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Taxonomy and phylogeny of the section Chaetoceros(Chaetocerotaceae,Bacillariophyta),with description of two new species

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Journal of Oceanology and Limnology 2024年第4期42卷 1286-1311页

作者： Xudan LU Mengyi ZHAI Nina LUNDHOLM Yang LI Guangdong Provincial Key Laboratory of biotechnology for Plant Development Guangzhou Key Laboratory of Subtropical Biodiversity and BiomonitoringCollege of Life ScienceSouth China Normal UniversityGuangzhou 510631China Natural History Museum of Denmark University of CopenhagenCopenhagen K 1353Denmark

Chaetoceros Ehrenberg is one of the most diverse genera of planktonic *** species in section Chaetoceros are characterized by cells and setae having numerous chloroplasts and being widely ***,the delimitations of some species are problematic because of limited morphological information in the classical *** strains of the section Chaetoceros were established,morphological features were studied using light and electron microscopy,and the hypervariable D 1-D 3 region of the nuclear ribosomal large subunit gene was sequenced to address phylogenetic *** species belonging to the section Chaetoceros were recorded,including two new species,*** *** *** *** hainanensis was characterized by straight chains,narrowly lanceolate to hexagonal apertures,sibling setae diverging in nearly right angles,stipule-shaped spines on terminal setae and arrowhead-shaped spines on intercalary *** had short straight chains,narrowly lanceolate apertures,arrowhead-shaped spines and circular poroids arranged in a grid pattern on terminal and intercalary *** phylogenetic analyses revealed six groups formed by 19 species within the section Chaetoceros,which was found to be *** subdivision of the section is still not well *** morphological characters within each group varied considerably and molecular information on more species are needed to enrich the phylogenetic profiling.

关键词： morphology large subunit ribosomal RNA encoding gene(LSU) section Chaetoceros Chaetoceros hainanensis Chaetoceros tridiscus

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Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2024年

作者： Sili Wang Jiancheng Huang Yanan Du Wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan Shi Bin Hong Xiaoying Bian Wen Liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science&Peking Union Medical College

Cobalamin (Cbl)-dependent radical S-adenosyl-L-methionine (SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual *** of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding *** the biosynthetic pathway of chuangxinmycin (CXM),a unique indole alkaloid antibiotic with potent anti-infective activity,functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process,which,however,remained to be reconstituted *** here report the dissection of this enzymatic process,which requires the incorporation of Cxm8,a Cbl-dependent radical SAM protein,with Cxm9,a DUF5825family protein that shares no homology to any proteins of known ***8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner,achieving CXM and a recently identified,C3-dimethylated *** biochemical characterization,isotope labeling,structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase *** is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

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Gut microbiota: a potential target for hyperuricemia and gout

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Food Science and Human Wellness 2024年

作者： Feiyan Zhao Shuying Yang Laiyu Kwok Hongbin Li Heping Zhang Zhihong Sun Inner Mongolia Key Laboratory of Dairy biotechnology and Engineering Key Laboratory of Dairy Products Processing， Ministry of Agriculture and Rural Affairs Key Laboratory of Dairy biotechnology and Engineering， Ministry of Education， Inner Mongolia Agricultural University Department of Rheumatology and Immunology， The Affiliated Hospital of Inner Mongolia Medical University， Inner Mongolia Key Laboratory for Pathogenesis and Diagnosis of Rheumatic and Autoimmune Diseases

Modern lifestyle and diet have increased the incidence rate of uric acid (UA) metabolism-related diseases like hyperuricemia (HUA) and gout， posing heavy economic burden to individual patients and their families and the society. Uric acid metabolism is a complex physiological process involving the kidney， intestine， and other organs. A number of factors together regulate UA metabolism， including genetics， diet， hormones， and the gut microbiota. This review summaries the gut microbiota features in subjects with HUA and gout， and the therapeutic effects of implementing microecological therapies (probiotics， prebiotics， or fecal microbiota transplant) that target modulate the gut microbiota and its downstream metabolism on the disease. Current evidence shows that these strategies are safe and promising in alleviate inflammation， reduce UA， and restoring a healthy gut microbiota in subjects with UA metabolism-related diseases. However， most clinical data are generated by animal studies. Therefore， we propose that vigorous human intervention trials should be conducted in the future to evaluate the therapeutic effects of microecological therapies in managing HUA and gout.

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Using NH_(2)-MIL-125(Ti)for efficient removal of Cr(Ⅵ)and Rh B from aqueous solutions:Competitive and cooperative behavior in the binary system

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Journal of Environmental Sciences 2024年第2期136卷 437-450页

作者： Lei Zheng Lixia Sun Jiangbo Qiu Junling Song Luyi Zou Yue Teng Yongzhong Zong Hongyan Yu School of Environmental and Civil Engineering Jiangnan UniversityWuxi 214122China School of Chemical and Material Engineering Jiangnan UniversityWuxi 214122China Kunming South Water Co. Ltd.Kunming 650501China Jiangsu Key Laboratory of Anaerobic biotechnology Jiangnan UniversityWuxi 214122China

The coexistence of inorganic and organic contaminants is a challenge for real-life water treatment ***,in this research,we used NH_2-MIL-125(Ti)to evaluate the single adsorption of hexavalent chromium(Cr(Ⅵ))or Rhodamine B(RhB)in an aqueous solution and further investigate simultaneous adsorption experiments to compare the adsorption behavior *** main influencing factors,for example,reaction time,initial concentration,reaction temperature,and pH were studied in *** all reaction systems,the pseudo-second-order kinetic and Langmuir isotherm models were well illuminated the adsorption progress of Cr(Ⅵ)and *** studies showed that the adsorption process was spontaneous and *** compared to the single system,the adsorption capacity of Cr(Ⅵ)in the binary system gradually decreased as the additive amount of RhB increased,whereas the adsorption capacity of RhB in the binary system was expanded *** the binary reaction system contained 100 mg/L Cr(Ⅵ),the removal rate of RhB increased to 97.58%.The formation of Cr(Ⅵ)-RhB and Cr(Ⅲ)-RhB complexes was the cause that provided facilitation for the adsorption of *** findings prove that the interactions during the water treatment process between contaminants may obtain additional benefits,contributing to a better adsorption capacity of co-existing contaminant.

关键词： Adsorption Heavy metal ion Organic dye Simultaneous removal Mechanism studies

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Efficient degradation of aqueous dichloromethane by an enhanced microbial electrolysis cell:Degradation kinetics,microbial community and metabolic mechanisms

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Journal of Environmental Sciences 2024年第5期139卷 150-159页

作者： Meng Wu Di Zhao Bing Gu ZiruWang Jun Hu Zhiliang Yu Jianming Yu College of Environment College of Biotechnology and BioengineeringCollaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China Shentuo Environment(Hangzhou)Co.Ltd. Hangzhou 311121China Zhejiang Tianyi Environmental Co.Ltd. Hangzhou 310000China

Dichloromethane(DCM)has been listed as a toxic and harmful water pollutant,and its re moval needs *** electrolysis cells(MECs)are viewed as a promising alterna tive for pollutant removal,which can be strengthened from two aspects:microbial inocula tion and *** this study,the MEC for DCM degradation was inoculated with the ac tive sludge enhanced by Methylobacterium rhodesianum H13(strain H13)and then acclimated in the form of a microbial fuel cell(MFC).Both the introduction of strain H13 and the initi ation in MFC form significantly promoted DCM *** degradation kinetics were fitted by the Haldane model,with V_(max),K_(h),K_(i)and v_(max)values of 103.2 mg/L/hr,97.8 mg/L268.3 mg/L and 44.7 mg/L/hr/cm^(2),*** cyclic voltammogram implies that DCM redox reactions became easier with the setup of MEC,and the electrochemical impedance spectrogram shows that the acclimated and enriched microbes reduced the charge transfe resistance from the electrode to the *** the biofilm,the dominant genera shifted from Geobacter to Hyphomicrobium in acclimation ***,Methylobacterium played an increasingly important *** metabolism mainly occurred through the hydrolytic glutathione S-transferase pathway,given that the gene dcmA was identified rather than the dhlA and P450/*** exogenous electrons facilitated the reduction of GSSG,directly o indirectly accelerating the GSH-catalyzed *** study provides support fo the construction of an efficient and stable MEC for DCM removal in water environment.

关键词： Dichloromethane Microbial electrolysis cells Metabolic pathways Electron transfer Degradation kinetics

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O-methyltransferase CbzMT catalyzes iterative 3,4-dimethylations for carbazomycin biosynthesis

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Engineering Microbiology 2024年第2期4卷 51-61页

作者： Baixin Lin Dashan Zhang Junbo Wang Yongjian Qiao Jinjin Wang Zixin Deng Lingxin Kong Delin You State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSchool of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200030China

Carbazomycins(1-8)are a subgroup of carbazole derivatives that contain oxygen at the C3 and C4 positions and an unusual asymmetric substitution *** of these compounds exhibit antifungal and antioxidant *** date,no systematic biosynthetic studies have been conducted on *** this study,carbazomycins A and B(1 and 2)were isolated from Streptomyces luteosporeus NRRL 2401 using a one-strain-many-compound(OSMAC)-guided natural product mining screen.A biosynthetic gene cluster(BGC)was iden-tified,and possible biosynthetic pathways for 1 and 2 were *** in vivo genetic manipulation of the O-methyltransferase-encoding gene cbzMT proved indispensable for 1 and 2 *** exclusion chro-matography indicated that CbzMT was active as a *** vitro biochemical assays confirmed that CbzMT could repeatedly act on the hydroxyl groups at C3 and C4,producing monomethylated 2 and dimethylated *** carbazomycin B(2)is not easily methylated;however,CbzMT seemingly prefers the dimethy-lation of the dihydroxyl substrate(12)to 1,even with a low conversion *** findings not only improve the understanding of carbazomycin biosynthesis but also expand the inventory of OMT-catalyzing it-erative methylations on different acceptor sites,paving the way for engineering biocatalysts to synthesize new active carbazomycin derivatives.

关键词： One-strain-many-compounds(OSMAC) Carbazole Carbazomycins O-methyltransferase Iterative methylation

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Prevotella and succinate treatments altered gut microbiota,increased laying performance,and suppressed hepatic lipid accumulation in laying hens

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Journal of Animal Science and biotechnology 2024年第2期15卷 844-861页

作者： Min Liu Zeyue Kang Xikang Cao Hongchao Jiao Xiaojuan Wang Jingpeng Zhao Hai Lin College of Animal Science and Technology Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and PreventionKey Laboratory of Efficient Utilization of Non‑Grain Feed Resources(Co‑Construction by Ministry and Province)Ministry of Agriculture and Rural AffairsShandong Agricultural UniversityTai’an 271018China

Background This work aimed to investigate the potential benefits of administering Prevotella and its primary metabolite succinate on performance,hepatic lipid accumulation and gut microbiota in laying *** One hundred and fifty 58-week-old Hyline Brown laying hens,with laying rate below 80%and plasma triglyceride(TG)exceeding 5 mmol/L,were used in this *** hens were randomly allocated into 5 groups and subjected to one of the following treatments:fed with a basal diet(negative control,NC),oral gavage of 3 mL/hen saline every other day(positive control,PC),gavage of 3 mL/hen Prevotella melaninogenica(10^(7)CFU/mL,PM)or 3 mL/hen Prevotella copri(10^(7)CFU/mL,***)every other day,and basal diet supplemented with 0.25%sodium succinate(Succinate).The results showed that PM and *** treatments significantly improved laying rate compared to the PC(P0.05).PM treatment increased(P<0.05)the mRNA levels of genes PGC-1βand APB-5B at week 4,and ACC and CPT-1 at week *** results indicated enhanced antioxidant activities at week 8,as evidenced by reduced hepatic malondialdehyde(MDA)level and improved antioxidant enzymes activities in PM and Succinate groups(P<0.05).Supplementing with Prevotella or succinate can alter the cecal ***,the abundance of Prevotella in the Succinate group was significantly higher than that in the other 4 groups at the family and genus levels(P<0.05).Conclusions Oral intake of Prevotella and dietary supplementation of succinate can ameliorate lipid metabolism of laying *** beneficial effect of Prevotella is consistent across different *** finding highlights that succinate,the primary metaboli

关键词： Fatty liver Gut microbiota Laying hen Prevotella Succinate

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An overview of pigment gland morphogenesis and its regulatory mechanism

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Journal of Cotton Research 2024年第2期7卷 207-214页

作者： SUN Yue YANG Ping HAN Yifei LI Huazu SUN Deli CHEN Jinhong ZHU Shuijin ZHAO Tianlun College of Agriculture and biotechnology Zhejiang UniversityHangzhou 310058China Agricultural Experiment Station Zhejiang UniversityHangzhou 310058China Institute of Hainan Zhejiang UniversitySanyaHainan 572025China

Cotton has enormous economic potential,providing high-quality protein,oil,and *** the comprehensive utilization of cottonseed is limited by the presence of pigment gland and its *** gland is a common characteristic of Gossypium genus and its relatives,appearing as visible dark opaque dots in most tissues and organs of cotton *** metabolites,such as gossypol,synthesized and stored in the cavities of pigment glands act as natural phytoalexins,but are toxic to humans and other monogastric ***,only a few cotton genes have been identified as being associated with pigment gland morphogenesis to date,and the developmental processes and regulatory mechanism involved in pigment gland formation remain largely ***,the research progress on the process of pigment gland morphogenesis and the genetic basis of cotton pigment glands is reviewed,for providing a theoretical basis for cultivating cotton with the ideal pigment gland trait.

关键词： Cotton Pigment gland morphogenesis Transcriptional regulation Terpenoids biosynthesis

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A novel semi-dominant allele of the transmembrane NAC transcription factor ZmNTL2 reduces the size of multiple maize organs

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The Crop Journal 2024年第3期12卷 676-687页

作者： Chuan Li Yun Bai Yuwei Hou Siyu Wang Yue Xin Tao Yu Jing Wang Xiaowei Liu Hongyang Yi Chao Xia Hai Lan Moju Cao State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Maize Research InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina Jilin Engineering Research Center for Crop biotechnology Breeding College of Plant ScienceJilin UniversityChangchun 130012JilinChina

Maize plant architecture influences planting density and,in turn,grain *** of the plant architecture-related traits can be described as organ *** describe a miniature maize mutant,Tiny plant 4(Tip4),which exhibits reduced size of multiple organs and exhibits a semi-dominant monofactorial inheritance *** cloning confirmed that a 4-bp deletion in the NAC TF with transmembrane motif 1-Like(NTL)gene ZmNTL2,denoted as ZmNTL2^(Δ),confers the Tip4 ***-PCR showed that ZmNTL2 was expressed in all tested ***2 functions as a transcriptional activator and is located in both the nucleus and *** mutation does not affect the mRNA abundance of ZmNTL2 locus,but it does result in the loss of transmembrane domain and confines the ZmNTL2^(Δ)protein to the *** out ZmNTL2 has no effect on maize organ size development,indicating that the 4-bp deletion might be a gain-of-function mutation in organ size *** transcriptome sequencing with cytokinin and auxin content determination suggests that the decreased organ size may be possibly mediated by changes in hormone homeostasis.

关键词： Organ size c-ray mutagenesis Membrane-bound NAC TF Hormone homeostasis Maize

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Discovery and mechanism of anti-hypertensive effect of a novel tripeptide(SYP) from medicinal fungus Ganoderma lingzhi

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Food Science and Human Wellness 2024年

作者： Qiang Wu Feijun Luo Jia Huang Ping Huang Yongnan Liu Xiaoling Wang Gaoqiang Liu Hunan Provincial Key Laboratory of Forestry biotechnology and International Cooperation Base of Science and Technology Innovation on Forest Resource biotechnology， Central South University of Forestry and Technology Microbial Variety Creation Center，Laboratory of Yuelushan Seed Industry College of Food and Chemical Engineering， Shaoyang University Laboratory of Molecular Nutrition， National Engineering Laboratory for Rice and Byproducts， Central South University of Forestry and Technology

Ganoderma lingzhi is a new species of the prize medicinal mushroom Ganoderma (Agaricomycetes). Using angiotensin I-converting enzyme (ACE) as a target， a tripeptide Ser-Tyr-Pro (SYP) was discovered with preponderant ACE inhibitory activity with an 50% inhibiting concentration (IC50) value of 62.50 μg/mL attribute to the formed salt bridge and hydrogen bonds between SYP and ACE. SYP even maintained superior bioactivity after intestinal digestion， and exerted no cytotoxicity， but presented incomplete bioavailability in blood of spontaneous hypertensive rats (SHRs). Furthermore， it performed antihypertensive effect in vivo by inhibiting the influx of Ca2+through activating endothelial NO synthase (eNOS)/NO/guanosine 3’，5’-cyclic monophosphate (cGMP) pathway， accompanied by attenuating angiotensin Ⅱ (Ang Ⅱ)/NADPH oxidase (NOX)/ROS pathway. This work not only discoverers a novel pharmacological ingredient from medicinal mushroom G. lingzhi for hypertension therapy， but also provides an insight into molecular mechanism of the ACE inhibitory peptide (ACEIP) on lowering blood pressure.

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