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Artemsieverolactones A—H,Eight Guaiane-Type Sesquiterpenoid Trimers from Artemisia sieversiana

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Chinese Journal of Chemistry 2024年第10期42卷 1084-1092页

作者： Wei Dong Xiao-Yan Huang Tian-Ze Li Yan-Mei Weng Chang-An Geng Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academyof Sciences Beijing 100049China

Eight new guaiane-type sesquiterpenoid trimers,artemsieverolactones A—H,possessing unprecedented scaffolds via biocatalyzed[4+2]Diels−Alder cycloaddition reactions were identified from Artemisia *** structures were determined by comprehensive spectroscopic data,single-crystal X-ray diffraction analyses,and ECD *** terms of structure,artemsieverolactones A—H are first examples of sesquiterpenoid trimers from guaiane-type sesquiterpenoid through four different[4+2]Diels−Alder cycloaddition *** fibrosis assay suggested that five compounds exhibited activity against HSC-LX2 with IC_(50)values ranging from 37.8 to 117.1μmol/*** most active artemsieverolactone B(2)displayed significant inhibitory activity against HSC-LX2 with IC_(50)value of 37.8μmol/L,which was 3 times more active than the positive drug silybin(IC_(50),139.7μmol/L).Preliminary mechanism study revealed that artemsieverolactone B could inhibit the deposition of human collagen typeⅠ(ColⅠ),human hyaluronic acid(HA),and human laminin(HL)with IC_(50)values of 40.4μmol/L(Col I),55.1μmol/L(HL),47.3μmol/L(HA),which was 2 to 3-fold more potent than silybin.

关键词： Artemisia sieversiana Artemsieverolactones A-H Guaiane-type sesquiterpenoid trimers Antihepatic fibrosis Extracellular matrix Cancer NMR spectroscopy X-ray diffraction

Comprehensive review on ethnomedicinal, phytochemistry and pharmacological profile of Ficus Religiosa L.

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1052-1057页

作者： Rahul Rawat Harish Kumar Neetu Singh Aakash Deep Balasubramanian Narasimhan Surender Singh Yadav Sanjiv Kumar Department of Pharmaceutical Sciences Chaudhary Bansi Lal University Department of botany Maharshi Dayanand University Faculty of Pharmaceutical Sciences Maharshi Dayanand University

Ficus religiosa L.(F. religiosa) or sacred fig is a large perennial tree belonging to the family Moraceae or mulberry family. Though the tree has pan-tropical distribution but originally it is indigenous to the Indian subcontinent and Indochina region. Popularly the tree is named "Pepal or bodhi tree". Traditionally, it is practiced for the treatment of asthma, nose bleeding, heart disorders, diabetes, wound healing, ear problems, constipation, hyperlipidemia, gonorrhea, ulcers and infectious disorders. Chemical analysis demonstrated the presence of numerous bioactives including tannins, phenols, saponins, sugars, alkaloids, methionine, terpenoids, flavonoids, glycosides, proteins, separated amino acids, essential and volatile oils and steroids etc., which are probably responsible for its diverse pharmacological actions. The present work is an attempt to compile up-to-date comprehensive information on F. religiosa that covers its taxonomy, ethnomedicinal importance, phytochemistry, pharmacological attributes and clinical trials. Keeping in mind the various health attributes of F. religiosa, future research can be aimed at in-depth elucidation of the structure-function relationship and multifactorial signalings pathways.

关键词： Ficus religiosa clinical trials ethnomedicine health benefits pharmacology phytoconstituents

Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice

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The Crop Journal 2024年第2期12卷 549-557页

作者： Yan Zheng Ei Ei Khine Khin Mar Thi Ei Ei Nyein Likun Huang Lihui Lin Xiaofang Xie Min Htay Wai Lin Khin Than Oo Myat Myat Moe San San Aye Weiren Wu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Department of botany Mawlamyine UniversityMon StateMawlamyineMyanmar Department of botany Dagon UniversityNorth DagonYangonMyanmar

Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq to detect QTL is often limited by inappropriate experimental designs, as evidenced by numerous practical studies. Most BSA-seq studies have utilized small to medium-sized populations, with F2populations being the most common choice. Nevertheless, theoretical studies have shown that using a large population with an appropriate pool size can significantly enhance the power and resolution of QTL detection in BSA-seq, with F_(3)populations offering notable advantages over F2populations. To provide an experimental demonstration, we tested the power of BSA-seq to identify QTL controlling days from sowing to heading(DTH) in a 7200-plant rice F_(3)population in two environments, with a pool size of approximately 500. Each experiment identified 34 QTL, an order of magnitude greater than reported in most BSA-seq experiments, of which 23 were detected in both experiments, with 17 of these located near41 previously reported QTL and eight cloned genes known to control DTH in rice. These results indicate that QTL mapping by BSA-seq in large F_(3)populations and multi-environment experiments can achieve high power, resolution, and reliability.

关键词： BSA-seq QTL mapping Large F3 population Multi-environment experiment Cross-validation

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Heavy metal pollution of river water and eco-friendly remediation using potent microalgal species

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Water Science and Engineering 2024年第1期17卷 41-50页

作者： Amudham Radha Amal Raj Prabhakaran Mylsamy V.Sivasankar B.Sathish Kumar Kiyoshi Omine T.G.Sunitha Phycological Research Laboratory Research Department of BotanyPachaiyappa's College(Affiliated to University of Madras)Chennai 600030India Research Department of Chemistry Pachaiyappa's College(Affiliated to University of Madras)Chennai 600030India Department of botany Sri Vidya Mandir Arts&Science College(Autonomous)KatteriUthangarai 636902India Department of Civil Engineering School of Engineering.Nagasaki UniversityNagasaki-Daigaku1-14 Bunkyo-machiNagasaki 8528521Japan

Pollution of rivers is mainly caused by anthropogenic activities such as discharge of effluent from industrial facilities,maintenance of sewage/effluent treatment plants,and dumping of solid waste on river *** study dealt with the pollution issues of the Cooum River in the well-known city of Chennai in South *** samples from 27 locations were collected and analyzed for 12 elements,including Ba,B,and Al,as well as heavy metals such as Pb,Cr,Mn,Fe,Co,Ni,Cu,Zn,and *** samples showed levels of these elements that exceeded World Health Organization *** correlation analysis revealed the inter-dependency among elements,and the contribution of each element based on factor loadings showed its percentage contribution compared to *** samples from six significant locations were chosen for remediation with three algae:Chlorella vulgaris,Scenedesmus dimorphus,and Phormedium *** uptake of pollutants led to the continuous growth of algae during the incubation period of 15 d,effectively removing heavy metals from the river *** increasing levels of algal counts and the chlorophyll a content confirmed the algal growth during the incubation period,followed by a declining stage after the incubation *** scanning electron microscopic images of algae before and after the remediation showed no remarkable modification of morphological *** study showed that the uptake of heavy metals using algae is an effective water pollution remediation measure,making the process practicable in the field on a large scale in the near future.

关键词： Heavy metal Cooum river Phycoremediation Microalgae Factor analysis

Novel wild edible mushroom Astraeus hygrometricus(Pers.)Morgan induces robust apoptosis on human acute lymphoblastic leukemia cells through a RONS-subsisted mitochondria-dependent pathway

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 67-77页

作者： Amrita Pal Ribhu Ray Anirban Chouni Subhadip Hajra Santanu Paul Department of botany University of CalcuttaKolkata 700019India Department of Cancer Chemoprevention Chittaranjan National Cancer InstituteKolkata 700026India

Objective:To explore the therapeutic effects of the novel wild edible mushroom Astraeus hygrometricus(Pers.)Morgan(***)on human acute lymphoblastic leukemia ***:Extensive screening of the antiproliferative and chemopreventive potential of different extracts from 5 wild mushrooms,***,Phallus sp.,Lentinus sp.,Tricholoma sp.,and Serpula *** performed against a panel of 6 cancer cell lines and normal cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** determination,cell cycle profiling,intracellular reactive oxygen species(ROS)and reactive nitrogen species(RNS),and mitochondrial membrane potential were analyzed by flow *** activity of caspases was measured colorimetrically,and the expression pattern of mitochondrial proteins was ***:The methanol extract of *** and MOLT-4 cells were identified as the most potent extract exhibiting antiproliferative activity and most sensitive cell line,*** mushroom extract induced robust selective apoptosis in MOLT-4 cells and arrested cell cycle progression at the G0/G1 *** extract disrupted the mitochondrial membrane potential and enhanced ROS production in MOLT-4 *** methanol extract induced apoptosis by downregulating the expression of Bcl-2,increasing the expression of Bax,and activating the caspase ***:The novel wild edible mushroom is a potential repository of biomolecules for the development of antileukemic drugs.

关键词： Mushroom Astraeus hygrometricus(Pers.)Morgan Apoptosis Antileukemic

sRNAminer, a swiss army knife in small RNA research

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Science China Life Sciences 2024年第10期67卷 2289-2290页

作者： Jiawen Zhao Zhonglong Guo Xiaozeng Yang State Key Laboratory of Plant Diversity and Specialty Crops Institute of Botanythe Chinese Academy of Sciences Co-Innovation Center for Sustainable Forestry in Southern China College of Life SciencesNanjing Forestry University

Small RNAs(sRNAs) are crucial noncoding RNA molecules that regulate gene expression across all kingdoms of life,continually revealing new insights through decades of research. Typically,sRNAs in plants are mainly categorized into microRNAs(miRNAs) and short interfering RNAs(siRNAs), with siRNAs predominantly consisting of phased small interfering RNAs(phasiRNAs) and heterochromatic siRNAs(hc-siRNAs)(Axtell and Meyers, 2018).

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The Structures and Regulatory Roles of Natural Products in Lipid Metabolism: Focus on Medicinal and Edible Plants

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Food Science and Human Wellness 2024年

作者： Xinjian Zhang Sheng Li Bodou Zhang Yu Zhang Key Laboratory of Phytochemistry and Natural Medicines， Kunming Institute of botany， Chinese Academy of Sciences University of Chinese Academy of Sciences

Lipids are essential for normal life activities and biological functions of the human body， and disorders of lipid metabolism produce a lipotoxic environment， endoplasmic reticulum (ER) stress， inflammation， and cell death， which can lead to a variety of diseases in the body. It has been found that lipid metabolism disorders are closely associated with brain injury disease， cancer， metabolic disease， cardiovascular disease (CVD)， respiratory disease and infectious disease. In recent years， many medicinal and edible plants such as Pueraria lobata， Gardenia jasminoides， Curcuma longa， citrus fruits， peanuts， etc. have shown great potential in regulating lipid metabolism and some of the hidden active components showed innovative mechanisms. AMPK， PPARγ， SIRT1， Foxp3， NLRP3， and Keap1 are increasingly recognized as therapeutic targets in the field of regulating lipid metabolism. This study aims to provide a comprehensive review of natural lipid-regulating modulators in medicinal and edible plants and their mechanism of actions， which offer valuable references for the discovery of natural lipid metabolism modulators and a therapeutic strategy for treatment of lipid metabolism-related diseases.

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ICE1 interacts with IDD14 to transcriptionally activate QQS to increase pollen germination and viability

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Journal of Integrative Plant Biology 2024年第8期66卷 1801-1819页

作者： Landi Luo Yan Zheng Xieshengyang Li Qian Chen Danni Yang Zhijia Gu Ya Yang Yunqiang Yang Xiangxiang Kong Yongping Yang CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical GardenThe Chinese Academy of SciencesXishuangbanna 666303China Germplasm Bank of Wild Species Yunnan Key Laboratory for Crop Wild Relatives OmicsKunming Institute of BotanyThe Chinese Academy of SciencesKunming 650201China School of Agriculture Yunnan UniversityKunming 650091China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyThe Chinese Academy of SciencesKunming 650201China

In flowering plants,sexual reproductive success depends on the production of viable pollen ***,the mechanisms by which QUA QUINE STARCH(QQS)regulates pollen development and how transcriptional activators facilitate the transcription of QQS in this process remain poorly ***,we demonstrate that INDUCER OF CBF EXPRESSION 1(ICE1),a basic helix–loop–helix(b HLH)transcription factor,acts as a key transcriptional activator and positively regulates QQS expression to increase pollen germination and viability in Arabidopsis thaliana by interacting with INDETERMINATE DOMAIN14(IDD14).In our genetic and biochemical experiments,overexpression of ICE1 greatly promoted both the activation of QQS and high pollen viability mediated by ***14 additively enhanced ICE1 function by promoting the binding of ICE1 to the QQS *** addition,mutation of ICE1 significantly repressed QQS expression;the impaired function of QQS and the abnormal anther dehiscence jointly affected pollen development of the ice1-2 *** results also showed that the enhancement of pollen activity by ICE1 depends on ***,QQS interacted with CUT1,the key enzyme for long-chain lipid *** interaction both promoted CUT1 activity and regulated pollen lipid metabolism,ultimately determining pollen hydration and *** results not only provide new insights into the key function of QQS in promoting pollen development by regulating pollen lipid metabolism,but also elucidate the mechanism that facilitates the transcription of QQS in this vital developmental process.

关键词： transcriptional metabolism jointly

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Historical biogeography and evolutionary diversification of Lilium(Liliaceae): New insights from plastome phylogenomics

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Plant Diversity 2024年第2期46卷 219-228页

作者： Nian Zhou Ke Miao Changkun Liu Linbo Jia Jinjin Hu Yongjiang Huang Yunheng Ji CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengduSichuan 610065China Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Population Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

Here, we infer the historical biogeography and evolutionary diversification of the genus Lilium. For this purpose, we used the complete plastomes of 64 currently accepted species in the genus Lilium(14plastomes were newly sequenced) to recover the phylogenetic backbone of the genus and a timecalibrated phylogenetic framework to estimate biogeographical history scenarios and evolutionary diversification rates of Lilium. Our results suggest that ancient climatic changes and geological tectonic activities jointly shaped the distribution range and drove evolutionary radiation of Lilium, including the Middle Miocene Climate Optimum(MMCO), the late Miocene global cooling, as well as the successive uplift of the Qinghai-Tibet Plateau(QTP) and the strengthening of the monsoon climate in East Asia during the late Miocene and the Pliocene. This case study suggests that the unique geological and climatic events in the Neogene of East Asia, in particular the uplift of QTP and the enhancement of monsoonal climate, may have played an essential role in formation of uneven distribution of plant diversity in the Northern Hemisphere.

关键词： Asian monsoon Climatic changes Distribution range Evolutionary complexity Radiative diversification Species diversity Qinghai-Tibet Plateau(QTP)

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