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Journal of Integrative Plant Biology 2019年第6期61卷 675-690页

作者： Wenzhu Guo Tong Lian Baobao Wang Jiantao Guan Dong Yuan Huan Wang Fardous Mohammad Safiul Azam Xing Wan Weixuan Wang Qiuju Liang Haiyang Wang Jinxing Tu Chunyi Zhang Ling Jiang College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China Plant Genetics Gembloux Agro-Bio TechUniversity of LiegeGembloux 5030Belgium biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Department of Chemistry and Chemical engineering Qilu Normal UniversityJinan 250200China School of Chemistry and Molecular engineering East China University of Science and TechnologyShanghai 200237China

As essential B vitamin for humans, folates accumulation in edible parts of crops, such as maize kernels, Is of great importance for human health. But its breeding is always limited by the prohibitive cost of folate profiling. The molecular breeding is a more executable and efficient way for folate fortification, but is limited by the molecular knowledge of folate regulation. Here we report the genetic mapping of folate quantitative trait loci (QTLs) using a segregated population crossed by two maize lines, one high in folate (GEMS31) and the other low in folate (DAN3130). Two folate QTLs on chromosome 5 were obtained by the combination of F2 whole-exome sequencing and F3 kernel-folate profiling. These two QTLs had been confirmed by bulk segregant analysis using F6 pooled DNA and F7 kernel-folate profiling, and were overlapped with QTLs identified by another segregated population. These two QTLs contributed 41.6% of phenotypic variation of 5-formyltetrahydrofolate, the most abundant storage form among folate derivatives in dry maize grains, in the GEMS31×DAN3130 population. Their fine mapping and functional analysis will reveal details of folate metabolism, and provide a basis for marker-assisted breeding aimed at the enrichment of folates in maize kernels.

关键词： Genetic mapping folate QTLs using a segregated population in maize^FA

Comparative Study on Five Sudanese Date (<i>Phoenix dactylifera</i>L.) Fruit Cultivars

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Food and Nutrition Sciences 2012年第9期3卷 1245-1251页

作者： Abdel Moneim E. Sulieman Itimad A. Abd Elhafise Awad M. Abdelrahim Center of Biosciences and biotechnology Faculty of Engineering and Technology University of Gezira Wad Medani Sudan Department of Food Science and Technology Faculty of Engineering and Technology University of Gezira Wad Medani Sudan

The date palm (Phoenix dactylifera L.) is one of mankind’s oldest cultivated plants. A date palm fruit is an important component of the diet in most of the hot arid and semi arid regions of the world. The present study aimed at investigating the physical and chemical properties as well as microbiological characteristics of five date palm cultivars cultivated in Sudan. The results showed that the physical characteristics like fruit weight, length, flesh thickness, seed weight differed significantly between the various cultivars. Although most of the cultivars had similar chemical components, there were some few differences. However, the microbiological analyses proved that no significant differences were found among the cultivars.

关键词： Amino Acids Carbohydrates Chemical Composition Dates Fatty Acids Salmonella

Modification of Titanium Dioxide for Wastewater Treatment Application and Its Recovery for Reuse

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Journal of Environmental Science and engineering(A) 2016年第10期5卷 498-510页

作者： Mike Agbesi Acheampong Duke Mensah Bonsu Antwi Department of Chemical engineering Faculty of Engineering and Technology Kumasi Technical University Kumasi 854 Ghana Department of Applied Environmental Microbiology School of Biotechnology Royal Institute of Technology Stocholm Sweden

Magnetic Fe3O4 nanomagnetic particles were synthesized by the titration co-precipitation method followed by coating by the sol-gel method with Titamiun dioxide. The photocalytic activities of different synthesized TiO2/Fe304 nanomagnetic particles with different molar ratios of TiO2 to Fe3O4 were investigated by the reduction of phosphate, nitrate and decolorizing of methyl blue solutions. X-ray diffraction was used to characterize the size, composition and morphology of the synthesized particles. The results obtained from these experiments indicate an increase in the photocatalytic activity as the amount of TiO2 coating increases. The results show a higher activity of the synthesized particles in the removal of phosphate, nitrate and methyl blue, which can be achieved at early reaction periods at about 70-80%. The activities were higher when the particles were incubated without UV illumination. This study shows that TiO2/Fe3O4 particles are effective in phosphate, nitrate and methyl blue removal in wastewater treatment.

关键词： Photocatalysis nanomagnetic particles phosphate nitrate methyl blue co-precipitation wastewater treatment X-raydiffraction.

A Rapid and Accurate CRISPR/Cas12b-Mediated Genotyping Assay for the Methylenetetrahydrofolate Reductase Gene Polymorphism C677T

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Biomedical and Environmental Sciences 2023年第6期36卷 561-565页

作者： SI Xin Xin ZHANG Quan LUO Zhi Dan ZHANG Zhen Yu WANG Yan SHAO Li Pei Jiangsu Key Laboratory of Marine Biological Resources and Environment Jiangsu Key Laboratory of Marine Pharmaceutical Compound ScreeningCo-Innovation Center of Jiangsu Marine Bio-industry TechnologySchool of PharmacyJiangsu Ocean UniversityLianyungang 222005JiangsuChina Department of Pathology The Second People's Hospital of LianyungangLianyungang 222001JiangsuChina Center for Cellular engineering Department of Transfusion Medicine and Cellular EngineeringNIH Clinical CenterBethesdaMDUSA

Human methylenetetrahydrofolate reductase(MTHFR),an essential enzyme in folate metabolism,catalyzes the conversion of5,10-methylenetetrahydrofolate to *** polymorphisms in the MTHFR gene have been found to be associat... 详细信息

关键词： metabolism C677T CRISPR/Cas

Total synthesis study of a cyclic hexadepsipeptide Veraguamide A

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Total synthesis study of a cyclic hexadepsipeptide Veraguami...

Recent progress of carbon-based metal-free materials in thermal-driven catalysis

2012长三角药物化学研讨会

作者： Dongyu Wang Xian Jia Ao Zhang School of pharmaceutical engineering Shenyang Pharmaceutical University Synthetic Organic & Medicinal Chemistry Laboratory(SOMCL) Shanghai Institute of Materia Medica(SIMM)Chinese Academy of Sciences

We have developed a practical method to assemble the natural product veraguamide A(1) by first preparing the three key fragments followed by optimization of the macrocyclization site. Although the synthetic product gave similar optical rotation to that reported for natural product, significant differences in the H and C NMR spectra were observed,especially the proton and carbon signals in the two N-MeVal moieties.

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Journal of Energy Chemistry 2021年第7期30卷 318-335页

作者： Shuchang Wu Linhui Yu Guodong Wen Zailai Xie Yangming Lin School of pharmaceutical and Materials engineering Taizhou UniversityTaizhou 318000ZhejiangChina Max Planck Institute for Chemical Energy Conversion Stiftstrasse 34-36Mülheim an der Ruhr 45470Germany Institute of Metal Research Chinese Academy of SciencesShenyang 110016LiaoningChina Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials Fuzhou UniversityFuzhou 350016FujianChina

The carbon-based metal-free materials as catalysts(named as carbocatalysts) have been attracting tremendous attentions in electric-,solar-and thermal-driven reactions *** to electrocatalysis and photocatalysis,the thermal-driven catalysis(thermocatalysis) including liquid phase and gas phase reactions involves wider scope and is relatively easy to realize practical large-scale *** the past several years,some striking achievements on the design of new carbon-based metal-free materials with well-defined structures and heteroatom groups as well as the revelation of new reaction mechanisms and active sites in thermocatalysis have been ***,comparative discussions regarding these recent achievements have been rarely *** this review,we systematically summarize and discuss six kinds of carbocatalysts and their applications in *** materials include typical oxygen-attached carbon,surface modified carbon(graft with certain organic compounds),mono-doped carbon,co-doped carbon,carbon nitride and materials with carbon as *** new reaction processes as well as the related reaction mechanisms,active sites and intermediates are reviewed ***,an outlook on the in-depth investigation of the metalfree carbocatalysis in the future is provided.

关键词： Carbocatalysis Metal-free Thermal-driven catalysis Active sites

Preparation and properties of rutin-hydrolysis enzymes from tartary buckwheat seeds

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Preparation and properties of rutin-hydrolysis enzymes from ...

Diagnostic usefulness of selected proteases and acute phase factors in patients with colorectal adenocarcinoma

中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Xiaodong Cui Zhuanhua Wang Key Laboratory of Chemical Biology and Molecular engineering of Ministry of Education Institute of BiotechnologyShanxi University

A functional protein was isolated from the seeds of Fagopyrum Tataricum Moench by salting out,anion exchange chromatography and size exclusion chromatography(SEC).It has an apparent molecular mass about 70 kDa as determined by *** its isoelectric point(pI) as determined by isoelectric focusing was *** protein has a specific catalysis activity when rutin was used as substrate and the optimal enzyme activity was seen at around pH 5 and 20% *** enzyme was named rutin-hydrolysis enzymes

关键词： Buckwheat Rutin-hydrolysis enzymes Properties

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World Journal of Gastroenterology 2021年第39期27卷 6673-6688页

作者： Tadeusz Sebzda Jan Gnus Barbara Dziadkowiec Miroslaw Latka Jakub Gburek Department of Pathophysiology Wroclaw Medical UniversityWroclaw 50-368Poland Department of Physiotherapy Wroclaw Medical UniversityWroclaw 50-355Poland Department of Biomedical engineering Wroclaw University of Science and TechnologyWroclaw 50-370Poland Department of pharmaceutical Biochemistry Wroclaw Medical UniversityWroclaw 50-556Poland

BACKGROUND Uncontrolled growth and loss of control over basic metabolic functions,leading to invasive proliferation and metastases,are the salient traits of malignant tumors in general and colorectal cancer in *** and metastases hinder effective tumor *** surgical techniques and radiotherapy can be used to remove tumor focus,only chemotherapy can eliminate dispersed neoplastic ***,the efficacy of the latter method is limited in the advanced stages of the ***,recognition of the mechanisms involved in neoplastic cell spreading is indispensable for developing effective *** To use a number of biomarkers involved in cancer progression and identify a panel that could be used for effective early *** We recruited 185 patients with colorectal adenocarcinoma(98 men,87 women with median age 63).Thirty-five healthy controls were sex and ***’staging was as follows:A=22,B=52,C=72,D=*** analyzed patients'blood serum before *** determined:(1)Cathepsin B(CB)with Barrett's method(fluorogenic substrate);(2)Leukocytic elastase(LE)in a complex with alpha 1 trypsin inhibitor(AAT)using the immunoenzymatic MERCK test;(3)Total sialic acid(TSA)with the colorimetric periodate-resorcinol method;(4)Lipid-bound sialic acid(LASA)with the colorimetric Taut's method;and(5)The antitrypsin activity(ATA)employing the colorimetric *** In patients,the values of the five biochemical parameters were as follows:CB=16.1±8.8 mU/L,LE=875±598μg/L,TSA=99±31 mg%,LASA=0.68±0.33 mg%,and ATA=3211±1504 U/*** for LASA,they were significantly greater than those of controls:CB=11.4±6.5 mU/L,LE=379±187μg/L,TSA=71.4±15.1 mg%,LASA=0.69±0.28 mg%,and ATA=2016±690 U/*** CB and LASA,the differences between the four Dukes’stages and controls were not statistically *** inter-stage differences for CB and LASA were also *** receiver operating characteristic(ROC)analysis revealed the potential dia

关键词： Colorectal cancer Cathepsin B Acute phase reactants Colorectal adenocarcinoma Acute phase factor

Tumor microenvironment responsive drug delivery systems

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Asian Journal of pharmaceutical Sciences 2020年第4期15卷 416-448页

作者： Qunye He Jun Chen Jianhua Yan Shundong Cai Hongjie Xiong Yanfei Liu Dongming Peng Miao Mo Zhenbao Liu Xiangya School of pharmaceutical Sciences Central South UniversityChangsha 410013China Department of Urology Xiangya HospitalCentral South UniversityChangsha 410008China School of Chemistry and Chemical engineering Central South UniversityChangsha 410083China School of Pharmacy Hunan University of Chinese MedicineChangsha 410208China

Conventional tumor-targeted drug delivery systems(DDSs)face challenges,such as unsatisfied systemic circulation,low targeting efficiency,poor tumoral penetration,and uncontrolled drug ***,tumor cellular molecules-triggered DDSs have aroused great interests in addressing such *** the introduction of several additional functionalities,the properties of these smart DDSs including size,surface charge and ligand exposure can response to different tumor microenvironments for a more efficient tumor targeting,and eventually achieve desired drug release for an optimized therapeutic *** review highlights the recent research progresses on smart tumor environment responsive drug delivery systems for targeted drug *** targeting strategies and functional moieties sensitive to a variety of tumor cellular stimuli,including pH,glutathione,adenosine-triphosphate,reactive oxygen species,enzyme and inflammatory factors are *** emphasis of this review is placed on their responsive mechanisms,drug loading models,drawbacks and *** typical multi-stimuli responsive DDSs are *** the main challenges and potential future development are discussed.

关键词： Cancer therapy Stimuli responsive Dynamic targeting Drug delivery system Controlled release