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Development and validation of a reversed-phase HPLC method for analysis of tetrahydrozoline hydrochloride in eye drop formulations

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Journal of Pharmaceutical Analysis 2012年第1期2卷 67-70页

作者： Fuad Al-Rimawi Wahbeh Zareer Salah Rabie Mazen Quod Faculty of Science and Technology Al-Quds University birzeit Pharmaceutical Company

A simple, precise, accurate, and stability-indicating method is developed and validated for analysis of tetrahydrozoline hydrochloride in eye drop formulations. Separation was achieved on a reversed-phase C8 column (125 mm 4.6 mm i.d., 5 mm) using a mobile phase consisting of acetonitrile/phosphate buffer of pH 3.0 (20:80, v/v) at a flow rate of 1.0 mL/min and UV detection at 240 nm. This method is validated according to United States Pharmacopeia requirements for new methods, which include accuracy, precision, selectivity, robustness, and linearity and range. This method shows enough selectivity, accuracy, precision, and linearity and range to satisfy Federal Drug Administration/International Conference on Harmonization regulatory requirements. The current method demonstrates good linearity over the range of 0.025–0.075 mg/mL of tetrahydrozoline with r2 0.999. The average recovery of the method is 100.8% with a relative standard deviation of 0.47%. The degree of reproducibility of the results obtained as a result of small deliberate variations in the method parameters and by changing analytical operators has proven that the method is robust and rugged.

关键词： Tetrahydrozoline hydrochloride Validation Precision Accuracy Linearity

Post-2015 Development Priorities for the Arab World

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Management Studies 2016年第2期4卷 49-59页

作者： Ibrahim Elnur Eileen Kuttab The American university in Cairo New Cairo Egypt birzeit university Birzeit Palestine

The paper addresses the failure of renewing the same millennium development goals （MDGs） format in measuring achievement in a region like the Middle East and North Africa （MENA） region which is drastically being transformed. A new approach focusing on ＂human security＂ principles based on freedom, dignity, justice, equality, solidarity, tolerance, and respect articulated in the millennium declaration is needed. Achieving this requires a more integrated, inclusive, and comprehensive development framework that is able to analyze and understand the context with its progress and setbacks. The paper realizes that measuring MDGs achievement does not only need a comprehensive integrated approach, but also a defmition of risks and challenges that the region faces. Issues like poverty, inequality, unemployment of graduates, personal and collective insecurity due to conflict, migration, and brain drain, food insecurity, and gender inequality are all issues that need to be redefined when analyzing the region to suit the context. The paper concludes that in order to understand the context, re-definition of concepts like poverty reduction, participation, and empowerment is needed to make concepts more relevant to the context. Lastly, the paper reflects the new call from youth for a new development model that is not based on market economy, ends political economy of the rentier states, and emphasizes a productive oriented economy that is able to generate employment and decent work. It also emphasizes democratic governance as an only path for a sustainable participatory development that can realize ambitions and aspirations of the majority of population.

关键词： human security poverty gender inequality empowerment millennium development goals (MDGs)

Groundwater Assessment for the NW of Auja Tamaseeh Basin in Tulkarem Area, West Bank

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Journal of Water Resource and Protection 2012年第6期4卷 407-413页

作者： Nizar Samhan Marwan Ghanem birzeit university Ramallah Palestine

The study aims to assess groundwater in Auja—Tamaseeh basin in Tulkarem area—West Bank. A steady state calibration flow model as well as solute transport model were built using the visual Modflow software. A stress period of 10 years (2005 - 2015) was assigned to study its tendency to contamination. The model results show that there is a pollution risk due to the human activities in the area. The groundwater situation will be harmful if there is no action done by the water-decision makers to preserve the aquifers from deterioration and contamination.

关键词： Groundwater Tulkarem West Bank Nitrate Chlorite Solute Transport Model

Spring Water Qualitative Assessment in Mountainous Areas, Case Study: Soreq Catchment/Ramallah/West Bank

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Journal of Water Resource and Protection 2015年第11期7卷 851-859页

作者： Hassan Jebreen Marwan Ghanem birzeit university Ramallah Palestine

The hydrochemical characteristics of spring waters in the Soreq-Catchment were determined to identify pollutants in the springs. The ion concentrations were within the allowable WHO limits except two springs located within the center of the populated areas. The water of most of the springs is contaminated with fecal coliform and total coliform. The concentration of nitrate shows moderate values below the WHO limits. The springs in the study area show higher concentrations of heavy metals (Zn, Cd, Mn, As, Co, Cu, Ni, Pb, Al, Fe, and V) exceeding the permissible standards set by WHO (2007). Most springs in the study area are of water type (Ca-Mg-HCO3-). Piper’s classification ranges from normal earth alkaline water with prevailing bicarbonate and chloride in both seasons. Comparing the quality of spring water with standards for different uses proved that some springs are unsuitable for human drinking purposes.

关键词： Hydrochemistry Soreq West Bank Spring Water

Feasibility of Protection Zones for Water Resources in Arid Areas: Case Study;Duyuk Nueimah Shosa Springs, Jericho, Palestine

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Journal of Environmental Protection 2015年第2期6卷 110-117页

作者： Marwan Ghanem Mahmoud Hammad birzeit university Rammallah Palestine IWRM Bethlehem Palestine

Urbanization and different human-economic activities put increasing pressure on the ground water quality, which is considered as the main drinking water resources in Palestine. Protecting the spring water resources in Palestine is one major issue for the continuity of the availability of the water resources. An economic feasibility study was conducted for the Nuewimah-Shosha-Dyuk spring system in order to assess the economical factor for the induced methodology of the protection zones. The spring system has multiple users from different sectors (i.e., domestic, agriculture, commercial and public use) and multi-year cost benefit analysis technique used to show the feasibility of water protection zones on the long run. The study shows that even in arid areas in Palestine, small quantities are derived from springs-implementation of water protection zones is still feasible;the results of this study emphasize on importance and feasibility of water resources protection zones.

关键词： Water Protection Zones Cost Benefit Analysis Protection Zones Guidelines Nueimah Spring System Jericho Area

THEORETICAL AND NUMERICAL STUDY OF THE BLOW UP IN A NONLINEAR VISCOELASTIC PROBLEM WITH VARIABLE-EXPONENT AND ARBITRARY POSITIVE ENERGY

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Acta Mathematica Scientia 2022年第1期42卷 141-154页

作者： Ala A.TALAHMEH Salim A.MESSAOUDI Mohamed ALAHYANE Mathematics Birzeit UniversityWest BankPalestine Mathematics University of SharjahP.O.Box 27272SharjahUAE Department of Mathematics RISEUniversity of SharjahP.O.Box 27272SharjahUAE

In this paper,we consider the following nonlinear viscoelastic wave equation with variable exponents:utt-△u+∫_(0)^(t)g(t-τ)△u(x,τ)dτ+μut=|u|^(p(x)-2)-u,whereμis a nonnegative constant and the exponent of nonlinearity p(·)and g are given *** arbitrary positive initial energy and specific conditions on the relaxation function g,we prove a finite-time blow-up *** also give some numerical applications to illustrate our theoretical results.

关键词： nonlinear damping blow up finite time variable nonlinearity arbitrary positive energy

Big data can help prepare nurses and improve patient outcomes by improving quality,safety,and outcomes

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Frontiers of Nursing 2023年第2期10卷 241-248页

作者： Muayyad Ahmad Salam H.Bani Hani Mohammad Abu Sabra Omar Almahmoud School of Nursing The University of JordanAmman 11942Jordan Department of Adult Health Nursing Faculty of NursingAl Al-Bayt UniversityMafraq 25113Jordan School of Nursing The University of Jordan-Aqaba CampusAqaba 77111Jordan Faculty of Nursing PharmacyNursing and Health Professions CollegeBirzeit UniversityBirzeit-Ramallah 627Palestine

Objectives:Big data has revolutionized nursing and health care and raised *** research aims to help nurses understand big data sets to provide better patient ***:This study used big data in nursing to improve patient *** data in nursing has sparked a global revolution and raised concerns,but few studies have focused on helping nurses understand big data to provide the best patient *** systematic review was conducted based on PRISMA ***,MEDLINE,CINAHL,Google Scholar,and ResearchGate were used for 2010-2020 ***:The most common use of big data in nursing was investigated in eight papers between 2015 and *** research showed improvements in patient outcomes and healthcare delivery when big data was used in the medical-surgical,emergency department,critical care unit,community,systems biology,and leadership *** data is not taught to ***:Big data applications in nursing and health care improve early intervention and *** data provides a comprehensive view of a patient’s status and social determinants of health,allowing treatment using all metaparadigms and avoiding a singular *** data can help prepare nurses and improve patient outcomes by improving quality,safety,and outcomes.

关键词： big data health nursing PRISMA quality of care

Spectroscopic Characterization of the Interaction between Dopamine and Human Serum Albumin

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Open Journal of Biophysics 2019年第2期9卷 110-130页

作者： Imtiaz M. Khalid Sawsan E. Abu Sharkh Husain Samamarh Rania Alfaqeeh Musa M. Abuteir Saqer M. Darwish Department of Chemistry Birzeit University Birzeit Palestine Department of Physics Al Quds University Beit Hanina Abu Dis al-Bireh Palestine

The interactions of HSA with DA have received great attention nowadays due to its significant effect in the biomedical field and overall health. The main aim of this work is to examine the interaction between DA and HSA at physiological conditions. Upon addition of DA to HSA, the fluorescence emission was quenched with quenching constant Kq = 1.32 × 109 L⋅mol−1⋅s−1 and the binding constant of DA with HSA is found to be K = 4.4 × 102 mainly indicating dynamic quenching. The HSA conformation was altered upon binding of DA to HSA with an increase in α-helix and a decrease in β-sheets suggesting unfolding of HSA secondary structure due to weak intermolecular interaction with HSA. In view of the evidence presented, it is important to understand the details of the interactions of HSA with DA which will be crucial in the design of new DA-inspired drugs and help revealing vital details to better understand the HSA’s role as a transporter for many drugs.

关键词： Dopamine HSA Binding Constant Non-Linear Stern-Volmer Plot Protein Secondary Structure FT-IR Spectroscopy

Generalized Oppositional Moth Flame Optimization with Crossover Strategy:An Approach for Medical Diagnosis

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Journal of Bionic Engineering 2021年第4期18卷 991-1010页

作者： Jianfu Xia Hongliang Zhang Rizeng Li Huiling Chen Hamza Turabieh Majdi Mafarja Zhifang Pan Department of General Surgery The Second Affiliated Hospital of Shanghai UniversityWenzhou 325000China Department of Computer Science and Artificial Intelligence Wenzhou UniversityWenzhou 325035China Department of Information Technology College of Computers and Information TechnologyP.O.Box11099Taif 21944Taif UniversityTaifSaudi Arabia Department of Computer Science Birzeit UniversityRamallah 72439Palestine The First Affiliated Hospital of Wenzhou Medical university Wenzhou 325000China

In the original Moth-Flame Optimization(MFO),the search behavior of the moth depends on the corresponding flame and the interaction between the moth and its corresponding flame,so it will get stuck in the local optimum easily when facing the multi-dimensional and high-dimensional optimization ***,in this work,a generalized oppositional MFO with crossover strategy,named GCMFO,is presented to overcome the mentioned *** the proposed GCMFO,GOBL is employed to increase the population diversity and expand the search range in the initialization and iteration jump phase based on the jump rate;crisscross search(CC)is adopted to promote the exploitation and/or exploration ability of *** proposed algorithm’s performance is estimated by organizing a series of experiments;firstly,the CEC2017 benchmark set is adopted to evaluate the performance of GCMFO in tackling high-dimensional and multimodal ***,GCMFO is applied to handle multilevel thresholding image segmentation *** last,GCMFO is integrated into kernel extreme learning machine classifier to deal with three medical diagnosis cases,including the appendicitis diagnosis,overweight statuses diagnosis,and thyroid cancer *** results and discussions show that the proposed approach outperforms the original MFO and other state-of-the-art algorithms on both convergence speed and *** also indicates that the presented GCMFO has a promising potential for application.

关键词： nature-inspired algorithm moth-flame optimization generalized opposition-based learning crisscross search medical diagnosis