题,跨尺度且多样化的干预措施不可或缺;以景观过程为框架的混合系统的建立,成为了跨学科规划与设计的关键。

关键词：水资源短缺干旱资源充沛模式非中心化基于景观的方法

Regulation of inflammasomes by ubiquitination

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Cellular & Molecular Immunology 2016年第6期13卷 722-728页

作者： Joseph S Bednash Rama K Mallampalli Division of Pulmonary Allergy and Critical Care Medicine Department of Medicine Acute Lung injury Center of Excellence University of Pittsburgh Pittsburgh PA 15213 USA Department of Cell Biology and Physiology and Bioengineering University of Pittsburgh Pittsburgh PA 15213 USA Medical Specialty Service line Veterans Affairs Pittsburgh Healthcare System Pittsburgh PA 15240 USA

Inflammasomes are multi-protein complexes that regulate the innate immune response by facilitating the release of inflammatory cytokines in response to pathogen exposure or cellular damage. Pro-inflammatory inflammasome signaling is vital to host defense and helps initiate the process of tissue repair following an insult to the host, but can be injurious, when excessive or chronic. As such, inflammasome activity is tightly regulated. Here we discuss one critical mechanism of inflammasome regulation, ubiquitination, that functions as a universal modulator of protein stability and trafficking. Recent studies have provided important insights into the regulation of inflammasome activation by protein ubiquitination. We review the molecular regulation of inflammasome function, specifically, as it relates to ubiquitination, and discuss the implications for the development of theraoeutics to soecificallv target aberrant inflammasome signaling.

关键词： deubiquitinase E3 ligase inflammasome innate immunity ubiqutin