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Gut liver brain axis in diseases:the implications for therapeutic interventions

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Signal Transduction and Targeted Therapy 2024年第1期9卷 79-104页

作者： Mengyao Yan Shuli Man Benyue Sun Long Ma Lanping Guo Luqi Huang Wenyuan Gao State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&Technology300457 TianjinChina National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityWeijin Road300072 TianjinChina

Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract,liver,and nervous *** the past few decades,breakthrough progress has been made in the gut liver brain axis,mainly through understanding its formation mechanism and increasing treatment *** this review,we discuss various complex networks including barrier permeability,gut hormones,gut microbial metabolites,vagus nerve,neurotransmitters,immunity,brain toxic metabolites,β-amyloid(Aβ)metabolism,and epigenetic regulation in the gut-liver-brain *** therapies containing antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation(FMT),polyphenols,low FODMAP diet and nanotechnology application regulate the gut liver brain ***,some special treatments targeting gut-liver axis include farnesoid X receptor(FXR)agonists,takeda G protein-coupled receptor 5(TGR5)agonists,glucagon-like peptide-1(GLP-1)receptor antagonists and fibroblast growth factor 19(FGF19)*** gut-brain axis embraces cognitive behavioral therapy(CBT),antidepressants and tryptophan metabolism-related *** liver-brain axis contains epigenetic regulation and Aβmetabolism-related *** the future,a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases.

关键词： metabolism therapeutic immunity

Can the venerated silk be the next generation nanobiomaterialfor biomedical device designing, regenerative medicine and drugdelivery? Prospects and hitches

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Bio-Design and Manufacturing 2019年第4期2卷 278-286页

作者： Rocktotpal Konwarh Department of biotechnology Addis Ababa Science and Technology University16417 Akaki KalityAddis AbabaEthiopia centre of Excellence NanotechnologyAddis Ababa Science and Technology University16417 Akaki KalityAddis AbabaEthiopia

Of late, the relevance of silk in a myriad of material science and biotechnological realms has been realized, as attested by the incessantly clambering number of reports and patents in the scienti fic repositories. The write-up is geared off with a scrutiny into the pertinence of the basic nano-structural features of silk, christened as the ‘queen of textile’ for exemplary bioengi- neering applications including designing and fabrication of devices for micro fluidics, opto fluidics, chemo/bio sensing, etc. Then, the major thrust of this short review is directed towards comprehending the prospects of using silk-based biomaterials (e.g. sca ffolds, electrospun membranes, films, hydrogels, bioinks) for tissue engineering and regenerative medicine as well as targeted delivery of various biomolecular cargoes/therapeutic agents, etc., as vouched by few avant-garde endeavours of the recent years. The write-up is entwined with a discussion on the various factors that could plausibly hinder the realization of silk as the next-generation nanobiomaterial, suggestions for some approaches to dodge and deal with the practical snags and what lies ahead!

关键词： Drug delivery Microfluidics Nanobiomaterial Regenerative medicine Silk Tissue engineering

Development of Molecular Marker Linked with Cercospora Leaf Spot (CLS) Disease Resistance in Vigna radiata, Cloning, and Expression for Evaluating Antifungal Activity against Cercospora canescens

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Phyton-International Journal of Experimental Botany 2023年第4期92卷 1289-1300页

作者： Maria Babar Siddra Ijaz Imran Ul Haq Muhammad Sarwar Khan centre of Agricultural Biochemistry and biotechnology(CABB) University of Agriculture FaisalabadFaisalabad38040Pakistan Department of Plant Pathology University of Agriculture FaisalabadFaisalabad38040Pakistan

We developed a molecular marker for MAS of mungbean resistant varieties against CLS from the consensus sequence(MB-CLsRG)of identified RGAs(MB-ClsRCaG1 and MB-ClsRCaG2).The MB-CLsRG sequence-specific primer pair was used to screen Cercospora leaf spot(CLS)resistant varieties of mungbean in genomic analysis that showed congruency with phenotypic *** of molecular marker linkage with CLS resistance was performed using rtPCR in transcriptomic *** sequenced PCR products showed 100%homology with MB-CLsRG sequence and putative disease resistance proteins that confirmed the linkage of molecular marker with CLS resistance in *** antifungal potential of MB-CLsRG gene encoding protein was *** MB-CLsRG gene sequence was cloned in the *** expression vector for recombinant protein *** recombinant protein was then investigated for its in vitro antifungal potential against Cercospora *** in vitro investigation showed strong antifungal activity of recombinant protein as it restricted the growth of fungal mycelial *** results validated the linkage of developed marker with CLS-resistant mungbean varieties;therefore,it can be used to screen resistant varieties from a large population in ***,the recombinant protein of the MB-CLsRG gene sequence revealed antifungal potential,which proved the gene sequence could be suitable to use in transgenic plants technology to develop fungal-resistant transgenic crops.

关键词： Molecular marker mungbean MAS recombinant protein antifungal potential

Near-infrared light switching nitric oxide nanogenerator with“linkage mechanism”for tumor targeting multimodal synergistic therapy

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Science China Chemistry 2023年第2期66卷 586-600页

作者： Wei Zhang Qize Xuan Qi Zhang Tong Wang Chen Wang Hui Li Chao Chen Ping Wang State Key Laboratory of Bioreactor Engineering Biomedical Nanotechnology CenterSchool of BiotechnologyEast China University of Science and TechnologyShanghai200237China Institute for Environmental Pollution and Health School of Environmental and Chemical EngineeringShanghai UniversityShanghai200444China Department of Bioproducts and Biosystems Engineering University of MinnesotaSt PaulMN55108USA

Gaseous therapy based on nitric oxide(NO),as a potential anti-tumor treatment strategy,has attracted great attention,but the targeted and controlled gas release in the tumor site still remains a *** addressing these difficulties,a near-infrared(NIR)light-triggered NO release nanogenerator with a“linkage mechanism”was designed on the basis of sodium nitroprussidedoped mesoporous Prussian blue nanoparticles,in which the outer structure was modified with p H-sensitive gatekeeper chitosan and tumor-targeting agent folic ***“linkage mechanism”can achieve precise release of NO under the control of photothermal effect at tumor site,which can couple photothermal therapy and gas therapy to address the premature release of gas during ***,the amount of released gas can be controlled by adjusting the irradiation time and laser ***,as-fabricated nanocomposites hold high photothermal conversion efficiency under NIR laser irradiation,resulting in the on-demand release of NO and chemotherapy *** released NO can inhibit the expression of hypoxiainducible factorα(HIF-1α)and alleviate the hypoxic tumor microenvironment,thereby enhancing the efficacy of ***,in vitro and in vivo experiments exhibited remarkable antitumor efficiency,and the synergistic gas/chemo/photothermal therapy of deep tumors was *** findings indicate an effective strategy to stimulate further the development of deep tumor therapy,which may provide new insights into other NO-related medical applications.

关键词： NO generator NIR-trigger NO release linkage mechanism gas therapy targeted synergistic therapy

Light-responsive nanomedicine for cancer immunotherapy

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药学学报:英文版 2023年第6期13卷 2346-2368页

作者： Weirong Kang Yuwei Liu Weiping Wang State Key Laboratory of Pharmaceutical biotechnology the University of Hong KongHong KongChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Laboratory of Molecular Engineering and Nanomedicine Dr.Li Dak-Sum Research Centrethe University of Hong KongHong KongChina

Immunotherapy emerged as a paradigm shift in cancer treatments, which can effectively inhibit cancer progression by activating the immune system. Remarkable clinical outcomes have been achieved through recent advances in cancer immunotherapy, including checkpoint blockades, adoptive cellular therapy, cancer vaccine, and tumor microenvironment modulation. However, extending the application of immunotherapy in cancer patients has been limited by the low response rate and side effects such as autoimmune toxicities. With great progress being made in nanotechnology, nanomedicine has been exploited to overcome biological barriers for drug delivery. Given the spatiotemporal control,light-responsive nanomedicine is of great interest in designing precise modality for cancer immunotherapy. Herein, we summarized current research utilizing light-responsive nanoplatforms to enhance checkpoint blockade immunotherapy, facilitate targeted delivery of cancer vaccines, activate immune cell functions, and modulate tumor microenvironment. The clinical translation potential of those designs is highlighted and challenges for the next breakthrough in cancer immunotherapy are discussed.

关键词： Light-responsive nanoparticles Photodynamic therapy Photothermal therapy Nanomedicine Cancer therapy Immunotherapy Photopharmacology Light-triggered drug release

Acaricidal activity of synthesized titanium dioxide nanoparticles using Calotropis gigantea against Rhipicephalus microplus and Haemaphysalis bispinosa

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 682-688页

作者： Sampath Marimuthu Abdul Abdul Rahuman Chidambaram Jayaseelan Arivarasan Vishnu Kirthi Thirunavukkarasu Santhoshkumar Kanayairam Velayutham Asokan Bagavan Chinnaperumal Kamaraj Gandhi Elango Moorthy Iyappan Chinnadurai Siva Loganathan Karthik Kokati Venkata Bhaskara Rao Unit of nanotechnology and Bioactive Natural Products Post Graduate and Research Department of ZoologyCAbdul Hakeem College Environmental biotechnology Division School of Bio Sciences and TechnologyVIT University

Objective:To assess the acaricidal activity of titanium dioxide nanoparticles(TiO_2 NPs)synthesized from flower aqueous extract of Calotropis gigantea(***)against the larvae of Rhipicephalus(Boophilus)microplus[R.(B.)microplus]and the adult of Haemaphrysalis bispinosa(***).Methods:The lyophilized *** flower aqueous extract of 50 mg was added with 100 mL of TiO(OH_2)(10 mM)and magnetically stirred for 6 *** TiO_2 NPs were characterized by X-ray diffraction(XRD).Fourier transform infrared spectroscopy(FTIR),Scanning electron microscopy(SEM),and Energy dispersive X-ray spectroscopy(EDX).The synthesised TiO_2 NPs were tested against the larvae of R(B.)microplus and adult of *** were exposed to filter paper impregnated ***:XRD confirmed the crystalline nature of the nanoparticles with the mean size of 10.52 *** functional groups for synthesized TiO_2NPs were 1405.19,and 1053.45 cm^(-1)for-NH_2 bending,primary amines and amides and 1053.84and 1078.45 cm^(-1)for *** micrographs of the synthesized TiO_2 NPs showed the aggregated and spherical in *** maximum efficacy was observed in the aqueous flower extract of *** and synthesized TiO_2 NPs against R.(B.)microplus(LC_(50)=24.63 and 5.43 mg/L and r^2=0.960 and 0.988)and against ***(LC_(50)=35.22 and 9.15 mg/L and r^2=0.969 and 0.969).***:The synthesized TiO_2 NPs were highly stable and had significant acaricidal activity against the larvae of R.(B.)microplus and adult of *** study provides the first report of synthesized TiO_2 NPs and possessed excellent anti-parasitic activity.

关键词： Rhipicephalus(Boophilus) microplus Haemaphysalis bispinosa Calotropis gigantean Titanium dioxide nanoparticles X-ray diffraction techniques Electron microscopic study

Kinetic adsorption of application of carbon nanotubes for Pb(Ⅱ) removal from aqueous solution

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Journal of Environmental Sciences 2009年第4期21卷 539-544页

作者： Nassereldeen A Kabbashi Muataz A Atieh Abdullah Al-Mamun Mohamed E S Mirghami MD Z Alam Noorahayu Yahya Bio-Environmental research Unit Department of Biotechnology Engineering International Islamic University MalaysiaJalan Gombak 50728 Malaysia Nanoscience and nanotechnology Group Department of Biotechnology Engineering International Islamic University MalaysiaJalan Gombak 507283 Malaysia Department of Chemical Engineering King Fahd University for Petroleum and MineralSaudi Arabia

The capability of carbon nanotubes （CNTs） to adsorb lead （Pb） in aqueous solution was investigated. Batch mode adsorption experiment was conducted to determine the effects of pH, agitation speed, CNTs dosage and contact time. The removal of Pb（II） reached maximum value 85% or 83% at pH 5 or 40 mg/L of CNTs, respectively. Higher correlation coefficients from Langmuir isotherm model indicates the strong adsorptions of Pb（II） on the surface of CNTs （adsorption capacity Xm = 102.04 mg/g）. The results indicates that the highest percentage removal of Pb （96.03%） can be achieved at pH 5, 40 mg/L of CNTs, contact time 80 min, and agitation speed 50 r/min.

关键词： lead removal carbon nanotubes kinetic modeling adsorption

Enhanced depolluting capabilities of microbial bioelectrochemical systems by synthetic biology

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Synthetic and Systems biotechnology 2023年第3期8卷 341-348页

作者： Le Tao Maoyong Song Guibin Jiang Key Laboratory of Environmental nanotechnology and Health Effects Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of ScienceBeijing100085 University of Chinese Academy of Sciences Beijing100049China

Microbial bioelectrochemical system(BES)is a promising sustainable technology for the electrical energy recovery and the treatment of recalcitrant and toxic *** microbial BESs,the conversion of harmful pollutants into harmless products can be catalyzed by microorganisms at the anode(Type I BES),chemical catalysts at the cathode(Type II BES)or microorganisms at the cathode(Type III BES).The application of synthetic biology in microbial BES can improve its pollutant removing *** biology techniques can promote EET kinetics,which is helpful for microbial anodic electro-respiration,expediting pollutant removing not only at the anode but also at the *** offer tools to promote biofilm development on the electrode,enabling more microorganisms residing on the electrode for subsequent catalytic reactions,and to overexpress the pollutant removing-related genes directly in microorganisms,contributing to the pollutant *** this work,based on the summarized aspects mentioned above,we describe the major synthetic biology strategies in designing and improving the pollutant removing capabilities of microbial ***,we discuss challenges and perspectives for future studies in the area.

关键词： Microbial bioelectrochemical system Extracellular electron transfer Synthetic biology Pollutant removing

Alginate and alginate composites for biomedical applications

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Asian Journal of Pharmaceutical Sciences 2021年第3期16卷 280-306页

作者： Raha Ahmad Raus Wan Mohd Fazli Wan Nawawi Ricca Rahman Nasaruddin Department of biotechnology Engineering International Islamic University MalaysiaKuala Lumpur 50728Malaysia Nanoscience and nanotechnology research Group(NanoRG) International Islamic University MalaysiaKuala Lumpur 50728Malaysia

Alginate is an edible heteropolysaccharide that abundantly available in the brown seaweed and the capsule of bacteria such as Azotobacter *** Pseudomonas *** to alginate gel forming capability,it is widely used in food,textile and paper industries;and to a lesser extent in biomedical applications as biomaterial to promote wound healing and tissue *** is evident from the rising use of alginate-based dressing for heavily exuding wound and their mass availability in the market ***,alginate also has *** in contact with physiological environment,alginate could gelate into softer structure,consequently limits its potential in the soft tissue regeneration and becomes inappropriate for the usage related to load bearing body *** cater this problem,wide range of materials have been added to alginate structure,producing sturdy composite *** instance,the incorporation of adhesive peptide and natural polymer or synthetic polymer to alginate moieties creates an improved composite material,which not only possesses better mechanical properties compared to native alginate,but also grants additional healing capability and promote better tissue *** addition,drug release kinetic and cell viability can be further improved when alginate composite is used as encapsulating *** this review,preparation of alginate and alginate composite in various forms(fibre,bead,hydrogel,and 3D-printed matrices)used for biomedical application is described first,followed by the discussion of latest trend related to alginate composite utilization in wound dressing,drug delivery,and tissue engineering applications.

关键词： Alginate Alginate composite Tissue engineering Wound dressing Drug delivery